| Deletion of the Ebf1, a mouse deafness gene, causes a dramatic increase in hair cells and support cells of the organ of Corti. | Deletion of the Ebf1, a mouse deafness gene, causes a dramatic increase in hair cells and support cells of the organ of Corti.
Powers KG, Wilkerson BA, Beach KE, Seo SS, Rodriguez JS, Baxter AN, Hunter SE, Bermingham-McDonogh O., Free PMC Article | 09/30/2024 |
| EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and Forms the Scala Tympani and Spiral Limbus during Inner Ear Development. | EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and Forms the Scala Tympani and Spiral Limbus during Inner Ear Development.
Kagoshima H, Ohnishi H, Yamamoto R, Yasumoto A, Tona Y, Nakagawa T, Omori K, Yamamoto N., Free PMC Article | 02/21/2024 |
| Transcription factor EBF1 mitigates neuropathic pain by rescuing Kv1.2 expression in primary sensory neurons. | Transcription factor EBF1 mitigates neuropathic pain by rescuing Kv1.2 expression in primary sensory neurons.
Liang Y, Sharma D, Wang B, Wang H, Feng X, Ma R, Berkman T, Char S, Bekker A, Tao YX., | 12/26/2023 |
| The transcription factor EBF1 non-cell-autonomously regulates cardiac growth and differentiation. | The transcription factor EBF1 non-cell-autonomously regulates cardiac growth and differentiation.
Kim EE, Shekhar A, Ramachandran J, Khodadadi-Jamayran A, Liu FY, Zhang J, Fishman GI., Free PMC Article | 11/7/2023 |
| MicroRNA-598 inhibition ameliorates LPS-induced acute lung injury in mice through upregulating Ebf1 expression. | MicroRNA-598 inhibition ameliorates LPS-induced acute lung injury in mice through upregulating Ebf1 expression.
Zhao Q, He L, Zhang J, Li H, Li W, Zhou Z, Li Y., Free PMC Article | 07/4/2023 |
| EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors. | EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors.
Lenaerts A, Kucinski I, Deboutte W, Derecka M, Cauchy P, Manke T, Göttgens B, Grosschedl R., Free PMC Article | 09/17/2022 |
| Age-Progressive and Gender-Dependent Bone Phenotype in Mice Lacking Both Ebf1 and Ebf2 in Prrx1-Expressing Mesenchymal Cells. | Age-Progressive and Gender-Dependent Bone Phenotype in Mice Lacking Both Ebf1 and Ebf2 in Prrx1-Expressing Mesenchymal Cells.
Nieminen-Pihala V, Rummukainen P, Wang F, Tarkkonen K, Ivaska KK, Kiviranta R., Free PMC Article | 05/21/2022 |
| EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene. | EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene.
Somasundaram R, Jensen CT, Tingvall-Gustafsson J, Åhsberg J, Okuyama K, Prasad M, Hagman JR, Wang X, Soneji S, Strid T, Ungerbäck J, Sigvardsson M., Free PMC Article | 12/4/2021 |
| B Lymphocyte Specification Is Preceded by Extensive Epigenetic Priming in Multipotent Progenitors. | B Lymphocyte Specification Is Preceded by Extensive Epigenetic Priming in Multipotent Progenitors.
Strid T, Okuyama K, Tingvall-Gustafsson J, Kuruvilla J, Jensen CT, Lang S, Prasad M, Somasundaram R, Åhsberg J, Cristobal S, Soneji S, Ungerbäck J, Sigvardsson M. | 10/2/2021 |
| Early B-cell Factor1 (Ebf1) promotes early osteoblast differentiation but suppresses osteoblast function. | Early B-cell Factor1 (Ebf1) promotes early osteoblast differentiation but suppresses osteoblast function.
Nieminen-Pihala V, Tarkkonen K, Laine J, Rummukainen P, Saastamoinen L, Nagano K, Baron R, Kiviranta R. | 09/4/2021 |
| SIAH2 is Expressed in Adipocyte Precursor Cells and Interacts with EBF1 and ZFP521 to Promote Adipogenesis. | SIAH2 is Expressed in Adipocyte Precursor Cells and Interacts with EBF1 and ZFP521 to Promote Adipogenesis.
Dang TN, Taylor JL, Kilroy G, Yu Y, Burk DH, Floyd ZE., Free PMC Article | 07/17/2021 |
| C/EBPalpha induces Ebf1 gene expression in common lymphoid progenitors. | C/EBPα induces Ebf1 gene expression in common lymphoid progenitors.
Barberi T, Cui C, Friedman AD., Free PMC Article | 03/6/2021 |
| The results suggest that EBF1 regulates metanephric development at the last stages of glomerular maturation through its actions in the stromal progenitor (Foxd1+) lineage where it mediates proper regulation of calcineurin/NFAT signaling and COX-2 expression. | Early B Cell Factor 1 (EBF1) Regulates Glomerular Development by Controlling Mesangial Maturation and Consequently COX-2 Expression.
