| FAF1 plays a key role in ischemic retinal damage and may be implicated in the pathogenesis of retinal ischemic disease | FAF1 mediates necrosis through JNK1-mediated mitochondrial dysfunction leading to retinal degeneration in the ganglion cell layer upon ischemic insult.
Yu C, Kim BS, Park M, Do YJ, Kong YY, Kim E., Free PMC Article | 05/11/2019 |
| Data suggest that Faf1 plays role in meiotic resumption in oocytes; Faf1 mRNA and protein are persistently present during oogenesis/oocyte maturation; Faf1 mRNA levels are similar in germinal vesicle (GV), GV breakdown, and metaphase II stages of oogenesis/oocyte maturation. Theses studies were conducted in oocytes during in vitro oocyte maturation. | Fas-associated protein factor 1 is involved in meiotic resumption in mouse oocytes.
Peng H, Huo J, Gao Y, Chen J, Yu X, Xiao T., Free PMC Article | 09/29/2018 |
| NLRP2 interacts with FAF1 under normal physiological conditions | NLRP2 and FAF1 deficiency blocks early embryogenesis in the mouse.
Peng H, Liu H, Liu F, Gao Y, Chen J, Huo J, Han J, Xiao T, Zhang W. | 04/28/2018 |
| These data demonstrate the presence of an FAF1-PARP1 axis that is involved in oxidative stress-induced necrosis and in the pathology of Parkinson's disease. | FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration.
Yu C, Kim BS, Kim E., Free PMC Article | 12/16/2017 |
| FAF1 knockdown immune cells were highly susceptible to RNA virus infection and showed low levels of inflammatory cytokines and type I interferon (IFN) production. | FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1.
Kim JH, Park ME, Nikapitiya C, Kim TH, Uddin MB, Lee HC, Kim E, Ma JY, Jung JU, Kim CJ, Lee JS., Free PMC Article | 11/25/2017 |
| Increased FAF1 expression triggers caspase-3 cleavage and activation, leading to hyperphosphorylated tau aggregation and subsequent neurofibrillary tangles formation, in turn initiating apoptosis. | Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice.
Kim JM, Kim SS, Lee YD. | 05/7/2016 |
| Taken together, these results suggest a new role for FAF1: that of a positive modulator for Parkinson's disease . | Accumulation of the parkin substrate, FAF1, plays a key role in the dopaminergic neurodegeneration.
Sul JW, Park MY, Shin J, Kim YR, Yoo SE, Kong YY, Kwon KS, Lee YH, Kim E. | 09/7/2013 |
| FAF1 is a novel inhibitory factor of canonical Wnt signaling pathway | Fas-associated factor 1 antagonizes Wnt signaling by promoting β-catenin degradation.
Zhang L, Zhou F, van Laar T, Zhang J, van Dam H, Ten Dijke P., Free PMC Article | 11/12/2011 |
| Capsaicin-induced cancer cell apoptosis involves FAF1, a TRPV1 associated protein. | Fas-associated factor 1 is a negative regulator in capsaicin induced cancer cell apoptosis.
Ghosh AK, Basu S. | 03/8/2010 |
| analysis of the negative feedback regulation of Aurora-A via phosphorylation of Fas-associated factor-1 | Negative feedback regulation of Aurora-A via phosphorylation of Fas-associated factor-1.
Jang MS, Sul JW, Choi BJ, Lee SJ, Suh JH, Kim NS, Kim WH, Lim DS, Lee CW, Kim E. | 01/21/2010 |
| Data show that Faf1 protein level is down-regulated during apoptosis in a caspase-3- and Apaf1-dependent manner. | Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells.
De Zio D, Ferraro E, D'Amelio M, Simoni V, Bordi M, Soroldoni D, Berghella L, Meyer BI, Cecconi F., Free PMC Article | 01/21/2010 |
| Analysis of FAF1 expression revealed that the protein is present in early preimplantation stages, while embryonic expression of Faf1 mRNA becomes appreciable at 4-cell stage. | Fas-associated factor (FAF1) is required for the early cleavage-stages of mouse embryo.
Adham IM, Khulan J, Held T, Schmidt B, Meyer BI, Meinhardt A, Engel W. | 01/21/2010 |