| Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding. | Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding.
Khan N, Pelletier D, McAlear TS, Croteau N, Veyron S, Bayne AN, Black C, Ichikawa M, Khalifa AAZ, Chaaban S, Kurinov I, Brouhard G, Bechstedt S, Bui KH, Trempe JF., Free PMC Article | 01/15/2022 |
| Associations of PRKN-PACRG SNPs and G x G and G x E interactions with the risk of hyperlipidaemia. | Associations of PRKN-PACRG SNPs and G × G and G × E interactions with the risk of hyperlipidaemia.
Zheng PF, Yin RX, Wei BL, Liu CX, Deng GX, Guan YZ., Free PMC Article | 05/8/2021 |
| The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC. | The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC.
Meschede J, Šadić M, Furthmann N, Miedema T, Sehr DA, Müller-Rischart AK, Bader V, Berlemann LA, Pilsl A, Schlierf A, Barkovits K, Kachholz B, Rittinger K, Ikeda F, Marcus K, Schaefer L, Tatzelt J, Winklhofer KF., Free PMC Article | 02/6/2021 |
| Mapping of the PARK2 and PACRG gene regulatory region with 96 SNPs, with a resolution of 1 SNP per 1 Kb for PARK2 gene regulatory region in a North Indian population, showed an involvement of 11 SNPs in determining the susceptibility towards leprosy. | Mapping of PARK2 and PACRG overlapping regulatory region reveals LD structure and functional variants in association with leprosy in unrelated indian population groups.
Chopra R, Ali S, Srivastava AK, Aggarwal S, Kumar B, Manvati S, Kalaiarasan P, Jena M, Garg VK, Bhattacharya SN, Bamezai RN., Free PMC Article | 01/11/2014 |
| PARK2 and PACRG are commonly downregulated in clear-cell renal cell carcinoma and are associated with aggressive disease and poor clinical outcome. | PARK2 and PACRG are commonly downregulated in clear-cell renal cell carcinoma and are associated with aggressive disease and poor clinical outcome.
Toma MI, Wuttig D, Kaiser S, Herr A, Weber T, Zastrow S, Koch R, Meinhardt M, Baretton GB, Wirth MP, Fuessel S. | 06/15/2013 |
| conducted high-density association mapping of PARK2/PACRG SNPs with leprosy and identified 69 SNPs significantly associated with leprosy in 198 single-case Vietnamese leprosy families | Linkage disequilibrium pattern and age-at-diagnosis are critical for replicating genetic associations across ethnic groups in leprosy.
Alter A, Fava VM, Huong NT, Singh M, Orlova M, Van Thuc N, Katoch K, Thai VH, Ba NN, Abel L, Mehra N, Alcaïs A, Schurr E. | 03/2/2013 |
| Elevated levels of PACRG result in increased neuronal autophagy. | Parkin co-regulated gene is involved in aggresome formation and autophagy in response to proteasomal impairment.
Taylor JM, Brody KM, Lockhart PJ. | 10/13/2012 |
| single nucleotide polymorphisms of PARK2 with leprosy susceptibility in Chinese population | Association study of the single nucleotide polymorphisms of PARK2 and PACRG with leprosy susceptibility in Chinese population.
Li J, Liu H, Liu J, Fu X, Yu Y, Yu G, Chen S, Chu T, Lu N, Bao F, Yuan C, Zhang F., Free PMC Article | 09/15/2012 |
| the association of polymorphisms rs9356058 and rs1040079 in gene PARK2/PACRG with leprosy | Leprosy epidemics during history increased protective allele frequency of PARK2/PACRG genes in the population of the Mljet Island, Croatia.
Bakija-Konsuo A, Mulić R, Boraska V, Pehlic M, Huffman JE, Hayward C, Marlais M, Zemunik T, Rudan I. | 01/14/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Mutation of PACRG was not identified as a cause of male infertility, but variation in the promoter was demonstrated to be a risk factor associated with azoospermia. | Molecular analysis of the PArkin co-regulated gene and association with male infertility.
Wilson GR, Sim ML, Brody KM, Taylor JM, McLachlan RI, O'Bryan MK, Delatycki MB, Lockhart PJ, Wilson GR, Sim ML, Brody KM, Taylor JM, McLachlan RI, O'Bryan MK, Delatycki MB, Lockhart PJ. | 05/31/2010 |
| PINK1, Omi/HtrA2 and parkin participate at different levels in mitochondrial quality control, converging through some overlapping and some distinct steps to maintain a common phenotype of healthy mitochondrial networks [REVIEW] | Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.
Dagda RK, Chu CT., Free PMC Article | 05/3/2010 |
| Thw results of this study suggested that point mutations in PACRG are not a common cause of EO-PD but haploinsufficiency for PACRG may be associated with disease. | Analysis of PArkin Co-Regulated Gene in a Taiwanese-ethnic Chinese cohort with early-onset Parkinson's disease.
Taylor JM, Wu RM, Farrer MJ, Delatycki MB, Lockhart PJ, Taylor JM, Wu RM, Farrer MJ, Delatycki MB, Lockhart PJ. | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians.
Velez DR, Hulme WF, Myers JL, Stryjewski ME, Abbate E, Estevan R, Patillo SG, Gilbert JR, Hamilton CD, Scott WK., Free PMC Article | 09/20/2009 |
| Suspected association of SNP's with leprosy is not borne out in Indian population. | Association study of major risk single nucleotide polymorphisms in the common regulatory region of PARK2 and PACRG genes with leprosy in an Indian population.
