| A Co-Expressed Natural Antisense RNA FCER1A-AS Controls IgE-Dependent Immunity by Promoting Expression of FcepsilonRIalpha. | A Co-Expressed Natural Antisense RNA FCER1A-AS Controls IgE-Dependent Immunity by Promoting Expression of FcεRIα.
Tang RY, Yin L, Yao L, Zhang QF, Chen XP., Free PMC Article | 08/25/2023 |
| IRF3 Activation in Mast Cells Promotes FcepsilonRI-Mediated Allergic Inflammation. | IRF3 Activation in Mast Cells Promotes FcεRI-Mediated Allergic Inflammation.
Choi YA, Dhakal H, Lee S, Kim N, Lee B, Kwon TK, Khang D, Kim SH., Free PMC Article | 06/14/2023 |
| Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcepsilonRI in mast cells. | Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcεRI in mast cells.
Zhou C, Li M, Liu Y, Wang X, Zhang S, Guan L, Hong J, Zhou W, Wu G, Diao W, Huang Q, Yang P., Free PMC Article | 03/11/2023 |
| House Dust Mite-Induced Allergic Airway Disease Is Independent of IgE and FcepsilonRIalpha. | House Dust Mite-Induced Allergic Airway Disease Is Independent of IgE and FcεRIα.
McKnight CG, Jude JA, Zhu Z, Panettieri RA Jr, Finkelman FD., Free PMC Article | 12/9/2017 |
| this study shows that mast cells co-cultured with macrophages alter protein expression of both cell types, and that mast cells transfer FceRI-encompassed cellular regions directly to macrophages during Francisella tularensis | Contribution of FcɛRI-associated vesicles to mast cell-macrophage communication following Francisella tularensis infection.
Rodriguez AR, Yu JJ, Navara C, Chambers JP, Guentzel MN, Arulanandam BP. | 07/1/2017 |
| Tim-3 acts at a receptor-proximal point to enhance Lyn kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI ligation. | Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation.
Phong BL, Avery L, Sumpter TL, Gorman JV, Watkins SC, Colgan JD, Kane LP., Free PMC Article | 05/28/2016 |
| Data indicate that white adipose tissue from IgE receptor FcR1-deficient Fcer1a(-/-) mice showed an increased expression of CCAAT-enhancer-binding protein-alpha (C-EBPalpha) and peroxisome proliferator-activated receptor-gamma (PPARgamma). | Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice.
Lee YJ, Liu C, Liao M, Sukhova GK, Shirakawa J, Abdennour M, Iamarene K, Andre S, Inouye K, Clement K, Kulkarni RN, Banks AS, Libby P, Shi GP., Free PMC Article | 04/16/2016 |
| Conferring expression of FcepsilonRI to dendritic cells decreases the severity of food allergy and asthma in disease-relevant models suggesting anti-inflammatory IgE/FcepsilonRI signals. | Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites.
Platzer B, Baker K, Vera MP, Singer K, Panduro M, Lexmond WS, Turner D, Vargas SO, Kinet JP, Maurer D, Baron RM, Blumberg RS, Fiebiger E., Free PMC Article | 03/12/2016 |
| IgE-mediated activation of dendritic cells via IgE receptors binding in allergic Th2-type inflammation appears to be immune regulatory rather than pro-inflammatory. (Review) | Functions of dendritic-cell-bound IgE in allergy.
Platzer B, Stout M, Fiebiger E., Free PMC Article | 01/30/2016 |
| Tetraspanin CD151 Is a Negative Regulator of FcepsilonRI-Mediated Mast Cell Activation | Tetraspanin CD151 Is a Negative Regulator of FcεRI-Mediated Mast Cell Activation.
Abdala-Valencia H, Bryce PJ, Schleimer RP, Wechsler JB, Loffredo LF, Cook-Mills JM, Hsu CL, Berdnikovs S., Free PMC Article | 11/28/2015 |
| Specific cross-linking of the high affinity immunoglobulin epsilon receptor on the surface of bone marrow-derived mast cells and heart mast cells elicits the release of enzymatically active renin protein. | IgE receptor-mediated mast-cell renin release.
Aldi S, Robador PA, Tomita K, Di Lorenzo A, Levi R, Aldi S, Robador PA, Tomita K, Di Lorenzo A, Levi R., Free PMC Articles: PMC3906484, PMC3906484 | 10/27/2015 |
| CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcepsilonRIalpha. | CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcεRIα.
Kataoka TR, Kumanogoh A, Fukuishi N, Ueshima C, Hirata M, Moriyoshi K, Tsuruyama T, Haga H. | 09/26/2015 |
| Zinc-binding MT1 and MT2 are key modulators of Fc epsilonRI-induced basophil production of IL-4. | Zinc-binding metallothioneins are key modulators of IL-4 production by basophils.
