| Carboxypeptidase M modulates BMSCs osteogenesis-adipogenesis via the MAPK/ERK pathway: An integrated single-cell and bulk transcriptomic study. | Carboxypeptidase M modulates BMSCs osteogenesis-adipogenesis via the MAPK/ERK pathway: An integrated single-cell and bulk transcriptomic study.
Liao Z, Zheng X, Li H, Deng Z, Feng S, Tan H, Zhao L. | 06/3/2024 |
| Our work shows for the first time that the interaction between CPM and kinin B1 receptor alters not only B1R pharmacology, but also modulates enzyme expression and activity. | Interactions between carboxypeptidase M and kinin B1 receptor in endothelial cells.
Guimarães PB, da Silva RF, Hoff CC, Fernandes L, Nakaie CR, Chagas JR, Carmona AK, Bader M, Pesquero JB. | 02/1/2020 |
| The rs12812500 variant of the CPM gene may increase silicosis susceptibility by affecting the expression of CPM, which may contribute to silicosis susceptibility with biological plausibility. | Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case-control study.
Chu M, Wu S, Wang W, Yu Y, Zhang M, Sang L, Tian T, Lu Y, Yuan W, Huang Q, Yi M, Gao Y, Xiao J, Lian Y, Zhuang X, Zhang ZF, Wu J., Free PMC Article | 11/16/2019 |
| Low CPM expression is associated with colorectal cancer. | MicroRNA-146a promote cell migration and invasion in human colorectal cancer via carboxypeptidase M/src-FAK pathway.
Lu D, Yao Q, Zhan C, Le-Meng Z, Liu H, Cai Y, Tu C, Li X, Zou Y, Zhang S., Free PMC Article | 10/14/2017 |
| CPM binding to extracellular loop 2 of the B1R results in positive allosteric modulation of B1R signaling, and disruption of this interaction could provide a novel therapeutic approach to reduce pathological B1R signaling. | Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor.
Zhang X, Tan F, Skidgel RA., Free PMC Article | 01/25/2014 |
| Carboxypeptidase M expression is lost in human renal cell carcinoma tumor cells, whereas it is abundant in tumor-associated foam cells and neovasculature. | Mapping of carboxypeptidase m in normal human kidney and renal cell carcinoma: expression in tumor-associated neovasculature and macrophages.
Denis CJ, Van Acker N, De Schepper S, De Bie M, Andries L, Fransen E, Hendriks D, Kockx MM, Lambeir AM., Free PMC Article | 04/20/2013 |
| novel marker and cellular player in lipid uptake and/or metabolism of activated macrophages by promoting foam cell formation | Carboxypeptidase-M is regulated by lipids and CSFs in macrophages and dendritic cells and expressed selectively in tissue granulomas and foam cells.
Tsakiris I, Torocsik D, Gyongyosi A, Dozsa A, Szatmari I, Szanto A, Soos G, Nemes Z, Igali L, Marton I, Takats Z, Nagy L, Dezso B., Free PMC Article | 04/21/2012 |
| CPM and B1Rs on cell membranes form a critical complex that potentiates B1R signaling. | Cross-talk between carboxypeptidase M and the kinin B1 receptor mediates a new mode of G protein-coupled receptor signaling.
Zhang X, Tan F, Brovkovych V, Zhang Y, Skidgel RA., Free PMC Article | 07/30/2011 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression.
Rietschel M, Mattheisen M, Frank J, Treutlein J, Degenhardt F, Breuer R, Steffens M, Mier D, Esslinger C, Walter H, Kirsch P, Erk S, Schnell K, Herms S, Wichmann HE, Schreiber S, Jöckel KH, Strohmaier J, Roeske D, Haenisch B, Gross M, Hoefels S, Lucae S, Binder EB, Wienker TF, Schulze TG, Schmäl C, Zimmer A, Juraeva D, Brors B, Bettecken T, Meyer-Lindenberg A, Müller-Myhsok B, Maier W, Nöthen MM, Cichon S. | 09/15/2010 |
| CPM amplification could be used as an alternative diagnostic tool for the diagnosis of well-differentiated liposarcoma/atypical lipomatous tumors. | Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma.
Erickson-Johnson MR, Seys AR, Roth CW, King AA, Hulshizer RL, Wang X, Asmann YW, Lloyd RV, Jacob EK, Oliveira AM. | 02/1/2010 |
| Cleavage of the C-terminal lysine residue of SDF-1alpha by CPM leads to attenuated chemotactic responses. | Carboxypeptidase M expressed by human bone marrow cells cleaves the C-terminal lysine of stromal cell-derived factor-1alpha: another player in hematopoietic stem/progenitor cell mobilization?
Marquez-Curtis L, Jalili A, Deiteren K, Shirvaikar N, Lambeir AM, Janowska-Wieczorek A. | 01/21/2010 |
| Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient b1 signaling from B2 agonists | Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient b1 signaling from B2 agonists.
Zhang X, Tan F, Zhang Y, Skidgel RA. | 01/21/2010 |
| Results report the crystallization of human carboxypeptidase M and its 3.0 angstrom crystal structure. | Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity.
Reverter D, Maskos K, Tan F, Skidgel RA, Bode W. | 01/21/2010 |
| Multiple transcription start sites in two regions ~30 kb apart are flanked by two unique functional promoters. Five major types of transcripts resulting from multiple transcription start sites and alternate splicing in the 5-prime region were identified. | Structure of the human carboxypeptidase M gene. Identification of a proximal GC-rich promoter and a unique distal promoter that consists of repetitive elements.
Li J, Rehli M, Timblin B, Tan F, Krause SW, Skidgel RA. | 10/1/2004 |
| CPM is membrane-bound via attachment of glycosylphosphatidylinositol at Ser406. Glu264 is a critical catalytic residue, whereas Glu260 affects stability and substrate kinetics. | Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring.
Tan F, Balsitis S, Black JK, Blöchl A, Mao JF, Becker RP, Schacht D, Skidgel RA., Free PMC Article | 10/1/2004 |