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    CR1 complement C3b/C4b receptor 1 (Knops blood group) [ Homo sapiens (human) ]

    Gene ID: 1378, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The Molecular Mechanisms of Complement Receptor 1-It Is Complicated.

    The Molecular Mechanisms of Complement Receptor 1-It Is Complicated.
    Hardy MP, Mansour M, Rowe T, Wymann S., Free PMC Article

    11/2/2023
    Complement receptor type 1 and 2 (CR1 and CR2) gene polymorphisms and plasma protein levels are associated with the Dengue disease severity.

    Complement receptor type 1 and 2 (CR1 and CR2) gene polymorphisms and plasma protein levels are associated with the Dengue disease severity.
    Diep NT, Giang NT, Diu NTT, Nam NM, Khanh LV, Quang HV, Hang NT, Mao CV, Son HV, Hieu NL, Linh PT, Sklan EH, Toan NL, Tong HV., Free PMC Article

    10/24/2023
    Genetic variant in complement receptor 1 (CR1, CD35) is associated with a cluster of severe fatal COVID-19 in a family.

    Genetic variant in complement receptor 1 (CR1, CD35) is associated with a cluster of severe fatal COVID-19 in a family.
    Danial-Farran N, Khlaila M, Avraham-Kelbert M, Chazan B, Khayat M, Winder A, Shalev S, Bisharat N., Free PMC Article

    09/11/2023
    Elucidation of the low-expressing erythroid CR1 phenotype by bioinformatic mining of the GATA1-driven blood-group regulome.

    Elucidation of the low-expressing erythroid CR1 phenotype by bioinformatic mining of the GATA1-driven blood-group regulome.
    Wu PC, Lee YQ, Möller M, Storry JR, Olsson ML., Free PMC Article

    09/7/2023
    Erythrocyte complement receptor 1 (ECR1) and erythrocyte-bound C4d (EC4d) in the prediction of poor pregnancy outcomes in systemic lupus erythematosus (SLE).

    Erythrocyte complement receptor 1 (ECR1) and erythrocyte-bound C4d (EC4d) in the prediction of poor pregnancy outcomes in systemic lupus erythematosus (SLE).
    Conklin J, Golpanian M, Engel A, Izmirly P, Belmont HM, Dervieux T, Buyon JP, Alexander RV., Free PMC Article

    02/14/2023
    Population-specific positive selection on low CR1 expression in malaria-endemic regions.

    Population-specific positive selection on low CR1 expression in malaria-endemic regions.
    Lorenzini PA, Gusareva ES, Ghosh AG, Ramli NAB, Preiser PR, Kim HL., Free PMC Article

    01/14/2023
    Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood.

    Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood.
    Landsem A, Emblem Å, Lau C, Christiansen D, Gerogianni A, Karlsen BO, Mollnes TE, Nilsson PH, Brekke OL., Free PMC Article

    01/14/2023
    CASP5 and CR1 as potential biomarkers for Kawasaki disease: an Integrated Bioinformatics-Experimental Study.

    CASP5 and CR1 as potential biomarkers for Kawasaki disease: an Integrated Bioinformatics-Experimental Study.
    Rahmati Y, Mollanoori H, Najafi S, Esmaeili S, Alivand MR., Free PMC Article

    01/29/2022
    Explore the role of CR1 genetic variants in late-onset Alzheimer's disease susceptibility.

    Explore the role of CR1 genetic variants in late-onset Alzheimer's disease susceptibility.
    Lu L, Yao QY, Ruan SS, Hu JW, Long WJ, Dai WZ, Ma T, Zhu XC.

    01/22/2022
    Immunoregulatory complement receptor-1 and leukocyte-associated Ig-like receptor-1 expression on leukocytes in Psoriasis vulgaris.

    Immunoregulatory complement receptor-1 and leukocyte-associated Ig-like receptor-1 expression on leukocytes in Psoriasis vulgaris.
    Hammad R, Hamdino M, El-Nasser AM, Sobhy A, Eldesoky NA, Mashaal AM, Ali HF., Free PMC Article

    10/2/2021
    A novel soluble complement receptor 1 fragment with enhanced therapeutic potential.

    A novel soluble complement receptor 1 fragment with enhanced therapeutic potential.
    Wymann S, Dai Y, Nair AG, Cao H, Powers GA, Schnell A, Martin-Roussety G, Leong D, Simmonds J, Lieu KG, de Souza MJ, Mischnik M, Taylor S, Ow SY, Spycher M, Butcher RE, Pearse M, Zuercher AW, Baz Morelli A, Panousis C, Wilson MJ, Rowe T, Hardy MP., Free PMC Article

    09/4/2021
    The Impact of Complement Genes on the Risk of Late-Onset Alzheimer's Disease.

    The Impact of Complement Genes on the Risk of Late-Onset Alzheimer's Disease.
    Carpanini SM, Harwood JC, Baker E, Torvell M, The Gerad Consortium, Sims R, Williams J, Morgan BP., Free PMC Article

    07/31/2021
    KDAS, a new blood group antigen in the Knops blood group system antithetical to KCAM.

