| Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes. | Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes.
de la Rosa Rodriguez MA, Deng L, Gemmink A, van Weeghel M, Aoun ML, Warnecke C, Singh R, Borst JW, Kersten S., Free PMC Article | 01/15/2022 |
| Hepatic synthesis of triacylglycerols containing medium-chain fatty acids is dominated by diacylglycerol acyltransferase 1 and efficiently inhibited by etomoxir. | Hepatic synthesis of triacylglycerols containing medium-chain fatty acids is dominated by diacylglycerol acyltransferase 1 and efficiently inhibited by etomoxir.
Wunderling K, Leopold C, Jamitzky I, Yaghmour M, Zink F, Kratky D, Thiele C., Free PMC Article | 10/30/2021 |
| Intestine-specific DGAT1 deficiency improves atherosclerosis in apolipoprotein E knockout mice by reducing systemic cholesterol burden. | Intestine-specific DGAT1 deficiency improves atherosclerosis in apolipoprotein E knockout mice by reducing systemic cholesterol burden.
Vujić N, Korbelius M, Sachdev V, Rainer S, Zimmer A, Huber A, Radović B, Kratky D., Free PMC Article | 08/7/2021 |
| Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway Inflammation. | Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway Inflammation.
Karagiannis F, Masouleh SK, Wunderling K, Surendar J, Schmitt V, Kazakov A, Michla M, Hölzel M, Thiele C, Wilhelm C. | 11/21/2020 |
| Hepatic VLDL secretion: DGAT1 determines particle size but not particle number, which can be supported entirely by DGAT2 | Hepatic VLDL secretion: DGAT1 determines particle size but not particle number, which can be supported entirely by DGAT2.
Irshad Z, Chmel N, Adya R, Zammit VA., Free PMC Article | 02/15/2020 |
| Study demonstrated that Dgat1-/- mice have alterations in the process of autophagy-mediated cytoplasmic liquid droplets mobilization in enterocytes, likely due to the impairments of autophagic vesicles turnover and lysosome acidification during early stage of dietary fat absorption. | DGAT1 deficiency disrupts lysosome function in enterocytes during dietary fat absorption.
Hung YH, Buhman KK., Free PMC Article | 10/26/2019 |
| Study shows that inactivation of DGAT1 or DGAT2 in adult mouse heart results in a moderate suppression of triglycerides (TG) synthesis and turnover. Partial inhibition of DGAT activity increases cardiac fatty acid oxidation without affecting PPARalpha signaling, myocardial energetics or contractile function. Thus, the two DGAT isoforms in the heart have partially redundant function. | The Role of Diacylglycerol Acyltransferase (DGAT) 1 and 2 in Cardiac Metabolism and Function.
Roe ND, Handzlik MK, Li T, Tian R., Free PMC Article | 10/12/2019 |
| hese results demonstrate that DGAT1 suppresses retinol-dependent Treg formation and suggest its potential as a therapeutic target for autoimmune inflammation. | DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis.
Graham KL, Werner BJ, Moyer KM, Patton AK, Krois CR, Yoo HS, Tverskoy M, LaJevic M, Napoli JL, Sobel RA, Zabel BA, Butcher EC., Free PMC Article | 05/4/2019 |
| data reveal an important role for DGAT activity and TG synthesis generally in averting ER stress and lipotoxicity, with specifically DGAT1 performing this function during stimulated lipolysis in adipocytes. | Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.
Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV Jr., Free PMC Article | 04/21/2018 |
| The endoplasmic reticulum-resident diacylglycerol acyltransferase 1 (DGAT1) selectively channels autophagy-liberated fatty acids into new, clustered lipid droplets that are in close proximity to mitochondria and are lipolytically degraded. | DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.
Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA., Free PMC Article | 09/30/2017 |
| TAG synthesis and levels of PUFA-TAGs were lowered by the diacylglycerol acyltransferase (DGAT)1 inhibitor, T863. The lipase inhibitor, Atglistatin, increased the levels of TAG in both WT and ATGL-deficient mouse Hepatic stellate cell (HSC). Both Atglistatin and T863 inhibited the induction of activation marker, alpha-smooth muscle actin, in rat HSCs, but not in mouse HSCs. | ATGL and DGAT1 are involved in the turnover of newly synthesized triacylglycerols in hepatic stellate cells.
Tuohetahuntila M, Molenaar MR, Spee B, Brouwers JF, Houweling M, Vaandrager AB, Helms JB., Free PMC Article | 08/26/2017 |
| DGAT1 does not contribute to this pathway, but uses exogenous FA and glycerol to synthesize a functionally distinct pool of TAG to which DGAT2 also contributes...in b3-agonist activated brown adipocytes, DGAT2 specifically enables channelling of de novo synthesized FA into a rapidly mobilized pool of TAG, which is simultaneously hydrolyzed to provide substrates for mitochondrial fatty acid oxidation. | Diacylglycerol acyltransferase 2 links glucose utilization to fatty acid oxidation in the brown adipocytes.
