| Results suggest that PU.1 and LDB1 play central roles in the formation of active chromatin structure whereas GATA2 directly activates the Ms4a2 promoter. | GATA2 and PU.1 Collaborate To Activate the Expression of the Mouse Ms4a2 Gene, Encoding FcεRIβ, through Distinct Mechanisms.
Ohmori S, Ishijima Y, Numata S, Takahashi M, Sekita M, Sato T, Chugun K, Yamamoto M, Ohneda K., Free PMC Article | 02/29/2020 |
| Analysis of the conformation and thermal stability of the high-affinity IgE Fc receptor beta chain polymorphic proteins has been presented. | Analysis of the conformation and thermal stability of the high-affinity IgE Fc receptor β chain polymorphic proteins.
Terada T, Takahashi T, Arikawa H, Era S. | 01/28/2017 |
| chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family | Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis.
Hálová I, Dráberová L, Bambousková M, Machyna M, Stegurová L, Smrž D, Dráber P., Free PMC Article | 06/1/2013 |
| Findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcepsilonRI and the IL-3 receptor. | SLP-76 is required for high-affinity IgE receptor- and IL-3 receptor-mediated activation of basophils.
Hidano S, Kitamura D, Kumar L, Geha RS, Goitsuka R. | 04/13/2013 |
| These observations strongly suggest a novel signaling pathway mediated by the cytoplasmic tail downstream of the FcepsilonRIbeta immunoreceptor tyrosine-based activation motif. | FcεRI-induced mast cell cytokine production critically involves an aspartic acid residue (D234) in the C-terminal intracellular domain of the FcεRIβ chain.
Terada T, Nunomura S, Shimokawa T, Murayama K, Era S, Kondo N, Ra C. | 09/24/2011 |
| FcRbeta is a critical element in mast cell synergistic degranulation response through FcepsilonRI & adenosine receptors. PI3K-signaling through FcRbeta-ITAM is a crucial participant in augmentation of FcepsilonRI-mediated degranulation by adenosine. | FcepsilonRI beta-chain ITAM amplifies PI3K-signaling to ensure synergistic degranulation response via FcepsilonRI and adenosine receptors.
Nunomura S, Gon Y, Yoshimaru T, Kashiwakura J, Kawakami T, Ra C. | 05/31/2010 |
| inhibition of FcepsilonRI-dependent mast cell activation can suppress allergic contact dermatitis | Abrogation of high-affinity IgE receptor-mediated mast cell activation at the effector phase prevents contact hypersensitivity to oxazolone.
Kobayashi M, Nunomura S, Gon Y, Endo D, Kishiro S, Fukunaga M, Kitahata Y, Terui T, Ra C. | 03/22/2010 |
| IgE signaling suppresses FcepsilonRIbeta expression. | IgE signaling suppresses FcepsilonRIbeta expression.
Brenzovich J, Macey M, Fernando J, Chong HJ, Barnstein B, Mirmonsef P, Morales JK, Kimura A, Cruz TD, Ryan JJ., Free PMC Article | 01/21/2010 |
| FcepsilonRI beta-chain regulates calcium uptake in mast cells via the immunoreceptor tyrosine-based activation motif. | The high-affinity immunoglobulin E receptor (FcepsilonRI) regulates mitochondrial calcium uptake and a dihydropyridine receptor-mediated calcium influx in mast cells: Role of the FcepsilonRIbeta chain immunoreceptor tyrosine-based activation motif.
Suzuki Y, Yoshimaru T, Inoue T, Nunomura S, Ra C. | 01/21/2010 |
| IgE receptors are expressed on sensory neurons in mice. Immunostaining revealed that the high affinity IgE receptor FcepsilonRI was expressed in cultured dorsal root ganglion cells. | Expression of Fc epsilon receptor I on primary sensory neurons in mice.
Andoh T, Kuraishi Y. | 01/21/2010 |
| The mouse Fc epsilon RI beta-chain gene promoter is functional only in mouse mast cell line PT18, but not in mono-macrophage and lymphoma cell lines. | Regulation of cell type-specific mouse Fc epsilon RI beta-chain gene expression by GATA-1 via four GATA motifs in the promoter.
Maeda K, Nishiyama C, Tokura T, Akizawa Y, Nishiyama M, Ogawa H, Okumura K, Ra C. | 01/21/2010 |
| Gene expression profiling after stimulation via high-affinity Fcepsilon receptor I (FcepsilonRI), showed the transcriptional levels of several CC chemokines were markedly increased. | Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fcepsilon receptor I cross-linking: an interspecies comparison.
Nakajima T, Inagaki N, Tanaka H, Tanaka A, Yoshikawa M, Tamari M, Hasegawa K, Matsumoto K, Tachimoto H, Ebisawa M, Tsujimoto G, Matsuda H, Nagai H, Saito H. | 01/21/2010 |
| FcepsilonRIbeta functions to both selectively amplify (degranulation and leukotriene secretion) and dampen (lymphokine) mast cell effector responses | The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production.
Furumoto Y, Nunomura S, Terada T, Rivera J, Ra C. | 01/21/2010 |