| Sestrin1, 2, and 3 are dispensable for female fertility in mice. | Sestrin1, 2, and 3 are dispensable for female fertility in mice.
Wang M, Chen W, Zeng X, Wang T, Sun Y, Yang Q., Free PMC Article | 06/25/2024 |
| Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine. | Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.
Cangelosi AL, Puszynska AM, Roberts JM, Armani A, Nguyen TP, Spinelli JB, Kunchok T, Wang B, Chan SH, Lewis CA, Comb WC, Bell GW, Helman A, Sabatini DM., Free PMC Article | 07/16/2022 |
| MiR-200c-3p targets SESN1 and represses the IL-6/AKT loop to prevent cholangiocyte activation and cholestatic liver fibrosis. | MiR-200c-3p targets SESN1 and represses the IL-6/AKT loop to prevent cholangiocyte activation and cholestatic liver fibrosis.
Song Y, Tran M, Wang L, Shin DJ, Wu J., Free PMC Article | 05/14/2022 |
| Forkhead box protein 1 transcriptionally activates sestrin1 to alleviate oxidized low-density lipoprotein-induced inflammation and lipid accumulation in macrophages. | Forkhead box protein 1 transcriptionally activates sestrin1 to alleviate oxidized low-density lipoprotein-induced inflammation and lipid accumulation in macrophages.
Gao F, Zhao Y, Zhang B, Xiao C, Sun Z, Gao Y, Dou X., Free PMC Article | 03/12/2022 |
| Aerobic exercise inhibits inflammatory response in atherosclerosis via Sestrin1 protein. | Aerobic exercise inhibits inflammatory response in atherosclerosis via Sestrin1 protein.
Sun Y, Wu Y, Jiang Y, Liu H. | 12/18/2021 |
| Sestrin1 exerts a cytoprotective role against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by potentiating Nrf2 activation via the modulation of Keap1. | Sestrin1 exerts a cytoprotective role against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by potentiating Nrf2 activation via the modulation of Keap1.
Yang F, Chen R. | 11/27/2021 |
| Sestrins are critical mediators of exercise benefits. Genetic ablation of Sestrins prevents mice from acquiring metabolic benefits of exercise and improving their endurance through training. Sestrin upregulation mimics both molecular and physiological effects of exercise, suggesting that it is a major effector of exercise metabolism. AKT and PGC1alpha are critical for the Sestrin effects in extending endurance. | Sestrins are evolutionarily conserved mediators of exercise benefits.
Kim M, Sujkowski A, Namkoong S, Gu B, Cobb T, Kim B, Kowalsky AH, Cho CS, Semple I, Ro SH, Davis C, Brooks SV, Karin M, Wessells RJ, Lee JH., Free PMC Article | 04/11/2020 |
| By upregulating AMPK and autophagic activities and suppressing mammalian target of rapamycin complex 1 and oxidative stress, sestrins counteract detrimental effects of doxorubicin on cardiomyocytes. | Cardioprotective roles of sestrin 1 and sestrin 2 against doxorubicin cardiotoxicity.
Li R, Huang Y, Semple I, Kim M, Zhang Z, Lee JH., Free PMC Article | 03/28/2020 |
| Sestrin 1 targets at the AMPK/mTORC1/autophagy pathway to inhibit cardiac hypertrophy by interaction with AMPK which is responsible for autophagy regulation. Taken together, our data indicate that Sestrin 1 regulates AMPK/mTORC1/autophagy axis to attenuate cardiac hypertrophy. | Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation.
Xue R, Zeng J, Chen Y, Chen C, Tan W, Zhao J, Dong B, Sun Y, Dong Y, Liu C., Free PMC Article | 02/24/2018 |
| Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK or TSC2. Surprisingly, when coexpressed with a GTP-bound constitutively active form of RagB (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids. | Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.
Peng M, Yin N, Li MO., Free PMC Article | 05/16/2015 |
| Sestrin1 and Sestrin2 therefore provide an important link between genotoxic stress, p53 and the mTOR signaling pathway. | p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
Budanov AV, Karin M., Free PMC Article | 01/21/2010 |
| The enhanced tumor susceptibility of p53+/- mice has made them one of several transgenic mouse models that are being considered as substitutes for standard 2-year rodent carcinogenicity assays. | Is p53 haploinsufficient for tumor suppression? Implications for the p53+/- mouse model in carcinogenicity testing.
Venkatachalam S, Tyner SD, Pickering CR, Boley S, Recio L, French JE, Donehower LA. | 01/21/2010 |