| SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway. | SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway.
Piao J, Su Z, He J, Zhu T, Fan F, Wang X, Yang Z, Zhan H, Luo D. | 08/1/2024 |
| S1PR3 inhibition protects against LPS-induced ARDS by inhibiting NF-kappaB and improving mitochondrial oxidative phosphorylation. | S1PR3 inhibition protects against LPS-induced ARDS by inhibiting NF-κB and improving mitochondrial oxidative phosphorylation.
Peng J, Tang R, He J, Yu Q, Wang D, Qi D., Free PMC Article | 06/13/2024 |
| Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of high-density lipoproteins and low-density lipoproteins in opposite ways. | Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of high-density lipoproteins and low-density lipoproteins in opposite ways.
Velagapudi S, Wang D, Poti F, Feuerborn R, Robert J, Schlumpf E, Yalcinkaya M, Panteloglou G, Potapenko A, Simoni M, Rohrer L, Nofer JR, von Eckardstein A., Free PMC Article | 05/10/2024 |
| Role of sphingosine kinase and sphingosine-1-phosphate receptor in the liver pathology of mice infected with Plasmodium berghei ANKA. | Role of sphingosine kinase and sphingosine-1-phosphate receptor in the liver pathology of mice infected with Plasmodium berghei ANKA.
Techarang T, Jariyapong P, Punsawad C., Free PMC Article | 05/7/2022 |
| Loss of sphingosine 1-phosphate receptor 3 gene function impairs injury-induced stromal angiogenesis in mouse cornea. | Loss of sphingosine 1-phosphate receptor 3 gene function impairs injury-induced stromal angiogenesis in mouse cornea.
Yasuda S, Sumioka T, Iwanishi H, Okada Y, Miyajima M, Ichikawa K, Reinach PS, Saika S., Free PMC Article | 04/17/2021 |
| FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages. | FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages.
Bryan AM, You JK, McQuiston T, Lazzarini C, Qiu Z, Sheridan B, Nuesslein-Hildesheim B, Del Poeta M., Free PMC Article | 02/13/2021 |
| Enhanced expression of the sphingosine-1-phosphate-receptor-3 causes acute myelogenous leukemia in mice. | Enhanced expression of the sphingosine-1-phosphate-receptor-3 causes acute myelogenous leukemia in mice.
Vorbach S, Gründer A, Zhou F, Koellerer C, Jutzi JS, Simoni M, Riccetti L, Valk PJ, Sanders MA, Müller-Tidow C, Nofer JR, Pahl HL, Potì F. | 08/29/2020 |
| Hyperglycemia-Triggered Sphingosine-1-Phosphate and Sphingosine-1-Phosphate Receptor 3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization. | Hyperglycemia-Triggered Sphingosine-1-Phosphate and Sphingosine-1-Phosphate Receptor 3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization.
Hu Y, Yang C, Shen G, Yang S, Cheng X, Cheng F, Rao J, Wang X., Free PMC Article | 08/22/2020 |
| This study demonstrated that S1P significantly promotes angiogenesis, inflammation, and barrier integrity, which was attenuated by inhibition of S1P2 or S1P3, suggesting that regulation of S1P2 and S1P3 is a novel therapeutic target for CNV. | The role of sphingosine 1-phosphate receptors on retinal pigment epithelial cells barrier function and angiogenic effects.
Terao R, Honjo M, Totsuka K, Miwa Y, Kurihara T, Aihara M. | 07/4/2020 |
| expression of SphK-1 and S1PR-3 in the lung tissues of malaria-infected mice with ALI/ARDS | Expression of sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 in malaria-associated acute lung injury/acute respiratory distress syndrome in a mouse model.
Punsawad C, Viriyavejakul P., Free PMC Article | 03/14/2020 |
| S1P is a potent osteoanabolic molecule, although S1P3 is not the sole receptor mediating this influence | Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase.
Heckt T, Brylka LJ, Neven M, Amling M, Schinke T., Free PMC Article | 03/14/2020 |
| S1P3 expression is associated with the development of autoimmune arthritis via inflammation-induced increases in S1P/S1P3 signaling that increase production of IL-6. | Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production.
Inoue T, Kohno M, Nagahara H, Murakami K, Sagawa T, Kasahara A, Kaneshita S, Kida T, Fujioka K, Wada M, Nakada H, Hla T, Kawahito Y., Free PMC Article | 02/15/2020 |
| the proinflammatory lipid sphingosine 1-phosphate (S1P) and its receptor, S1P receptor 3 (S1PR3), trigger itch and pain behaviors via distinct molecular and cellular mechanisms. | S1PR3 Mediates Itch and Pain via Distinct TRP Channel-Dependent Pathways.
