| Involvement of Cannabinoid Receptors and Adenosine A2B Receptor in Enhanced Migration of Lung Cancer A549 Cells Induced by gamma-Ray Irradiation. | Involvement of Cannabinoid Receptors and Adenosine A2B Receptor in Enhanced Migration of Lung Cancer A549 Cells Induced by γ-Ray Irradiation.
Oyama M, Sakamoto M, Kitabatake K, Shiina K, Kitahara D, Onozawa S, Nishino K, Sudo Y, Tsukimoto M. | 01/7/2024 |
| The resurgence of the Adora2b receptor as an immunotherapeutic target in pancreatic cancer. | The resurgence of the Adora2b receptor as an immunotherapeutic target in pancreatic cancer.
Strickland LN, Faraoni EY, Ruan W, Yuan X, Eltzschig HK, Bailey-Lundberg JM., Free PMC Article | 05/25/2023 |
| CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer. | CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer.
Faraoni EY, Singh K, Chandra V, Le Roux O, Dai Y, Sahin I, O'Brien BJ, Strickland LN, Li L, Vucic E, Warner AN, Pruski M, Clark T, Van Buren G, Thosani NC, Bynon JS, Wray CJ, Bar-Sagi D, Poulsen KL, Vornik LA, Savage MI, Sei S, Mohammed A, Zhao Z, Brown PH, Mills T, Eltzschig HK, McAllister F, Bailey-Lundberg JM., Free PMC Article | 04/6/2023 |
| Adenosine Receptor A2B Negatively Regulates Cell Migration in Ovarian Carcinoma Cells. | Adenosine Receptor A2B Negatively Regulates Cell Migration in Ovarian Carcinoma Cells.
Campos-Contreras ADR, González-Gallardo A, Díaz-Muñoz M, Vázquez-Cuevas FG., Free PMC Article | 05/28/2022 |
| Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity. | Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.
Gnad T, Navarro G, Lahesmaa M, Reverte-Salisa L, Copperi F, Cordomi A, Naumann J, Hochhäuser A, Haufs-Brusberg S, Wenzel D, Suhr F, Jespersen NZ, Scheele C, Tsvilovskyy V, Brinkmann C, Rittweger J, Dani C, Kranz M, Deuther-Conrad W, Eltzschig HK, Niemi T, Taittonen M, Brust P, Nuutila P, Pardo L, Fleischmann BK, Blüher M, Franco R, Bloch W, Virtanen KA, Pfeifer A., Free PMC Article | 11/13/2021 |
| Tumor-derived exosomes promote angiogenesis via adenosine A2B receptor signaling. | Tumor-derived exosomes promote angiogenesis via adenosine A(2B) receptor signaling.
Ludwig N, Yerneni SS, Azambuja JH, Gillespie DG, Menshikova EV, Jackson EK, Whiteside TL., Free PMC Article | 10/2/2021 |
| Involvement of CD73 and A2B Receptor in Radiation-Induced DNA Damage Response and Cell Migration in Human Glioblastoma A172 Cells. | Involvement of CD73 and A2B Receptor in Radiation-Induced DNA Damage Response and Cell Migration in Human Glioblastoma A172 Cells.
Kitabatake K, Kaji T, Tsukimoto M. | 10/2/2021 |
| Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/beta-Catenin Pathway Stimulation by Regulating GSK3b Activity. | Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/β-Catenin Pathway Stimulation by Regulating GSK3b Activity.
Kim J, Shin JY, Choi YH, Lee SY, Jin MH, Kim CD, Kang NG, Lee S., Free PMC Article | 06/19/2021 |
| Systematic deletion of adenosine receptors reveals novel roles in inflammation and pyroptosis in THP-1 macrophages. | Systematic deletion of adenosine receptors reveals novel roles in inflammation and pyroptosis in THP-1 macrophages.
Eudy BJ, da Silva RP. | 05/1/2021 |
| Insulin requires A2B adenosine receptors to modulate the L-arginine/nitric oxide signalling in the human fetoplacental vascular endothelium from late-onset preeclampsia. | Insulin requires A(2B) adenosine receptors to modulate the L-arginine/nitric oxide signalling in the human fetoplacental vascular endothelium from late-onset preeclampsia.
Salsoso R, Mate A, Toledo F, Vázquez CM, Sobrevia L. | 04/17/2021 |
| Characterization of cancer-related somatic mutations in the adenosine A2B receptor. | Characterization of cancer-related somatic mutations in the adenosine A(2B) receptor.
Wang X, Jespers W, Bongers BJ, Habben Jansen MCC, Stangenberger CM, Dilweg MA, Gutiérrez-de-Terán H, IJzerman AP, Heitman LH, van Westen GJP. | 03/27/2021 |
| Adenosine receptor 2B activity promotes autonomous growth, migration as well as vascularization of head and neck squamous cell carcinoma cells. | Adenosine receptor 2B activity promotes autonomous growth, migration as well as vascularization of head and neck squamous cell carcinoma cells.
Wilkat M, Bast H, Drees R, Dünser J, Mahr A, Azoitei N, Marienfeld R, Frank F, Brhel M, Ushmorov A, Greve J, Goldberg-Bockhorn E, Theodoraki MN, Doescher J, Laban S, Schuler PJ, Hoffmann TK, Brunner C. | 03/27/2021 |
| Cysteine redox state regulates human beta2-adrenergic receptor binding and function. | Cysteine redox state regulates human β2-adrenergic receptor binding and function.
