| ANXA3 interference inactivates ERK/ELK1 pathway to mitigate inflammation and apoptosis in sepsis-associated acute lung injury. | ANXA3 interference inactivates ERK/ELK1 pathway to mitigate inflammation and apoptosis in sepsis-associated acute lung injury.
Liang J, Zhang J, Fan J, Chen S, Wu W. | 03/1/2024 |
| Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia. | Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia.
Su C, Liu M, Yao X, Hao W, Ma J, Ren Y, Gao X, Xin L, Ge L, Yu Y, Wei M, Yang J., Free PMC Article | 01/30/2024 |
| BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis. | BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis.
Chen W, Zhao S, Xing J, Yu W, Rao T, Zhou X, Ruan Y, Li S, Xia Y, Song T, Zou F, Li W, Cheng F. | 11/22/2023 |
| MicroRNA-150 and its target ETS-domain transcription factor 1 contribute to inflammation in diabetic photoreceptors. | MicroRNA-150 and its target ETS-domain transcription factor 1 contribute to inflammation in diabetic photoreceptors.
Yu F, Ko ML, Ko GY., Free PMC Article | 03/19/2022 |
| The Elk1/MMP-9 axis regulates E-cadherin and occludin in ventilator-induced lung injury. | The Elk1/MMP-9 axis regulates E-cadherin and occludin in ventilator-induced lung injury.
Tao Z, Jie Y, Mingru Z, Changping G, Fan Y, Haifeng W, Yuelan W., Free PMC Article | 01/29/2022 |
| Critical Protein-Protein Interactions Determine the Biological Activity of Elk-1, a Master Regulator of Stimulus-Induced Gene Transcription. | Critical Protein-Protein Interactions Determine the Biological Activity of Elk-1, a Master Regulator of Stimulus-Induced Gene Transcription.
Thiel G, Backes TM, Guethlein LA, Rössler OG., Free PMC Article | 11/27/2021 |
| The Ap-2alpha/Elk-1 axis regulates Sirpalpha-dependent tumor phagocytosis by tumor-associated macrophages in colorectal cancer. | The Ap-2α/Elk-1 axis regulates Sirpα-dependent tumor phagocytosis by tumor-associated macrophages in colorectal cancer.
Wang X, Luo X, Chen C, Tang Y, Li L, Mo B, Liang H, Yu S., Free PMC Article | 10/16/2021 |
| Ternary complex factor regulates pancreatic islet size and blood glucose homeostasis in transgenic mice. | Ternary complex factor regulates pancreatic islet size and blood glucose homeostasis in transgenic mice.
Lesch A, Backes TM, Langfermann DS, Rössler OG, Laschke MW, Thiel G. | 07/10/2021 |
| Loss of ELK1 has differential effects on age-dependent organ fibrosis. | Loss of ELK1 has differential effects on age-dependent organ fibrosis.
Cairns JT, Habgood A, Edwards-Pritchard RC, Joseph C, John AE, Wilkinson C, Stewart ID, Leslie J, Blaxall BC, Susztak K, Alberti S, Nordheim A, Oakley F, Jenkins G, Tatler AL., Free PMC Article | 10/31/2020 |
| Elk-1 transcriptionally regulates ZC3H4 expression to promote silica-induced epithelial-mesenchymal transition. | Elk-1 transcriptionally regulates ZC3H4 expression to promote silica-induced epithelial-mesenchymal transition.
Jiang R, Gao Q, Chen M, Yu T. | 10/24/2020 |
| Protein inhibitor of activated STAT1 Ser(503) phosphorylation-mediated Elk-1 SUMOylation promotes neuronal survival in APP/PS1 mice. | Protein inhibitor of activated STAT1 Ser(503) phosphorylation-mediated Elk-1 SUMOylation promotes neuronal survival in APP/PS1 mice.
Liu SY, Ma YL, Hsu WL, Chiou HY, Lee EHY., Free PMC Article | 09/5/2020 |
| Elk1 mediated FGF2-induced inhibition of endothelial-to-myofibroblast transition via inhibition of TGF-beta-induced transcriptional activation of alpha-smooth muscle actin promoter by myocardin-related transcription factor-A. | Fibroblast growth factor signals regulate transforming growth factor-β-induced endothelial-to-myofibroblast transition of tumor endothelial cells via Elk1.
Akatsu Y, Takahashi N, Yoshimatsu Y, Kimuro S, Muramatsu T, Katsura A, Maishi N, Suzuki HI, Inazawa J, Hida K, Miyazono K, Watabe T., Free PMC Article | 05/9/2020 |
| MicroRNA-139-3p regulates osteoblast differentiation and apoptosis by targeting ELK1 and interacting with long noncoding RNA ODSM. | MicroRNA-139-3p regulates osteoblast differentiation and apoptosis by targeting ELK1 and interacting with long noncoding RNA ODSM.
