| Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses. | Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses.
Roh WS, Yoo JH, Dravid SM, Mannaioni G, Krizman EN, Wahl P, Robinson MB, Traynelis SF, Lee CJ, Han KS., | 08/20/2024 |
| KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages. | KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages.
Hwang YS, Cho HJ, Park ES, Lim J, Yoon HR, Kim JT, Yoon SR, Jung H, Choe YK, Kim YH, Lee CH, Kwon YT, Kim BY, Lee HG., Free PMC Article | 02/20/2024 |
| Thrombin-mediated activation of PAR1 enhances doxorubicin-induced cardiac injury in mice. | Thrombin-mediated activation of PAR1 enhances doxorubicin-induced cardiac injury in mice.
Grover SP, Bharathi V, Posma JJ, Griffin JH, Palumbo JS, Mackman N, Antoniak S., Free PMC Article | 02/20/2024 |
| Intrinsic Expression of Coagulation Factors and Protease Activated Receptor 1 (PAR1) in Photoreceptors and Inner Retinal Layers. | Intrinsic Expression of Coagulation Factors and Protease Activated Receptor 1 (PAR1) in Photoreceptors and Inner Retinal Layers.
Goldberg Z, Sher I, Qassim L, Chapman J, Rotenstreich Y, Shavit-Stein E., Free PMC Article | 02/20/2024 |
| Thrombin-PAR1 signaling in pancreatic cancer promotes an immunosuppressive microenvironment. | Thrombin-PAR1 signaling in pancreatic cancer promotes an immunosuppressive microenvironment.
Schweickert PG, Yang Y, White EE, Cresswell GM, Elzey BD, Ratliff TL, Arumugam P, Antoniak S, Mackman N, Flick MJ, Konieczny SF., Free PMC Article | 02/20/2024 |
| The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability. | The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability.
Peng S, Grace MS, Gondin AB, Retamal JS, Dill L, Darby W, Bunnett NW, Abogadie FC, Carbone SE, Tigani T, Davis TP, Poole DP, Veldhuis NA, McIntyre P., Free PMC Article | 02/20/2024 |
| Data show that bone marrow kinase on the X chromosome (BMX) specifically repressed thrombin-PAR1 (protease-activated receptor-1) signaling in endothelial cells by directly phosphorylating PAR1 and promoting its internalization and deactivation. | BMX Represses Thrombin-PAR1-Mediated Endothelial Permeability and Vascular Leakage During Early Sepsis.
Li Z, Yin M, Zhang H, Ni W, Pierce RW, Zhou HJ, Min W., Free PMC Article | 02/20/2024 |
| Cell type-specific mechanisms coupling protease-activated receptor-1 to infectious colitis pathogenesis. | Cell type-specific mechanisms coupling protease-activated receptor-1 to infectious colitis pathogenesis.
Boucher AA, Rosenfeldt L, Mureb D, Shafer J, Sharma BK, Lane A, Crowther RR, McKell MC, Whitt J, Alenghat T, Qualls J, Antoniak S, Mackman N, Flick MJ, Steinbrecher KA, Palumbo JS., Free PMC Article | 02/20/2024 |
| this study shows that PAR1 deletion causes enhanced osteoclastogenesis in response to inflammatory signals through a Notch2-dependent mechanism | Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism.
Jastrzebski S, Kalinowski J, Mun S, Shin B, Adapala NS, Jacome-Galarza CE, Mirza F, Aguila HL, Drissi H, Sanjay A, Canalis E, Lee SK, Lorenzo JA., Free PMC Article | 02/20/2024 |
| Thrombin exclusively induced MCP-1 via the MAPK-ERK and PI3K-AKT pathways. MCP-1 produced by mIVDs induced macrophage migration and thrombin treatment increased MMP-3 production to induce mIVD degeneration. These effects of thrombin on mIVDs were abrogated by a PAR1 inhibitor and suggest that thrombin may be a novel factor capable of stimulating cytokine activity implicated in the regulation several aspects of mIVDs | Effect of Thrombin-Induced MCP-1 and MMP-3 Production Via PAR1 Expression in Murine Intervertebral Discs.
Takayama Y, Ando T, Ichikawa J, Haro H., Free PMC Article | 02/20/2024 |
| these findings identify PAR1 as an important regulator of glutamatergic signaling in the hippocampus and a possible target molecule to limit brain damage during hemorrhagic stroke. | PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology.
Sweeney AM, Fleming KE, McCauley JP, Rodriguez MF, Martin ET, Sousa AA, Leapman RD, Scimemi A., Free PMC Article | 02/20/2024 |
| Perivascular fibrosis around coronary vessels was reduced in Ang II-treated PAR-1-/- mice compared to WT mice. In addition, PAR-1 deficiency significantly attenuated Ang II induction of inflammatory cytokines and profibrotic genes in the aortas compared to WT mice. Finally, PAR-1 deficiency had no effect on Ang II-induced heart hypertrophy. | Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation.
Antoniak S, Cardenas JC, Buczek LJ, Church FC, Mackman N, Pawlinski R., Free PMC Article | 02/20/2024 |
| These data suggest that the ability of PAR1 activation to potentiate NMDA receptor function may underlie its harmful actions during injury. | Protease-activated receptor 1-dependent neuronal damage involves NMDA receptor function.
