| Citrullination, a novel posttranslational modification of elastin, is involved in COPD pathogenesis. | Citrullination, a novel posttranslational modification of elastin, is involved in COPD pathogenesis.
Murphy MP, Zieger M, Henry M, Meleady P, Mueller C, McElvaney NG, Reeves EP. | 10/10/2024 |
| Altered Elastin Turnover, Immune Response, and Age-Related Retinal Thinning in a Transgenic Mouse Model With RPE-Specific HTRA1 Overexpression. | Altered Elastin Turnover, Immune Response, and Age-Related Retinal Thinning in a Transgenic Mouse Model With RPE-Specific HTRA1 Overexpression.
Navneet S, Ishii M, Rohrer B., Free PMC Article | 07/24/2024 |
| Constitutive Modeling of Mouse Arteries Suggests Changes in Directional Coupling and Extracellular Matrix Remodeling That Depend on Artery Type, Age, Sex, and Elastin Amounts. | Constitutive Modeling of Mouse Arteries Suggests Changes in Directional Coupling and Extracellular Matrix Remodeling That Depend on Artery Type, Age, Sex, and Elastin Amounts.
Kailash KA, Hawes JZ, Cocciolone AJ, Bersi MR, Mecham RP, Wagenseil JE. | 03/12/2024 |
| High-Intensity Focused Ultrasound Increases Collagen and Elastin Fiber Synthesis by Modulating Caveolin-1 in Aging Skin. | High-Intensity Focused Ultrasound Increases Collagen and Elastin Fiber Synthesis by Modulating Caveolin-1 in Aging Skin.
Oh S, Rhee DY, Batsukh S, Son KH, Byun K., Free PMC Article | 09/29/2023 |
| A new mouse model of elastin haploinsufficiency highlights the importance of elastin to vascular development and blood pressure regulation. | A new mouse model of elastin haploinsufficiency highlights the importance of elastin to vascular development and blood pressure regulation.
Brengle BM, Lin M, Roth RA, Jones KD, Wagenseil JE, Mecham RP, Halabi CM. | 03/22/2023 |
| Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy. | Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy.
Zhang R, Xu X, Chen X, Hao C, Ji Z, Zuo P, Yang M, Ma G, Li Y., Free PMC Article | 08/27/2022 |
| Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD. | Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD.
Benjamin JT, Plosa EJ, Sucre JM, van der Meer R, Dave S, Gutor S, Nichols DS, Gulleman PM, Jetter CS, Han W, Xin M, Dinella PC, Catanzarite A, Kook S, Dolma K, Lal CV, Gaggar A, Blalock JE, Newcomb DC, Richmond BW, Kropski JA, Young LR, Guttentag SH, Blackwell TS., Free PMC Article | 09/11/2021 |
| Whole exome sequencing in patients with Williams-Beuren syndrome followed by disease modeling in mice points to four novel pathways that may modify stenosis risk. | Whole exome sequencing in patients with Williams-Beuren syndrome followed by disease modeling in mice points to four novel pathways that may modify stenosis risk.
Parrish PCR, Liu D, Knutsen RH, Billington CJ, Mecham RP, Fu YP, Kozel BA., Free PMC Article | 08/28/2021 |
| Elastin homeostasis is altered with pelvic organ prolapse in cultures of vaginal cells from a lysyl oxidase-like 1 knockout mouse model. | Elastin homeostasis is altered with pelvic organ prolapse in cultures of vaginal cells from a lysyl oxidase-like 1 knockout mouse model.
Jameson SA, Swaminathan G, Dahal S, Couri B, Kuang M, Rietsch A, Butler RS, Ramamurthi A, Damaser MS., Free PMC Article | 06/12/2021 |
| Elastin haploinsufficiency in mice has divergent effects on arterial remodeling with aging depending on sex. | Elastin haploinsufficiency in mice has divergent effects on arterial remodeling with aging depending on sex.
Hawes JZ, Cocciolone AJ, Cui AH, Griffin DB, Staiculescu MC, Mecham RP, Wagenseil JE., Free PMC Article | 01/2/2021 |
| The Elastin-Derived Peptide VGVAPG Does Not Activate the Inflammatory Process in Mouse Cortical Astrocytes In Vitro. | The Elastin-Derived Peptide VGVAPG Does Not Activate the Inflammatory Process in Mouse Cortical Astrocytes In Vitro.
Szychowski KA, Gmiński J., Free PMC Article | 12/26/2020 |
| Tropoelastin: an in vivo imaging marker of dysfunctional matrix turnover during abdominal aortic dilation. | Tropoelastin: an in vivo imaging marker of dysfunctional matrix turnover during abdominal aortic dilation.
Lavin B, Lacerda S, Andia ME, Lorrio S, Bakewell R, Smith A, Rashid I, Botnar RM, Phinikaridou A., Free PMC Article | 10/24/2020 |
| Document an unexpected heterogeneity in vascular cells that produce elastin and their roles in formation of the elastic laminae. | Heterogeneous Cellular Contributions to Elastic Laminae Formation in Arterial Wall Development.
Lin CJ, Staiculescu MC, Hawes JZ, Cocciolone AJ, Hunkins BM, Roth RA, Lin CY, Mecham RP, Wagenseil JE., Free PMC Article | 07/4/2020 |
| Data (including data from studies in mutant mice and cells from such mice) suggest that elastin-derived peptides are involved in regulation of lipid storage in hepatocytes; thus, elastin-derived peptides may play role in development and progression of non-alcoholic fatty liver. | Production of Elastin-Derived Peptides Contributes to the Development of Nonalcoholic Steatohepatitis.
