| Magnesium Status, Genetic Variants of Magnesium-Related Ion Channel Transient Receptor Potential Membrane Melastatin 6 (TRPM6) and the Risk of Gestational Diabetes Mellitus in Chinese Pregnant Women: A Nested Case-Control Study. | Magnesium Status, Genetic Variants of Magnesium-Related Ion Channel Transient Receptor Potential Membrane Melastatin 6 (TRPM6) and the Risk of Gestational Diabetes Mellitus in Chinese Pregnant Women: A Nested Case-Control Study.
Huang S, Ge Y, Li Y, Cui N, Tan L, Guo S, Wang S, Hao L, Lei G, Yang X. | 11/27/2023 |
| Transcriptional Control of Trpm6 by the Nuclear Receptor FXR. | Transcriptional Control of Trpm6 by the Nuclear Receptor FXR.
Kim EY, Lee JM., Free PMC Article | 03/19/2022 |
| Evidence for the expression of TRPM6 and TRPM7 in cardiomyocytes from all four chamber walls of the human heart. | Evidence for the expression of TRPM6 and TRPM7 in cardiomyocytes from all four chamber walls of the human heart.
Andriulė I, Pangonytė D, Almanaitytė M, Patamsytė V, Kuprytė M, Karčiauskas D, Mubagwa K, Mačianskienė R., Free PMC Article | 11/13/2021 |
| data unambiguously confirm that CaM and S100A1 share the same binding domain at the TRPM6 N-terminus although the ligand-binding mechanism is different. | TRPM6 N-Terminal CaM- and S100A1-Binding Domains.
Zouharova M, Herman P, Hofbauerová K, Vondrasek J, Bousova K., Free PMC Article | 02/1/2020 |
| The homozygous c.3311C>T (p.Pro1104Leu) variant of the TRPM6 gene probably underlies hypocalcemia secondary to hypomagnesemia in this pedigree. | [Analysis of TRPM6 gene variant in a pedigree affected with hypocalcemia secondary to hypomagnesemia].
Tan J, Yan T, Li Z, Huang J, Cai R. | 09/28/2019 |
| Exome sequencing identifies a novel frameshift variant in TRPM6 causing hypomagnesemia with secondary hypocalcemia. | Exome sequencing identifies a novel frameshift variant causing hypomagnesemia with secondary hypocalcemia.
Azim MK, Mehnaz A, Ahmed JZ, Mujtaba G., Free PMC Article | 08/10/2019 |
| The TRPM6 rs2274924 polymorphism may be associated with susceptibility to epilepsy following stroke, and the C allele may be associated with increased risk of post-stroke epilepsy. | Increased risk of post-stroke epilepsy in Chinese patients with a TRPM6 polymorphism.
Fu CY, Chen SJ, Cai NH, Liu ZH, Zhang M, Wang PC, Zhao JN. | 04/6/2019 |
| Results identified high expression of TRPM6 to be indicative of a prolonged overall survival in colorectal patients. Computational analysis suggest that TRPM6 may be targeted by hsalet7g and hsalet7f1. | Identification of key tumorigenesis‑related genes and their microRNAs in colon cancer.
Xie B, Zhao R, Bai B, Wu Y, Xu Y, Lu S, Fang Y, Wang Z, Maswikiti EP, Zhou X, Pan H, Han W. | 12/22/2018 |
| Spectrometric analysis identified phosphorylation sites in TRPM6 protein. | Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases.
Cai N, Bai Z, Nanda V, Runnels LW., Free PMC Article | 10/27/2018 |
| These findings confirm that TRPM6 cannot be replaced by TRPM7, and that TRPM6/7 complexes and TRPM6/7-mediated Mg(2+) influx are indispensable in human epithelial colon cells. | TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon.
Luongo F, Pietropaolo G, Gautier M, Dhennin-Duthille I, Ouadid-Ahidouch H, Wolf FI, Trapani V., Free PMC Article | 10/20/2018 |
| Knockout of TRPM6 or inactivation of its kinase results in global changes in histone S/T phosphorylation and changes the transcription of hundreds of genes. | Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression.
Krapivinsky G, Krapivinsky L, Renthal NE, Santa-Cruz A, Manasian Y, Clapham DE., Free PMC Article | 07/28/2018 |
| Results found that the haplotype containing two common TRPM6 SNPs (rs3750425 and rs2274924) increases the risk for proton pump inhibitor-induced hypomagnesemia. | Common single nucleotide polymorphisms in transient receptor potential melastatin type 6 increase the risk for proton pump inhibitor-induced hypomagnesemia: a case-control study.
Hess MW, de Baaij JH, Broekman MM, Bisseling TM, Haarhuis BJ, Tan AC, Te Morsche RH, Hoenderop JG, Bindels RJ, Drenth JP. | 10/14/2017 |
| TNF-alpha rescues the EGFR tyrosine kinase inhibitor-induced decrease in TRPM6 expression and Mg2+ influx mediated via the activation of an NF-kappaB signaling pathway. | Up-Regulation of Transient Receptor Potential Melastatin 6 Channel Expression by Tumor Necrosis Factor-α in the Presence of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor.
