| Analysis of ADAM12-Mediated Ephrin-A1 Cleavage and Its Biological Functions. | Analysis of ADAM12-Mediated Ephrin-A1 Cleavage and Its Biological Functions.
Ieguchi K, Tomita T, Takao T, Omori T, Mishima T, Shimizu I, Tognolini M, Lodola A, Tsunoda T, Kobayashi S, Wada S, Maru Y., Free PMC Article | 05/1/2021 |
| By using MALDI-MSI, this study simultaneously shows the distribution and spatial localization of ephrin A1, as well as additional cardiac proteins, thus offering valuable information for the elucidation of molecular partners, mediators, and targets of ephrin A1 action in cardiac muscle. | Anatomical-Molecular Distribution of EphrinA1 in Infarcted Mouse Heart Using MALDI Mass Spectrometry Imaging.
Lefcoski S, Kew K, Reece S, Torres MJ, Parks J, Reece S, de Castro Brás LE, Virag JAI., Free PMC Article | 08/17/2019 |
| EphA2 mAb treatment could partially inhibit LPSinduced inactivation of EphBEphrin B3 signalling, while Ephrin B3 overexpression could abrogate LPSinduced activation of EphA2Ephrin A1 signalling. EphB1/Ephrin B3 signalling may antagonise the EphA2/Ephrin A1dependent pathway following LPS treatment. | Eph/ephrin signalling serves a bidirectional role in lipopolysaccharide‑induced intestinal injury.
Xiong Y, Li KX, Wei H, Jiao L, Yu SY, Zeng L., Free PMC Article | 10/20/2018 |
| Collectively, these data suggest that ATRA attenuates bleomycin-induced pulmonary fibrosis by regulating EphA2-EphrinA1 and PI3K-Akt signaling. | All-trans retinoic acid attenuates bleomycin-induced pulmonary fibrosis via downregulating EphA2-EphrinA1 signaling.
Leem AY, Shin MH, Douglas IS, Song JH, Chung KS, Kim EY, Jung JY, Kang YA, Chang J, Kim YS, Park MS. | 09/16/2017 |
| Lipopolysaccharide exposure significantly up-regulated EphA2 and EphrinA1 expression. | Inhibition of EphA2/EphrinA1 signal attenuates lipopolysaccharide-induced lung injury.
Hong JY, Shin MH, Douglas IS, Chung KS, Kim EY, Jung JY, Kang YA, Kim SK, Chang J, Kim YS, Park MS. | 07/8/2017 |
| Activation of EphA1-Epha receptor axis attenuates diabetic nephropathy in mice. | Activation of EphA1-Epha receptor axis attenuates diabetic nephropathy in mice.
Li Y, Yan H, Wang F, Huang S, Zhang Y, Wang Z, Zhong M, Zhang W. | 06/3/2017 |
| Following ephrin-A1 stimulation, truncated EphA2 did not detectably interfere with the phosphorylation of endogenous EphA2, and it potentiated cell adhesion possibly through modulation of integrin avidity. | Truncated EphA2 likely potentiates cell adhesion via integrins as well as infiltration and/or lodgment of a monocyte/macrophage cell line in the red pulp and marginal zone of the mouse spleen, where ephrin-A1 is prominently expressed in the vasculature.
Konda N, Saeki N, Nishino S, Ogawa K. | 04/29/2017 |
| ADAM12 enhanced ephrin-A1 cleavage in response to transforming growth factor-betra1 in primary tumors. | ADAM12-cleaved ephrin-A1 contributes to lung metastasis.
Ieguchi K, Tomita T, Omori T, Komatsu A, Deguchi A, Masuda J, Duffy SL, Coulthard MG, Boyd A, Maru Y. | 06/14/2014 |
| S100A8 and ephrin-A1 contribute to lung metastasis. | Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 4.
Ieguchi K, Omori T, Komatsu A, Tomita T, Deguchi A, Maru Y. | 02/15/2014 |
| We used in utero electroporation-mediated EphA7 overexpression in developing somatosensory corticothalamic axons to dissect EphA7/ephrin-A-dependent mechanisms involved in regulating both initial targeting and postnatal growth of the CT projections. | Role of EphA/ephrin--a signaling in the development of topographic maps in mouse corticothalamic projections.