Romier B, Ivaldi C, Sartelet H, Heinz A, Schmelzer CEH, Garnotel R, Guillot A, Jonquet J, Bertin E, Guéant JL, Alberto JM, Bronowicki JP, Amoyel J, Hocine T, Duca L, Maurice P, Bennasroune A, Martiny L, Debelle L, Durlach V, Blaise S. | 07/28/2018 |
| Elastin insufficiency triggers structural defects and abnormal remodeling of renal vascular signaling involving AT1R-mediated vascular mechanotransduction and renal hyperfiltration with increased blood pressure sensitivity to dietary sodium contributing to systolic hypertension. | Elastin insufficiency causes hypertension, structural defects and abnormal remodeling of renal vascular signaling.
Owens EA, Jie L, Reyes BAS, Van Bockstaele EJ, Osei-Owusu P. | 06/16/2018 |
| findings strongly suggested that elastin crosslinking and LOXL1 were co-associated with liver cirrhosis, while selective inhibition of LOXL1 arrested disease progression by reducing crosslinking of elastin. | Inhibition of lysyl oxidase-like 1 (LOXL1) expression arrests liver fibrosis progression in cirrhosis by reducing elastin crosslinking.
Zhao W, Yang A, Chen W, Wang P, Liu T, Cong M, Xu A, Yan X, Jia J, You H. | 06/16/2018 |
| Elastin-Derived Peptides Promote Abdominal Aortic Aneurysm Formation by Modulating M1/M2 Macrophage Polarization | Elastin-Derived Peptides Promote Abdominal Aortic Aneurysm Formation by Modulating M1/M2 Macrophage Polarization.
Dale MA, Xiong W, Carson JS, Suh MK, Karpisek AD, Meisinger TM, Casale GP, Baxter BT., Free PMC Article | 09/30/2017 |
| mTOR-sensitive perturbation of smooth muscle cell mechanosensing contributes to elastin aortopathy. | mTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice.
Jiao Y, Li G, Li Q, Ali R, Qin L, Li W, Qyang Y, Greif DM, Geirsson A, Humphrey JD, Tellides G., Free PMC Article | 09/9/2017 |
| Deficient circumferential growth is the predominant mechanism for moderate obstructive aortic disease resulting from partial elastin deficiency in Williams syndrome. | Deficient Circumferential Growth Is the Primary Determinant of Aortic Obstruction Attributable to Partial Elastin Deficiency.
Jiao Y, Li G, Korneva A, Caulk AW, Qin L, Bersi MR, Li Q, Li W, Mecham RP, Humphrey JD, Tellides G., Free PMC Article | 06/24/2017 |
| Elevations of whole lung HMGB1 level were associated with impaired alveolar development and aberrant elastin production in 85% O2-exposed newborn lungs. | High-Mobility Group Box-1 Protein Disrupts Alveolar Elastogenesis of Hyperoxia-Injured Newborn Lungs.
Yu B, Li X, Wan Q, Han W, Deng C, Guo C. | 12/17/2016 |
| Eln was ubiquitously present, with enrichment in regions with cardiomyocyte differentiation, while there was an inverse correlation between ColI and cardiomyocyte differentiation. | Endogenous Optical Signals Reveal Changes of Elastin and Collagen Organization During Differentiation of Mouse Embryonic Stem Cells.
Thimm TN, Squirrell JM, Liu Y, Eliceiri KW, Ogle BM., Free PMC Article | 07/16/2016 |
| Lung histology revealed aberrant elastin production and impaired lung septation in oxygen-exposed lungs, while tropoelastin, integrin alphav, fibulin-1, fibulin-2 and fibulin-4 gene expression were elevated. | Aberrant elastin remodeling in the lungs of O₂-exposed newborn mice; primarily results from perturbed interaction between integrins and elastin.
Han W, Guo C, Liu Q, Yu B, Liu Z, Yang J, Deng C. | 10/31/2015 |
| Data suggest that expression of elastin in uterus, vagina, and bladder is down-regulated both in naturally aging mice and in mouse model of accelerated ovarian aging; such down-regulation may lead to pelvic floor disorders. | Decreased expression of elastin and lysyl oxidase family genes in urogenital tissues of aging mice.
Jiang Y, Zong W, Luan H, Liu JH, Zhang AZ, Li XL, Liu SY, Zhang SQ, Gao JG. | 09/26/2015 |
| Data indicate significantly reduced volumetric density of elastin and collagen and thinner skin dermis were observed in Marfan mice. | Quantification of aortic and cutaneous elastin and collagen morphology in Marfan syndrome by multiphoton microscopy.
Cui JZ, Tehrani AY, Jett KA, Bernatchez P, van Breemen C, Esfandiarei M. | 05/16/2015 |
| These results suggest that elastin haploinsufficiency adversely impacts pulmonary angiogenesis. | Lung matrix and vascular remodeling in mechanically ventilated elastin haploinsufficient newborn mice.
Hilgendorff A, Parai K, Ertsey R, Navarro E, Jain N, Carandang F, Peterson J, Mokres L, Milla C, Preuss S, Alcazar MA, Khan S, Masumi J, Ferreira-Tojais N, Mujahid S, Starcher B, Rabinovitch M, Bland R., Free PMC Article | 05/2/2015 |