Hill RZ, Morita T, Brem RB, Bautista DM., Free PMC Article | 10/19/2019 |
| This study identified S1P3 as a pathogenic mediator in an ischemic brain along with underlying mechanisms, involving its modulation of microglial activation and M1 polarization. | Sphingosine 1-phosphate receptor subtype 3 (S1P(3)) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization.
Gaire BP, Song MR, Choi JW., Free PMC Article | 01/19/2019 |
| Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases. | Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases.
Gril B, Paranjape AN, Woditschka S, Hua E, Dolan EL, Hanson J, Wu X, Kloc W, Izycka-Swieszewska E, Duchnowska R, Pęksa R, Biernat W, Jassem J, Nayyar N, Brastianos PK, Hall OM, Peer CJ, Figg WD, Pauly GT, Robinson C, Difilippantonio S, Bialecki E, Metellus P, Schneider JP, Steeg PS., Free PMC Article | 12/22/2018 |
| There is considerable sexual dimorphism in the vascular and metabolic responses of aged mice and that reduced signaling through S1PR3 could be one mechanism to explain these effects. | Sexual dimorphism of metabolic and vascular dysfunction in aged mice and those lacking the sphingosine 1-phosphate receptor 3.
Cao AT, Mackova M, Kerage D, Brindley DN, Hemmings DG. | 06/30/2018 |
| The findings of this study demonstrated that S1P3 and Sphk1 are mediators of inflammatory signaling and are upregulated in astrocytes in response to injury. | Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes.
Dusaban SS, Chun J, Rosen H, Purcell NH, Brown JH., Free PMC Article | 03/31/2018 |
| Sphingosine-1-phosphate receptor 3 (S1PR3) mediates multiple aspects of the inflammatory response during sepsis. | S1PR3 Signaling Drives Bacterial Killing and Is Required for Survival in Bacterial Sepsis.
Hou J, Chen Q, Wu X, Zhao D, Reuveni H, Licht T, Xu M, Hu H, Hoeft A, Ben-Sasson SA, Shu Q, Fang X. | 12/30/2017 |
| The absence of S1P3 appears responsible for a lower availability of calcium during fatigue. | S1P3 receptor influences key physiological properties of fast-twitch extensor digitorum longus muscle.
Germinario E, Bondì M, Cencetti F, Donati C, Nocella M, Colombini B, Betto R, Bruni P, Bagni MA, Danieli-Betto D. | 12/16/2017 |
| These results highlight an important role for S1PR3 in Hematopoietic stem and progenitor cell niche occupancy. | Sphingosine-1-Phosphate Receptor-3 Supports Hematopoietic Stem and Progenitor Cell Residence Within the Bone Marrow Niche.
Ogle ME, Olingy CE, Awojoodu AO, Das A, Ortiz RA, Cheung HY, Botchwey EA., Free PMC Article | 12/16/2017 |
| S1P3 deletion protects mouse soleus from age-related drop in muscle mass, force, and regenerative capacity. | Ablation of S1P(3) receptor protects mouse soleus from age-related drop in muscle mass, force, and regenerative capacity.
Bondì M, Germinario E, Pirazzini M, Zanetti G, Cencetti F, Donati C, Gorza L, Betto R, Bruni P, Danieli-Betto D. | 08/5/2017 |
| The finding that S1P3 receptor- and Galpha13-mediated RhoA activation is responsible for protection against ischemia/reperfusion suggests that selective targeting of S1P3 receptors could provide therapeutic benefits in ischemic heart disease. | Selective coupling of the S1P(3) receptor subtype to S1P-mediated RhoA activation and cardioprotection.
Yung BS, Brand CS, Xiang SY, Gray CB, Means CK, Rosen H, Chun J, Purcell NH, Brown JH, Miyamoto S., Free PMC Article | 06/3/2017 |
| The role of the S1PR3/PDGFR-beta/Akt pathway in sphingosine-1-phosphate -induced endothelial progenitor cells migration and angiogenesis | Sphingosine-1-Phosphate Induces the Migration and Angiogenesis of Epcs Through the Akt Signaling Pathway via Sphingosine-1-Phosphate Receptor 3/Platelet-Derived Growth Factor Receptor-β.
Wang H, Cai KY, Li W, Huang H. | 08/13/2016 |
| P2RY8 promotes clustering of activated B cells within follicles in a follicular dendritic cell (FDC)-dependent manner. | The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination.
Muppidi JR, Lu E, Cyster JG., Free PMC Article | 05/28/2016 |
| Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P3 signaling axis | Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P3 signaling axis.
Mori H, Izawa T, Tanaka E. | 05/7/2016 |