| Enam expression is regulated by Msx2. | Enam expression is regulated by Msx2.
Ruspita I, Das P, Miyoshi K, Noma T, Snead ML, Bei M., | 10/11/2023 |
| Data suggest that a specific quantity of enamelin is critical for normal enamel formation. | Enamelin is critical for ameloblast integrity and enamel ultrastructure formation.
Hu JC, Hu Y, Lu Y, Smith CE, Lertlam R, Wright JT, Suggs C, McKee MD, Beniash E, Kabir ME, Simmer JP., Free PMC Article | 02/14/2015 |
| enamelin genotype, which affects enamel integrity, and food hardness influence bodyweight gain in postnatal and young adult mice | Bodyweight assessment of enamelin null mice.
Chan AH, Lertlam R, Simmer JP, Wang CN, Hu JC., Free PMC Article | 11/16/2013 |
| The enamelin mutation was associated with earlier forming enamel defects.The study supported the critical involvement of amelogenin and enamelin in enamel mineralization. | Phenotype-genotype correlations in mouse models of amelogenesis imperfecta caused by Amelx and Enam mutations.
Coxon TL, Brook AH, Barron MJ, Smith RN., Free PMC Article | 03/16/2013 |
| enamelin acts as an adhesion molecule and is involved in ameloblast cell differentiation during the early stages of tooth development | Histological and immunohistochemical analyses of molar tooth germ in enamelin-deficient mouse.
Sawada T, Sekiguchi H, Uchida T, Yamashita H, Shintani S, Yanagisawa T. | 08/13/2011 |
| The results suggested that Wnt/beta-catenin signaling could function in enamelin gene expression by direct interaction through two conserved LEF1 responsive elements on the enamelin gene in ameloblast-like cells. | Beta-catenin/LEF1 activated enamelin expression in ameloblast-like cells.
Tian H, Lv P, Ma K, Zhou C, Gao X. | 09/13/2010 |
| This study provides new insights into the molecular control of Enam cell- and stage-specific expression. | Identifying promoter elements necessary for enamelin tissue-specific expression.
Papagerakis P, Hu Y, Ye L, Feng JQ, Simmer JP, Hu JC., Free PMC Article | 01/21/2010 |
| Mice lacking expression of the AmelX, Enam and Mmp20 genes have been generated. | Human and mouse enamel phenotypes resulting from mutation or altered expression of AMEL, ENAM, MMP20 and KLK4.
Wright JT, Hart TC, Hart PS, Simmons D, Suggs C, Daley B, Simmer J, Hu J, Bartlett JD, Li Y, Yuan ZA, Seow WK, Gibson CW., Free PMC Article | 01/21/2010 |
| enamelin is essential for proper enamel matrix organization and mineralization | Enamel defects and ameloblast-specific expression in Enam knock-out/lacz knock-in mice.
Hu JC, Hu Y, Smith CE, McKee MD, Wright JT, Yamakoshi Y, Papagerakis P, Hunter GK, Feng JQ, Yamakoshi F, Simmer JP., Free PMC Article | 01/21/2010 |
| new insights into regulatory mechanisms governing enamelin expression | Distal cis-regulatory elements are required for tissue-specific expression of enamelin (Enam).
Hu Y, Papagerakis P, Ye L, Feng JQ, Simmer JP, Hu JC., Free PMC Article | 01/21/2010 |
| the amelogenesis imperfecta phenotype is linked to a C > T transition in exon 8 of the enamelin gene | A mutation in the enamelin gene in a mouse model.
Seedorf H, Klaften M, Eke F, Fuchs H, Seedorf U, Hrabe de Angelis M. | 01/21/2010 |