| ROS in diabetic atria regulate SK2 degradation by Atrogin-1 through the NF-kappaB signaling pathway. | ROS in diabetic atria regulate SK2 degradation by Atrogin-1 through the NF-κB signaling pathway.
Xu J, Zhang D, Ma Y, Du H, Wang Y, Luo W, Wang R, Yi F., Free PMC Article | 04/13/2024 |
| MPP2 interacts with SK2 to rescue the excitability of glutamatergic neurons in the BLA and facilitate the extinction of conditioned fear in mice. | MPP2 interacts with SK2 to rescue the excitability of glutamatergic neurons in the BLA and facilitate the extinction of conditioned fear in mice.
Peng X, Chen P, Zhang Y, Wu K, Ji N, Gao J, Wang H, Zhang YM, Xu T, Hua R., Free PMC Article | 02/7/2024 |
| Predisposition of Neonatal Maternal Separation to Visceral Hypersensitivity via Downregulation of Small-Conductance Calcium-Activated Potassium Channel Subtype 2 (SK2) in Mice. | Predisposition of Neonatal Maternal Separation to Visceral Hypersensitivity via Downregulation of Small-Conductance Calcium-Activated Potassium Channel Subtype 2 (SK2) in Mice.
Wu K, Gao JH, Hua R, Peng XH, Wang H, Zhang YM., Free PMC Article | 09/11/2021 |
| PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome. | PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome.
Sun J, Liu Y, Zhu G, Cato C, Hao X, Qian L, Lin W, Adhikari R, Luo Y, Baudry M, Bi X., Free PMC Article | 12/12/2020 |
| SK2 plasticity and excitability modulation are essential for specific forms of motor learning. | SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces.
Grasselli G, Boele HJ, Titley HK, Bradford N, van Beers L, Jay L, Beekhof GC, Busch SE, De Zeeuw CI, Schonewille M, Hansel C., Free PMC Article | 04/25/2020 |
| Junctophilin 2, as junctional membrane complex (JMC) protein, is an important regulator of the cardiac SK channels | Functional interaction of Junctophilin 2 with small- conductance Ca(2+) -activated potassium channel subtype 2(SK2) in mouse cardiac myocytes.
Fan HK, Luo TX, Zhao WD, Mu YH, Yang Y, Guo WJ, Tu HY, Zhang Q., Free PMC Article | 07/20/2019 |
| results indicate that FBXO-32 contributes to SK2 down-regulation and that the F-box domain is essential for FBXO-32 function. | F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria.
Ling TY, Yi F, Lu T, Wang XL, Sun X, Willis MS, Wu LQ, Shen WK, Adelman JP, Lee HC., Free PMC Article | 06/1/2019 |
| SK2 channels regulate mitochondrial respiration and mitochondrial Ca(2+) uptake. | SK2 channels regulate mitochondrial respiration and mitochondrial Ca(2+) uptake.
Honrath B, Matschke L, Meyer T, Magerhans L, Perocchi F, Ganjam GK, Zischka H, Krasel C, Gerding A, Bakker BM, Bünemann M, Strack S, Decher N, Culmsee C, Dolga AM., Free PMC Article | 02/17/2018 |
| Probing the responsible cellular mechanisms pinpoints a disturbance in the expression and function of small-conductance Ca(2+)-activated K(+) (SK) channels and reveals an important role for both SK2 and SK3 channels in normal regulation of serotinin (5-HT) neuronal excitability. | Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels.
Sargin D, Oliver DK, Lambe EK., Free PMC Article | 12/16/2017 |
| SK2 is nuclear in primary neurons and, unexpectedly, overexpressed SK2 is neurotoxic in a dose-dependent manner.. We also found that SK2 is hyperphosphorylated in the brain samples from a model of HD, the BACHD mice.Our results identify a novel regulator of mutant huntingtin-mediated neurotoxicity and provide a new target for developing developing therapies for Huntington disease | Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease.
Moruno-Manchon JF, Uzor NE, Blasco-Conesa MP, Mannuru S, Putluri N, Furr-Stimming EE, Tsvetkov AS., Free PMC Article | 05/20/2017 |
| Thus, MPP2 is a novel synaptic scaffold that is required for proper synaptic localization and function of SK2-containing channels. | Membrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel function.
Kim G, Luján R, Schwenk J, Kelley MH, Aguado C, Watanabe M, Fakler B, Maylie J, Adelman JP., Free PMC Article | 01/14/2017 |
| In addition to a well-established role for KCa2.x channels in migration, blockade of these channels was potently cytotoxic in breast cancer cell lines. | Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines.
Abdulkareem ZA, Gee JM, Cox CD, Wann KT., Free PMC Article | 10/22/2016 |
| Atrial SK2 and SK3 are significantly down-regulated from accelerated turnover in diabetic mice, resulting in action potential prolongation and arrhythmias. | Down-regulation of the small conductance calcium-activated potassium channels in diabetic mouse atria.