Torii M, Rakic P, Levitt P., Free PMC Article | 06/8/2013 |
| Elevated levels of ephrin-A1 may contribute to diabetic keratopathies by persistently engaging EphA2 and prohibiting Akt-dependent corneal epithelial repair processes. | EphA2/Ephrin-A1 signaling complexes restrict corneal epithelial cell migration.
Kaplan N, Fatima A, Peng H, Bryar PJ, Lavker RM, Getsios S., Free PMC Article | 04/28/2012 |
| Data indicate that ephrin-A1 regulates cardiac valve development, making ephrin-A1-deficient mice a novel model for congenital heart defects. | Regulation of heart valve morphogenesis by Eph receptor ligand, ephrin-A1.
Frieden LA, Townsend TA, Vaught DB, Delaughter DM, Hwang Y, Barnett JV, Chen J., Free PMC Article | 03/19/2011 |
| Cooperation between Slit2 and ephrin-A1 regulates a balance between the pro- and antiangiogenic functions of Slit2. | Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis.
Dunaway CM, Hwang Y, Lindsley CW, Cook RS, Wu JY, Boothby M, Chen J, Brantley-Sieders DM., Free PMC Article | 02/26/2011 |
| ephrin-A1 has a positive role in tumor growth in vivo, and are consistent with previous reports of ephrin-A1 acting through EphA receptors in the tumor microenvironment in vivo. | A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.
Zhang W, Zeng X, Briggs KJ, Beaty R, Simons B, Chiu Yen RW, Tyler MA, Tsai HC, Ye Y, Gesell GS, Herman JG, Baylin SB, Watkins DN., Free PMC Article | 09/7/2010 |
| Radiotherapy-induced changes in ephrin-A1 gene expression related with angiogenesis may modulate microenvironment and influence responsiveness of tumors. | The proangiogenic factor ephrin-A1 is up-regulated in radioresistant murine tumor by irradiation.
Nojiri K, Iwakawa M, Ichikawa Y, Imadome K, Sakai M, Nakawatari M, Ishikawa K, Ishikawa A, Togo S, Tsujii H, Shimada H, Imai T. | 01/21/2010 |
| HIF-2alpha plays an essential role in vascular remodeling during tumor vascularization through activation of at least ephrin A1. | Hypoxia-inducible transcription factor-2alpha in endothelial cells regulates tumor neovascularization through activation of ephrin A1.
Yamashita T, Ohneda K, Nagano M, Miyoshi C, Kaneko N, Miwa Y, Yamamoto M, Ohneda O, Fujii-Kuriyama Y. | 01/21/2010 |
| Increased expression of ephrin-A1 accelerated the malignant progression of the intestinal adenoma to invasive tumors. | Ephrin-A1 promotes the malignant progression of intestinal tumors in Apc(min/+) mice.
Shi L, Itoh F, Itoh S, Takahashi S, Yamamoto M, Kato M. | 01/21/2010 |
| Ephrins A1 and A5 are substrates for a cross-linking enzyme, tissue transglutaminase, which mediates the formation of oligomeric ephrin. | Tissue transglutaminase clusters soluble A-type ephrins into functionally active high molecular weight oligomers.
Alford SC, Bazowski J, Lorimer H, Elowe S, Howard PL. | 01/21/2010 |
| When NIH3T3 cells were plated onto an ephrinA1-coated surface, the cells both adhered and spread. | EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas).
Carter N, Nakamoto T, Hirai H, Hunter T. | 01/21/2010 |
| Whole-mount in situ hybridization revealed overlapping expression of the Epha1 receptor and its high-affinity ligands ephrin A1 (Efna1) and ephrin A3 (Efna3) in the primitive streak and the posterior paraxial mesoderm during early mouse development. | Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development.
Duffy SL, Steiner KA, Tam PP, Boyd AW. | 01/21/2010 |
| Immunohistological analyses reveal strong ephrin-A1 expression in lung tissue, low expression in cortical areas of lymph nodes, and none in T cell/B cell areas of the spleen. | Ephrin-A1 suppresses Th2 cell activation and provides a regulatory link to lung epithelial cells.
Wohlfahrt JG, Karagiannidis C, Kunzmann S, Epstein MM, Kempf W, Blaser K, Schmidt-Weber CB. | 01/21/2010 |