| Impaired Hepatic Very Low-Density Lipoprotein Secretion Promotes Tumorigenesis and Is Accelerated with Fabp1 Deletion. | Impaired Hepatic Very Low-Density Lipoprotein Secretion Promotes Tumorigenesis and Is Accelerated with Fabp1 Deletion.
Newberry EP, Molitor EA, Liu A, Chong K, Liu X, Alonso C, Mato JM, Davidson NO., | 08/7/2024 |
| Single-cell RNA-sequencing atlas reveals an FABP1-dependent immunosuppressive environment in hepatocellular carcinoma. | Single-cell RNA-sequencing atlas reveals an FABP1-dependent immunosuppressive environment in hepatocellular carcinoma.
Tang W, Sun G, Ji GW, Feng T, Zhang Q, Cao H, Wu W, Zhang X, Liu C, Liu H, Huang T, Liu L, Xia Y, Wang X., Free PMC Article | 11/29/2023 |
| Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting ubiquitylation and degradation of FABP1. | Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting ubiquitylation and degradation of FABP1.
You H, Wen X, Wang X, Zhu C, Chen H, Bu L, Zhang J, Qu S. | 10/4/2023 |
| The proximal intestinal Fatty Acid-Binding Proteins liver FABP (LFABP) and intestinal FABP (IFABP) differentially modulate whole body energy homeostasis but are not centrally involved in net dietary lipid absorption: Studies of the LFABP/IFABP double knockout mouse. | The proximal intestinal Fatty Acid-Binding Proteins liver FABP (LFABP) and intestinal FABP (IFABP) differentially modulate whole body energy homeostasis but are not centrally involved in net dietary lipid absorption: Studies of the LFABP/IFABP double knockout mouse.
Gajda AM, Tawfeeq HR, Lackey AI, Zhou YX, Kanaan H, Pappas A, Xu H, Kodukula S, Storch J., Free PMC Article | 11/12/2022 |
| Anterior gradient 2 increases long-chain fatty acid uptake via stabilizing FABP1 and facilitates lipid accumulation. | Anterior gradient 2 increases long-chain fatty acid uptake via stabilizing FABP1 and facilitates lipid accumulation.
Wang Y, Jia M, Liang C, Sheng N, Wang X, Wang F, Luo Y, Jiang J, Cai L, Niu H, Zhu D, Nesa EU, Young CY, Yuan H., Free PMC Article | 01/22/2022 |
| High Glucose and Liver Fatty Acid Binding Protein Gene Ablation Differentially Impact Whole Body and Liver Phenotype in High-Fat Pair-Fed Mice. | High Glucose and Liver Fatty Acid Binding Protein Gene Ablation Differentially Impact Whole Body and Liver Phenotype in High-Fat Pair-Fed Mice.
Martin GG, Landrock D, McIntosh AL, Milligan S, Landrock KK, Kier AB, Mackie J, Schroeder F. | 06/12/2021 |
| Two fatty acid-binding proteins expressed in the intestine interact differently with endocannabinoids. | Two fatty acid-binding proteins expressed in the intestine interact differently with endocannabinoids.
Lai MP, Katz FS, Bernard C, Storch J, Stark RE., Free PMC Article | 01/16/2021 |
| FABP1 controls hepatic transport and biotransformation of Delta(9)-THC. | FABP1 controls hepatic transport and biotransformation of Δ(9)-THC.
Elmes MW, Prentis LE, McGoldrick LL, Giuliano CJ, Sweeney JM, Joseph OM, Che J, Carbonetti GS, Studholme K, Deutsch DG, Rizzo RC, Glynn SE, Kaczocha M., Free PMC Article | 10/24/2020 |
| The results suggest that the up-regulation of FABP1 may be related to abnormal fat metabolism. This makes FABP1 potentially a novel pathobiochemical indicator for studying kidney abnormalities in the mdx-4cv model of dystrophinopathy. | Proteomic and cell biological profiling of the renal phenotype of the mdx-4cv mouse model of Duchenne muscular dystrophy.
