| Dihydrofolate reductase activity controls neurogenic transitions in the developing neocortex. | Dihydrofolate reductase activity controls neurogenic transitions in the developing neocortex.
Saha S, Jungas TT, Ohayon D, Audouard C, Ye T, Fawal MA, Davy A. | 09/13/2023 |
| Endothelial NOX4 aggravates eNOS uncoupling by decreasing dihydrofolate reductase after subarachnoid hemorrhage. | Endothelial NOX4 aggravates eNOS uncoupling by decreasing dihydrofolate reductase after subarachnoid hemorrhage.
Gao SQ, Shi JJ, Xue-Wang, Miao SH, Li T, Gao CC, Han YL, Qiu JY, Zhuang YS, Zhou ML. | 12/10/2022 |
| endothelial Rb positively impacts arterial function by supporting vasoprotective endothelial DHFR/nitric oxide pathway activity, leading to reduced abdominal aortic aneurysm development. | Endothelial retinoblastoma protein reduces abdominal aortic aneurysm development via promoting DHFR/NO pathway-mediated vasoprotection.
Cao Y, Xiong D, Kong R, Dai G, Zhong M, Li L, Zhang J, Jiang L, Li H. | 01/18/2020 |
| The study reports arrested hematopoiesis and vascular relaxation defects in mice with a point mutation, Thr136Ala substitution in Dhfr. | Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr.
Thoms JA, Knezevic K, Liu JJ, Glaros EN, Thai T, Qiao Q, Campbell H, Packham D, Huang Y, Papathanasiou P, Tunningley R, Whittle B, Yeung AW, Chandrakanthan V, Hesson L, Chen V, Wong JW, Purton LE, Ward RL, Thomas SR, Pimanda JE., Free PMC Article | 09/17/2016 |
| S-nitrosylation of DHFR at cysteine 7 by eNOS-derived NO is crucial for DHFR stability. | Endothelial Nitric Oxide Synthase-Derived Nitric Oxide Prevents Dihydrofolate Reductase Degradation via Promoting S-Nitrosylation.
Cai Z, Lu Q, Ding Y, Wang Q, Xiao L, Song P, Zou MH., Free PMC Article | 02/6/2016 |
| demonstrate that dihydrofolate reductase activity is also a feature of the mitochondria in both rat and mouse but this is not due to a second enzyme | An active second dihydrofolate reductase enzyme is not a feature of rat and mouse, but they do have activity in their mitochondria.
Hughes L, Carton R, Minguzzi S, McEntee G, Deinum EE, O'Connell MJ, Parle-McDermott A. | 10/3/2015 |
| Robust and processive unfolding/degradation of some substrates with very stable protein domains, including mDHFR and titin(I27) . | Protein unfolding and degradation by the AAA+ Lon protease.
Gur E, Vishkautzan M, Sauer RT., Free PMC Article | 06/2/2012 |
| protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency | Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
Crabtree MJ, Hale AB, Channon KM., Free PMC Article | 09/24/2011 |
| Dhfr has a role in folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation | Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation.
Iskandar BJ, Rizk E, Meier B, Hariharan N, Bottiglieri T, Finnell RH, Jarrard DF, Banerjee RV, Skene JH, Nelson A, Patel N, Gherasim C, Simon K, Cook TD, Hogan KJ., Free PMC Article | 05/31/2010 |
| Data reveal a key role for dihydrofolate reductase in eNOS coupling by maintaining the tetrahyrobiopterin (BH4):dihydrobiopterin (BH2) ratio, particularly in conditions of low total biopterin availability. | Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.
Crabtree MJ, Tatham AL, Hale AB, Alp NJ, Channon KM., Free PMC Article | 01/21/2010 |
| E2F-responsive dihydrofolate reductase promoter regulates the balance between acetylation and methylation of histone H3 lysine 9 | Balance between acetylation and methylation of histone H3 lysine 9 on the E2F-responsive dihydrofolate reductase promoter.
Nicolas E, Roumillac C, Trouche D., Free PMC Article | 01/21/2010 |
| mechanical stability of mouse dihydrofolate reductase is dominated by local interactions within the protein structure | Influence of substrate binding on the mechanical stability of mouse dihydrofolate reductase.
Junker JP, Hell K, Schlierf M, Neupert W, Rief M., Free PMC Article | 01/21/2010 |
| translocation of the DHFR domain was greatly impaired when it was separated from the signal-anchor sequence | Translocation of a long amino-terminal domain through ER membrane by following signal-anchor sequence.
Kida Y, Mihara K, Sakaguchi M., Free PMC Article | 01/21/2010 |
| Crystal structures are reported for NADPH ternary complexes with PY1011 and mouse DHFR (mDHFR), refined to 2.2 A resolution. | New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions.
Cody V, Pace J, Chisum K, Rosowsky A. | 01/21/2010 |