| Somatic cell-derived BMPs induce premature meiosis in male germ cells during the embryonic stage by upregulating Dazl expression. | Somatic cell-derived BMPs induce premature meiosis in male germ cells during the embryonic stage by upregulating Dazl expression.
Zhang L, Li Y, Hu Y, Chen M, Cen C, Chen M, Lin L, Zhou J, Wang M, Cui X, Tang F, Gao F. | 02/19/2022 |
| The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation. Mutagenesis of putative DAZL-binding sites in these mRNAs mimics the effect of DAZL depletion. These findings demonstrate that DAZL regulates translation of maternal mRNAs, functioning both as the translational repressor and activator during oocyte maturation. | The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation.
Yang CR, Rajkovic G, Daldello EM, Luong XG, Chen J, Conti M., Free PMC Article | 07/18/2020 |
| These DAZL functions as a master regulator of a post-transcriptional mRNA program essential for germ cell survival. | DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions.
Zagore LL, Sweet TJ, Hannigan MM, Weyn-Vanhentenryck SM, Jobava R, Hatzoglou M, Zhang C, Licatalosi DD., Free PMC Article | 12/14/2019 |
| The 3'-UTR-dependent suppression of DAZL in mouse follicular oocytes is required for the progression of normal pre-implantation development. | Requirement of the 3'-UTR-dependent suppression of DAZL in oocytes for pre-implantation mouse development.
Fukuda K, Masuda A, Naka T, Suzuki A, Kato Y, Saga Y., Free PMC Article | 07/7/2018 |
| Down-regulated expression of Sox9 and Dazl may play important roles in MBP-induced testis injury. | Mono-butyl phthalate-induced mouse testis injury is associated with oxidative stress and down-regulated expression of Sox9 and Dazl.
Du J, Xiong D, Zhang Q, Li X, Liu X, You H, Ding S, Yang X, Yuan J. | 10/7/2017 |
| DAZL and CPEB1 regulate mRNA translation during oocyte maturation. | DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation.
Sousa Martins JP, Liu X, Oke A, Arora R, Franciosi F, Viville S, Laird DJ, Fung JC, Conti M., Free PMC Article | 01/14/2017 |
| findings demonstrate that DAZL associates with mRNA of Tet1, a catalyst of 5-hydroxylation of methyl-cytosine, and enhances Tet1 mRNA translation; DAZL enhances TET1-mediated cytosine hydroxymethylation in embryonic stem cells that are actively reprogramming to a pluripotent ground state | DAZL regulates Tet1 translation in murine embryonic stem cells.
Welling M, Chen HH, Muñoz J, Musheev MU, Kester L, Junker JP, Mischerikow N, Arbab M, Kuijk E, Silberstein L, Kharchenko PV, Geens M, Niehrs C, van de Velde H, van Oudenaarden A, Heck AJ, Geijsen N., Free PMC Article | 04/23/2016 |
| Both yeast and mouse contain an RNA-binding protein, Rim4 and DAZL, respectively, that functions in translation and forms SDS-resistant aggregates during gametogenesis. | Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis.
Berchowitz LE, Kabachinski G, Walker MR, Carlile TM, Gilbert WV, Schwartz TU, Amon A., Free PMC Article | 01/30/2016 |
| Our findings strengthen the importance of RA and Dazl in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 induction and function | Retinoic acid activates two pathways required for meiosis in mice.
Koubova J, Hu YC, Bhattacharyya T, Soh YQ, Gill ME, Goodheart ML, Hogarth CA, Griswold MD, Page DC., Free PMC Article | 11/7/2015 |
| Data indicate that the germ cell-specific RNA binding protein DAZL limits both pluripotency and somatic differentiation in nascent primordial germ cells (PGCs). | DAZL limits pluripotency, differentiation, and apoptosis in developing primordial germ cells.
Chen HH, Welling M, Bloch DB, Muñoz J, Mientjes E, Chen X, Tramp C, Wu J, Yabuuchi A, Chou YF, Buecker C, Krainer A, Willemsen R, Heck AJ, Geijsen N., Free PMC Article | 07/25/2015 |
| demonstrate that Boll is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl | A developmental stage-specific switch from DAZL to BOLL occurs during fetal oogenesis in humans, but not mice.
He J, Stewart K, Kinnell HL, Anderson RA, Childs AJ., Free PMC Article | 07/19/2014 |
| Studies indicate that in Dazl-Knockout mice, cord/tubule-like structures, OSE invaginations and clusters of steroidogenic cells became increasingly prominent with age, but these abnormal structures remained benign. | The fate of granulosa cells following premature oocyte loss and the development of ovarian cancers.
