| Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes). | Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes).
Chapouly C, Hollier PL, Guimbal S, Cornuault L, Gadeau AP, Renault MA. | 12/19/2020 |
| Identify Dhh (desert hedgehog) as a downstream effector of Klf2, whose expression in endothelial cells is upregulated by shear stress and decreased by inflammatory cytokines. | Restoring Endothelial Function by Targeting Desert Hedgehog Downstream of Klf2 Improves Critical Limb Ischemia in Adults.
Caradu C, Couffinhal T, Chapouly C, Guimbal S, Hollier PL, Ducasse E, Bura-Rivière A, Dubois M, Gadeau AP, Renault MA. | 10/5/2019 |
| the critical role of Dhh in maintaining blood nerve barrier integrity and demonstrates for the first time that endothelial dysfunction is sufficient to induce neuropathy | Impaired Hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy: implication in diabetes.
Chapouly C, Yao Q, Vandierdonck S, Larrieu-Lahargue F, Mariani JN, Gadeau AP, Renault MA. | 12/17/2016 |
| In organogenesis of the ovary, production of Dhh/Ihh in granulosa cells requires growth differentiation factor 9 from the oocyte. | Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells.
Liu C, Peng J, Matzuk MM, Yao HH., Free PMC Article | 03/19/2016 |
| increased expression in cell bodies of cutaneous sensory nerves of dorsal root ganglia as compared with skin epithelia | Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches.
Peterson SC, Eberl M, Vagnozzi AN, Belkadi A, Veniaminova NA, Verhaegen ME, Bichakjian CK, Ward NL, Dlugosz AA, Wong SY., Free PMC Article | 01/16/2016 |
| The results demonstrate a pivotal role for dhh in maintof this study aining myelination. Furthermore, dhh signaling reveals a potential target for therapeutic intervention to prevent and treat demyelination of peripheral nerves in compression neuropathies | Desert hedgehog is a mediator of demyelination in compression neuropathies.
Jung J, Frump D, Su J, Wang W, Mozaffar T, Gupta R. | 12/19/2015 |
| Hedgehog signaling is impaired in aged mice. Hegdehog-dependent regulation of angiogenesis and myogenesis involves distinct mechanisms. | Hedgehog-dependent regulation of angiogenesis and myogenesis is impaired in aged mice.
Renault MA, Robbesyn F, Chapouly C, Yao Q, Vandierdonck S, Reynaud A, Belloc I, Traiffort E, Ruat M, Desgranges C, Gadeau AP. | 01/11/2014 |
| Data indicate that the centrosomal protein DZIP1 interacts with GLI3 transcription factor in the cytoplasm and regulates Hedgehog signaling and ciliogenesis. | Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis.
Wang C, Low WC, Liu A, Wang B., Free PMC Article | 12/14/2013 |
| Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival. | Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival.
Renault MA, Chapouly C, Yao Q, Larrieu-Lahargue F, Vandierdonck S, Reynaud A, Petit M, Jaspard-Vinassa B, Belloc I, Traiffort E, Ruat M, Duplàa C, Couffinhal T, Desgranges C, Gadeau AP. | 06/29/2013 |
| Desert hedgehog-dependent transcription in T cells promotes T helper (Th)2 cell transcriptional programs and differentiation, exacerbating allergic disease. | Tissue-derived hedgehog proteins modulate Th differentiation and disease.
Furmanski AL, Saldana JI, Ono M, Sahni H, Paschalidis N, D'Acquisto F, Crompton T., Free PMC Article | 05/18/2013 |
| During recovery of hematopoiesis after irradiation, and under conditions of stress-induced erythropoiesis, erythrocyte differentiation was accelerated in both spleen and bone marrow of Dhh-deficient mice compared with wild type. | Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog.
Lau CI, Outram SV, Saldaña JI, Furmanski AL, Dessens JT, Crompton T., Free PMC Article | 07/21/2012 |
| The findings suggest that Sertoli cells coordinate Dhh-dependent spermatogenesis events via Ptc1 and Smo prior to the first meiotic division and in postmeiotic (haploid) cells, particularly during the first half of spermiogenesis. | Expression of Patched-1 and Smoothened in testicular meiotic and post-meiotic cells.
Morales CR, Fox A, El-Alfy M, Ni X, Argraves WS. | 02/8/2010 |
| A single identified glial signal, desert hedgehog, plays a critical role in controlling the integrity of peripheral nervous tissue, in line with its critical role in nerve sheath development. | The structural and functional integrity of peripheral nerves depends on the glial-derived signal desert hedgehog.
Sharghi-Namini S, Turmaine M, Meier C, Sahni V, Umehara F, Jessen KR, Mirsky R., Free PMC Article | 01/21/2010 |
| Inactivation of Nf1 in the glial lineage in vitro at embryonic day 12.5 + 1, but not earlier (neural crest) or later (mature Schwann cell), results in colony-forming cells capable of multilineage differentiation. | Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells.
Wu J, Williams JP, Rizvi TA, Kordich JJ, Witte D, Meijer D, Stemmer-Rachamimov AO, Cancelas JA, Ratner N., Free PMC Article | 01/21/2010 |
| results demonstrate a functional desert hedgehog(HH) pathway in the follicle and identify granulosa cells as at least one of the potential targets of HH signaling | The hedgehog signaling pathway in the mouse ovary.
Russell MC, Cowan RG, Harman RM, Walker AL, Quirk SM. | 01/21/2010 |
| combinatorial expression of the paracrine factor Dhh and nuclear transcription factor Sf1 is required for Leydig cell development | Distinct roles for steroidogenic factor 1 and desert hedgehog pathways in fetal and adult Leydig cell development.
Park SY, Tong M, Jameson JL. | 01/21/2010 |
| Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis | Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis.
Yao HH, Whoriskey W, Capel B., Free PMC Article | 01/21/2010 |
| Prominent role of hedgehog signaling in the communication between granulosa cells and developing theca cells. | Hedgehog signaling in mouse ovary: Indian hedgehog and desert hedgehog from granulosa cells induce target gene expression in developing theca cells.
Wijgerde M, Ooms M, Hoogerbrugge JW, Grootegoed JA. | 01/21/2010 |
| transgenic skin developed lesions reminiscent of human basal cell carcinoma | An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis.
Adolphe C, Narang M, Ellis T, Wicking C, Kaur P, Wainwright B. | 01/21/2010 |