Furukawa C, Fujii N, Manabe A, Matsunaga T, Endo S, Hasegawa H, Ito Y, Yamaguchi M, Yamazaki Y, Ikari A. | 09/23/2017 |
| A homozygous frame-shift mutation in the TRPM6 gene is associated with Hereditary hypomagnesemia with secondary hypocalcemia. | A Novel Homozygous Mutation in the Transient Receptor Potential Melastatin 6 Gene: A Case Report.
Altıncık A, Schlingmann KP, Tosun MS., Free PMC Article | 01/14/2017 |
| Data show that resistant cells express lower amounts of the transient receptor potential cation channel subfamily M TRPM6 and 7, both involved in magnesium transport. | Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin.
Castiglioni S, Cazzaniga A, Trapani V, Cappadone C, Farruggia G, Merolle L, Wolf FI, Iotti S, Maier JAM., Free PMC Article | 10/22/2016 |
| The Different Roles of The Channel-Kinases TRPM6 and TRPM7 | The Different Roles of The Channel-Kinases TRPM6 and TRPM7.
Cabezas-Bratesco D, Brauchi S, González-Teuber V, Steinberg X, Valencia I, Colenso C. | 05/21/2016 |
| we showed that two serum magnesium associated loci, MUC1 and TRPM6, had significant effect modification with progestin use and insulin levels, respectively, in European Americans. | Genetic loci for serum magnesium among African-Americans and gene-environment interaction at MUC1 and TRPM6 in European-Americans: the Atherosclerosis Risk in Communities (ARIC) study.
Tin A, Köttgen A, Folsom AR, Maruthur NM, Tajuddin SM, Nalls MA, Evans MK, Zonderman AB, Friedrich CA, Boerwinkle E, Coresh J, Kao WH., Free PMC Article | 01/16/2016 |
| N-Myc can promote neuroblastoma cell proliferation through up-regulation of the channel kinases TRPM6 and TRPM7 | N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation.
Zhang Z, Faouzi M, Huang J, Geerts D, Yu H, Fleig A, Penner R., Free PMC Article | 08/8/2015 |
| TRPM6 mRNA and protein levels in atrial fibrillation group were elevated markedly in comparison with sinus rhythm group. | Increased TRPM6 expression in atrial fibrillation patients contribute to atrial fibrosis.
Zhang YJ, Ma N, Su F, Liu H, Mei J. | 08/1/2015 |
| Knowledge of TRPM6 functioning is of vital importance to decipher its role in Mg handling and will, in particular, provide a molecular basis for achieving a better understanding of Mg mal(re)absorption and hence systemic Mg balance. | Mg2+ homeostasis: the balancing act of TRPM6.
van der Wijst J, Bindels RJ, Hoenderop JG. | 02/28/2015 |
| Data indicate heteromer formation between channel kinases TRPM6 and TRPM7 influences the biological activity of the ion channels. | TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions.
Brandao K, Deason-Towne F, Zhao X, Perraud AL, Schmitz C., Free PMC Article | 01/31/2015 |
| We conclude that the new TRPM6 missense mutations lead to dysregulated intestinal/renal Mg(2+) (re)absorption as a consequence of loss of TRPM6 channel function. | New TRPM6 missense mutations linked to hypomagnesemia with secondary hypocalcemia.
Lainez S, Schlingmann KP, van der Wijst J, Dworniczak B, van Zeeland F, Konrad M, Bindels RJ, Hoenderop JG., Free PMC Article | 11/22/2014 |
| TRPM6 kinase activity is linked to channel activity through a kinase-independent mechanism involving the dimerization motif binding to a pocket within the kinase domain. | Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction.
van der Wijst J, Blanchard MG, Woodroof HI, Macartney TJ, Gourlay R, Hoenderop JG, Bindels RJ, Alessi DR., Free PMC Article | 07/12/2014 |
| TRPM6 modulates the functionality of TRPM7, and the TRPM6 kinase plays a critical role in tuning the phenotype of the TRPM7.M6 channel complex. | The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels.
Zhang Z, Yu H, Huang J, Faouzi M, Schmitz C, Penner R, Fleig A., Free PMC Article | 04/26/2014 |
| Two novel mutations in Chinese sisters with familial hypomagnesemia with secondary hypocalcemia were found: one frameshift mutation (c.1196delC) and one non-sense mutation (c.4577G>A). Both patients were compound heterozygotes for these mutations. | Novel TRPM6 mutations in familial hypomagnesemia with secondary hypocalcemia.
Zhao Z, Pei Y, Huang X, Liu Y, Yang W, Sun J, Si N, Xing X, Li M, Wang O, Jiang Y, Zhang X, Xia W. | 10/19/2013 |