Pitman JL, McNeilly AS, McNeilly JR, Hays LE, Bagby GC Jr, Sawyer HR, McNatty KP. | 08/31/2013 |
| alternative splicing of exon8 of mDazl leads to the generation of the novel splice variant, Dazl-Delta8. | Mouse Dazl and its novel splice variant functions in translational repression of target mRNAs in embryonic stem cells.
Xu X, Tan X, Lin Q, Schmidt B, Engel W, Pantakani DV. | 07/20/2013 |
| DAZL was translocated to stress granules upon heat stress. Furthermore, stress granule assembly was significantly diminished in the early male germ cells of Dazl-knockout mice. DAZL induced the sequestration of signaling molecules such as RACK. | DAZL is essential for stress granule formation implicated in germ cell survival upon heat stress.
Kim B, Cooke HJ, Rhee K. | 03/10/2012 |
| structures suggest that the number of DAZL molecules bound to GUU triplets in the 3'-UTR provides a method for modulating the translation of a target RNA | Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.
Jenkins HT, Malkova B, Edwards TA., Free PMC Article | 01/28/2012 |
| If DAZL expression is reduced, then follicles can grow to the late follicular stage despite declining levels of circulating FSH, leading to more follicles ovulating and increased litter size. | Decreased oocyte DAZL expression in mice results in increased litter size by modulating follicle-stimulating hormone-induced follicular growth.
McNeilly JR, Watson EA, White YA, Murray AA, Spears N, McNeilly AS. | 01/14/2012 |
| Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells. | Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells.
Gill ME, Hu YC, Lin Y, Page DC., Free PMC Article | 07/16/2011 |
| CPEB1 regulates Dazl post-transcriptionally, and that DAZL is essential for meiotic maturation and embryonic cleavage | Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.
Chen J, Melton C, Suh N, Oh JS, Horner K, Xie F, Sette C, Blelloch R, Conti M., Free PMC Article | 05/21/2011 |
| Stra8 and Dazl are highly expressed in premeiotic germ cells that do not undergo further differentiation in aged mouse ovaries. | Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment.
Niikura Y, Niikura T, Tilly JL., Free PMC Article | 06/28/2010 |
| Dazl contributes to the differentiation of embryonic stem cells into germ cells. | The dazzle in germ cell differentiation.
Kerr CL, Cheng L. | 04/12/2010 |
| Dazl is a master gene controlling germ cell differentiation and that ectopic expression of Dazl promotes the dynamic differentiation of mouse ES cells into gametes in vitro. | Dazl promotes germ cell differentiation from embryonic stem cells.
Yu Z, Ji P, Cao J, Zhu S, Li Y, Zheng L, Chen X, Feng L. | 02/22/2010 |
| Mouse DAZL protein can bind to 3'UTR of mTex19.1 mRNAs and may repress mTex19.1 expression at the translational level.Confirmed by both electrophoretic mobility shift assay and translation assay in Zebrafish embryo detecting the luciferase activity. | DAZL binds to 3'UTR of Tex19.1 mRNAs and regulates Tex19.1 expression.
Zeng M, Lu Y, Liao X, Li D, Sun H, Liang S, Zhang S, Ma Y, Yang Z. | 02/8/2010 |
| Data show that EBs expressed Oct-4, OTR, OT, and DAZL. | Embryoid bodies from mouse stem cells express oxytocin receptor, Oct-4 and DAZL.
Stefanidis K, Loutradis D, Anastasiadou V, Beretsos P, Bletsa R, Dinopoulou V, Lekka K, Elenis E, Kiapekou E, Koussoulakos S, Fotinos A, Antsaklis A. | 01/21/2010 |
| report establishes the translational regulator Dazl as a component of pluripotency, genetic, and epigenetic programs at multiple time points of germ cell development. | Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro.
Haston KM, Tung JY, Reijo Pera RA., Free PMC Article | 01/21/2010 |
| study shows that extrinsic & intrinsic factors regulate meiotic initiation in embryos; DAZL, which is expressed by postmigratory germ cells, is a key intrinsic factor, enabling those cells to initiate meiosis in response to retinoic acid | Germ cell-intrinsic and -extrinsic factors govern meiotic initiation in mouse embryos.
Lin Y, Gill ME, Koubova J, Page DC. | 01/21/2010 |