Nelson T, Velazquez H, Troiano N, Fretz JA., Free PMC Article | 05/30/2020 |
| Conditional deletion of Ebf1 in mesenchymal stem cells altered their cellular composition, chromatin structure and gene expression profiles, including the reduced expression of adhesion-related genes. Functionally, the stromal-specific Ebf1 inactivation results in impaired adhesion of hematopoietic stem cells, leading to reduced quiescence and diminished myeloid output. | EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential.
Derecka M, Herman JS, Cauchy P, Ramamoorthy S, Lupar E, Grün D, Grosschedl R. | 04/25/2020 |
| EBF1 heterozygosity resulted in the deregulation of at least eight transcription factors involved in lymphopoiesis and the deregulation of key proteins playing crucial roles in survival, development, and differentiation of pro-B lymphocytes. | Comprehensive Proteomic Investigation of Ebf1 Heterozygosity in Pro-B Lymphocytes Utilizing Data Independent Acquisition.
Musa YR, Boller S, Puchalska M, Grosschedl R, Mittler G. | 09/22/2018 |
| Down-regulation of EBF1 (and EBF2) genes leads to a severe impairment of myelin formation in Schwann cells. | The Transcription Factors EBF1 and EBF2 Are Positive Regulators of Myelination in Schwann Cells.
Moruzzo D, Nobbio L, Sterlini B, Consalez GG, Benfenati F, Schenone A, Corradi A. | 07/7/2018 |
| The authors show that transcription factors Lhx2 and Ebf specify olfactory receptor enhancers by binding in a functionally cooperative fashion to stereotypically spaced motifs that defy heterochromatin. | Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons.
Monahan K, Schieren I, Cheung J, Mumbey-Wafula A, Monuki ES, Lomvardas S., Free PMC Article | 06/16/2018 |
| the interaction of the CCR4-NOT complex with EBF1 diversifies the function of EBF1 in a context-dependent manner and may coordinate transcriptional and post-transcriptional gene regulation. | Interaction of CCR4-NOT with EBF1 regulates gene-specific transcription and mRNA stability in B lymphopoiesis.
Yang CY, Ramamoorthy S, Boller S, Rosenbaum M, Rodriguez Gil A, Mittler G, Imai Y, Kuba K, Grosschedl R., Free PMC Article | 06/3/2017 |
| C-terminal domain enables permissive B cell lineage-specific changes in progenitor chromatin | Pioneering Activity of the C-Terminal Domain of EBF1 Shapes the Chromatin Landscape for B Cell Programming.
Boller S, Ramamoorthy S, Akbas D, Nechanitzky R, Burger L, Murr R, Schübeler D, Grosschedl R. | 08/20/2016 |
| Pax5 and Ebf1 collaborate to modulate the transcriptional response to Notch signaling, and their combined heterozygous loss allows for T-lineage conversion of B cell progenitors. | Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors.
Ungerbäck J, Åhsberg J, Strid T, Somasundaram R, Sigvardsson M., Free PMC Article | 09/12/2015 |
| a dramatic increase in the frequency of pro-B cell leukemia was observed in mice with combined heterozygous mutations in the Ebf1 and Pax5 genes, revealing a synergistic effect of combined dose reduction of these proteins | Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency.
Prasad MA, Ungerbäck J, Åhsberg J, Somasundaram R, Strid T, Larsson M, Månsson R, De Paepe A, Lilljebjörn H, Fioretos T, Hagman J, Sigvardsson M., Free PMC Article | 09/5/2015 |
| EBF1 is an important regulator of adipose morphology and fat cell lipolysis and may constitute a link between White adipose tissue inflammation, altered lipid metabolism, adipose hypertrophy, and insulin resistance. | Early B cell factor 1 regulates adipocyte morphology and lipolysis in white adipose tissue.
Gao H, Mejhert N, Fretz JA, Arner E, Lorente-Cebrián S, Ehrlund A, Dahlman-Wright K, Gong X, Strömblad S, Douagi I, Laurencikiene J, Dahlman I, Daub CO, Rydén M, Horowitz MC, Arner P., Free PMC Article | 06/20/2015 |
| Ebf1 has a significant and novel role in glomerular development, podocyte maturation, and the maintenance of kidney integrity and function. | Early B-cell factor 1 is an essential transcription factor for postnatal glomerular maturation.
Fretz JA, Nelson T, Velazquez H, Xi Y, Moeckel GW, Horowitz MC., Free PMC Article | 02/14/2015 |
| Our results suggest that Bach2 functions with Bach1 and EBF1 to promote B cell development by repressing myeloid genes in common lymphoid progenitor cells | The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program.
Itoh-Nakadai A, Hikota R, Muto A, Kometani K, Watanabe-Matsui M, Sato Y, Kobayashi M, Nakamura A, Miura Y, Yano Y, Tashiro S, Sun J, Ikawa T, Ochiai K, Kurosaki T, Igarashi K. | 01/24/2015 |
| EBF1 functions as a key integrator of signal transduction, inflammation, and metabolism | Early B-cell factor-1 (EBF1) is a key regulator of metabolic and inflammatory signaling pathways in mature adipocytes.
Griffin MJ, Zhou Y, Kang S, Zhang X, Mikkelsen TS, Rosen ED., Free PMC Article | 02/15/2014 |