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    CLDN4 claudin 4 [ Homo sapiens (human) ]

    Gene ID: 1364, updated on 18-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Immunohistochemical Expression of Claudin-1 and Claudin-4 in Urothelial Carcinoma of the Urinary Bladder.

    Immunohistochemical Expression of Claudin-1 and Claudin-4 in Urothelial Carcinoma of the Urinary Bladder.
    Elsayed AM, Mahmoud EI, Salem MM, Khairy RA., Free PMC Article

    02/29/2024
    Expression of Claudin-4 and D2-40 and their significance in prostatic adenocarcinoma.

    Expression of Claudin-4 and D2-40 and their significance in prostatic adenocarcinoma.
    Kabra H, Mohanty NR, Tripathy S, Mohanty M, Senapati U, Rath J.

    02/26/2024
    Diagnostic Utility of Claudin4 and Comparison with BerEp4 as a Marker for Metastatic Adenocarcinoma in Serous Effusions.

    Diagnostic Utility of Claudin4 and Comparison with BerEp4 as a Marker for Metastatic Adenocarcinoma in Serous Effusions.
    Mangla G, Bakshi P, Agarwal P, Verma K.

    10/13/2023
    [Effects of Fusobacterium nucleus derived outer membrane vesicles on claudin-4 expression in oral epithelial cells].

    [Effects of Fusobacterium nucleus derived outer membrane vesicles on claudin-4 expression in oral epithelial cells].
    Yang CL, Yang M, Wang YF, Song CC, DU GH, Tang GY.

    05/12/2023
    CLDN4 as a Novel Diagnostic and Prognostic Biomarker and Its Association with Immune Infiltrates in Ovarian Cancer.

    CLDN4 as a Novel Diagnostic and Prognostic Biomarker and Its Association with Immune Infiltrates in Ovarian Cancer.
    Hu P, Lei L, Wang Y, Tian X, Wei X, Jiang N, Liu L., Free PMC Article

    04/19/2023
    BAP1 and Claudin-4, But Not MTAP, Reliably Distinguish Borderline and Low-grade Serous Ovarian Tumors From Peritoneal Mesothelioma.

    BAP1 and Claudin-4, But Not MTAP, Reliably Distinguish Borderline and Low-grade Serous Ovarian Tumors From Peritoneal Mesothelioma.
    Devins KM, Zukerberg L, Watkins JC, Hung YP, Oliva E.

    02/14/2023
    Computational study of ion permeation through claudin-4 paracellular channels.

    Computational study of ion permeation through claudin-4 paracellular channels.
    Berselli A, Alberini G, Benfenati F, Maragliano L., Free PMC Article

    10/22/2022
    CLDN4 promotes growth of acute myeloid leukemia cells via regulating AKT and ERK1/2 signaling.

    CLDN4 promotes growth of acute myeloid leukemia cells via regulating AKT and ERK1/2 signaling.
    Hao S, Yang C, Song P, Shi H, Zou Y, Chen M, Wu X, Yin Y, Yu Z, Zhu W, Li M.

    07/16/2022
    TGF-beta induces GBM mesenchymal transition through upregulation of CLDN4 and nuclear translocation to activate TNF-alpha/NF-kappaB signal pathway.

    TGF-β induces GBM mesenchymal transition through upregulation of CLDN4 and nuclear translocation to activate TNF-α/NF-κB signal pathway.
    Yan T, Tan Y, Deng G, Sun Z, Liu B, Wang Y, Yuan F, Sun Q, Hu P, Gao L, Tian D, Chen Q., Free PMC Article

    04/30/2022
    Increased integrity of cell-cell junctions accompanied by increased expression of claudin 4 in keratinocytes stimulated with vitamin D3.

    Increased integrity of cell-cell junctions accompanied by increased expression of claudin 4 in keratinocytes stimulated with vitamin D3.
    Minowa E, Kurashige Y, Islam ST, Yoshida K, Sakakibara S, Okada Y, Fujita Y, Bolortsetseg D, Murai Y, Abiko Y, Saitoh M.

    01/22/2022
    Association of the Tight Junction Protein Claudin-4 with Lung Function and Exacerbations in Chronic Obstructive Pulmonary Disease.

    Association of the Tight Junction Protein Claudin-4 with Lung Function and Exacerbations in Chronic Obstructive Pulmonary Disease.
    Park S, Lee PH, Baek AR, Park JS, Lee J, Park SW, Kim DJ, Jang AS., Free PMC Article

    11/27/2021
    Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut.

    Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut.
    Vecchio AJ, Rathnayake SS, Stroud RM., Free PMC Article

    11/27/2021
    Identification of Significant Genes and Pathways in Acute Pancreatitis via Bioinformatical Analysis.

