| High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology. | High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology.
Siddam AD, Duot M, Coomson SY, Anand D, Aryal S, Weatherbee BAT, Audic Y, Paillard L, Lachke SA., Free PMC Article | 04/19/2023 |
| Long noncoding RNA uc.230/CUG-binding protein 1 axis sustains intestinal epithelial homeostasis and response to tissue injury. | Long noncoding RNA uc.230/CUG-binding protein 1 axis sustains intestinal epithelial homeostasis and response to tissue injury.
Yu TX, Kalakonda S, Liu X, Han N, Chung HK, Xiao L, Rao JN, He TC, Raufman JP, Wang JY., Free PMC Article | 10/22/2022 |
| Increased nuclear but not cytoplasmic activities of CELF1 protein leads to muscle wasting. | Increased nuclear but not cytoplasmic activities of CELF1 protein leads to muscle wasting.
Cox DC, Guan X, Xia Z, Cooper TA., Free PMC Article | 08/14/2021 |
| CELF1 promotes vascular endothelial growth factor degradation resulting in impaired microvasculature in heart failure. | CELF1 promotes vascular endothelial growth factor degradation resulting in impaired microvasculature in heart failure.
Chang KT, Wang LH, Lin YM, Cheng CF, Wang GS. | 07/24/2021 |
| The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development. | The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development.
Aryal S, Viet J, Weatherbee BAT, Siddam AD, Hernandez FG, Gautier-Courteille C, Paillard L, Lachke SA., Free PMC Article | 10/31/2020 |
| RNA-seq analysis of mouse neocortical polysomes demonstrated that the translation of distinct mRNA isoforms of the RNA binding protein (RBP), Elavl4, in radial glia progenitors and early neurons depends on its alternative 5' UTRs. 5' UTR-driven Elavl4 isoform-specific translation depends on upstream control by another RBP, Celf1. Celf1 regulation of Elavl4 translation dictates development of glutamatergic neurons. | Translational derepression of Elavl4 isoforms at their alternative 5' UTRs determines neuronal development.
Popovitchenko T, Park Y, Page NF, Luo X, Krsnik Z, Liu Y, Salamon I, Stephenson JD, Kraushar ML, Volk NL, Patel SM, Wijeratne HRS, Li D, Suthar KS, Wach A, Sun M, Arnold SJ, Akamatsu W, Okano H, Paillard L, Zhang H, Buyske S, Kostovic I, De Rubeis S, Hart RP, Rasin MR., Free PMC Article | 08/1/2020 |
| miR-206 helped rescue myogenic deficiency by inhibiting CUGBP1 accumulation in cell models of myotonic dystrophy. These data suggest that increased miR-206 levels in myoblasts may lead to better skeletal muscle differentiation. | Mir-206 partially rescues myogenesis deficiency by inhibiting CUGBP1 accumulation in the cell models of myotonic dystrophy.
Dong W, Chen X, Wang M, Zheng Z, Zhang X, Xiao Q, Peng X. | 01/18/2020 |
| These results indicate that CELF1 target RNAs are aberrantly spliced in the Type 1 diabetic heart leading to abnormal gene expression. | CELF1 contributes to aberrant alternative splicing patterns in the type 1 diabetic heart.
Belanger K, Nutter CA, Li J, Tasnim S, Liu P, Yu P, Kuyumcu-Martinez MN., Free PMC Article | 01/19/2019 |
| this study shows that the absence of Celf1 causes neonatal cardiac dysfunction and transcriptome changes | Neonatal cardiac dysfunction and transcriptome changes caused by the absence of Celf1.
Giudice J, Xia Z, Li W, Cooper TA., Free PMC Article | 05/26/2018 |
| Results found that the blood level of CUGBP1 in mice was decreased during the progression of acute myocardial infarction (AMI) and demonstrate that CUGBP1 is functionally important in AMI. This finding reveals the roles of CUGBP1 in the heart not only during development but also in cardiac disease. | Reconstitution of HuR-Inhibited CUGBP1 Expression Protects Cardiomyocytes from Acute Myocardial Infarction-Induced Injury.
Gu L, Wang H, Wang J, Guo Y, Tang Y, Mao Y, Chen L, Lou H, Ji G. | 03/17/2018 |
| Increased CELF1 expression down-regulates Cx43 mRNA level in the dilated cardiomyopathy heart. | CELF1 Mediates Connexin 43 mRNA Degradation in Dilated Cardiomyopathy.
Chang KT, Cheng CF, King PC, Liu SY, Wang GS. | 11/4/2017 |
| lncBATE10 can decoy Celf1 from Pgc1alpha, thereby protecting Pgc1alpha mRNA from repression by Celf1 | Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators.
Bai Z, Chai XR, Yoon MJ, Kim HJ, Lo KA, Zhang ZC, Xu D, Siang DTC, Walet ACE, Xu SH, Chia SY, Chen P, Yang H, Ghosh S, Sun L., Free PMC Article | 09/30/2017 |
| Study concludes that CUGBP1 is a critical regulator of insulin secretion via activating PDE3B. | RNA-binding protein CUGBP1 regulates insulin secretion via activation of phosphodiesterase 3B in mice.
