| Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model. | Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model.
Ahmed M, Tezera LB, Herbert N, Chambers M, Reichmann MT, Nargan K, Kloverpris H, Karim F, Hlatshwayo M, Madensein R, Habesh M, Hoque M, Steyn AJC, Elkington PT, Leslie AJ., Free PMC Article | 07/8/2024 |
| CD200R promotes high glucose-induced oxidative stress and damage in human retinal pigment epithelial cells by activating the mTOR signaling pathway. | CD200R promotes high glucose-induced oxidative stress and damage in human retinal pigment epithelial cells by activating the mTOR signaling pathway.
Hu Y, Wei T, Gao S, Gao N, Chen L, Cheng Q. | 06/28/2024 |
| Inflammatory dendritic cells restrain CD11b[+]CD4[+] CTLs via CD200R in human NSCLC. | Inflammatory dendritic cells restrain CD11b(+)CD4(+) CTLs via CD200R in human NSCLC.
Lin M, Chen D, Shao Z, Liu Q, Hao Z, Xin Z, Chen Y, Wu W, Chen X, He T, Wu D, Wu P. | 03/5/2024 |
| Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy. | Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy.
Tang Y, Liu W, Kadu S, Johnson O, Hasanali ZS, Kelly A, Shestov A, Pajarillo R, Greenblatt E, Holmes M, Wang LP, Shih N, O'Connor RS, Ruella M, Garfall AL, Allman D, Vogl DT, Cohen A, June CH, Sheppard NC., Free PMC Article | 01/12/2024 |
| The Role of CD200-CD200 Receptor in Human Blood and Lymphatic Endothelial Cells in the Regulation of Skin Tissue Inflammation. | The Role of CD200-CD200 Receptor in Human Blood and Lymphatic Endothelial Cells in the Regulation of Skin Tissue Inflammation.
Rütsche D, Michalak-Micka K, Zielinska D, Moll H, Moehrlen U, Biedermann T, Klar AS., Free PMC Article | 04/23/2022 |
| Tumor-Infiltrating T Cells Concurrently Overexpress CD200R with Immune Checkpoints PD-1, CTLA-4, and TIM-3 in Non-Small-Cell Lung Cancer. | Tumor-Infiltrating T Cells Concurrently Overexpress CD200R with Immune Checkpoints PD-1, CTLA-4, and TIM-3 in Non-Small-Cell Lung Cancer.
Su Y, Yamazaki S, Morisue R, Suzuki J, Yoshikawa T, Nakatsura T, Tsuboi M, Ochiai A, Ishii G. | 10/16/2021 |
| Up-regulation of CD200/CD200R1 Immunomodulatory Axis of Allogenic Peripheral Blood Mononuclear Cells in a Co-culture with Adipose-derived Mesenchymal Stem Cells. | Up-regulation of CD200/CD200R1 Immunomodulatory Axis of Allogenic Peripheral Blood Mononuclear Cells in a Co-culture with Adipose-derived Mesenchymal Stem Cells.
Heidari N, Mohammadi M, Rezaee MA, Amini AA, Fakhari S, Rahmani MR. | 10/2/2021 |
| Identification of a novel conserved signaling motif in CD200 receptor required for its inhibitory function. | Identification of a novel conserved signaling motif in CD200 receptor required for its inhibitory function.
Timmerman LM, de Graaf JF, Satravelas N, Kesmir Ç, Meyaard L, van der Vlist M., Free PMC Article | 09/4/2021 |
| Identification of the CD200R1 promoter and the association of its polymorphisms with the risk of Parkinson's disease. | Identification of the CD200R1 promoter and the association of its polymorphisms with the risk of Parkinson's disease.
Lin S, He L, Shen R, Fang F, Pan H, Zhu X, Wang M, Zhou Z, Liu Z, Wang X, Fang S, Sun X, Wang Y, Chen S, Ding J. | 06/26/2021 |
| Review of the CD200-CD200R axis, including the biology behind CD200-CD200R interaction and the role(s) it plays in tumor microenvironment and tumor growth, and activation/effector functions of T cells; discussion of CD200-CD200R's role as potential checkpoint molecules for cancer immunotherapy | CD200-CD200R Pathway in the Regulation of Tumor Immune Microenvironment and Immunotherapy.
Liu JQ, Hu A, Zhu J, Yu J, Talebian F, Bai XF., Free PMC Article | 02/15/2020 |
| Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis | Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis.
Fraser SD, Sadofsky LR, Kaye PM, Hart SP., Free PMC Article | 06/9/2018 |
| we demonstrated for the first time that CD200R is highly expressed on cells involved in type 2 immune responses, namely on Th2, Tc2, ILC2, and basophils. All these cell types play a role in type 2 inflammation. | The immunoglobulin superfamily member CD200R identifies cells involved in type 2 immune responses.
Blom LH, Martel BC, Larsen LF, Hansen CV, Christensen MP, Juel-Berg N, Litman T, Poulsen LK. | 03/31/2018 |
| Residual CD200 activity may prevent completion of abortions via induction of Treg cells. In chronic histiocytic intervillositis, infiltrating maternal effector T cells may block Treg induction. An autocrine role for CD200-CD200R interaction versus inhibition of soluble CD200 by soluble CD200R is discussed. | Changes in expression of the CD200 tolerance-signaling molecule and its receptor (CD200R) by villus trophoblasts during first trimester missed abortion and in chronic histiocytic intervillositis.
