| Differential regulation of STARD1, STARD4 and STARD6 in the human ovary. | Differential regulation of STARD1, STARD4 and STARD6 in the human ovary.
Yahya NA, King SR, Shi B, Shaaban A, Whitfield NE, Yan C, Kordus RJ, Whitman-Elia GF, LaVoie HA., | 07/29/2024 |
| Membrane specificity of the human cholesterol transfer protein STARD4. | Membrane specificity of the human cholesterol transfer protein STARD4.
Talandashti R, van Ek L, Gehin C, Xue D, Moqadam M, Gavin AC, Reuter N. | 06/7/2024 |
| SREBF2-STARD4 axis confers sorafenib resistance in hepatocellular carcinoma by regulating mitochondrial cholesterol homeostasis. | SREBF2-STARD4 axis confers sorafenib resistance in hepatocellular carcinoma by regulating mitochondrial cholesterol homeostasis.
Yue X, Kong Y, Zhang Y, Sun M, Liu S, Wu Z, Gao L, Liang X, Ma C., Free PMC Article | 02/11/2023 |
| [Steroidogenic acute regulatory protein-related lipid transfer 4 (StarD4) promotes breast cancer cell proliferation and its mechanism]. | [Steroidogenic acute regulatory protein-related lipid transfer 4 (StarD4) promotes breast cancer cell proliferation and its mechanism].
Huang T, Shan R, Zhang M, Li L, Huang J, Liu B, Zhou W., Free PMC Article | 01/8/2022 |
| STARD4 promotes breast cancer cell malignancy. | STARD4 promotes breast cancer cell malignancy.
Zhang M, Xiang Z, Wang F, Shan R, Li L, Chen J, Liu BA, Huang J, Sun LQ, Zhou WB., Free PMC Article | 07/31/2021 |
| STARD4 has a conserved alpha-helix/beta-grip fold with a deep hydrophobic pocket.STARD4 binds sterol in the pocket and transport sterol between liposomes. Sterol binding requires a conformational change to form a complementary pocket. | Structural analysis of human sterol transfer protein STARD4.
Tan L, Tong J, Chun C, Im YJ. | 07/25/2020 |
| Knockdown of STARD4, a sterol transporter, leads to large changes in the lipidome. STARD4-KD cells also have large changes in their mRNA profile. There is an increase in cellular cholesterol, including in late endosomes. These results indicate that STARD4 plays important roles in lipid homeostasis. | Stable reduction of STARD4 alters cholesterol regulation and lipid homeostasis.
Iaea DB, Spahr ZR, Singh RK, Chan RB, Zhou B, Bareja R, Elemento O, Di Paolo G, Zhang X, Maxfield FR., Free PMC Article | 07/18/2020 |
| This study shows that nonvesicular sterol transport mechanisms and STARD4 in particular account for a large fraction of sterol transport between the plasma membrane and the ERC. | Role of STARD4 in sterol transport between the endocytic recycling compartment and the plasma membrane.
Iaea DB, Mao S, Lund FW, Maxfield FR., Free PMC Article | 06/3/2017 |
| Studies show the 3 steroidogenic acute regulatory-related lipid transfer (START) domain proteins StarD4, StarD5 and StarD6 have a similar lipid binding pocket specific for sterols (cholesterol in particular), but differing regulation and localization. | The StarD4 subfamily of steroidogenic acute regulatory-related lipid transfer (START) domain proteins: new players in cholesterol metabolism.
Calderon-Dominguez M, Gil G, Medina MA, Pandak WM, RodrÃguez-Agudo D., Free PMC Article | 11/22/2014 |
| The data indicate a role for STARD4 in nonvesicular transport of cholesterol from the plasma membrane and the endocytic recycling compartment to the endoplasmic reticulum and perhaps other intracellular compartments as well. | STARD4 knockdown in HepG2 cells disrupts cholesterol trafficking associated with the plasma membrane, ER, and ERC.
Garbarino J, Pan M, Chin HF, Lund FW, Maxfield FR, Breslow JL., Free PMC Article | 04/27/2013 |
| cholesterol transport mediated by STARD4 is an important component of the cholesterol homeostasis regulatory machinery | STARD4 abundance regulates sterol transport and sensing.
Mesmin B, Pipalia NH, Lund FW, Ramlall TF, Sokolov A, Eliezer D, Maxfield FR., Free PMC Article | 02/25/2012 |
| Study provide strong evidence for StarD4 as a highly regulated, non-vesicular, directional, intracellular transporter of cholesterol which plays a key role in the maintenance of intracellular cholesterol homeostasis. | Subcellular localization and regulation of StarD4 protein in macrophages and fibroblasts.
Rodriguez-Agudo D, Calderon-Dominguez M, Ren S, Marques D, Redford K, Medina-Torres MA, Hylemon P, Gil G, Pandak WM., Free PMC Article | 10/29/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| StarD4-accelerated 7 alpha-OOH transfer to mitochondria resulted in greater susceptibility to free radical lipid peroxidation and loss of membrane potential than in a non-StarD4 control. | StarD4-mediated translocation of 7-hydroperoxycholesterol to isolated mitochondria: deleterious effects and implications for steroidogenesis under oxidative stress conditions.
Korytowski W, Rodriguez-Agudo D, Pilat A, Girotti AW., Free PMC Article | 03/15/2010 |
| StarD4 plays an important role as a directional cholesterol transporter in the maintenance of cellular cholesterol homeostasis | Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation.
Rodriguez-Agudo D, Ren S, Wong E, Marques D, Redford K, Gil G, Hylemon P, Pandak WM., Free PMC Article | 01/21/2010 |
| Induction of STARD4 depended on both transcription factor ATF6 and an ERSE-like element in its promoter. | Regulation of human STARD4 gene expression under endoplasmic reticulum stress.
Yamada S, Yamaguchi T, Hosoda A, Iwawaki T, Kohno K. | 01/21/2010 |
| StarD4 is regulated by sterols via SREBP-2, and StarD5 is activated by ER stress cholesterol metabolism; they serve different functions | Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress.
Soccio RE, Adams RM, Maxwell KN, Breslow JL. | 01/21/2010 |