Wang Y, Wang K, Hu Z, Zhou H, Zhang L, Wang H, Li G, Zhang S, Cao X, Shi F., Free PMC Article | 12/14/2019 |
| These data establish that low-level ERK signaling through ELK4 (and ELK1) promotes innate-like alphabeta CD8(+) T cell differentiation, tuning conventional versus innate-like development. | ERK Signaling Controls Innate-like CD8(+) T Cell Differentiation via the ELK4 (SAP-1) and ELK1 Transcription Factors.
Maurice D, Costello P, Sargent M, Treisman R., Free PMC Article | 07/6/2019 |
| the effects of vitamin C inhibiting the apo(a) expression were attenuated by ELK1siRNA and Tet2siRNA. These results suggested vitamin C down-regulate apo(a) expression via Tet2-dependent DNA demethylation in HepG2 cells | Vitamin C down-regulate apo(a) expression via Tet2-dependent DNA demethylation in HepG2 cells.
Qu K, Ma XF, Li GH, Zhang H, Liu YM, Zhang K, Zeng JF, Lei JJ, Wei DH, Wang Z. | 03/25/2017 |
| These data reveal a novel role for Elk1 regulating ITGB6 expression and highlight how dysregulation of Elk1 can contribute to human disease. | Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression.
Tatler AL, Habgood A, Porte J, John AE, Stavrou A, Hodge E, Kerama-Likoko C, Violette SM, Weinreb PH, Knox AJ, Laurent G, Parfrey H, Wolters PJ, Wallace W, Alberti S, Nordheim A, Jenkins G., Free PMC Article | 11/12/2016 |
| A role for Elk-1 in the transcriptional regulation of DUSP5 | Dual Specificity Phosphatase 5, a Specific Negative Regulator of ERK Signaling, Is Induced by Serum Response Factor and Elk-1 Transcription Factor.
Buffet C, Catelli MG, Hecale-Perlemoine K, Bricaire L, Garcia C, Gallet-Dierick A, Rodriguez S, Cormier F, Groussin L., Free PMC Article | 07/30/2016 |
| TNF-alpha modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1. | TNF-α modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1.
Al-Sadi R, Guo S, Ye D, Ma TY., Free PMC Article | 07/5/2014 |
| novel GrB-EH(ITSN)-dependent pathogenic p38(MAPK)/Elk-1 signaling pathway involved in the poorly understood process of PL formation in severe PAH. | A novel p38 mitogen-activated protein kinase/Elk-1 transcription factor-dependent molecular mechanism underlying abnormal endothelial cell proliferation in plexogenic pulmonary arterial hypertension.
Patel M, Predescu D, Tandon R, Bardita C, Pogoriler J, Bhorade S, Wang M, Comhair S, Ryan-Hemnes A, Chen J, Machado R, Husain A, Erzurum S, Predescu S., Free PMC Article | 02/8/2014 |
| Data show that formation of a Krupple-like factor KLF4, pELK-1, and histone de-acetylase 2 (HDAC2) multiprotein complex dependent on the SM22alpha G/C Repressor element. | Cooperative binding of KLF4, pELK-1, and HDAC2 to a G/C repressor element in the SM22α promoter mediates transcriptional silencing during SMC phenotypic switching in vivo.
Salmon M, Gomez D, Greene E, Shankman L, Owens GK., Free PMC Article | 12/8/2012 |
| increased protein levels, phosphorylation and nuclear localization of Elk-1 observed in exon-1 and full-length Huntington's disease models could be a compensatory mechanism activated by striatal cells that contributes to neuroprotection | Activation of Elk-1 participates as a neuroprotective compensatory mechanism in models of Huntington's disease.
Anglada-Huguet M, Giralt A, Perez-Navarro E, Alberch J, Xifró X. | 06/2/2012 |
| Characterizes an orthologous rat short isoform derived from an in-frame downstream start codon. | Opposing roles of Elk-1 and its brain-specific isoform, short Elk-1, in nerve growth factor-induced PC12 differentiation.
Vanhoutte P, Nissen JL, Brugg B, Gaspera BD, Besson MJ, Hipskind RA, Caboche J. | 03/15/2012 |
| Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes | Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes.
Ge X, Chen C, Hui X, Wang Y, Lam KS, Xu A., Free PMC Article | 12/10/2011 |
| Elk-1 phosphorylation downstream from extracellular signal-regulated kinase is a key molecular event involved in long-term neuronal and behavioral adaptations to cocaine. | Alterations of molecular and behavioral responses to cocaine by selective inhibition of Elk-1 phosphorylation.
Besnard A, Bouveyron N, Kappes V, Pascoli V, Pagès C, Heck N, Vanhoutte P, Caboche J., Free PMC Article | 11/19/2011 |
| we aimed to identify the critical promoter regions of SPG4 gene and effects of Elk1 on SPG4 gene expression | SPG4 gene promoter regulation via Elk1 transcription factor.
Canbaz D, Kırımtay K, Karaca E, Karabay A. | 06/25/2011 |