Zhai K, Gu L, Yang Z, Mao Y, Jin M, Chang Y, Yuan Q, Leblais V, Wang H, Fischmeister R, Ji G. | 09/2/2017 |
| the oncoprotein gankyrin (Gank) preferentially binds to and triggers degradation of dephosphorylated CUGBP1 (de-ph-S302-CUGBP1) or S302A mutant CUGBP1. | RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner.
Lewis K, Valanejad L, Cast A, Wright M, Wei C, Iakova P, Stock L, Karns R, Timchenko L, Timchenko N., Free PMC Article | 09/2/2017 |
| Our studies support the existence of an RNA regulon containing Signal Recognition Particle mRNAs that is controlled by CELF1. One implication is that altered function of CELF1 in myotonic dystrophy may contribute to changes in the extracellular matrix of affected muscle through defects in secretion | The CELF1 RNA-Binding Protein Regulates Decay of Signal Recognition Particle mRNAs and Limits Secretion in Mouse Myoblasts.
Russo J, Lee JE, López CM, Anderson J, Nguyen TP, Heck AM, Wilusz J, Wilusz CJ., Free PMC Article | 08/19/2017 |
| CELF1 downregulates Cyp19a1 (Aromatase) posttranscriptionally to achieve high concentrations of testosterone compatible with spermiogenesis completion. | Hypogonadism Associated with Cyp19a1 (Aromatase) Posttranscriptional Upregulation in Celf1 Knockout Mice.
Boulanger G, Cibois M, Viet J, Fostier A, Deschamps S, Pastezeur S, Massart C, Gschloessl B, Gautier-Courteille C, Paillard L., Free PMC Article | 05/7/2016 |
| developmental stage-specific compatibility of CELF-dependent splice variants dictates their effects on cardiac health and function | Gene Expression Analyses during Spontaneous Reversal of Cardiomyopathy in Mice with Repressed Nuclear CUG-BP, Elav-Like Family (CELF) Activity in Heart Muscle.
Dasgupta T, Coram RJ, Stillwagon SJ, Ladd AN., Free PMC Article | 01/30/2016 |
| Differential expression of CELF1 in development plays a role in alternative splicing of vesicular trafficking genes in postnatal heart development. | Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development.
Giudice J, Xia Z, Wang ET, Scavuzzo MA, Ward AJ, Kalsotra A, Wang W, Wehrens XH, Burge CB, Li W, Cooper TA., Free PMC Article | 10/3/2015 |
| Celf1 plays a distinctive and negative role in terminal myocyte differentiation, which partially contribute to DM1 RNA toxicity. | Celf1 regulates cell cycle and is partially responsible for defective myoblast differentiation in myotonic dystrophy RNA toxicity.
Peng X, Shen X, Chen X, Liang R, Azares AR, Liu Y. | 08/29/2015 |
| These results indicate that JNK2 is essential for maintenance of normal intestinal epithelial homeostasis and maturation under biological conditions by differentially modulating HuR and CUGBP1. | Jnk2 deletion disrupts intestinal mucosal homeostasis and maturation by differentially modulating RNA-binding proteins HuR and CUGBP1.
Chung HK, Rao JN, Zou T, Liu L, Xiao L, Gu H, Turner DJ, Yang P, Wang JY., Free PMC Article | 08/23/2014 |
| CELF1 and CELF2 may underlie conserved, developmentally regulated, tissue-specific processes in vertebrate embryos | Diversity and conservation of CELF1 and CELF2 RNA and protein expression patterns during embryonic development.
Blech-Hermoni Y, Stillwagon SJ, Ladd AN., Free PMC Article | 01/4/2014 |
| Mitochondrial biogenesis occurs in the presence of increased CUG-BP1 and AUF1, suggesting that reductions in known mRNA destabilizing proteins likely does not contribute to exercise-induced mitochondrial biogenesis. | Exercise training increases the expression and nuclear localization of mRNA destabilizing proteins in skeletal muscle.
Matravadia S, Martino VB, Sinclair D, Mutch DM, Holloway GP. | 12/7/2013 |
| these results strongly support a role for -mediated alternative splicing in the regulation of contractile gene expression, achieved in part through modulating the activity of SRF, a key cardiac transcription factor. | Gene expression analyses implicate an alternative splicing program in regulating contractile gene expression and serum response factor activity in mice.
Dasgupta T, Stillwagon SJ, Ladd AN., Free PMC Article | 09/14/2013 |
| This review is focused on the role of a conserved, multifunctional RNA-binding protein, CUGBP1, in the development of aging phenotype in the liver. | The role of CUGBP1 in age-dependent changes of liver functions.
Jones K, Timchenko L, Timchenko NA., Free PMC Article | 06/29/2013 |
| disruption of Celf1 gene is also responsible for a fully penetrant delayed first wave of spermatogenesis, and a delay of steroidogenesis may be the cause for the delay of germ cells differentiation | Inactivation of the Celf1 gene that encodes an RNA-binding protein delays the first wave of spermatogenesis in mice.
Cibois M, Boulanger G, Audic Y, Paillard L, Gautier-Courteille C., Free PMC Article | 06/15/2013 |