    KDAS, a new blood group antigen in the Knops blood group system antithetical to KCAM.
    Scharberg EA, Rink G, Schulz D, Rothenberger S, Stürtzel A, Gillhuber N, Seyboth S, Bugert P.

    07/3/2021
    Two novel antithetical KN blood group antigens may contribute to more than a quarter of all KN antisera in Europe.

    Two novel antithetical KN blood group antigens may contribute to more than a quarter of all KN antisera in Europe.
    Grueger D, Zeretzke A, Habicht CP, Skaik Y, Wagner FF, Scharberg EA, Costelloe A, Martens J, Verboom M, Bugert P, Schneeweiss C.

    07/3/2021
    First Report of CR1 Polymorphisms and Soluble CR1 Levels Associated with Late Onset Alzheimer's Disease (LOAD) in Latin America.

    First Report of CR1 Polymorphisms and Soluble CR1 Levels Associated with Late Onset Alzheimer's Disease (LOAD) in Latin America.
    Kretzschmar GC, Antoniazzi AAH, Oliveira LC, Nisihara RM, Petzl-Erler ML, de Souza RLR, Boldt ABW.

    06/12/2021
    Complement receptor 1 genetic polymorphism contributes to sporadic Alzheimer's disease susceptibility in Caucasians: a meta-analysis.

    Complement receptor 1 genetic polymorphism contributes to sporadic Alzheimer's disease susceptibility in Caucasians: a meta-analysis.
    Yuan H, Du L, Ge P., Free PMC Article

    05/22/2021
    Expression of Cripto-1 predicts poor prognosis in stage I non-small cell lung cancer.

    Expression of Cripto-1 predicts poor prognosis in stage I non-small cell lung cancer.
    Xu C, Yuan Q, Hu H, Wang W, Zhang Q, Li L, Wang J, Yang R., Free PMC Article

    05/8/2021
    Mechanistic Understanding of Cell Recognition and Immune Reaction via CR1/CR3 by HAP- and SiO2-NPs.

    Mechanistic Understanding of Cell Recognition and Immune Reaction via CR1/CR3 by HAP- and SiO(2)-NPs.
    Ding T, Sun J., Free PMC Article

    02/13/2021
    Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM in the blood of Japanese Alzheimer's disease patients.

    Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM in the blood of Japanese Alzheimer's disease patients.
    Mitsumori R, Sakaguchi K, Shigemizu D, Mori T, Akiyama S, Ozaki K, Niida S, Shimoda N., Free PMC Article

    11/21/2020
    Impacts of CR1 genetic variants on cerebrospinal fluid and neuroimaging biomarkers in alzheimer's disease.

    Impacts of CR1 genetic variants on cerebrospinal fluid and neuroimaging biomarkers in alzheimer's disease.
    Zhu XC, Dai WZ, Ma T., Free PMC Article

    11/21/2020
    Altered Expression of Complement Regulatory Proteins CD35, CD46, CD55, and CD59 on Leukocyte Subsets in Individuals Suffering From Coronary Artery Disease.

    Altered Expression of Complement Regulatory Proteins CD35, CD46, CD55, and CD59 on Leukocyte Subsets in Individuals Suffering From Coronary Artery Disease.
    Mishra N, Mohata M, Narang R, Lakshmy R, Hazarika A, Pandey RM, Das N, Luthra K., Free PMC Article

    10/3/2020
    CR1 clustering significantly and dose dependently reduces the TLR9-induced expression of activation markers, cytokine production, proliferation, and antibody production by tonsillar B cells, but has no effect on the TLR7-induced functions.

    Complement Receptor Type 1 (CR1, CD35), the Inhibitor of BCR-Mediated Human B Cell Activation, Differentially Regulates TLR7, and TLR9 Induced Responses.
    Mácsik-Valent B, Nagy K, Fazekas L, Erdei A., Free PMC Article

    07/18/2020
    CR1 as a complement inhibitor.

    Complement Receptor 1 (CR1/CD35)-expressing retinal pigment epithelial cells as a potential therapy for age-related macular degeneration.
    Simmons KT, Mazzilli JL, Mueller-Ortiz SL, Domozhirov AY, Garcia CA, Zsigmond EM, Wetsel RA.

    04/11/2020
    In donor blood with high and medium CR1 numbers.

    Key role of the number of complement receptor 1 on erythrocytes for binding of Escherichia coli to erythrocytes and for leukocyte phagocytosis and oxidative burst in human whole blood.
    Brekke OL, Christiansen D, Kisserli A, Fure H, Dahl JA, Donvito B, Reveil B, Ludviksen JK, Tabary T, Mollnes TE, Cohen JHM.

    01/25/2020
    CR1 SNPs associated with decreased erythrocyte CR1 increased Alzheimer's disease (AD) risk, whereas a CR1 SNP associated with increased erythrocyte CR1 decreased AD risk. SNP effects on erythrocyte CR1 likely underlie the association of CR1 polymorphisms with AD risk.

    Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1.
    Johansson JU, Brubaker WD, Javitz H, Bergen AW, Nishita D, Trigunaite A, Crane A, Ceballos J, Mastroeni D, Tenner AJ, Sabbagh M, Rogers J., Free PMC Article

    09/28/2019
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