| TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation. | TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation.
Zhu J, Ao X, Liu Y, Zhou S, Hou Y, Yan Z, Zhou L, Chen H, Wang P, Liang X, Xie D, Gao S, Zhou PK, Gu Y., Free PMC Article | 09/16/2024 |
| Interaction of lncRNA Gm2044 and EEF2 promotes estradiol synthesis in ovarian follicular granulosa cells. | Interaction of lncRNA Gm2044 and EEF2 promotes estradiol synthesis in ovarian follicular granulosa cells.
Hu K, Wang C, Xu Y, Li F, Han X, Song C, Liang M., Free PMC Article | 08/25/2023 |
| eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior. | eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior.
Ma X, Li L, Li Z, Huang Z, Yang Y, Liu P, Guo D, Li Y, Wu T, Luo R, Xu J, Ye WC, Jiang B, Shi L., Free PMC Article | 10/15/2022 |
| Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2alpha and eEF2. | Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2.
Lizarazo S, Yook Y, Tsai NP., Free PMC Article | 07/23/2022 |
| The phosphorylation status of eukaryotic elongation factor-2 indicates neural activity in the brain. | The phosphorylation status of eukaryotic elongation factor-2 indicates neural activity in the brain.
Yoon SH, Song WS, Oh SP, Kim YS, Kim MH., Free PMC Article | 04/9/2022 |
| Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression. | Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression.
Li W, Ali T, Zheng C, Liu Z, He K, Shah FA, Ren Q, Rahman SU, Li N, Yu ZJ, Li S., Free PMC Article | 09/11/2021 |
| Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice. | Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice.
Gosrani SP, Jester HM, Zhou X, Ryazanov AG, Ma T., Free PMC Article | 07/10/2021 |
| PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation. | PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation.
Shen Y, Zhang ZC, Cheng S, Liu A, Zuo J, Xia S, Liu X, Liu W, Jia Z, Xie W, Han J. | 04/17/2021 |
| Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes. | Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes.
Gerashchenko MV, Nesterchuk MV, Smekalova EM, Paulo JA, Kowalski PS, Akulich KA, Bogorad R, Dmitriev SE, Gygi S, Zatsepin T, Anderson DG, Gladyshev VN, Koteliansky VE., Free PMC Article | 01/2/2021 |
| Myostatin inhibits eEF2K-eEF2 by regulating AMPK to suppress protein synthesis. | Myostatin inhibits eEF2K-eEF2 by regulating AMPK to suppress protein synthesis.
Deng Z, Luo P, Lai W, Song T, Peng J, Wei HK. | 11/11/2017 |
| IL-6 induces the activation of the Stat3 signaling and promotes the downmodulation of the p90RSK/eEF2 and mTOR/p70S6K axes, while it does not affect the activation of AKT. | IL-6 impairs myogenic differentiation by downmodulation of p90RSK/eEF2 and mTOR/p70S6K axes, without affecting AKT activity.
Pelosi M, De Rossi M, Barberi L, Musarò A., Free PMC Article | 02/14/2015 |
| Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death. | Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death.
Schwer CI, Lehane C, Guelzow T, Zenker S, Strosing KM, Spassov S, Erxleben A, Heimrich B, Buerkle H, Humar M., Free PMC Article | 05/31/2014 |
| AMPKalpha2 controls cardiac p70S6K under normoxia and regulates eEF-2 but not the mTOR-p70S6K pathway during ischemia. | Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart.
Demeulder B, Zarrinpashneh E, Ginion A, Viollet B, Hue L, Rider MH, Vanoverschelde JL, Beauloye C, Horman S, Bertrand L. | 07/6/2013 |
| The MKK3/6-p38gamma/delta pathway mediated an inhibitory phosphorylation of eukaryotic elongation factor 2 (eEF2) kinase, which in turn promoted eEF2 activation (dephosphorylation) and subsequent TNF-alpha elongation. | Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis.
González-Terán B, Cortés JR, Manieri E, Matesanz N, Verdugo Á, Rodríguez ME, González-Rodríguez Á, Valverde ÁM, Martín P, Davis RJ, Sabio G., Free PMC Article | 03/16/2013 |
| Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development | Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development.
Liu S, Bachran C, Gupta P, Miller-Randolph S, Wang H, Crown D, Zhang Y, Wein AN, Singh R, Fattah R, Leppla SH., Free PMC Article | 11/3/2012 |
| induced by basic fibroblast growth factor via mitogen-activated protein kinase | Methylation of eukaryotic elongation factor 2 induced by basic fibroblast growth factor via mitogen-activated protein kinase.
Jung GA, Shin BS, Jang YS, Sohn JB, Woo SR, Kim JE, Choi G, Lee KM, Min BH, Lee KH, Park GH., Free PMC Article | 03/24/2012 |
| eEF-2 is activated by both lithium and GSK-3, whereas, lithium treatment and inhibition of GSK-3 have opposing effects on eEF-2. | Identification of eukaryotic elongation factor-2 as a novel cellular target of lithium and glycogen synthase kinase-3.
Karyo R, Eskira Y, Pinhasov A, Belmaker R, Agam G, Eldar-Finkelman H. | 02/12/2011 |
| eEF-2 phosphorylation has a role in protein synthesis for memory consolidation | Post-training dephosphorylation of eEF-2 promotes protein synthesis for memory consolidation.
Im HI, Nakajima A, Gong B, Xiong X, Mamiya T, Gershon ES, Zhuo M, Tang YP., Free PMC Article | 03/15/2010 |
| Data show that the levels of active eEF2 increased and decreased in BDNF transgenic and BDNF knock-out mice, respectively. | Brain-derived neurotrophic factor enhances the basal rate of protein synthesis by increasing active eukaryotic elongation factor 2 levels and promoting translation elongation in cortical neurons.
Takei N, Kawamura M, Ishizuka Y, Kakiya N, Inamura N, Namba H, Nawa H., Free PMC Article | 01/21/2010 |
| eIF2alpha phosphorylation is required for phosphorylation of eukaryotic elongation factor 2 (eEF-2) during nutrient starvation | A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses.
Py BF, Boyce M, Yuan J., Free PMC Article | 01/21/2010 |
| exogenous ROS inhibit mTOR, eIF2alpha, and eEF2, mTOR and eEF2 were largely refractory to ROS generated under moderate hypoxia (0.5% O(2)). | Hypoxic reactive oxygen species regulate the integrated stress response and cell survival.
Liu L, Wise DR, Diehl JA, Simon MC., Free PMC Article | 01/21/2010 |
| A mouse that was mutant for the gene, Dph4, was identified. | Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development.
Webb TR, Cross SH, McKie L, Edgar R, Vizor L, Harrison J, Peters J, Jackson IJ., Free PMC Article | 01/21/2010 |