| GPR116 overexpression correlates with poor prognosis in gastric cancer. | GPR116 overexpression correlates with poor prognosis in gastric cancer.
Zheng T, Sun M, Liu L, Lan Y, Wang L, Lin F., Free PMC Article | 02/12/2022 |
| Screening for bacterial enzymes synthesizing GPR119 agonist in cAMP-responsive cells. | Screening for bacterial enzymes synthesizing GPR119 agonist in cAMP-responsive cells.
Jia J, Chen Y, Xu L, Yang Y, Xu X, Ding H, Jia C, Gao H, Guo P, Hu R. | 06/12/2021 |
| GPR119 Is a Potent Regulator of Human Sebocyte Biology. | GPR119 Is a Potent Regulator of Human Sebocyte Biology.
Markovics A, Angyal Á, Tóth KF, Ádám D, Pénzes Z, Magi J, Pór Á, Kovács I, Törőcsik D, Zouboulis CC, Bíró T, Oláh A. | 04/13/2021 |
| GPR119 is the oleoyl-lysophosphatidylinositol receptor that is required for GLP-1 secretion in enteroendocrine cells. | Oleoyl-lysophosphatidylinositol enhances glucagon-like peptide-1 secretion from enteroendocrine L-cells through GPR119.
Arifin SA, Paternoster S, Carlessi R, Casari I, Ekberg JH, Maffucci T, Newsholme P, Rosenkilde MM, Falasca M. | 12/1/2018 |
| Angelica dahurica extract-treated cells showed significant increases in GPR119 activation, intracellular cAMP levels, GLP-1 levels and glucose-stimulated insulin secretion as compared with controls | Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119.
Park EY, Kim EH, Kim CY, Kim MH, Choung JS, Oh YS, Moon HS, Jun HS., Free PMC Article | 07/22/2017 |
| Describe novel small-molecule GPR119 agonists with high receptor selectivity and capacity to induce glucose-stimulated insulin secretion. | Discovery and characterization of novel small molecule agonists of G protein-coupled receptor 119.
Zhang SY, Li J, Xie X., Free PMC Article | 04/11/2015 |
| The GPR119 agonist, HD0471042 increased intracellular cAMP levels in stably human GPR119 expressing CHO cells. | Novel GPR119 agonist HD0471042 attenuated type 2 diabetes mellitus.
Ha TY, Kim YS, Kim CH, Choi HS, Yang J, Park SH, Kim DH, Rhee JK. | 01/10/2015 |
| Oxidized-LDL significantly induces lincRNA-DYNLRB2-2 expression, which promotes ABCA1-mediated cholesterol efflux and inhibits inflammation through GPR119 in THP-1 cells. | A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.
Hu YW, Yang JY, Ma X, Chen ZP, Hu YR, Zhao JY, Li SF, Qiu YR, Lu JB, Wang YC, Gao JJ, Sha YH, Zheng L, Wang Q., Free PMC Article | 12/20/2014 |
| Replacement of the three methyl groups in 1 with metabolically stable moieties led to the identification of compound 34, a potent and efficacious GPR119 agonist with improved pharmacokinetic (PK) properties. | Discovery and optimization of arylsulfonyl 3-(pyridin-2-yloxy)anilines as novel GPR119 agonists.
Zhang JK, Li AR, Yu M, Wang Y, Zhu J, Kayser F, Medina JC, Siegler K, Conn M, Shan B, Grillo MP, Eksterowicz J, Coward P, Liu JJ. | 04/26/2014 |
| transfection of GLUTag cells with recombinant human GPR119 results in a constitutive and apparently ligand-independent increase of proglucagon gene promoter activity and proglucagon mRNA content. | Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.
Chepurny OG, Bertinetti D, Diskar M, Leech CA, Afshari P, Tsalkova T, Cheng X, Schwede F, Genieser HG, Herberg FW, Holz GG., Free PMC Article | 04/5/2014 |
| Results provide evidence of an islet-gastrointestinal distribution of GPR119, its expression in pancreatic beta and alpha cells, and its possible involvement in islet function. | GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function.
Odori S, Hosoda K, Tomita T, Fujikura J, Kusakabe T, Kawaguchi Y, Doi R, Takaori K, Ebihara K, Sakai Y, Uemoto S, Nakao K. | 05/4/2013 |
| Data suggest that GPR119 activation/up-regulation in skeletal muscle impairs fatty acid and glucose oxidation; diet-induced obesity appears to up-regulate skeletal muscle GPR119. | GPR119 regulates genetic markers of fatty acid oxidation in cultured skeletal muscle myotubes.
Cornall LM, Mathai ML, Hryciw DH, Simcocks AC, O'Brien PE, Wentworth JM, McAinch AJ. | 04/20/2013 |
| Data show that Phe-V:13 can serve as an aromatic lock for the proposed active conformation of the Trp-VI:13 rotameric switch, being involved in the global movement of TM-V and TM-VI in 7TM receptor activation. | A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors.
Holst B, Nygaard R, Valentin-Hansen L, Bach A, Engelstoft MS, Petersen PS, Frimurer TM, Schwartz TW., Free PMC Article | 04/12/2010 |
| findings show that N-oleoyldopamine (OLDA)& structurally related hydroxybenzyl amides are robust activators of GPR119; studies indicate that multiple, distinct classes of lipid amides, acting via GPR119, may be important modulators of glucose homeostasis | N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119.
Chu ZL, Carroll C, Chen R, Alfonso J, Gutierrez V, He H, Lucman A, Xing C, Sebring K, Zhou J, Wagner B, Unett D, Jones RM, Behan DP, Leonard J., Free PMC Article | 03/22/2010 |
| GPR119 therefore represents a novel and attractive potential target for the therapy of obesity and related metabolic disorders. | Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents.
Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C. | 01/21/2010 |