| MCM8 interacts with DDX5 to promote R-loop resolution. | MCM8 interacts with DDX5 to promote R-loop resolution.
Wen C, Cao L, Wang S, Xu W, Yu Y, Zhao S, Yang F, Chen ZJ, Zhao S, Yang Y, Qin Y., Free PMC Article | 08/13/2024 |
| DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection. | DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection.
Xu J, Liu LY, Zhi FJ, Song YJ, Zhang ZH, Li B, Zheng FY, Gao PC, Zhang SZ, Zhang YY, Zhang Y, Qiu Y, Jiang B, Li YQ, Peng C, Chu YF., Free PMC Article | 02/20/2024 |
| Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein DDX5. | Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein DDX5.
Louis TL, Wong WH, Yao P, Kurd NS, Tysl T, Indralingam CS, Ma S, Huang WJM, Chang JT., Free PMC Article | 07/19/2023 |
| Identification of DDX5 as an indispensable activator of the glucocorticoid receptor in adipocyte differentiation. | Identification of DDX5 as an indispensable activator of the glucocorticoid receptor in adipocyte differentiation.
Hokimoto S, Funakoshi-Tago M, Tago K. | 03/10/2023 |
| RNA binding protein DDX5 restricts RORgammat[+] Treg suppressor function to promote intestine inflammation. | RNA binding protein DDX5 restricts RORγt(+) T(reg) suppressor function to promote intestine inflammation.
Ma S, Yang Q, Chen N, Zheng A, Abbasi N, Wang G, Patel PR, Cho BS, Yee BA, Zhang L, Chu H, Evans SM, Yeo GW, Zheng Y, Huang WJM., Free PMC Article | 02/11/2023 |
| The indispensable role of the RNA helicase DDX5 in tumorigenesis induced by the myeloproliferative neoplasm-associated JAK2V617F mutant. | The indispensable role of the RNA helicase DDX5 in tumorigenesis induced by the myeloproliferative neoplasm-associated JAK2V617F mutant.
Takeda K, Tago K, Funakoshi-Tago M. | 01/7/2023 |
| RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine. | RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine.
Long T, Abbasi N, Hernandez JE, Li Y, Sayed IM, Ma S, Iemolo A, Yee BA, Yeo GW, Telese F, Ghosh P, Das S, Huang WJM., Free PMC Article | 08/20/2022 |
| RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes. | RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes.
Xia Q, Cui G, Fan Y, Wang X, Hu G, Wang L, Luo X, Yang L, Cai Q, Xu K, Guo W, Gao M, Li Y, Wu J, Li W, Chen J, Qi H, Peng G, Yao H., Free PMC Article | 05/15/2021 |
| RNA helicase p68 inhibits the transcription and post-transcription of Pkd1 in ADPKD. | RNA helicase p68 inhibits the transcription and post-transcription of Pkd1 in ADPKD.
Zhang L, Li LX, Zhou JX, Harris PC, Calvet JP, Li X., Free PMC Article | 05/8/2021 |
| RNA helicase DDX5 suppresses IFN-I antiviral innate immune response by interacting with PP2A-Cbeta to deactivate IRF3. | RNA helicase DDX5 suppresses IFN-I antiviral innate immune response by interacting with PP2A-Cβ to deactivate IRF3.
Zan J, Xu R, Tang X, Lu M, Xie S, Cai J, Huang Z, Zhang J. | 03/13/2021 |
| Induction of DEAD Box helicase 5 in early adipogenesis is regulated by Ten-eleven translocation 2. | Induction of DEAD Box helicase 5 in early adipogenesis is regulated by Ten-eleven translocation 2.
Cho M, Lee E, Shon J, Choi MJ, Park JH, Park YJ. | 10/24/2020 |
| Findings contribute to the understanding of the complex nature of MBP post-transcriptional control in immature oligodendrocytes where DDX5 appears to affect the abundance of MBP proteins via distinct but converging mechanisms. | Dual role of the RNA helicase DDX5 in post-transcriptional regulation of myelin basic protein in oligodendrocytes.
Hoch-Kraft P, White R, Tenzer S, Krämer-Albers EM, Trotter J, Gonsior C. | 12/7/2019 |
| Using an inducible knockout mouse model study reveals essential role for Ddx5 in spermatogonial maintenance and show that Ddx5 is indispensable for male fertility. Ddx5 regulates appropriate splicing of key genes necessary for spermatogenesis and can also act as a transcriptional co-activator. Ddx5 interacts with PLZF, a transcription factor required for germline maintenance, to co-regulate select target genes. | DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia.
