| Altered conformational dynamics contribute to species-specific effects of cytochrome c mutations on caspase activation. | Altered conformational dynamics contribute to species-specific effects of cytochrome c mutations on caspase activation.
Chin TC, Wilbanks SM, Ledgerwood EC., Free PMC Article | 08/14/2024 |
| MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma. | MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma.
Olarewaju O, Hu Y, Tsay HC, Yuan Q, Eimterbäumer S, Xie Y, Qin R, Ott M, Sharma AD, Balakrishnan A., Free PMC Article | 07/19/2024 |
| Thioredoxin Reductase 2 Synergizes with Cytochrome c, Somatic to Alleviate Doxorubicin-Induced Oxidative Stress in Cardiomyocytes and Mouse Myocardium. | Thioredoxin Reductase 2 Synergizes with Cytochrome c, Somatic to Alleviate Doxorubicin-Induced Oxidative Stress in Cardiomyocytes and Mouse Myocardium.
Li C, Lai H, Cai X, Liu Y, Hong L, Huang X, Shao L. | 04/7/2023 |
| Dysregulated autophagy is linked to BAX oligomerization and subsequent cytochrome c release in 6-hydroxydopmaine-treated neuronal cells. | Dysregulated autophagy is linked to BAX oligomerization and subsequent cytochrome c release in 6-hydroxydopmaine-treated neuronal cells.
Chung Y, Kim Y, Yun N, Oh YJ. | 09/11/2021 |
| ablation of Cyt c in neurons leads to severe behavioral abnormalities and premature death without detectable neuronal loss. | Ablation of Cytochrome c in Adult Forebrain Neurons Impairs Oxidative Phosphorylation Without Detectable Apoptosis.
Pinto M, Vempati UD, Diaz F, Peralta S, Moraes CT., Free PMC Article | 08/17/2019 |
| the amount of cytochrome c in lymphomyeloid cells does not affect their development and normal functioning | Mouse lymphomyeloid cells can function with significantly decreased expression levels of cytochrome C.
Shilov ES, Kislyakov IV, Gorshkova EA, Zvartsev RV, Drutskaya MS, Mufazalov IA, Skulachev VP, Nedospasov SA. | 10/17/2015 |
| Abeta oligomers bind to BAK on the membrane and induce apoptotic BAK pores and cytochrome c release | Beta-amyloid oligomers activate apoptotic BAK pore for cytochrome c release.
Kim J, Yang Y, Song SS, Na JH, Oh KJ, Jeong C, Yu YG, Shin YK., Free PMC Article | 06/27/2015 |
| Data suggest that peroxidase activation of cytochrome c may induce apoptosis and contribute to anti-cancer properties of alpha-tocopherol succinate. | Structural re-arrangement and peroxidase activation of cytochrome c by anionic analogues of vitamin E, tocopherol succinate and tocopherol phosphate.
Yanamala N, Kapralov AA, Djukic M, Peterson J, Mao G, Klein-Seetharaman J, Stoyanovsky DA, Stursa J, Neuzil J, Kagan VE., Free PMC Article | 02/14/2015 |
| Data indicate that mitochondrial alpha 7 nicotinic acetylcholine receptors (alpha7 nAChRs) regulate cytochrome c (cyt c) release by engaging intramitochondrial protein kinases. | α7 nicotinic acetylcholine receptors control cytochrome c release from isolated mitochondria through kinase-mediated pathways.
Gergalova G, Lykhmus O, Komisarenko S, Skok M. | 11/22/2014 |
| proposed that mutation of residue 41, and interaction with cardiolipin, increase peroxidase activity by altering the 40-57 Omega loop and its hydrogen bond network with the propionate of haem ring A; these changes enhance access of hydrogen peroxide and substrate to the haem | Enhancing the peroxidase activity of cytochrome c by mutation of residue 41: implications for the peroxidase mechanism and cytochrome c release.
Josephs TM, Morison IM, Day CL, Wilbanks SM, Ledgerwood EC. | 06/28/2014 |
| Data indicate that Y48H missense mutation of cytochrome c (CYCS) gene is associated with respiratory reduction and increased apoptosis in fibroblast. | Mutations of cytochrome c identified in patients with thrombocytopenia THC4 affect both apoptosis and cellular bioenergetics.
De Rocco D, Cerqua C, Goffrini P, Russo G, Pastore A, Meloni F, Nicchia E, Moraes CT, Pecci A, Salviati L, Savoia A. | 04/19/2014 |
| Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function. | Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function.
Ferrer PE, Frederick P, Gulbis JM, Dewson G, Kluck RM., Free PMC Article | 07/28/2012 |
| mitochondrial import and direct electron transfer from cytochrome c to Rac1 modulates mitochondrial H(2)O(2) production in alveolar macrophages pulmonary fibrosis. | Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis.
Osborn-Heaford HL, Ryan AJ, Murthy S, Racila AM, He C, Sieren JC, Spitz DR, Carter AB., Free PMC Article | 03/24/2012 |
| Fluoride exposure significantly elevated the protein expressions of cytochrome c and active caspase-3. | Fluoride-induced apoptosis and gene expression profiling in mice sperm in vivo.
Sun Z, Niu R, Wang B, Jiao Z, Wang J, Zhang J, Wang S, Wang J. | 02/18/2012 |
| Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation. | Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation.
Gogada R, Prabhu V, Amadori M, Scott R, Hashmi S, Chandra D., Free PMC Article | 10/22/2011 |
| High concentration glucose administration caused significantly increased expression of NF-kappaB, Bax and cytochrome C. | Effects of high concentration glucose on the expression of NF-kappaB, Bax and cytochrome C and apoptosis of islet cells in mice.
Liang Y, Zhang M, Xia N, Yang Y, Feng L. | 06/18/2011 |
| Membrane-associated XIAP induces mitochondrial outer membrane permeabilization leading to cytochrome c and Smac release, which is dependent on Bax and Bak. | Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization.
Owens TW, Foster FM, Valentijn A, Gilmore AP, Streuli CH., Free PMC Article | 02/1/2010 |
| Both neurons and cancer cells strictly inhibit cytochrome c-mediated apoptosis by a mechanism dependent on glucose metabolism. | Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c.
Vaughn AE, Deshmukh M., Free PMC Article | 01/21/2010 |
| results suggest that activation of mitochondrial ATP-dependent potassium channels protects neurons against apoptosis by preventing cytochrome c release from the mitochondria | Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release.
Liu D, Lu C, Wan R, Auyeung WW, Mattson MP. | 01/21/2010 |
| The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c. | The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c.
Karpinich NO, Tafani M, Rothman RJ, Russo MA, Farber JL. | 01/21/2010 |