| Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation. | Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation.
Dewa KI, Arimura N, Kakegawa W, Itoh M, Adachi T, Miyashita S, Inoue YU, Hizawa K, Hori K, Honjoya N, Yagishita H, Taya S, Miyazaki T, Usui C, Tatsumoto S, Tsuzuki A, Uetake H, Sakai K, Yamakawa K, Sasaki T, Nagai J, Kawaguchi Y, Sone M, Inoue T, Go Y, Ichinohe N, Kaibuchi K, Watanabe M, Koizumi S, Yuzaki M, Hoshino M., Free PMC Article | 02/12/2024 |
| DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models. | DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models.
Liu H, Caballero-Florán RN, Hergenreder T, Yang T, Hull JM, Pan G, Li R, Veling MW, Isom LL, Kwan KY, Huang ZJ, Fuerst PG, Jenkins PM, Ye B., Free PMC Article | 04/26/2023 |
| Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice. | Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice.
Lim CS, Kim MJ, Choi JE, Islam MA, Lee YK, Xiong Y, Shim KW, Yang JE, Lee RU, Lee J, Park P, Kwak JH, Seo H, Kim CH, Lee JH, Lee YS, Hwang SK, Lee K, Lee JA, Kaang BK., Free PMC Article | 03/19/2022 |
| DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors. | DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.
Chen P, Liu Z, Zhang Q, Lin D, Song L, Liu J, Jiao HF, Lai X, Zou S, Wang S, Zhou T, Li BM, Zhu L, Pan BX, Fei E., Free PMC Article | 02/19/2022 |
| DSCAM Mutation Impairs Motor Cortex Network Dynamic and Voluntary Motor Functions. | DSCAM Mutation Impairs Motor Cortex Network Dynamic and Voluntary Motor Functions.
Laflamme OD, Lemieux M, Thiry L, Bretzner F. | 09/26/2020 |
| DSCAM2J mutation alters the repertoire of gaits according to the mouse's age and speed, and prevents fast gaits. | Age- and speed-dependent modulation of gaits in DSCAM(2J) mutant mice.
Thiry L, Lemieux M, Bretzner F., Free PMC Article | 05/4/2019 |
| The diversity resides on the adhesive side, positioning DSCAM as a generalized modulator of cell adhesion during neural development. | DSCAM promotes self-avoidance in the developing mouse retina by masking the functions of cadherin superfamily members.
Garrett AM, Khalil A, Walton DO, Burgess RW., Free PMC Article | 12/22/2018 |
| Results identify DSCAM-cell-adhesion molecule-mediated inhibition as a regulator of circuit-level neuronal plasticity in the adult mice retina. | DSCAM-mediated control of dendritic and axonal arbor outgrowth enforces tiling and inhibits synaptic plasticity.
Simmons AB, Bloomsburg SJ, Sukeena JM, Miller CJ, Ortega-Burgos Y, Borghuis BG, Fuerst PG., Free PMC Article | 07/7/2018 |
| Findings indicate Down syndrome cell adhesion molecule (Dscam) as a permissive signal that promotes the growth and fasciculation of retinal ganglion cell (RGC) axons, controlling the timing of when RGC axons reach their targets. | DSCAM promotes axon fasciculation and growth in the developing optic pathway.
Bruce FM, Brown S, Smith JN, Fuerst PG, Erskine L., Free PMC Article | 05/12/2018 |
| Together, these results demonstrate that different cell types have different dependencies on the PDZ-interacting C-termini of DSCAM and DSCAML1 for function, indicating multiple intracellular molecular mechanisms are involved. | Replacing the PDZ-interacting C-termini of DSCAM and DSCAML1 with epitope tags causes different phenotypic severity in different cell populations.
Garrett AM, Tadenev AL, Hammond YT, Fuerst PG, Burgess RW., Free PMC Article | 10/28/2017 |
| work presents the correlation between DSCAM gene overexpression and a dysregulation of the P21-activated kinases pathway. | Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension.
Pérez-Núñez R, Barraza N, Gonzalez-Jamett A, Cárdenas AM, Barnier JV, Caviedes P. | 07/1/2017 |
| DSCAM mutation induces dystonic hypertonia and a disruption of locomotor gaits. | Motor hypertonia and lack of locomotor coordination in mutant mice lacking DSCAM.
Lemieux M, Laflamme OD, Thiry L, Boulanger-Piette A, Frenette J, Bretzner F., Free PMC Article | 11/19/2016 |
| DSCAM mutation reduces or abolishes spinal reflexes in both neonatal isolated spinal cords and adult mice. | Role of DSCAM in the development of the spinal locomotor and sensorimotor circuits.
