| Loss of claudin-3 expression increases colitis risk by promoting Gut Dysbiosis. | Loss of claudin-3 expression increases colitis risk by promoting Gut Dysbiosis.
Ahmad R, Kumar B, Thapa I, Talmon GA, Salomon J, Ramer-Tait AE, Bastola DK, Dhawan P, Singh AB., Free PMC Article | 12/1/2023 |
| Claudin-3 facilitates the progression and mediates the tumorigenic effects of TGF-beta in glioblastoma multiforme. | Claudin-3 facilitates the progression and mediates the tumorigenic effects of TGF-β in glioblastoma multiforme.
Sun Z, Yan T, Jiang H, Cai J, Zhu X, Chen Q. | 08/16/2023 |
| Claudin-3 is a novel intestinal integrity marker in patients with alopecia areata: Correlation with the disease severity. | Claudin-3 is a novel intestinal integrity marker in patients with alopecia areata: Correlation with the disease severity.
Rafik D, Younis I, Atef R, Eid H. | 04/15/2023 |
| Tight junction formation by a claudin mutant lacking the COOH-terminal PDZ domain-binding motif. | Tight junction formation by a claudin mutant lacking the COOH-terminal PDZ domain-binding motif.
Fujiwara S, Nguyen TP, Furuse K, Fukazawa Y, Otani T, Furuse M., Free PMC Article | 10/22/2022 |
| Comparison of claudin-3 and claudin-4 expression in bilateral and unilateral breast cancer. | Comparison of claudin-3 and claudin-4 expression in bilateral and unilateral breast cancer.
Szade J, Kunc M, Pieczyńska-Uziębło B, Świerblewski M, Biernat W, Jassem J, Senkus E. | 08/21/2021 |
| Nglycosylation and receptor tyrosine kinase signaling affect claudin3 levels in colorectal cancer cells. | N‑glycosylation and receptor tyrosine kinase signaling affect claudin‑3 levels in colorectal cancer cells.
Pérez AG, Andrade-Da-Costa J, De Souza WF, De Souza Ferreira M, Boroni M, De Oliveira IM, Freire-Neto CA, Fernandes PV, De Lanna CA, Souza-Santos PT, Morgado-Díaz JA, De-Freitas-Junior JCM., Free PMC Article | 07/10/2021 |
| Claudin-1 and Claudin-3 as Molecular Regulators of Myelination in Leukoaraiosis Patients. | Claudin-1 and Claudin-3 as Molecular Regulators of Myelination in Leukoaraiosis Patients.
Chen Y, Zheng Z, Mei A, Huang H, Lin F., Free PMC Article | 07/10/2021 |
| All Benign and Malignant Apocrine Breast Lesions Over-Express Claudin 1 and 3 and Are Negative for Claudin 4. | All Benign and Malignant Apocrine Breast Lesions Over-Express Claudin 1 and 3 and Are Negative for Claudin 4.
Shousha S, Anscombe O, McFarlane T., Free PMC Article | 04/3/2021 |
| abnormal nuclear expression of claudin-3 was observed in 69.6% cases | [Claudin-3 expression in gastric cancer].
Danilova NV, Anikina KA, Oleynikova NA, Vychuzhanin DV, Malkov PG. | 06/6/2020 |
| CLDN3, CK5, and CK14 in combination with ER, PR and HER2 indicate an association with BRCA1 mutation status in women with early breast cancer. | Association of Cytokeratin 5 and Claudin 3 expression with BRCA1 and BRCA2 germline mutations in women with early breast cancer.
Danzinger S, Tan YY, Rudas M, Kastner MT, Weingartshofer S, Muhr D, Singer CF., Free PMC Article | 12/14/2019 |
| the findings of the present study demonstrated that the expression levels of CLDN1, 3, 7 and 8 varied between laryngeal squamous carcinoma tissues and nonneoplastic tissues | Identification of claudin‑1, ‑3, ‑7 and ‑8 as prognostic markers in human laryngeal carcinoma.
Zhou S, Piao X, Wang C, Wang R, Song Z., Free PMC Article | 11/30/2019 |
| Atopic dermatitis lesional skin had decreased claudin-3 expression in sweat glands, which was accompanied by sweat leakage. Study results show the crucial role of claudin-3 in preventing sweat gland leakage and suggest that the pathogenesis of dermatoses accompanied by hypohidrosis involves abnormally decreased claudin-3. | Claudin-3 Loss Causes Leakage of Sweat from the Sweat Gland to Contribute to the Pathogenesis of Atopic Dermatitis.
Yamaga K, Murota H, Tamura A, Miyata H, Ohmi M, Kikuta J, Ishii M, Tsukita S, Katayama I. | 05/25/2019 |
| Claudin3 promoter methylation status (HR: 5.67; 95% CI: 2.2714.17) but not claudin3 expression was an independent predictor of survival. Claudin3 promoter hypermethylation reduces claudin3 expression and independently predicts poor prognosis. | Methylation of the claudin‑3 promoter predicts the prognosis of advanced gastric adenocarcinoma.