Malhotra D, Darvishi K, Lohra M, Kumar H, Grover C, Sood S, Reddy BS, Bamezai RN, Malhotra D, Darvishi K, Lohra M, Kumar H, Grover C, Sood S, Reddy BS, Bamezai RN. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (6) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Molecular analysis of the PArkin co-regulated gene and association with male infertility.
Wilson GR, Sim ML, Brody KM, Taylor JM, McLachlan RI, O'Bryan MK, Delatycki MB, Lockhart PJ, Wilson GR, Sim ML, Brody KM, Taylor JM, McLachlan RI, O'Bryan MK, Delatycki MB, Lockhart PJ. Analysis of PArkin Co-Regulated Gene in a Taiwanese-ethnic Chinese cohort with early-onset Parkinson's disease.
Taylor JM, Wu RM, Farrer MJ, Delatycki MB, Lockhart PJ, Taylor JM, Wu RM, Farrer MJ, Delatycki MB, Lockhart PJ. Association study of major risk single nucleotide polymorphisms in the common regulatory region of PARK2 and PACRG genes with leprosy in an Indian population.
Malhotra D, Darvishi K, Lohra M, Kumar H, Grover C, Sood S, Reddy BS, Bamezai RN, Malhotra D, Darvishi K, Lohra M, Kumar H, Grover C, Sood S, Reddy BS, Bamezai RN. Genetic analysis of parkin co-regulated gene (PACRG) in patients with early-onset parkinsonism.
Deng H, Le WD, Xie WJ, Pan TH, Zhang X, Jankovic J, Deng H, Le WD, Xie WJ, Pan TH, Zhang X, Jankovic J. Susceptibility to leprosy is associated with PARK2 and PACRG.
Mira MT, Alcaïs A, Nguyen VT, Moraes MO, Di Flumeri C, Vu HT, Mai CP, Nguyen TH, Nguyen NB, Pham XK, Sarno EN, Alter A, Montpetit A, Moraes ME, Moraes JR, Doré C, Gallant CJ, Lepage P, Verner A, Van De Vosse E, Hudson TJ, Abel L, Schurr E, Mira MT, Alcaïs A, Nguyen VT, Moraes MO, Di Flumeri C, Vu HT, Mai CP, Nguyen TH, Nguyen NB, Pham XK, Sarno EN, Alter A, Montpetit A, Moraes ME, Moraes JR, Doré C, Gallant CJ, Lepage P, Verner A, Van De Vosse E, Hudson TJ, Abel L, Schurr E. | 03/13/2008 |
| PACRG is regulated by the ubiquitin-proteasomal system and may play a role in the pathogenesis of Parkinson's disease. | Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases.
Taylor JM, Song YJ, Huang Y, Farrer MJ, Delatycki MB, Halliday GM, Lockhart PJ. | 01/21/2010 |
| The observed features of genotypic distribution by PACRG marker point to the influence of the considered marker on the incidence of tuberculosis. | [Study of the polymorphic markers--the PARK2 and PACRG genes due to the incidence of pulmonary tuberculosis in two districts of the Republic of Tyva].
Udina IG, Kordicheva SIu, Pospelov LE, Malenko AF, Gergert VIa, Pospelov AL, Matrashkin AG, Kyzyl-Ool MM, Nachin AA, Zhivotovskiĭ LA. | 01/21/2010 |
| Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy | Susceptibility to leprosy is associated with PARK2 and PACRG.
Mira MT, Alcaïs A, Nguyen VT, Moraes MO, Di Flumeri C, Vu HT, Mai CP, Nguyen TH, Nguyen NB, Pham XK, Sarno EN, Alter A, Montpetit A, Moraes ME, Moraes JR, Doré C, Gallant CJ, Lepage P, Verner A, Van De Vosse E, Hudson TJ, Abel L, Schurr E, Mira MT, Alcaïs A, Nguyen VT, Moraes MO, Di Flumeri C, Vu HT, Mai CP, Nguyen TH, Nguyen NB, Pham XK, Sarno EN, Alter A, Montpetit A, Moraes ME, Moraes JR, Doré C, Gallant CJ, Lepage P, Verner A, Van De Vosse E, Hudson TJ, Abel L, Schurr E. | 01/21/2010 |
| PACRG is linked to parkin via a bi-directional promoter | Identification of a novel gene linked to parkin via a bi-directional promoter.
West AB, Lockhart PJ, O'Farell C, Farrer MJ. | 01/21/2010 |
| Glup/PACRG forms a large molecular chaperone complex, suppresses cell death induced by accumulation of unfolded Pael receptor, facilitates the formation of Pael-R inclusions,and is a component of Lewy bodies in Parkinson's disease | A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.
Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R. | 01/21/2010 |
| candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm | Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia.
Agirre X, Román-Gómez J, Vázquez I, Jiménez-Velasco A, Garate L, Montiel-Duarte C, Artieda P, Cordeu L, Lahortiga I, Calasanz MJ, Heiniger A, Torres A, Minna JD, Prósper F. | 01/21/2010 |
| mutation of PACRG plays little or no role in the development of early-onset parkinsonism | Genetic analysis of parkin co-regulated gene (PACRG) in patients with early-onset parkinsonism.
Deng H, Le WD, Xie WJ, Pan TH, Zhang X, Jankovic J, Deng H, Le WD, Xie WJ, Pan TH, Zhang X, Jankovic J. | 01/21/2010 |