| A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models. | A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models.
Stabach PR, Sims D, Gomez-Bañuelos E, Zehentmeier S, Dammen-Brower K, Bernhisel A, Kujawski S, Lopez SG, Petri M, Goldman DW, Lester ER, Le Q, Ishaq T, Kim H, Srivastava S, Kumar D, Pereira JP, Yarema KJ, Koumpouras F, Andrade F, Braddock DT., Free PMC Article | 09/20/2024 |
| Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue. | Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue.
Montorsi L, Pitcher MJ, Zhao Y, Dionisi C, Demonti A, Tull TJ, Dhami P, Ellis RJ, Bishop C, Sanderson JD, Jain S, D'Cruz D, Gibbons DL, Winkler TH, Bemark M, Ciccarelli FD, Spencer J., Free PMC Article | 07/16/2024 |
| The deficiency of DNASE1L3 does not affect systemic sclerosis pathogenesis in two inducible murine models of the disease. | The deficiency of DNASE1L3 does not affect systemic sclerosis pathogenesis in two inducible murine models of the disease.
Garreau A, Santa P, Dubois M, Brisou D, Levionnois É, Laurent P, Ferriere A, Roubertie A, Loizon S, Duluc D, Blanco P, Contin-Bordes C, Truchetet ME, Sisirak V. | 06/17/2024 |
| Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice. | Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice.
Engavale M, Hernandez CJ, Infante A, LeRoith T, Radovan E, Evans L, Villarreal J, Reilly CM, Sutton RB, Keyel PA., | 12/6/2023 |
| DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer. | DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer.
Li W, Nakano H, Fan W, Li Y, Sil P, Nakano K, Zhao F, Karmaus PW, Grimm SA, Shi M, Xu X, Mizuta R, Kitamura D, Wan Y, Fessler MB, Cook DN, Shats I, Li X, Li L., Free PMC Article | 09/13/2023 |
| B cell-intrinsic DNase1L3 is essential for the T cell-independent type II response in mice. | B cell-intrinsic DNase1L3 is essential for the T cell-independent type II response in mice.
Kato K, Haniuda K, Fukao S, Kitamura D. | 05/31/2023 |
| Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus. | Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus.
Korn MA, Steffensen M, Brandl C, Royzman D, Daniel C, Winkler TH, Nitschke L., Free PMC Article | 03/31/2023 |
| Comparison of the secretory murine DNase1 family members expressed in Pichia pastoris. | Comparison of the secretory murine DNase1 family members expressed in Pichia pastoris.
Verhülsdonk L, Mannherz HG, Napirei M., Free PMC Article | 11/6/2021 |
| Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction. | Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction.
Chan RWY, Serpas L, Ni M, Volpi S, Hiraki LT, Tam LS, Rashidfarrokhi A, Wong PCH, Tam LHP, Wang Y, Jiang P, Cheng ASH, Peng W, Han DSC, Tse PPP, Lau PK, Lee WS, Magnasco A, Buti E, Sisirak V, AlMutairi N, Chan KCA, Chiu RWK, Reizis B, Lo YMD., Free PMC Article | 12/12/2020 |
| Cell-free DNA in blood circulation is generated by DNase1L3 and caspase-activated DNase. | Cell-free DNA in blood circulation is generated by DNase1L3 and caspase-activated DNase.
Watanabe T, Takada S, Mizuta R. | 07/11/2020 |
| These results support a distinct role of DNASE1L3 as a regulator of the physical form and availability of cell-free DNA and may have important implications for the mechanism whereby this enzyme prevents autoimmunity. | Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA.
Serpas L, Chan RWY, Jiang P, Ni M, Sun K, Rashidfarrokhi A, Soni C, Sisirak V, Lee WS, Cheng SH, Peng W, Chan KCA, Chiu RWK, Reizis B, Lo YMD., Free PMC Article | 03/16/2019 |
| DNase1 and DNase1-like 3 are independently expressed and thus provide dual host protection against deleterious effects of intravascular neutrophil extracellular traps. | Host DNases prevent vascular occlusion by neutrophil extracellular traps.
Jiménez-Alcázar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ, Long AT, Bilyy R, Krenn V, Renné C, Renné T, Kluge S, Panzer U, Mizuta R, Mannherz HG, Kitamura D, Herrmann M, Napirei M, Fuchs TA. | 03/17/2018 |
| Study reports that DNASE1L3-deficient mice rapidly develop autoantibodies to DNA and chromatin, followed by an systemic lupus erythematosus-like disease. Circulating DNASE1L3 is produced by dendritic cells and macrophages, and its levels inversely correlate with anti-DNA antibody response. | Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity.
Sisirak V, Sally B, D'Agati V, Martinez-Ortiz W, Özçakar ZB, David J, Rashidfarrokhi A, Yeste A, Panea C, Chida AS, Bogunovic M, Ivanov II, Quintana FJ, Sanz I, Elkon KB, Tekin M, Yalçınkaya F, Cardozo TJ, Clancy RM, Buyon JP, Reizis B., Free PMC Article | 01/14/2017 |
| DNase gamma, but not CAD, is the effector endonuclease for INDF in cells undergoing necrosis. | DNase γ is the effector endonuclease for internucleosomal DNA fragmentation in necrosis.
Mizuta R, Araki S, Furukawa M, Furukawa Y, Ebara S, Shiokawa D, Hayashi K, Tanuma S, Kitamura D., Free PMC Article | 08/23/2014 |
| serum contains two nucleases, DNase1 and DNase1l3, which may substitute or cooperate with each other during DNA degradation, providing effective clearance after exposure or release from dying cells. | Murine serum nucleases--contrasting effects of plasmin and heparin on the activities of DNase1 and DNase1-like 3 (DNase1l3).
Napirei M, Ludwig S, Mezrhab J, Klöckl T, Mannherz HG. | 01/21/2010 |
| These results suggest that DNasegamma provides an alternative mechanism for inducing nuclear changes when the working apoptotic cascade is unsuitable for caspase-activated DNase activation. | Stage-specific expression of DNasegamma during B-cell development and its role in B-cell receptor-mediated apoptosis in WEHI-231 cells.
Shiokawa D, Shika Y, Araki S, Sunaga S, Mizuta R, Kitamura D, Tanuma S. | 01/21/2010 |
| A comparison of the expression and transport of DNAse1 from rats and DNAse1L3 from mice is reported. | Comparative characterization of rat deoxyribonuclease 1 (Dnase1) and murine deoxyribonuclease 1-like 3 (Dnase1l3).
Napirei M, Wulf S, Eulitz D, Mannherz HG, Kloeckl T., Free PMC Article | 01/21/2010 |