Zhang Z, Yu W, Chen S, Chen Y, Chen L, Zhang S., Free PMC Article | 10/13/2018 |
| Immunohistochemical expression levels of cytoplasmic claudins 3 and 7 appear to be novel prognostic factors in triple-negative breast cancer. | High-level cytoplasmic claudin 3 expression is an independent predictor of poor survival in triple-negative breast cancer.
Jääskeläinen A, Soini Y, Jukkola-Vuorinen A, Auvinen P, Haapasaari KM, Karihtala P., Free PMC Article | 10/6/2018 |
| CLDN3 could be further evaluated as a novel biomarker for predicting the prognosis of lung squamous cell carcinoma (SqCC) and as a target for the treatment of lung SqCC in the future. | Claudin-3 Inhibits Lung Squamous Cell Carcinoma Cell Epithelial-mesenchymal Transition and Invasion via Suppression of the Wnt/β-catenin Signaling Pathway.
Che J, Yue D, Zhang B, Zhang H, Huo Y, Gao L, Zhen H, Yang Y, Cao B., Free PMC Article | 08/25/2018 |
| We describe a novel workflow, completely covering the analysis of CLDN3 as an exemplary exosome-based biomarker for prostate cancer from in vitro profiling of cancer exosomes over in silico identification and in vitro retesting to clinical validation. | Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker.
Worst TS, von Hardenberg J, Gross JC, Erben P, Schnölzer M, Hausser I, Bugert P, Michel MS, Boutros M., Free PMC Article | 03/24/2018 |
| Data indicate that CDH11, ICAM1 and CLDN3 were overexpressed in tumors when compared to normal esophagus, normal gastric and non-dysplastic Barrett's. | Genomic similarity between gastroesophageal junction and esophageal Barrett's adenocarcinomas.
Ferrer-Torres D, Nancarrow DJ, Kuick R, Thomas DG, Nadal E, Lin J, Chang AC, Reddy RM, Orringer MB, Taylor JM, Wang TD, Beer DG., Free PMC Article | 01/20/2018 |
| Study provide first biochemically and clinically validated evidence to support a colorectal cancer-suppressive function of claudin-3 by serving as a conjoint rheostat for regulating Stat-3 and Wnt/beta-catenin-signaling. | Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling.
Ahmad R, Kumar B, Chen Z, Chen X, Müller D, Lele SM, Washington MK, Batra SK, Dhawan P, Singh AB., Free PMC Article | 12/9/2017 |
| These tumor samples express CD44 protein at low rather than high levels. There is no correlation between CLDN3 gene expression and protein expression in these CPTAC samples; hence, the claudin-low subtype defined by gene expression is not the same group of tumors as that defined by low expression of CLDN3 protein. | Glycoproteins in Claudin-Low Breast Cancer Cell Lines Have a Unique Expression Profile.
Yen TY, Bowen S, Yen R, Piryatinska A, Macher BA, Timpe LC., Free PMC Article | 10/21/2017 |
| Increased expression of intestinal epithelial claudin-1 with downregulation of claudin-3 has been observed in intestinal inflammatory disorders. | Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation.
Garcia-Hernandez V, Quiros M, Nusrat A., Free PMC Article | 08/26/2017 |
| Data show that the charge of Lys65 in claudin 1 (Cldn1) and Glu158 in claudin 3 (Cldn3), and of Gln57 in claudin 5 (Cldn5) are necessary for tight junction (TJ) strand formation. | Polar and charged extracellular residues conserved among barrier-forming claudins contribute to tight junction strand formation.
Piontek A, Rossa J, Protze J, Wolburg H, Hempel C, Günzel D, Krause G, Piontek J. | 08/26/2017 |
| Mislocalization claudin-3 to nucleus in colon cancer and mislocalization claudin-4 to nucleus in adenomas of the colon were detected for the first time. . | [The expression of claudins in colonic neoplasms].
Oleinikova NA, Kharlova OA, Mal'kov PG, Danilova NV. | 07/1/2017 |
| Reg I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4. | Role of regenerating gene I in claudin expression and barrier function in the small intestine.
Kitayama Y, Fukui H, Hara K, Eda H, Kodani M, Yang M, Sun C, Yamagishi H, Tomita T, Oshima T, Watari J, Takasawa S, Miwa H. | 07/1/2017 |
| Intracellular zinc has an essential role in the maintenance of the intestinal epithelial tight junction barrier through regulation of occludin proteolysis and claudin-3 transcription. | Cellular zinc is required for intestinal epithelial barrier maintenance via the regulation of claudin-3 and occludin expression.
Miyoshi Y, Tanabe S, Suzuki T. | 06/24/2017 |
| permeability barriers and affected cell morphology, proliferation, migration, AKT signaling, and gene expression. When claudins are exogenously expressed, ARPE-19 more closely model native RPE. | Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression.
Peng S, Wang SB, Singh D, Zhao PY, Davis K, Chen B, Adelman RA, Rizzolo LJ. | 06/3/2017 |