Clark DA, Dmetrichuk JM, McCready E, Dhesy-Thind S, Arredondo JL. | 03/24/2018 |
| MMP12-producing monocyte-derived cells in gingival tissue of periodontitis patients also had reduced CD200R surface levels. Treatment with a CD200R ligand reduced CSF2-induced MMP12 production in these cells. This novel association of the CD200/CD200R pathway with MMP12 production by monocyte-derived cells may play a key role in PD progression. | Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200R(low) Monocyte-Derived Cells in Periodontitis.
Björnfot Holmström S, Clark R, Zwicker S, Bureik D, Kvedaraite E, Bernasconi E, Nguyen Hoang AT, Johannsen G, Marsland BJ, Boström EA, Svensson M. | 12/30/2017 |
| Coexpression of CD200R-CD28 enhances function in WT1-specific T-cell receptor - transduced human primary T cells. | A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia.
Oda SK, Daman AW, Garcia NM, Wagener F, Schmitt TM, Tan X, Chapuis AG, Greenberg PD., Free PMC Article | 12/23/2017 |
| Our findings suggest a promising role of CD200R as a prognostic marker in predicting elevated recurrence and reduced survival, and a potential therapeutic target in treating hepatocellular carcinoma. | CD200R, a co-inhibitory receptor on immune cells, predicts the prognosis of human hepatocellular carcinoma.
Sun H, Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C. | 12/9/2017 |
| we revealed a critical role for CD200R signaling in limiting the growth and metastasis of CD200(+) tumors. | A Critical Role for CD200R Signaling in Limiting the Growth and Metastasis of CD200+ Melanoma.
Liu JQ, Talebian F, Wu L, Liu Z, Li MS, Wu L, Zhu J, Markowitz J, Carson WE 3rd, Basu S, Bai XF., Free PMC Article | 08/5/2017 |
| Constitutively expressed Siglec-9 inhibits LPS-induced CCR7, but enhances IL-4-induced CD200R expression in human macrophages. | Constitutively expressed Siglec-9 inhibits LPS-induced CCR7, but enhances IL-4-induced CD200R expression in human macrophages.
Higuchi H, Shoji T, Iijima S, Nishijima K. | 01/28/2017 |
| Inflammatory Bowel Disease patients showed a significant decrease in the percentage of plasmacytoid dendritic cells and myeloid dendritic cells expressing CD200R1 compared to that of the control group. | Reduced Dendritic Cells Expressing CD200R1 in Children with Inflammatory Bowel Disease: Correlation with Th17 and Regulatory T Cells.
Elshal MF, Aldahlawi AM, Saadah OI, McCoy JP., Free PMC Article | 10/8/2016 |
| CD200-CD200R1 signaling may be required for human pregnancy success. | The CD200 tolerance-signaling molecule and its receptor, CD200R1, are expressed in human placental villus trophoblast and in peri-implant decidua by 5 weeks' gestation.
Clark DA, Arredondo JL, Dhesy-Thind S. | 09/3/2016 |
| This is the first report of CD200R1 expression by human epithelial tumor cells, and specifically, early-stage human breast cancer cells. It is also the first report of CD200R1 expression by term placental villous trophoblasts. | The Receptor for the CD200 Tolerance-Signaling Molecule Associated with Successful Pregnancy is Expressed by Early-Stage Breast Cancer Cells in 80% of Patients and by Term Placental Trophoblasts.
Clark DA, Dhesy-Thind S, Arredondo JL, Ellis PM, Ramsay JA. | 07/30/2016 |
| data show that the expression of CD200R, CD95 and CD95L was influenced by cardiac surgery and imply the role of these membrane molecules in cell regulation-inhibition and apoptosis following cardiac surgery. | Inhibitory CD200R and proapoptotic CD95/CD95L molecules on innate immunity cells are modulated by cardiac surgery.
Holmannova D, Kolackova M, Mandak J, Kunes P, Holubcova Z, Krejsek J, Vlaskova D, Andrys C. | 07/16/2016 |
| The authors showed that the viral orthologues e127 from rat cytomegalovirus and K14 from human herpesvirus 8 do not bind the activating CD200R-like proteins from their respective species, although they do bind the inhibitory receptors. | Herpesvirus orthologues of CD200 bind host CD200R but not related activating receptors.
Kwong LS, Akkaya M, Barclay AN, Hatherley D., Free PMC Article | 06/4/2016 |
| The proportion of CD200R1+ cells in PBMCs, peripheral CD14+ cells and CD4+ T cells was significantly lower in rheumatoid arthritis patients compared to controls. | Aberrant CD200/CD200R1 expression and its potential role in Th17 cell differentiation, chemotaxis and osteoclastogenesis in rheumatoid arthritis.
Ren Y, Yang B, Yin Y, Leng X, Jiang Y, Zhang L, Li Y, Li X, Zhang F, He W, Zhang X, Cao X. | 05/30/2015 |
| We demonstrate a significant correlation between CD200R1 positive cells and disease severity in rheumatoid arthritis (RA) patients, thus indicating the relevance of the CD200/CD200R1 signaling pathway potential involvement in the pathogenesis of RA. | Decreased CD200R expression on monocyte-derived macrophages correlates with Th17/Treg imbalance and disease activity in rheumatoid arthritis patients.
Gao S, Hao B, Yang XF, Chen WQ. | 01/31/2015 |