| Hepatic HIF2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency. | Hepatic HIF2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency.
Prajapati M, Zhang JZ, Chiu L, Chong GS, Mercadante CJ, Kowalski HL, Delaney B, Anderson JA, Guo S, Aghajan M, Bartnikas TB., Free PMC Article | 10/8/2024 |
| Differential but complementary roles of HIF-1alpha and HIF-2alpha in the regulation of bone homeostasis. | Differential but complementary roles of HIF-1α and HIF-2α in the regulation of bone homeostasis.
Lee SY, Kim SJ, Park KH, Lee G, Oh Y, Ryu JH, Huh YH., Free PMC Article | 08/22/2024 |
| Positive feedback regulation of lncRNA PVT1 and HIF2alpha contributes to clear cell renal cell carcinoma tumorigenesis and metastasis. | Positive feedback regulation of lncRNA PVT1 and HIF2α contributes to clear cell renal cell carcinoma tumorigenesis and metastasis.
Zhang MX, Zhang LZ, Fu LM, Yao HH, Tan L, Feng ZH, Li JY, Lu J, Pan YH, Shu GN, Li PJ, Tang YM, Liao ZY, Wei JH, Chen W, Guo JP, Luo JH, Chen ZH., Free PMC Article | 07/26/2024 |
| EPAS1 expression contributes to maintenance of the primordial follicle pool in the mouse ovary. | EPAS1 expression contributes to maintenance of the primordial follicle pool in the mouse ovary.
Martin JH, Bernstein IR, Lyons JM, Brady AR, Mabotuwana NS, Stanger SJ, De Oliveira CS, Damyanova KB, Nixon B, Lord T., Free PMC Article | 04/22/2024 |
| Chronic hypoxia impairs skeletal muscle repair via HIF-2alpha stabilization. | Chronic hypoxia impairs skeletal muscle repair via HIF-2α stabilization.
Yin A, Fu W, Elengickal A, Kim J, Liu Y, Bigot A, Mamchaoui K, Call JA, Yin H., Free PMC Article | 04/11/2024 |
| Activation of Intestinal HIF2alpha Ameliorates Iron-Refractory Anemia. | Activation of Intestinal HIF2α Ameliorates Iron-Refractory Anemia.
Yu Y, Su Y, Yang S, Liu Y, Lin Z, Das NK, Wu Q, Zhou J, Sun S, Li X, Yue W, Shah YM, Min J, Wang F., Free PMC Article | 03/29/2024 |
| PDGFRbeta + cell HIF2alpha is dispensable for white adipose tissue metabolic remodeling and hepatic lipid accumulation in obese mice. | PDGFRβ + cell HIF2α is dispensable for white adipose tissue metabolic remodeling and hepatic lipid accumulation in obese mice.
Yao T, Wei D, Tian X, Zhao L, Wan Q, Zhang X, Cai J, Li S, Diao B, Feng S, Shan B, Shao M, Wu Y., Free PMC Article | 03/25/2024 |
| Hypoxia-inducible factor-2alpha promotes fibrosis in non-alcoholic fatty liver disease by enhancing glutamine catabolism and inhibiting yes-associated protein phosphorylation in hepatic stellate cells. | Hypoxia-inducible factor-2α promotes fibrosis in non-alcoholic fatty liver disease by enhancing glutamine catabolism and inhibiting yes-associated protein phosphorylation in hepatic stellate cells.
Yan R, Cai H, Zhou X, Bao G, Bai Z, Ge RL., Free PMC Article | 03/20/2024 |
| Disruption of hypoxia-inducible factor-2alpha in neutrophils decreases colitis-associated colon cancer. | Disruption of hypoxia-inducible factor-2α in neutrophils decreases colitis-associated colon cancer.
Singhal R, Kotla NK, Solanki S, Huang W, Bell HN, El-Derany MO, Castillo C, Shah YM., | 01/8/2024 |
| Myeloid Hif2alpha is not essential to maintain systemic iron homeostasis. | Myeloid Hif2α is not essential to maintain systemic iron homeostasis.
Jain C, Parimi S, Huang W, Hannifin S, Singhal R, Das NK, Lee KE, Shah YM., Free PMC Article | 11/6/2023 |
| Impairment of HIF-2alpha Expression Induced the Compensatory Overexpression of the HIF-1alpha/SDF-1 Axis to Promote Wound Healing. | Impairment of HIF-2α Expression Induced the Compensatory Overexpression of the HIF-1α/SDF-1 Axis to Promote Wound Healing.
Yamashita T, Vuong CK, Ngo NH, Osaka M, Hiramatsu Y, Ohneda O. | 10/26/2023 |
| Effects of long-term tubular HIF-2alpha overexpression on progressive renal fibrosis in a chronic kidney disease model. | Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
Kim DA, Lee MR, Oh HJ, Kim M, Kong KH., Free PMC Article | 03/29/2023 |
| Hypoxia-Inducible Factor 2alpha Attenuates Renal Ischemia-Reperfusion Injury by Suppressing CD36-Mediated Lipid Accumulation in Dendritic Cells in a Mouse Model. | Hypoxia-Inducible Factor 2α Attenuates Renal Ischemia-Reperfusion Injury by Suppressing CD36-Mediated Lipid Accumulation in Dendritic Cells in a Mouse Model.