Legrand JMD, Chan AL, La HM, Rossello FJ, Änkö ML, Fuller-Pace FV, Hobbs RM., Free PMC Article | 06/15/2019 |
| The results highlight a novel molecular mechanism underlying stability of neurogenesis-associated mRNAs controlled by the Klf4/Ddx5/Stau1 axis during mammalian corticogenesis. | Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis.
Moon BS, Bai J, Cai M, Liu C, Shi J, Lu W., Free PMC Article | 03/3/2018 |
| Study provided strong evidence that mammalian DDX5 and S. cerevisiae Dbp2 are functionally conserved especially in cellular metabolism, despite enzymatic differences. | Characterization of the mammalian DEAD-box protein DDX5 reveals functional conservation with S. cerevisiae ortholog Dbp2 in transcriptional control and glucose metabolism.
Xing Z, Wang S, Tran EJ., Free PMC Article | 09/23/2017 |
| these results reveal important functions of DDX5 in regulating reprogramming and highlight the importance of a Ddx5-miR125b-Rybp axis in controlling cell fate. | RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions.
Li H, Lai P, Jia J, Song Y, Xia Q, Huang K, He N, Ping W, Chen J, Yang Z, Li J, Yao M, Dong X, Zhao J, Hou C, Esteban MA, Gao S, Pei D, Hutchins AP, Yao H. | 08/5/2017 |
| DDX5 is a crucial factor involved in the complex transcriptional cascade of events that regulate adipogenesis and is essential for the initiation of adipogenesis. | DDX5/p68 RNA helicase expression is essential for initiating adipogenesis.
Ramanathan N, Lim N, Stewart CL., Free PMC Article | 07/16/2016 |
| Data indicate that Arf tumor suppressor blocks the functional interaction between c-Myc and p68 DEAD-box protein (DDX5). | Arf tumor suppressor disrupts the oncogenic positive feedback loop including c-Myc and DDX5.
Tago K, Funakoshi-Tago M, Itoh H, Furukawa Y, Kikuchi J, Kato T, Suzuki K, Yanagisawa K. | 04/25/2015 |
| Downregulation of DDX5 and DDX17 protein expression during myogenesis and epithelial-to-mesenchymal transdifferentiation contributes to the switching of splicing programs during these processes. | RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation.
Dardenne E, Polay Espinoza M, Fattet L, Germann S, Lambert MP, Neil H, Zonta E, Mortada H, Gratadou L, Deygas M, Chakrama FZ, Samaan S, Desmet FO, Tranchevent LC, Dutertre M, Rimokh R, Bourgeois CF, Auboeuf D. | 04/18/2015 |
| p68 levels may have an important role in influencing the decision between cell-cycle arrest and apoptosis in response to DNA damage. | The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage.
Nicol SM, Bray SE, Black HD, Lorimore SA, Wright EG, Lane DP, Meek DW, Coates PJ, Fuller-Pace FV., Free PMC Article | 09/21/2013 |
| our data demonstrate that Ddx5 and SRA function as coactivators of Notch signaling. | RNA helicase Ddx5 and the noncoding RNA SRA act as coactivators in the Notch signaling pathway.
Jung C, Mittler G, Oswald F, Borggrefe T. | 06/22/2013 |
| Data indicate that transcriptional coregulator ddx5/ddx17 RNA helicases can simultaneously regulate the transcriptional activity and alternative splicing of NFAT5 transcription factor. | Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor.
Germann S, Gratadou L, Zonta E, Dardenne E, Gaudineau B, Fougère M, Samaan S, Dutertre M, Jauliac S, Auboeuf D. | 01/26/2013 |
| Solution structures of the double-stranded RNA-binding domains from RNA helicase A. | Solution structures of the double-stranded RNA-binding domains from RNA helicase A.
Nagata T, Tsuda K, Kobayashi N, Shirouzu M, Kigawa T, Güntert P, Yokoyama S, Muto Y. | 10/20/2012 |
| study shows that mrhl RNA plays a negative role in Wnt signaling in mouse spermatogonial cells through its interaction with p68 | mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells.
Arun G, Akhade VS, Donakonda S, Rao MR., Free PMC Article | 10/13/2012 |
| The interaction between CDX2 transcription factor and DDX5 RNA helicase | [The interaction between CDX2 transcription factor and DDX5 RNA helicase].
Liskovykh MA, Davydov-Sinitsin AP, Marilovtseva EV, Tomilin AN, Tolkunova EN. | 03/17/2012 |