Irshad Z, Dimitri F, Christian M, Zammit VA., Free PMC Article | 08/26/2017 |
| these results support a model where Dgat1 and Dgat2 function coordinately to regulate the process of dietary fat absorption by preferentially synthesizing TAG for incorporation into distinct subcellular TAG pools in enterocytes. | Dgat1 and Dgat2 regulate enterocyte triacylglycerol distribution and alter proteins associated with cytoplasmic lipid droplets in response to dietary fat.
Hung YH, Carreiro AL, Buhman KK., Free PMC Article | 08/19/2017 |
| Study provides evidence that although DGAT1 in the hematopoietic compartment does not impact the overall lipid content of atherosclerotic plaques, it exerts reciprocal effects on inflammation and fibrosis, two processes that control plaque vulnerability. | Acyl-CoA:Diacylglycerol Acyltransferase 1 Expression Level in the Hematopoietic Compartment Impacts Inflammation in the Vascular Plaques of Atherosclerotic Mice.
Vujic N, Porter Abate J, Schlager S, David T, Kratky D, Koliwad SK., Free PMC Article | 07/15/2017 |
| Our findings provide insight into a novel role of DGAT1 and identify a pathway by which intestinal DGAT1 deficiency affects whole-body cholesterol homeostasis in mice | Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism.
Sachdev V, Leopold C, Bauer R, Patankar JV, Iqbal J, Obrowsky S, Boverhof R, Doktorova M, Scheicher B, Goeritzer M, Kolb D, Turnbull AV, Zimmer A, Hoefler G, Hussain MM, Groen AK, Kratky D., Free PMC Article | 06/3/2017 |
| g. This study implied a function role of DGAT1 in the synthesis of TAG, insulin resistance, and intramuscular fat deposition. | Analysis of Differentially Expressed Genes in Gastrocnemius Muscle between DGAT1 Transgenic Mice and Wild-Type Mice.
Ying F, Gu H, Xiong Y, Zuo B., Free PMC Article | 04/29/2017 |
| Total retinyl-ester synthase activity was reduced in both dgat1(-/-) retina and retinal pigment epithelium. | Diacylglycerol O-acyltransferase type-1 synthesizes retinyl esters in the retina and retinal pigment epithelium.
Kaylor JJ, Radu RA, Bischoff N, Makshanoff J, Hu J, Lloyd M, Eddington S, Bianconi T, Bok D, Travis GH., Free PMC Article | 02/6/2016 |
| F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression | F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression.
Mo X, Yang C, Wang X, Burkhardt BR, Li Y, Xia H, Cao X., Free PMC Article | 01/2/2016 |
| loss of DGAT1 reproduces the lipid abnormalities seen in severe human heart failure. | Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.
Liu L, Trent CM, Fang X, Son NH, Jiang H, Blaner WS, Hu Y, Yin YX, Farese RV Jr, Homma S, Turnbull AV, Eriksson JW, Hu SL, Ginsberg HN, Huang LS, Goldberg IJ., Free PMC Article | 02/14/2015 |
| TNFalpha mediates saturated fatty acid-induced osteoclastogenesis that can be prevented by DGAT activation or supplementation with OA. | Palmitic acid and DGAT1 deficiency enhance osteoclastogenesis, while oleic acid-induced triglyceride formation prevents it.
Drosatos-Tampakaki Z, Drosatos K, Siegelin Y, Gong S, Khan S, Van Dyke T, Goldberg IJ, Schulze PC, Schulze-Späte U., Free PMC Article | 12/20/2014 |
| Compared with wild-type mice, triglyceride and DGAT1 content were approximately fourfold and 50% increased in posterior tibial muscle of the transgenic mice, respectively, while a little increase in cardiac muscle. | Upregulation of triglyceride synthesis in skeletal muscle overexpressing DGAT1.
Yang F, Wei Z, Ding X, Liu X, Ge X, Song G, Li G, Guo H., Free PMC Article | 01/4/2014 |
| Diacylglycerol acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release. | Diacylglycerol acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release.
Lin HV, Chen D, Shen Z, Zhu L, Ouyang X, Vongs A, Kan Y, Levorse JM, Kowalik EJ Jr, Szeto DM, Yao X, Xiao J, Chen S, Liu J, Garcia-Calvo M, Shin MK, Pinto S., Free PMC Article | 06/29/2013 |
| Intestinal DGAT1 inhibition or deficiency acutely delayed gastric emptying and inhibited chylomicron secretion; however, the latter occurred when gastric emptying was normal or when lipid was administered directly into the small intestine. | Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying.
Ables GP, Yang KJ, Vogel S, Hernandez-Ono A, Yu S, Yuen JJ, Birtles S, Buckett LK, Turnbull AV, Goldberg IJ, Blaner WS, Huang LS, Ginsberg HN., Free PMC Article | 03/9/2013 |
| analysis ofsubstrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases | Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases.
Eichmann TO, Kumari M, Haas JT, Farese RV Jr, Zimmermann R, Lass A, Zechner R., Free PMC Article | 02/9/2013 |
| Deletion of DGAT1 in mice provides a model of leanness and extended lifespan that is independent of calorie restriction. | Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.
Streeper RS, Grueter CA, Salomonis N, Cases S, Levin MC, Koliwad SK, Zhou P, Hirschey MD, Verdin E, Farese RV Jr., Free PMC Article | 06/9/2012 |