Rambacher KM, Moniri NH., Free PMC Article | 11/21/2020 |
| APIP is crucial for cardioprotection against myocardial infarction by virtue of binding to and stabilizing ADORA2B, thereby dampening ischemic heart injury. | Cardioprotective role of APIP in myocardial infarction through ADORA2B.
Lim B, Jung K, Gwon Y, Oh JG, Roh JI, Hong SH, Kho C, Park WJ, Lee HW, Bae JW, Jung YK., Free PMC Article | 07/18/2020 |
| Our results indicate that A2B receptors contribute to radiation resistance in a cancer-cell-specific manner, and may be a promising target for radiosensitizers in cancer radiotherapy. | Involvement of adenosine A2B receptor in radiation-induced translocation of epidermal growth factor receptor and DNA damage response leading to radioresistance in human lung cancer cells.
Kitabatake K, Yoshida E, Kaji T, Tsukimoto M. | 07/11/2020 |
| Activation of ADORA2B associates with an anti-inflammatory response in several tissue and diseases. In tissues from pregnant women with gestational diabetes mellitus, ADORA2B is overexpressed and correlates with hyperglycaemia and oxidative stress. ADORA2B shows low affinity for adenosine and its activation results in triggering intracellular signaling cascades lowering the inflammatory response. [review] | Involvement of A(2B) adenosine receptors as anti-inflammatory in gestational diabesity.
Cabalín C, Villalobos-Labra R, Toledo F, Sobrevia L. | 06/20/2020 |
| ADORA2B-AMPK signaling cascade-induced 2,3-biphosphoglycerate production promotes O2 delivery by erythrocytes to counteract kidney hypoxia and progression of chronic kidney disease | Erythrocyte Adenosine A2B Receptor-Mediated AMPK Activation: A Missing Component Counteracting CKD by Promoting Oxygen Delivery.
Peng Z, Luo R, Xie T, Zhang W, Liu H, Wang W, Tao L, Kellems RE, Xia Y., Free PMC Article | 05/2/2020 |
| Cancer associated fibroblasts-CD73 expression is enhanced via an adenosine-A2B receptor-mediated feedforward circuit triggered by tumor cell death, which enforces the CD73-checkpoint. | CD73 on cancer-associated fibroblasts enhanced by the A(2B)-mediated feedforward circuit enforces an immune checkpoint.
Yu M, Guo G, Huang L, Deng L, Chang CS, Achyut BR, Canning M, Xu N, Arbab AS, Bollag RJ, Rodriguez PC, Mellor AL, Shi H, Munn DH, Cui Y., Free PMC Article | 04/11/2020 |
| Reciprocal positive regulation of HIF and the A2B receptor in a hypoxic microenvironment thus enhances glycolytic and mitochondrial metabolism in osteoclasts to drive increased bone resorption. | The Adenosine A(2B) Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments.
Knowles HJ., Free PMC Article | 12/21/2019 |
| ADO inhibits oxalate transport by reducing PAT1 surface expression as shown by biotinylation studies. We conclude that ADO inhibits oxalate transport by lowering PAT1 surface expression in C2 cells through signaling pathways including the A2B AR, PKC, and phospholipase C | Adenosinergic signaling inhibits oxalate transport by human intestinal Caco2-BBE cells through the A(2B) adenosine receptor.
Jung D, Alshaikh A, Ratakonda S, Bashir M, Amin R, Jeon S, Stevens J, Sharma S, Ahmed W, Musch M, Hassan H., Free PMC Article | 07/6/2019 |
| A2B adenosine receptor in MDA-MB-231 breast cancer cells diminishes ERK1/2 phosphorylation by activation of MAPK-phosphatase-1 | The A2B adenosine receptor in MDA-MB-231 breast cancer cells diminishes ERK1/2 phosphorylation by activation of MAPK-phosphatase-1.
Koussémou M, Lorenz K, Klotz KN., Free PMC Article | 02/9/2019 |
| this study demonstrated that the Haemophilus influenzae infection stimulated A2A and A2B adenosine receptors. | Blood-Brain Barrier in a Haemophilus influenzae Type a In Vitro Infection: Role of Adenosine Receptors A(2A) and A(2B).
Caporarello N, Olivieri M, Cristaldi M, Scalia M, Toscano MA, Genovese C, Addamo A, Salmeri M, Lupo G, Anfuso CD. | 02/9/2019 |
| CD73-depedent elevation of plasma adenosine signaling via ADORA2B-mediated protein kinase A phosphorylation, ubiquitination and proteasome degradation of erythrocyte ENT1 is a novel feed-forward signaling network underlying initial hypoxic adaptation and retention upon re-exposure. | Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.
Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Nemkov T, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC, Xia Y., Free PMC Article | 11/17/2018 |
| hypoxia increased expression of adenosine receptor 2B (A2BR) in human breast cancer cells through the transcriptional activity of hypoxia-inducible factor 1. | Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment.
Lan J, Lu H, Samanta D, Salman S, Lu Y, Semenza GL., Free PMC Article | 11/10/2018 |
| monocyte-derived macrophages from ankylosing spondylitis patients expressed increased levels of A2AAR and reduced levels of A1 and A2BAR compared to healthy controls | Ankylosing spondylitis monocyte-derived macrophages express increased level of A(2A) adenosine receptor and decreased level of ectonucleoside triphosphate diphosphohydrolase-1 (CD39), A(1) and A(2B) adenosine receptors.
Akhtari M, Zargar SJ, Mahmoudi M, Vojdanian M, Rezaeimanesh A, Jamshidi A. | 10/20/2018 |