Dowling P, Zweyer M, Raucamp M, Henry M, Meleady P, Swandulla D, Ohlendieck K. | 07/11/2020 |
| LFABP(-/-) mice are protected from a high-fat feeding-induced decline in exercise capacity, displaying an approximate doubling of running distance compared with WT mice. | Muscle metabolic reprogramming underlies the resistance of liver fatty acid-binding protein (LFABP)-null mice to high-fat feeding-induced decline in exercise capacity.
Xu H, Gajda AM, Zhou YX, Panetta C, Sifnakis Z, Fatima A, Henderson GC, Storch J., Free PMC Article | 06/27/2020 |
| Data show that fatty acid binding protein 1 (Fabp1) overexpression in the mouse liver blocked the protective effect of exercise via inhibiting autophagy flux. | Long-term exercise prevents hepatic steatosis: a novel role of FABP1 in regulation of autophagy-lysosomal machinery.
Pi H, Liu M, Xi Y, Chen M, Tian L, Xie J, Chen M, Wang Z, Yang M, Yu Z, Zhou Z, Gao F., Free PMC Article | 06/13/2020 |
| Both FABP1 and SCP-2 participate in regulating the Brain endocannabinoids (EC) system in the brain. | Sterol Carrier Protein-2/Sterol Carrier Protein-x/Fatty Acid Binding Protein-1 Ablation Impacts Response of Brain Endocannabinoid to High-Fat Diet.
Martin GG, Seeger DR, McIntosh AL, Milligan S, Chung S, Landrock D, Dangott LJ, Golovko MY, Murphy EJ, Kier AB, Schroeder F. | 05/16/2020 |
| Albumin-Cre-mediated L-Fabp deletion revealed recombination in hepatocytes and hepatic stellate cells (HSC). GFAP-Cre and PDGFRbeta-Cre-mediated L-Fabp deletion demonstrated recombination only in HSCs. Alb-Cre-mediated L-Fabp deletion were protected against high saturated fat-induced steatosis and fibrosis, phenocopying germline L-Fabp(-/-) mice. Mice with HSC-specific L-Fabp had no changes in fibrosis. | Hepatocyte and stellate cell deletion of liver fatty acid binding protein reveals distinct roles in fibrogenic injury.
Newberry EP, Xie Y, Lodeiro C, Solis R, Moritz W, Kennedy S, Barron L, Onufer E, Alpini G, Zhou T, Blaner WS, Chen A, Davidson NO., Free PMC Article | 05/16/2020 |
| perilipin 5 and liver fatty acid binding protein function to restore quiescence in mouse hepatic stellate cells | Perilipin 5 and liver fatty acid binding protein function to restore quiescence in mouse hepatic stellate cells.
Lin J, Zheng S, Attie AD, Keller MP, Bernlohr DA, Blaner WS, Newberry EP, Davidson NO, Chen A., Free PMC Article | 07/27/2019 |
| the data indicated that FABP1 may play important roles in Delta(9)-THC uptake and elimination as well as Delta(9)-THC induction of genes regulating hepatic EC levels and downstream targets in lipid metabolism. | Structural and Functional Interaction of Δ(9)-Tetrahydrocannabinol with Liver Fatty Acid Binding Protein (FABP1).
Huang H, McIntosh AL, Martin GG, Dangott LJ, Kier AB, Schroeder F. | 07/20/2019 |
| These findings suggested that ablation of the Scp-2/Scp-x gene in Fabp1 null mice exacerbated hepatic endocannabinoid (EC) accumulation and antagonized the impact of high fat diet on hepatic EC levels-suggesting both proteins play important roles in regulating the hepatic EC system. | Scp-2/Scp-x ablation in Fabp1 null mice differentially impacts hepatic endocannabinoid level depending on dietary fat.