Ugajin T, Nishida K, Yamasaki S, Suzuki J, Mita M, Kubo M, Yokozeki H, Hirano T. | 08/15/2015 |
| Loss of Tespa1 in mouse mast cells led to hyper-responsiveness to stimulation via FcepsilonRI. | Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.
Wang D, Zheng M, Qiu Y, Guo C, Ji J, Lei L, Zhang X, Liang J, Lou J, Huang W, Dong B, Wu S, Wang J, Ke Y, Cao X, Zhou YT, Lu L., Free PMC Article | 03/21/2015 |
| IgE-mediated allergic hypersensitivity provokes release of renin from both cultured and resident cardiac mast cells. | IgE receptor-mediated mast-cell renin release.
Aldi S, Robador PA, Tomita K, Di Lorenzo A, Levi R, Aldi S, Robador PA, Tomita K, Di Lorenzo A, Levi R., Free PMC Articles: PMC3906484, PMC3906484 | 09/20/2014 |
| Overexpression of miR-142-3p enhances FcepsilonRI-mediated degranulation. | miR-142-3p enhances FcεRI-mediated degranulation in mast cells.
Yamada Y, Kosaka K, Miyazawa T, Kurata-Miura K, Yoshida T. | 03/22/2014 |
| Findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcepsilonRI and the IL-3 receptor. | SLP-76 is required for high-affinity IgE receptor- and IL-3 receptor-mediated activation of basophils.
Hidano S, Kitamura D, Kumar L, Geha RS, Goitsuka R. | 04/13/2013 |
| OX40L engagement impairs FcepsilonRI activation and Gab2/PI3K/Akt, but not Syk/LAT, phosphorylation | Modulation of FcεRI-dependent mast cell response by OX40L via Fyn, PI3K, and RhoA.
Sibilano R, Frossi B, Suzuki R, D'Incà F, Gri G, Piconese S, Colombo MP, Rivera J, Pucillo CE. | 11/17/2012 |
| FcepsilonRI, but not FcgammaR, signals induce prostaglandin D2 and E2 production from basophils | FcεRI, but not FcγR, signals induce prostaglandin D2 and E2 production from basophils.
Ugajin T, Satoh T, Kanamori T, Aritake K, Urade Y, Yokozeki H., Free PMC Article | 04/14/2012 |
| data implicate Fyn as the major positive mediator of STAT5 after FcepsilonRI engagement and demonstrate importantly distinct roles for STAT5A and STAT5B in mast cell function. | Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production.
Pullen NA, Barnstein BO, Falanga YT, Wang Z, Suzuki R, Tamang TD, Khurana MC, Harry EA, Draber P, Bunting KD, Mizuno K, Wilson BS, Ryan JJ., Free PMC Article | 03/10/2012 |
| Reduced IgE/antigen-mediated passive cutaneous anaphylaxis is detected in mice with Piga-deficient mast cells. | Impaired FcεRI stability, signaling, and effector functions in murine mast cells lacking glycosylphosphatidylinositol-anchored proteins.
Hazenbos WL, Wu P, Eastham-Anderson J, Kinoshita T, Brown EJ., Free PMC Article | 12/24/2011 |
| The PI3K binding site is involved in FcepsilonRI-dependent ARF1 activation and granule translocation to the plasma membrane in the degranulation process, further dissecting the signals required for degranulation. | Gab2, via PI-3K, regulates ARF1 in FcεRI-mediated granule translocation and mast cell degranulation.
Nishida K, Yamasaki S, Hasegawa A, Iwamatsu A, Koseki H, Hirano T. | 09/24/2011 |
| Data show that EGFR, via interaction with FcvarepsilonRI and integrin alpha(5), is necessary for allergic inflammation associated with cellular interaction. | Integrin α(5) interacts with EGFR, is necessary for FcɛRI signaling and is necessary for allergic inflammation in relation with angiogenesis.
Kim Y, Kim K, Park D, Eom S, Park H, Lee H, Lee YS, Choe J, Hahn JH, Kim YM, Ro JY, Jeoung D. | 06/18/2011 |
| Itk plays both positive and negative roles, while Btk primarily plays a positive role in mast cell FcepsilonRI-induced cytokine secretion. | Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependent mast cell responses.
Iyer AS, Morales JL, Huang W, Ojo F, Ning G, Wills E, Baines JD, August A., Free PMC Article | 05/21/2011 |
| Whereas FcepsilonRI required Lyn and Syk for NTAL phosphorylation, Kit appeared to directly phosphorylate NTAL. | Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells.
Iwaki S, Spicka J, Tkaczyk C, Jensen BM, Furumoto Y, Charles N, Kovarova M, Rivera J, Horejsi V, Metcalfe DD, Gilfillan AM., Free PMC Article | 03/8/2011 |