Hamill CE, Mannaioni G, Lyuboslavsky P, Sastre AA, Traynelis SF., Free PMC Article | 02/20/2024 |
| These results identify a novel aspect of the crosstalk between FGF and thrombin signaling pathways which both play important roles in tissue repair and angiogenesis. | Thrombin induces rapid PAR1-mediated non-classical FGF1 release.
Duarte M, Kolev V, Soldi R, Kirov A, Graziani I, Oliveira SM, Kacer D, Friesel R, Maciag T, Prudovsky I., Free PMC Article | 02/20/2024 |
| analysis of cytokine and chemokine release downstream of PAR1 activation in the context of fibroproliferative lung disease [review] | Signaling pathways involved in proteinase-activated receptor1-induced proinflammatory and profibrotic mediator release following lung injury.
Mercer PF, Deng X, Chambers RC. | 02/20/2024 |
| S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis. | S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.
Deng L, Costa F, Blake KJ, Choi S, Chandrabalan A, Yousuf MS, Shiers S, Dubreuil D, Vega-Mendoza D, Rolland C, Deraison C, Voisin T, Bagood MD, Wesemann L, Frey AM, Palumbo JS, Wainger BJ, Gallo RL, Leyva-Castillo JM, Vergnolle N, Price TJ, Ramachandran R, Horswill AR, Chiu IM., | 11/27/2023 |
| PAR1 regulates sepsis-induced vascular endothelial barrier dysfunction by mediating ERM phosphorylation via the RhoA/ROCK signaling pathway. | PAR1 regulates sepsis-induced vascular endothelial barrier dysfunction by mediating ERM phosphorylation via the RhoA/ROCK signaling pathway.
Zhao L, Hu J, Zheng P, Mi B, Chen Z, Zhao X, Wu J, Wang Y. | 11/6/2023 |
| PARIN5, a Novel Thrombin Receptor Antagonist Modulates a Streptozotocin Mice Model for Diabetic Encephalopathy. | PARIN5, a Novel Thrombin Receptor Antagonist Modulates a Streptozotocin Mice Model for Diabetic Encephalopathy.
Golderman V, Goldberg Z, Gofrit SG, Dori A, Maggio N, Chapman J, Sher I, Rotenstreich Y, Shavit-Stein E., Free PMC Article | 03/1/2023 |
| Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma. | Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma.
Gao Y, Xu Q, Li X, Guo Y, Zhang B, Jin Y, Zhu C, Shen Y, Yang P, Shi Y, Jin R, Liu D, Ouyang Y, Liu X, Wang W, Chen D, Yang T., Free PMC Article | 04/23/2022 |
| Ischemic stroke in PAR1 KO mice: Decreased brain plasmin and thrombin activity along with decreased infarct volume. | Ischemic stroke in PAR1 KO mice: Decreased brain plasmin and thrombin activity along with decreased infarct volume.
Shavit-Stein E, Mindel E, Gofrit SG, Chapman J, Maggio N., Free PMC Article | 10/16/2021 |
| F2r negatively regulates osteoclastogenesis through inhibiting the Akt and NFkappaB signaling pathways. | F2r negatively regulates osteoclastogenesis through inhibiting the Akt and NFκB signaling pathways.
Zhang Y, Wang H, Zhu G, Qian A, Chen W., Free PMC Article | 08/28/2021 |
| Brain Protease Activated Receptor 1 Pathway: A Therapeutic Target in the Superoxide Dismutase 1 (SOD1) Mouse Model of Amyotrophic Lateral Sclerosis. | Brain Protease Activated Receptor 1 Pathway: A Therapeutic Target in the Superoxide Dismutase 1 (SOD1) Mouse Model of Amyotrophic Lateral Sclerosis.
Shavit-Stein E, Abu Rahal I, Bushi D, Gera O, Sharon R, Gofrit SG, Pollak L, Mindel K, Maggio N, Kloog Y, Chapman J, Dori A., Free PMC Article | 02/27/2021 |
| KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease. | KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.
Billi AC, Ludwig JE, Fritz Y, Rozic R, Swindell WR, Tsoi LC, Gruzska D, Abdollahi-Roodsaz S, Xing X, Diaconu D, Uppala R, Camhi MI, Klenotic PA, Sarkar MK, Husni ME, Scher JU, McDonald C, Kahlenberg JM, Midura RJ, Gudjonsson JE, Ward NL., Free PMC Article | 02/6/2021 |
| Blocking the Thrombin Receptor Promotes Repair of Demyelinated Lesions in the Adult Brain. | Blocking the Thrombin Receptor Promotes Repair of Demyelinated Lesions in the Adult Brain.
Yoon H, Choi CI, Triplet EM, Langley MR, Kleppe LS, Kim HN, Simon WL, Scarisbrick IA., Free PMC Article | 08/22/2020 |
| High Protease-activated receptor-1 is associated with renal injury and interstitial fibrosis during chronic obstructive nephropathy. | Protease-activated receptor-1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy.
Waasdorp M, de Rooij DM, Florquin S, Duitman J, Spek CA., Free PMC Article | 07/4/2020 |