| Mecom mutation related to radioulnar synostosis with amegakaryocytic thrombocytopenia reduces HSPCs in mice. | Mecom mutation related to radioulnar synostosis with amegakaryocytic thrombocytopenia reduces HSPCs in mice.
Nagai K, Niihori T, Muto A, Hayashi Y, Abe T, Igarashi K, Aoki Y., Free PMC Article | 09/20/2023 |
| EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment. | EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment.
Masamoto Y, Chiba A, Mizuno H, Hino T, Hayashida H, Sato T, Bando M, Shirahige K, Kurokawa M., Free PMC Article | 04/19/2023 |
| Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia. | Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia.
Tanaka A, Nakano TA, Nomura M, Yamazaki H, Bewersdorf JP, Mulet-Lazaro R, Hogg S, Liu B, Penson A, Yokoyama A, Zang W, Havermans M, Koizumi M, Hayashi Y, Cho H, Kanai A, Lee SC, Xiao M, Koike Y, Zhang Y, Fukumoto M, Aoyama Y, Konuma T, Kunimoto H, Inaba T, Nakajima H, Honda H, Kawamoto H, Delwel R, Abdel-Wahab O, Inoue D., Free PMC Article | 09/3/2022 |
| Evi1 upregulates Fbp1 and supports progression of acute myeloid leukemia through pentose phosphate pathway activation. | Evi1 upregulates Fbp1 and supports progression of acute myeloid leukemia through pentose phosphate pathway activation.
Mizuno H, Koya J, Masamoto Y, Kagoya Y, Kurokawa M., Free PMC Article | 10/9/2021 |
| EVI1 and GATA2 misexpression induced by inv(3)(q21q26) contribute to megakaryocyte-lineage skewing and leukemogenesis. | EVI1 and GATA2 misexpression induced by inv(3)(q21q26) contribute to megakaryocyte-lineage skewing and leukemogenesis.
Yamaoka A, Suzuki M, Katayama S, Orihara D, Engel JD, Yamamoto M., Free PMC Article | 06/19/2021 |
| PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response. | PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response.
Ye J, Huang A, Wang H, Zhang AMY, Huang X, Lan Q, Sato T, Goyama S, Kurokawa M, Deng C, Sander M, Schaeffer DF, Li W, Kopp JL, Xie R., Free PMC Article | 04/17/2021 |
| Deletion of the Prdm3 Gene Causes a Neuronal Differentiation Deficiency in P19 Cells. | Deletion of the Prdm3 Gene Causes a Neuronal Differentiation Deficiency in P19 Cells.
Leszczyński P, Śmiech M, Salam Teeli A, Haque E, Viger R, Ogawa H, Pierzchała M, Taniguchi H., Free PMC Article | 03/6/2021 |
| The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development. | The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development.
Shull LC, Sen R, Menzel J, Goyama S, Kurokawa M, Artinger KB., Free PMC Article | 12/19/2020 |
| Prdm3 and Prdm16 cooperatively maintain hematopoiesis and clonogenic potential. | Prdm3 and Prdm16 cooperatively maintain hematopoiesis and clonogenic potential.
McGlynn KA, Sun R, Vonica A, Rudzinskas S, Zhang Y, Perkins AS. | 10/31/2020 |
| All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia. | All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.
Nguyen CH, Bauer K, Hackl H, Schlerka A, Koller E, Hladik A, Stoiber D, Zuber J, Staber PB, Hoelbl-Kovacic A, Purton LE, Grebien F, Wieser R., Free PMC Article | 09/12/2020 |
| EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription. | EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription.
Ayoub E, Wilson MP, McGrath KE, Li AJ, Frisch BJ, Palis J, Calvi LM, Zhang Y, Perkins AS., Free PMC Article | 01/5/2019 |
| These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs | EVI1 promotes cell proliferation in HBx-induced hepatocarcinogenesis as a critical transcription factor regulating lncRNAs.
Huang JF, Wang Y, Liu F, Liu Y, Zhao CX, Guo YJ, Sun SH., Free PMC Article | 12/16/2017 |
| Gata2 heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice | GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis.
Katayama S, Suzuki M, Yamaoka A, Keleku-Lukwete N, Katsuoka F, Otsuki A, Kure S, Engel JD, Yamamoto M. | 09/30/2017 |
| EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias. | The MDS and EVI1 complex locus (MECOM) isoforms regulate their own transcription and have different roles in the transformation of hematopoietic stem and progenitor cells.
