| Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum. | Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum.
Takagi S, Balu DT, Coyle JT., Free PMC Article | 12/4/2021 |
| Study demonstrates that robust and selective demethylation of two CpG sites is associated with postnatal activation of the Dao gene and consequent removal of D-serine within the cerebellum. | Selective demethylation of two CpG sites causes postnatal activation of the Dao gene and consequent removal of D-serine within the mouse cerebellum.
Cuomo M, Keller S, Punzo D, Nuzzo T, Affinito O, Coretti L, Carella M, de Rosa V, Florio E, Boscia F, Avvedimento VE, Cocozza S, Errico F, Usiello A, Chiariotti L., Free PMC Article | 08/1/2020 |
| We show that prolonged treatment with selegiline fails to reduce aberrant astrocytic GABA levels and rescue memory impairment in APP/PS1 mice, an animal model of AD, because of increased activity in compensatory genes for a GABA-synthesizing enzyme, diamine oxidase (DAO) | Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease.
Park JH, Ju YH, Choi JW, Song HJ, Jang BK, Woo J, Chun H, Kim HJ, Shin SJ, Yarishkin O, Jo S, Park M, Yeon SK, Kim S, Kim J, Nam MH, Londhe AM, Kim J, Cho SJ, Cho S, Lee C, Hwang SY, Kim SW, Oh SJ, Cho J, Pae AN, Lee CJ, Park KD., Free PMC Article | 05/2/2020 |
| age- and gender-dependent D-amino acid oxidase activity in mouse brain and peripheral tissues: implication for aging and neurodegeneration | Age- and gender-dependent D-amino acid oxidase activity in mouse brain and peripheral tissues: implication for aging and neurodegeneration.
Kim SH, Shishido Y, Sogabe H, Rachadech W, Yorita K, Kato Y, Fukui K. | 09/21/2019 |
| This work provides the most complete baseline analysis of L- and D-amino acids in the brains of wild-type and mutant mice lacking D-amino acid oxidase activity. | Variations of L- and D-amino acid levels in the brain of wild-type and mutant mice lacking D-amino acid oxidase activity.
Du S, Wang Y, Weatherly CA, Holden K, Armstrong DW. | 05/12/2018 |
| findings reveal that DAO is a microbiota-regulated host innate immune factor that modulates growth of both pathogens and commensals, primarily in the small intestine | Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota.
Sasabe J, Miyoshi Y, Rakoff-Nahoum S, Zhang T, Mita M, Davis BM, Hamase K, Waldor MK., Free PMC Article | 02/3/2018 |
| some significant in vivo effects of DAOR199W on motor neuron function (i.e. kyphosis and loss of motor neurons) were detected which were most marked in females and could contribute to the earlier onset of neurological signs in double transgenic females compared to SOD1G93A littermates, highlighting the importance of recognizing gender effects present in animal models of ALS | Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons.
Kondori NR, Paul P, Robbins JP, Liu K, Hildyard JCW, Wells DJ, de Belleroche JS., Free PMC Article | 12/30/2017 |
| Long-term spatial memory is unaltered in Dao-/- mice. | Searching for cognitive enhancement in the Morris water maze: better and worse performance in D-amino acid oxidase knockout (Dao(-/-)) mice.
Pritchett D, Taylor AM, Barkus C, Engle SJ, Brandon NJ, Sharp T, Foster RG, Harrison PJ, Peirson SN, Bannerman DM., Free PMC Article | 12/24/2016 |
| Dao-/- mice demonstrated enhanced spatial recognition memory and no sleep or circadian rhythm disruption. | d-amino acid oxidase knockout (Dao(-/-) ) mice show enhanced short-term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption.
Pritchett D, Hasan S, Tam SK, Engle SJ, Brandon NJ, Sharp T, Foster RG, Harrison PJ, Bannerman DM, Peirson SN., Free PMC Article | 10/17/2015 |
| In d-Amino acid oxidase (-/-) mice, approximately twice as many Dopamine-like neurons fired in a bursting pattern than in DAO(+/-) or DAO(+/+) mice. Data provide the first direct evidence that DAO modulates VTA DA neuron activity | Increased burst-firing of ventral tegmental area dopaminergic neurons in D-amino acid oxidase knockout mice in vivo.
Schweimer JV, Coullon GS, Betts JF, Burnet PW, Engle SJ, Brandon NJ, Harrison PJ, Sharp T. | 07/4/2015 |
| The retinal levels of d-serine are tightly controlled during the first week of postnatal life and vary according to deficiencies in either DAO/ | The postnatal development of D-serine in the retinas of two mouse strains, including a mutant mouse with a deficiency in D-amino acid oxidase and a serine racemase knockout mouse.
