| The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4. | The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4.
Luzzio A, Edie S, Palmer K, Caddle LB, Urban R, Goodwin LO, Welsh IC, Reinholdt LG, Bergstrom DE, Cox TC, Donahue LR, Murray SA. | 08/1/2023 |
| Inactivation of Fgf3 and Fgf4 within the Fgf3/Fgf4/Fgf15 gene cluster reveals their redundant requirement for mouse inner ear induction and embryonic survival. | Inactivation of Fgf3 and Fgf4 within the Fgf3/Fgf4/Fgf15 gene cluster reveals their redundant requirement for mouse inner ear induction and embryonic survival.
Zelarayan L, Vendrell V, Domínguez-Frutos E, López-Hernández I, Schimmang-Alonso K, Alonso MT, Alvarez Y, Maier H, Anderson MJ, Lewandoski M, Schimmang T., Free PMC Article | 05/14/2022 |
| results indicate that Fgf3 hypomethylation and gene overexpression, but not protein expression, occurred in the early stage of oral carcinogenesis induced by DBP | Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene.
Sun YW, Chen KM, Imamura Kawasawa Y, Salzberg AC, Cooper TK, Caruso C, Aliaga C, Zhu J, Gowda K, Amin S, El-Bayoumy K., Free PMC Article | 12/16/2017 |
| We demonstrate that elevated BMP4 depletes PSM progenitors in vitro, phenocopying the Fgf3 mutant, suggesting that excessive BMP signals cause the Fgf3 axis defect. To test this in vivo we increased BMP signaling in Fgf3 mutants by removing one copy of Noggin, which encodes a BMP antagonist. | An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension.
Anderson MJ, Schimmang T, Lewandoski M., Free PMC Article | 05/27/2017 |
| FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing beta-catenin signaling. | FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling.
Liu C, Gu S, Sun C, Ye W, Song Z, Zhang Y, Chen Y., Free PMC Article | 12/14/2013 |
| Ectopic expression of Fgf3 leads to aberrant lineage segregation in the mouse parthenote preimplantation embryos. | Ectopic expression of Fgf3 leads to aberrant lineage segregation in the mouse parthenote preimplantation embryos.
Chen YH, Yu J. | 03/23/2013 |
| Data suggest that Fgf3/Fgfr3 signaling is required for maintenance of Gnrh (gonadotropin-releasing hormone) neurons in aging hypothalamus; postnatal Gnrh system is plastic/resilient, able to override preexisting defects and respond to external cues. | Opposite-sex housing reactivates the declining GnRH system in aged transgenic male mice with FGF signaling deficiency.
Rochester JR, Chung WC, Hayes TB, Tsai PS., Free PMC Article | 03/2/2013 |
| Fgf3 and Fgf10 are not required for specification of cardiovascular progenitors, but rather for their normal developmental coordination. | Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development.
Urness LD, Bleyl SB, Wright TJ, Moon AM, Mansour SL., Free PMC Article | 10/1/2011 |
| Microarray analysis was used to identify prospective placode genes that were differently expressed in control and Fgf3(-)(/)(-)embryos. | FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a.
Urness LD, Paxton CN, Wang X, Schoenwolf GC, Mansour SL., Free PMC Article | 05/31/2010 |
| alterations in dosage of the Fgf3 gene cause dental morphological changes in genetically engineered mutants | Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition.
Charles C, Lazzari V, Tafforeau P, Schimmang T, Tekin M, Klein O, Viriot L., Free PMC Article | 02/22/2010 |
| Fgf3 is not required for mouse forebrain development whereas Fgf8 has a central role during this process. | Differential requirements for Fgf3 and Fgf8 during mouse forebrain development.
Theil T, Dominguez-Frutos E, Schimmang T. | 01/21/2010 |
| Although many reports have pointed to the role of FGF3 in otic regionalisation, we provide evidence that FGF3 is not sufficient to govern this process. | Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain.
Vázquez-Echeverría C, Dominguez-Frutos E, Charnay P, Schimmang T, Pujades C. | 01/21/2010 |
| Disruption in an Fgf3, -10/Dlx5 signaling cascade is operant in molecular mechanisms of inner ear teratogenesis by excess retinoic acid. | Retinoic acid-induced inner ear teratogenesis caused by defective Fgf3/Fgf10-dependent Dlx5 signaling.
Liu W, Levi G, Shanske A, Frenz DA. | 01/21/2010 |
| Data show in mouse that Fgf3 is required during morphogenesis for both auditory and vestibular function. | Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium.
Hatch EP, Noyes CA, Wang X, Wright TJ, Mansour SL., Free PMC Article | 01/21/2010 |
| Fgf3 gene is developmentally regulated by sonic hedgehog (Shh) signalling | Regulatory analysis of the mouse Fgf3 gene: control of embryonic expression patterns and dependence upon sonic hedgehog (Shh) signalling.
Powles N, Marshall H, Economou A, Chiang C, Murakami A, Dickson C, Krumlauf R, Maconochie M. | 01/21/2010 |
| transforming capacity of FGF3 attached to phospholipid membrane | FGF3 attached to a phosholipid membrane anchor gains a high transforming capacity. Implications of microdomains for FGF3 cell transformation.
Köhl R, Antoine M, Reimers K, Kiefer P. | 01/21/2010 |
| signalling by FGFR3 plays a more prominent role in cartilage maturation and vascular invasion at the chondro-osseous junction | Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development.
Amizuka N, Davidson D, Liu H, Valverde-Franco G, Chai S, Maeda T, Ozawa H, Hammond V, Ornitz DM, Goltzman D, Henderson JE. | 01/21/2010 |
| inducible expression in mammary gland and mammary gland neoplasms | Inducible expression of FGF-3 in mouse mammary gland.
Ngan ES, Ma ZQ, Chua SS, DeMayo FJ, Tsai SY., Free PMC Article | 01/21/2010 |
| Results suggest that Runx2 mediates the functions of epithelial FGF signals regulating Fgf3 expression in the dental mesenchyme and that Fgf3 may be a direct target gene of Runx2. | Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis.
Aberg T, Wang XP, Kim JH, Yamashiro T, Bei M, Rice R, Ryoo HM, Thesleff I. | 01/21/2010 |
| Fgf-3 transcription is activated by SOX7 and GATA-4, which bind competitively | SOX7 and GATA-4 are competitive activators of Fgf-3 transcription.
Murakami A, Shen H, Ishida S, Dickson C. | 01/21/2010 |
| Over expression of FGF-3 results in abnormal prostate and Wolffian duct development | Ectopic expression of FGF-3 results in abnormal prostate and Wolffian duct development.
Chua SS, Ma ZQ, Gong L, Lin SH, DeMayo FJ, Tsai SY. | 01/21/2010 |