Maicas M, Vázquez I, Alis R, Marcotegui N, Urquiza L, Cortés-Lavaud X, Cristóbal I, García-Sánchez MA, Odero MD. | 08/19/2017 |
| the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa from EVI1-induced suppression. | EVI1 Interferes with Myeloid Maturation via Transcriptional Repression of Cebpa, via Binding to Two Far Downstream Regulatory Elements.
Wilson M, Tsakraklides V, Tran M, Xiao YY, Zhang Y, Perkins AS., Free PMC Article | 12/17/2016 |
| Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF, acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF levels. | A murine model of acute myeloid leukemia with Evi1 overexpression and autocrine stimulation by an intracellular form of GM-CSF in DA-3 cells.
Cardona ME, Simonson OE, Oprea II, Moreno PM, Silva-Lara MF, Mohamed AJ, Christensson B, Gahrton G, Dilber MS, Smith CI, Arteaga HJ. | 10/22/2016 |
| Survivin partially regulates HSC function by modulating the Evi-1 transcription factor and its downstream targets | Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1.
Fukuda S, Hoggatt J, Singh P, Abe M, Speth JM, Hu P, Conway EM, Nucifora G, Yamaguchi S, Pelus LM., Free PMC Article | 04/11/2015 |
| Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia. | Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.
Nishikawa S, Arai S, Masamoto Y, Kagoya Y, Toya T, Watanabe-Okochi N, Kurokawa M. | 02/14/2015 |
| Prdm16 and Prdm3 control postnatal BAT identity and function. | Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.
Harms MJ, Ishibashi J, Wang W, Lim HW, Goyama S, Sato T, Kurokawa M, Won KJ, Seale P., Free PMC Article | 12/20/2014 |
| Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. | Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.
Bard-Chapeau EA, Szumska D, Jacob B, Chua BQ, Chatterjee GC, Zhang Y, Ward JM, Urun F, Kinameri E, Vincent SD, Ahmed S, Bhattacharya S, Osato M, Perkins AS, Moore AW, Jenkins NA, Copeland NG., Free PMC Article | 11/8/2014 |
| Lack of ME leads to a complex defect in both osseous and non-osseous musculoskeletal tissues. | Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia.
Juneja SC, Vonica A, Zeiss C, Lezon-Geyda K, Yatsula B, Sell DR, Monnier VM, Lin S, Ardito T, Eyre D, Reynolds D, Yao Z, Awad HA, Yu H, Wilson M, Honnons S, Boyce BF, Xing L, Zhang Y, Perkins AS., Free PMC Article | 10/25/2014 |
| PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL) fusion protein (MFP) leukemia | Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia.
Zhang Y, Owens K, Hatem L, Glass CH, Karuppaiah K, Camargo F, Perkins AS., Free PMC Article | 12/14/2013 |
| Cotransduction of Evi1 and the shortest isoform of C/EBPbeta, liver inhibitory protein (LIP), induced acute myeloid leukemia with short latencies in a mouse bone marow transplantation model. | The shortest isoform of C/EBPβ, liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model.
Watanabe-Okochi N, Yoshimi A, Sato T, Ikeda T, Kumano K, Taoka K, Satoh Y, Shinohara A, Tsuruta T, Masuda A, Yokota H, Yatomi Y, Takahashi K, Kitaura J, Kitamura T, Kurokawa M. | 08/10/2013 |
| Transient Evi1 transfection inhibited TGF-beta-induced transcriptional activity and reversed the growth inhibitory effect of TGF-beta in MC-26 mouse colon cancer cells. | Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer.
Deng X, Cao Y, Liu Y, Li F, Sambandam K, Rajaraman S, Perkins AS, Fields AP, Hellmich MR, Townsend CM Jr, Thompson EA, Ko TC., Free PMC Article | 05/11/2013 |
| Evi1 is a key regulator of adipogenic competency | An Evi1-C/EBPβ complex controls peroxisome proliferator-activated receptor γ2 gene expression to initiate white fat cell differentiation.
Ishibashi J, Firtina Z, Rajakumari S, Wood KH, Conroe HM, Steger DJ, Seale P., Free PMC Article | 02/23/2013 |