    Identification of Significant Genes and Pathways in Acute Pancreatitis via Bioinformatical Analysis.
    Ji R, Chen Y, Chen W, Wang Y, Gong F, Huang S, Xie R, Zhong M, Liu Z, Yang Z, Fei J, Mao E, Chen E.

    10/2/2021
    The role of claudin-4 in the development of gastric cancer.

    The role of claudin-4 in the development of gastric cancer.
    Liu W, Li M.

    09/25/2021
    CLDN4 silencing promotes proliferation and reduces chemotherapy sensitivity of gastric cancer cells through activation of the PI3K/Akt signalling pathway.

    CLDN4 silencing promotes proliferation and reduces chemotherapy sensitivity of gastric cancer cells through activation of the PI3K/Akt signalling pathway.
    Luo J, Wang H, Chen H, Gan G, Zheng Y.

    09/11/2021
    Comparison of claudin-3 and claudin-4 expression in bilateral and unilateral breast cancer.

    Comparison of claudin-3 and claudin-4 expression in bilateral and unilateral breast cancer.
    Szade J, Kunc M, Pieczyńska-Uziębło B, Świerblewski M, Biernat W, Jassem J, Senkus E.

    08/21/2021
    Screening approaches against claudin-4 focusing on therapeutics through molecular docking and the analysis of their relative dynamics: a theoretical approach.

    Screening approaches against claudin-4 focusing on therapeutics through molecular docking and the analysis of their relative dynamics: a theoretical approach.
    Rambabu M, Jayanthi S.

    07/17/2021
    Knockdown of CRAD suppresses the growth and promotes the apoptosis of human lung cancer cells via Claudin 4.

    Knockdown of CRAD suppresses the growth and promotes the apoptosis of human lung cancer cells via Claudin 4.
    Cui A, Xue Y, Wang X, Huang Y, Han X, Li X, Niu D, Niu S, Zhao Y, Yang X, Yu W., Free PMC Article

    04/17/2021
    Zinc finger protein 703 induces EMT and sorafenib resistance in hepatocellular carcinoma by transactivating CLDN4 expression.

    Zinc finger protein 703 induces EMT and sorafenib resistance in hepatocellular carcinoma by transactivating CLDN4 expression.
    Wang H, Xu H, Ma F, Zhan M, Yang X, Hua S, Li W, Li Y, Lu L., Free PMC Article

    04/13/2021
    All Benign and Malignant Apocrine Breast Lesions Over-Express Claudin 1 and 3 and Are Negative for Claudin 4.

    All Benign and Malignant Apocrine Breast Lesions Over-Express Claudin 1 and 3 and Are Negative for Claudin 4.
    Shousha S, Anscombe O, McFarlane T., Free PMC Article

    04/3/2021
    Role of Nuclear Claudin-4 in Renal Cell Carcinoma.

    Role of Nuclear Claudin-4 in Renal Cell Carcinoma.
    Owari T, Sasaki T, Fujii K, Fujiwara-Tani R, Kishi S, Mori S, Mori T, Goto K, Kawahara I, Nakai Y, Miyake M, Luo Y, Tanaka N, Kondoh M, Fujimoto K, Kuniyasu H., Free PMC Article

    03/20/2021
    Claudin-4 shows superior specificity for mesothelioma vs non-small-cell lung carcinoma compared with MOC-31 and Ber-EP4.

    Claudin-4 shows superior specificity for mesothelioma vs non-small-cell lung carcinoma compared with MOC-31 and Ber-EP4.
    Naso JR, Churg A.

    10/31/2020
    Targeting claudin-4 enhances chemosensitivity of pancreatic ductal carcinomas.

    Targeting claudin-4 enhances chemosensitivity of pancreatic ductal carcinomas.
    Sasaki T, Fujiwara-Tani R, Kishi S, Mori S, Luo Y, Ohmori H, Kawahara I, Goto K, Nishiguchi Y, Mori T, Sho M, Kondo M, Kuniyasu H., Free PMC Article

    08/29/2020
    Claudin-4 immunohistochemistry is a useful pan-carcinoma marker for serous effusion specimens.

    Claudin-4 immunohistochemistry is a useful pan-carcinoma marker for serous effusion specimens.
    Vojtek M, Walsh MD, Papadimos DJ, Shield PW.

    08/22/2020
    in Basaloid squamous cell carcinomas , SOX2 and PCNA had diffuse staining patterns in almost all cancer cells. SOX2 overexpression had little effect on the expression levels of claudin4, occludin and PCNA

    Differential expression of claudin‑4, occludin, SOX2 and proliferating cell nuclear antigen between basaloid squamous cell carcinoma and squamous cell carcinoma.
    Sato F, Bhawal UK, Tojyo I, Fujita S, Murata SI, Muragaki Y.

    12/28/2019
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