Martin GG, Seeger DR, McIntosh AL, Chung S, Milligan S, Landrock D, Dangott LJ, Golovko MY, Murphy EJ, Kier AB, Schroeder F., Free PMC Article | 06/29/2019 |
| The data indicated that FABP1 impacts hepatocyte EC levels by binding EC and differentially impacts their intracellular hydrolysis (2-AG) and uptake (AEA). | Impact of Fabp1 Gene Ablation on Uptake and Degradation of Endocannabinoids in Mouse Hepatocytes.
McIntosh AL, Huang H, Landrock D, Martin GG, Li S, Kier AB, Schroeder F. | 06/22/2019 |
| Cathepsin B regulates VLDL secretion and free fatty acid uptake via cleavage of LFABP, which occurs in response to oleic acid exposure. | Cathepsin B regulates hepatic lipid metabolism by cleaving liver fatty acid-binding protein.
Thibeaux S, Siddiqi S, Zhelyabovska O, Moinuddin F, Masternak MM, Siddiqi SA., Free PMC Article | 02/16/2019 |
| Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice | Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice.
Milligan S, Martin GG, Landrock D, McIntosh AL, Mackie JT, Schroeder F, Kier AB., Free PMC Article | 04/21/2018 |
| role of Fabp1/Scp-2 in hepatic phytol metabolism | Impact of Fabp1/Scp-2/Scp-x gene ablation (TKO) on hepatic phytol metabolism in mice.
Storey SM, Huang H, McIntosh AL, Martin GG, Kier AB, Schroeder F., Free PMC Article | 01/20/2018 |
| Individually ablating SCPx or SCP2/SCPx elicited concomitant upregulation of L-FABP. | Impact of dietary phytol on lipid metabolism in SCP2/SCPX/L-FABP null mice.
Milligan S, Martin GG, Landrock D, McIntosh AL, Mackie JT, Schroeder F, Kier AB., Free PMC Article | 10/21/2017 |
| Lack of a significant decrease in the flux of HDL-[(3)H]CE to biliary FC or bile acids in FABP1(-/-) mice indicates the likely compensation of its function by an as yet unidentified mechanism. Taken together, these studies demonstrate that FABP1 and SCP2 facilitate the preferential movement of HDL-CEs to bile for final elimination | Intracellular cholesterol transport proteins enhance hydrolysis of HDL-CEs and facilitate elimination of cholesterol into bile.
Wang J, Bie J, Ghosh S., Free PMC Article | 09/2/2017 |
| data showed that Fabp1 gene ablation markedly diminished the impact of high-fat diet on brain endocannabinoid levels, especially in male mice | Fabp1 gene ablation inhibits high-fat diet-induced increase in brain endocannabinoids.
Martin GG, Landrock D, Chung S, Dangott LJ, Seeger DR, Murphy EJ, Golovko MY, Kier AB, Schroeder F., Free PMC Article | 07/29/2017 |
| Studies show that despite overall tertiary structure similarity, the hFABP1 differs significantly from rat FABP1 in secondary structure, much larger ligand binding cavity, and affinities/specificities for some ligands. Moreover, while both mouse and hFABP1 mediate ligand induction of PPARA, they differ markedly in genes induced. | Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias.
Schroeder F, McIntosh AL, Martin GG, Huang H, Landrock D, Chung S, Landrock KK, Dangott LJ, Li S, Kaczocha M, Murphy EJ, Atshaves BP, Kier AB., Free PMC Article | 07/22/2017 |
| FABP1 knockout increased brain levels of arachidonic acid-containing endocannabinoids | FABP-1 gene ablation impacts brain endocannabinoid system in male mice.
Martin GG, Chung S, Landrock D, Landrock KK, Huang H, Dangott LJ, Peng X, Kaczocha M, Seeger DR, Murphy EJ, Golovko MY, Kier AB, Schroeder F., Free PMC Article | 06/24/2017 |