Yi F, Ling TY, Lu T, Wang XL, Li J, Claycomb WC, Shen WK, Lee HC., Free PMC Article | 05/30/2015 |
| enhanced SK2 channel control over NMDAR contributes to LTP impairment via increased PP2A activity following context dependent sensitization to morphine. | Increased small conductance calcium-activated potassium type 2 channel-mediated negative feedback on N-methyl-D-aspartate receptors impairs synaptic plasticity following context-dependent sensitization to morphine.
Fakira AK, Portugal GS, Carusillo B, Melyan Z, Morón JA., Free PMC Article | 11/22/2014 |
| This study reveleated that outer hair cells of SK2 knockout mice had few small efferent terminals. Synaptic cisterns were present, but smaller than those of wild-type littermates. | Ultrastructure of cisternal synapses on outer hair cells of the mouse cochlea.
Fuchs PA, Lehar M, Hiel H., Free PMC Article | 08/30/2014 |
| SK2 and SK3 channels are expressed in different populations of motoneurons in rats and mice but not in cats | Expression of postsynaptic Ca2+-activated K+ (SK) channels at C-bouton synapses in mammalian lumbar -motoneurons.
Deardorff AS, Romer SH, Deng Z, Bullinger KL, Nardelli P, Cope TC, Fyffe RE., Free PMC Article | 08/10/2013 |
| Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction. | Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction.
Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C., Free PMC Article | 06/8/2013 |
| Virtually all Cav2.1 clusters are colocalized in Purkinje cells with two types of calcium-activated potassium channels, SK2 and BK. | Quantitative localization of Cav2.1 (P/Q-type) voltage-dependent calcium channels in Purkinje cells: somatodendritic gradient and distinct somatic coclustering with calcium-activated potassium channels.
Indriati DW, Kamasawa N, Matsui K, Meredith AL, Watanabe M, Shigemoto R., Free PMC Article | 04/27/2013 |
| A developmental increase and gradient in SK2-containing channel surface expression is found that underlie the influence on neurotransmission. | Developmental profile of SK2 channel expression and function in CA1 neurons.
Ballesteros-Merino C, Lin M, Wu WW, Ferrandiz-Huertas C, Cabañero MJ, Watanabe M, Fukazawa Y, Shigemoto R, Maylie J, Adelman JP, Luján R., Free PMC Article | 03/16/2013 |
| Sleep spindle occurrence is shaped by SK2-channel-mediated repetitive reticular thalamic nucleus neuron bursting & contributes to augmented NREMS consolidation & arousal threshold. | Sustaining sleep spindles through enhanced SK2-channel activity consolidates sleep and elevates arousal threshold.
Wimmer RD, Astori S, Bond CT, Rovó Z, Chatton JY, Adelman JP, Franken P, Lüthi A., Free PMC Article | 01/26/2013 |
| Long-lasting plasticity of intrinsic excitability in dendrites results from changes in the gain of the SK2 channel regulatory mechanism of neurons. | SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells.
Ohtsuki G, Piochon C, Adelman JP, Hansel C., Free PMC Article | 10/6/2012 |
| increasing SK2 channel activity, or preventing ischemia-induced loss of synaptic SK2 channels, are promising and novel approaches to neuroprotection following cerebral ischemia | SK2 channels are neuroprotective for ischemia-induced neuronal cell death.
Allen D, Nakayama S, Kuroiwa M, Nakano T, Palmateer J, Kosaka Y, Ballesteros C, Watanabe M, Bond CT, Luján R, Maylie J, Adelman JP, Herson PS., Free PMC Article | 01/14/2012 |
| Results indicate that SK2-L directs synaptic SK2-containing channel expression and is important for normal synaptic signaling, plasticity and learning. | The SK2-long isoform directs synaptic localization and function of SK2-containing channels.
Allen D, Bond CT, Luján R, Ballesteros-Merino C, Lin MT, Wang K, Klett N, Watanabe M, Shigemoto R, Stackman RW Jr, Maylie J, Adelman JP., Free PMC Article | 08/20/2011 |
| Thus, SK2-sh as a downstream target of cytokines, provide a promising target for additional investigation regarding potential therapeutic intervention.(SH2-SH PROTEIN, MOUSE) | Identification and characterization of a novel, shorter isoform of the small conductance Ca2+ -activated K+ channel SK2.
Murthy SR, Teodorescu G, Nijholt IM, Dolga AM, Grissmer S, Spiess J, Blank T. | 07/25/2011 |
| These data indicate an abnormal expression of SK channels and a possible dysfunction of these channels in pilocarpine-treated epileptic rats. | Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats.
Oliveira MS, Skinner F, Arshadmansab MF, Garcia I, Mello CF, Knaus HG, Ermolinsky BS, Otalora LF, Garrido-Sanabria ER., Free PMC Article | 11/13/2010 |