Romero GE, Lockridge AD, Morgans CW, Bandyopadhyay D, Miller RF., Free PMC Article | 05/30/2015 |
| DAO deficiency reduces D-serine level in retina and increases NMDA receptor expression. | Retinal NMDA receptor function and expression are altered in a mouse lacking D-amino acid oxidase.
Gustafson EC, Morgans CW, Tekmen M, Sullivan SJ, Esguerra M, Konno R, Miller RF., Free PMC Article | 08/16/2014 |
| D-amino acids and DAO have pivotal neurotransmission functions in the central nervous system. (Review) | D-Amino acids in the brain and mutant rodents lacking D-amino-acid oxidase activity.
Yamanaka M, Miyoshi Y, Ohide H, Hamase K, Konno R. | 03/9/2013 |
| D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects. | D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects.
El Sayed SM, El-Magd RM, Shishido Y, Yorita K, Chung SP, Tran DH, Sakai T, Watanabe H, Kagami S, Fukui K. | 02/2/2013 |
| results suggest that DAO, together with myeloperoxidase, may play an important role in antibacterial systems in mammals | Protective role of D-amino acid oxidase against Staphylococcus aureus infection.
Nakamura H, Fang J, Maeda H., Free PMC Article | 05/12/2012 |
| DAO has a pivotal role in motoneuron degeneration through D-serine regulation, with inactivity of DAO being a common feature between the mSOD1 ALS mouse model and mutant DAO-associated familial ALS. | D-amino acid oxidase controls motoneuron degeneration through D-serine.
Sasabe J, Miyoshi Y, Suzuki M, Mita M, Konno R, Matsuoka M, Hamase K, Aiso S., Free PMC Article | 03/17/2012 |
| Results confirm the role of D-amino acid oxidase (DAO) in D-serine metabolism, and provide a tool to investigate DAO, an enzyme currently of considerable interest in the pathophysiology and therapy of schizophrenia. | D-amino acid oxidase knockdown in the mouse cerebellum reduces NR2A mRNA.
Burnet PW, Anderson PN, Chen L, Nikiforova N, Harrison PJ, Wood MJ. | 07/9/2011 |
| data show enhanced PPI responses and enhanced PPI-disruptive effects of NMDA antagonists in DAO-/- mice . | Behavioral characterization of a mutant mouse strain lacking D-amino acid oxidase activity.
Zhang M, Ballard ME, Basso AM, Bratcher N, Browman KE, Curzon P, Konno R, Meyer AH, Rueter LE. | 04/2/2011 |
| Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase | Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase.
Mitchell J, Paul P, Chen HJ, Morris A, Payling M, Falchi M, Habgood J, Panoutsou S, Winkler S, Tisato V, Hajitou A, Smith B, Vance C, Shaw C, Mazarakis ND, de Belleroche J., Free PMC Article | 05/31/2010 |
| Hypofunctional Dao 1 mutation elevated brain levels of D-serine. Mice with both Dao1 and Grin 1 mutations had improved social approach spatial memory retention, reversal of latent inhibition, and partial normalized startle responses. | Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice.
Labrie V, Wang W, Barger SW, Baker GB, Roder JC., Free PMC Article | 05/10/2010 |
| D-amino acid oxidase may be a promising therapeutic target to improve cognitive flexibility and inhibitory learning in psychiatric disorders such as schizophrenia and anxiety syndromes. | Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice.
Labrie V, Duffy S, Wang W, Barger SW, Baker GB, Roder JC., Free PMC Article | 01/21/2010 |
| Its physiological role is in metabolizing endogenous and exogenous D-amino acids. | [Mutant mouse lacking D-amino-acid oxidase activity].
Konno R. | 01/21/2010 |
| These results suggest that the abundant D-amino-acids in the mutant mouse brain facilitate hippocampal LTP and spatial learning. | Spatial learning and long-term potentiation of mutant mice lacking D-amino-acid oxidase.
Maekawa M, Watanabe M, Yamaguchi S, Konno R, Hori Y. | 01/21/2010 |
| Lacks DAO activity and shown for the first time it has increased occupancy of the NMDAR glycine site due to elevated extracellular D-serine levels and has enhanced NMDAR function in vivo. | Behavioral and biochemical characterization of a mutant mouse strain lacking D-amino acid oxidase activity and its implications for schizophrenia.
Almond SL, Fradley RL, Armstrong EJ, Heavens RB, Rutter AR, Newman RJ, Chiu CS, Konno R, Hutson PH, Brandon NJ. | 01/21/2010 |