Thiry L, Lemieux M, D Laflamme O, Bretzner F., Free PMC Article | 11/19/2016 |
| Results suggest that down syndrome cell adhesion molecule collaborates with deleted in colorectal cancer to regulate microtubule dynamics via direct binding to dynamic TUBB3 in Netrin-1-induced axon branching. | Coordinated interaction of Down syndrome cell adhesion molecule and deleted in colorectal cancer with dynamic TUBB3 mediates Netrin-1-induced axon branching.
Huang H, Shao Q, Qu C, Yang T, Dwyer T, Liu G., Free PMC Article | 12/19/2015 |
| Our results indicate an important role of DSCAM and DSCAML1 in the development of cortical neural network. | DSCAM and DSCAML1 regulate the radial migration and callosal projection in developing cerebral cortex.
Zhang L, Huang Y, Chen JY, Ding YQ, Song NN. | 08/8/2015 |
| DSCAM colocalizes in developmentally dynamic patterns with adhesion and synaptic proteins in the mouse retina. | Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina.
de Andrade GB, Kunzelman L, Merrill MM, Fuerst PG., Free PMC Article | 06/27/2015 |
| The findings of this study are as follows: (1) DSCAM is sufficient to drive cell death (2) dendrite avoidance defects in the Dscam loss-of-function retina do not reflect a role for DSCAM, and necessary and sufficient to target neurites. | DSCAM promotes refinement in the mouse retina through cell death and restriction of exploring dendrites.
Li S, Sukeena JM, Simmons AB, Hansen EJ, Nuhn RE, Samuels IS, Fuerst PG., Free PMC Article | 06/20/2015 |
| A novel splice isoform of Dscam causes defects in lamination of type 2 and type 6 cone bipolar cells in Dscam mutant mice. | A novel mouse Dscam mutation inhibits localization and shedding of DSCAM.
Schramm RD, Li S, Harris BS, Rounds RP, Burgess RW, Ytreberg FM, Fuerst PG., Free PMC Article | 06/29/2013 |
| DSCAM contributes to pyramidal neuron morphogenesis by regulating dendrite arborization and spine formation during cortical circuit development | DSCAM contributes to dendrite arborization and spine formation in the developing cerebral cortex.
Maynard KR, Stein E., Free PMC Article | 02/2/2013 |
| somal clustering and fasciculation observed in the Dscam mutant retina are not unique to Dscam deficiency and are manifested distinctively by different retinal cell types. | Neuronal clustering and fasciculation phenotype in Dscam- and Bax-deficient mouse retinas.
Keeley PW, Sliff BJ, Lee SC, Fuerst PG, Burgess RW, Eglen SJ, Reese BE., Free PMC Article | 08/18/2012 |
| Data indicate that the mammalian DSCAM gene is critical for the formation of the central nervous system. | Dscam mutation leads to hydrocephalus and decreased motor function.
Xu Y, Ye H, Shen Y, Xu Q, Zhu L, Liu J, Wu JY., Free PMC Article | 04/28/2012 |
| DSCAM is not required for Netrin-induced commissural axon outgrowth and guidance in mice. | Genetic analysis of DSCAM's role as a Netrin-1 receptor in vertebrates.
Palmesino E, Haddick PC, Tessier-Lavigne M, Kania A., Free PMC Article | 03/10/2012 |
| Deletion of Dscam in specific cell types causes cell-type-autonomous cell body spacing defects, indicating that DSCAM mediates arborization and spacing by acting within given cell types. | Cell autonomy of DSCAM function in retinal development.
Fuerst PG, Bruce F, Rounds RP, Erskine L, Burgess RW., Free PMC Article | 02/18/2012 |
| overexpression of DSCAM in the cerebral cortex might play an important role in the learning and memory defects of amyloid precursor protein transgenic mice. | Expression and significance of DSCAM in the cerebral cortex of APP transgenic mice.
Jia YL, Jing LJ, Li JY, Lu JJ, Han R, Wang SY, Peng T, Jia YJ. | 07/9/2011 |
| A novel null allele of mouse Dscam survives to adulthood on an inbred C3H background with reduced phenotypic variability. | A novel null allele of mouse DSCAM survives to adulthood on an inbred C3H background with reduced phenotypic variability.
Fuerst PG, Harris BS, Johnson KR, Burgess RW., Free PMC Article | 02/26/2011 |