Qu J, Li D, Jin J, Sun N, Wu J, Yang C, Wu L, Zhuang S, Wu H, Chen R, Ren Y, Zhong C, Ying L, Zhang Y, Yuan X, Zhang M., Free PMC Article | 02/11/2023 |
| Conditional Deletion of HIF-2alpha in Mouse Nucleus Pulposus Reduces Fibrosis and Provides Mild and Transient Protection From Age-Dependent Structural Changes in Intervertebral Disc. | Conditional Deletion of HIF-2α in Mouse Nucleus Pulposus Reduces Fibrosis and Provides Mild and Transient Protection From Age-Dependent Structural Changes in Intervertebral Disc.
Johnston SN, Madhu V, Shapiro IM, Risbud MV., Free PMC Article | 01/21/2023 |
| Tailless and hypoxia inducible factor-2alpha cooperate to sustain proangiogenic states of retinal astrocytes in neonatal mice. | Tailless and hypoxia inducible factor-2α cooperate to sustain proangiogenic states of retinal astrocytes in neonatal mice.
Duan LJ, Jiang Y, Shi Y, Fong GH., Free PMC Article | 01/14/2023 |
| HIF-2alpha Inhibits Ameloblast Differentiation via Hey2 in Tooth Development. | HIF-2α Inhibits Ameloblast Differentiation via Hey2 in Tooth Development.
Kimura S, Takeshita N, Oyanagi T, Seki D, Jiang W, Hidaka K, Fukumoto S, Takahashi I, Takano-Yamamoto T. | 11/29/2022 |
| Myostatin/HIF2alpha-Mediated Ferroptosis is Involved in Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease. | Myostatin/HIF2α-Mediated Ferroptosis is Involved in Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease.
Zhang L, Li D, Chang C, Sun Y., Free PMC Article | 10/8/2022 |
| EP300 promotes renal tubular epithelial cell fibrosis by increasing HIF2alpha expression in diabetic nephropathy. | EP300 promotes renal tubular epithelial cell fibrosis by increasing HIF2α expression in diabetic nephropathy.
Gong Y, Dou Y, Wang L, Wang X, Zhao Z. | 09/10/2022 |
| Myeloid PHD2 deficiency accelerates neointima formation via Hif-1alpha. | Myeloid PHD2 deficiency accelerates neointima formation via Hif-1α.
Christoph M, Pfluecke C, Mensch M, Augstein A, Jellinghaus S, Ende G, Mierke J, Franke K, Wielockx B, Ibrahim K, Poitz DM. | 08/27/2022 |
| Hypoxia-Induced Scleral HIF-2alpha Upregulation Contributes to Rises in MMP-2 Expression and Myopia Development in Mice. | Hypoxia-Induced Scleral HIF-2α Upregulation Contributes to Rises in MMP-2 Expression and Myopia Development in Mice.
Wu W, Su Y, Hu C, Tao H, Jiang Y, Zhu G, Zhu J, Zhai Y, Qu J, Zhou X, Zhao F., Free PMC Article | 07/16/2022 |
| HIF-2alpha Preserves Mitochondrial Activity and Glucose Sensing in Compensating beta-Cells in Obesity. | HIF-2α Preserves Mitochondrial Activity and Glucose Sensing in Compensating β-Cells in Obesity.
Moon JS, Riopel M, Seo JB, Herrero-Aguayo V, Isaac R, Lee YS., Free PMC Article | 07/2/2022 |
| Adipocyte HIF2alpha functions as a thermostat via PKA Calpha regulation in beige adipocytes. | Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes.
Han JS, Jeon YG, Oh M, Lee G, Nahmgoong H, Han SM, Choi J, Kim YY, Shin KC, Kim J, Jo K, Choe SS, Park EJ, Kim S, Kim JB., Free PMC Article | 06/11/2022 |
| Intestinal HIF-2alpha Regulates GLP-1 Secretion via Lipid Sensing in L-Cells. | Intestinal HIF-2α Regulates GLP-1 Secretion via Lipid Sensing in L-Cells.
Mooli RGR, Mukhi D, Pasupulati AK, Evers SS, Sipula IJ, Jurczak M, Seeley RJ, Shah YM, Ramakrishnan SK., Free PMC Article | 04/30/2022 |
| Intestinal hypoxia-inducible factor 2alpha regulates lactate levels to shape the gut microbiome and alter thermogenesis. | Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis.
Wu Q, Liang X, Wang K, Lin J, Wang X, Wang P, Zhang Y, Nie Q, Liu H, Zhang Z, Liu J, Pang Y, Jiang C. | 04/16/2022 |
| Neuronal deficiency of hypoxia-inducible factor 2alpha increases hypoxic-ischemic brain injury in neonatal mice. | Neuronal deficiency of hypoxia-inducible factor 2α increases hypoxic-ischemic brain injury in neonatal mice.
Sun D, Lu F, Sheldon A, Jiang X, Ferriero DM., Free PMC Article | 04/9/2022 |