| Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis. | Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis.
Akkoc Y, Dalci K, Karakas HE, Erbil-Bilir S, Yalav O, Sakman G, Celik F, Arikan S, Zeybek U, Ergin M, Akkiz H, Dilege E, Dengjel J, Dogan-Ekici AI, Gozuacik D., Free PMC Article | 01/11/2023 |
| Cardiotrophin-1 contributes to metabolic adaptations through the regulation of lipid metabolism and to the fasting-induced fatty acid mobilization. | Cardiotrophin-1 contributes to metabolic adaptations through the regulation of lipid metabolism and to the fasting-induced fatty acid mobilization.
Carneros D, Medina-Gómez G, Giralt M, León-Camacho M, Campbell M, Moreno-Aliaga MJ, Villarroya F, Bustos M. | 05/1/2021 |
| Cardiotrophin-1 Deficiency Abrogates Atherosclerosis Progression. | Cardiotrophin-1 Deficiency Abrogates Atherosclerosis Progression.
Miteva K, Baptista D, Montecucco F, Asrih M, Burger F, Roth A, Fraga-Silva RA, Stergiopulos N, Mach F, Brandt KJ., Free PMC Article | 12/5/2020 |
| Cardiotrophin-1 participates in the endogenous response that opposes renal damage by counteracting the inflammatory, apoptotic and fibrotic processes | Cardiotrophin-1 opposes renal fibrosis in mice: Potential prevention of chronic kidney disease.
Perretta-Tejedor N, Muñoz-Félix JM, Düwel A, Quiros-Luis Y, Fernández-Martín JL, Morales AI, López-Hernández FJ, López-Novoa JM, Martínez-Salgado C. | 07/25/2020 |
| findings support the notion that cardiotrophin-1 (CT-1) is a critical regulator of inflammation and suggest that rCT-1 could be a molecule with potential therapeutic application in inflammatory conditions | Cardiotrophin-1 is an anti-inflammatory cytokine and promotes IL-4-induced M2 macrophage polarization.
Carneros D, Santamaría EM, Larequi E, Vélez-Ortiz JM, Reboredo M, Mancheño U, Perugorria MJ, Navas P, Romero-Gómez M, Prieto J, Hervás-Stubbs S, Bustos M. | 06/20/2020 |
| These results suggest that CT-1 may be a potent candidate for the early prevention and treatment of Alzheimer disease. | The Effects of Cardiotrophin-1 on Early Synaptic Mitochondrial Dysfunction and Synaptic Pathology in APPswe/PS1dE9 Mice.
Wang D, Liu X, Liu Y, Li S, Wang C. | 04/14/2018 |
| Identify cardiotrophin-1 as a powerful cytokine promoting mesenchymal stromal cell engraftment and thus improving cell therapy of the infarcted myocardium. | In Vivo Functional Selection Identifies Cardiotrophin-1 as a Cardiac Engraftment Factor for Mesenchymal Stromal Cells.
Bortolotti F, Ruozi G, Falcione A, Doimo S, Dal Ferro M, Lesizza P, Zentilin L, Banks L, Zacchigna S, Giacca M. | 10/28/2017 |
| CT-1 mRNA levels in adipose tissue showed significant circadian fluctuations in young WT mice. Clock genes displayed a circadian rhythm in adipose tissue of both wild-type (WT) and CT-1-/- mice. However, the pattern was altered in CT-1-/- mice toward a lower percentage of the rhythm or lower amplitude, especially for Bmal1 and Clock. | Role of cardiotrophin-1 in the regulation of metabolic circadian rhythms and adipose core clock genes in mice and characterization of 24-h circulating CT-1 profiles in normal-weight and overweight/obese subjects.
López-Yoldi M, Stanhope KL, Garaulet M, Chen XG, Marcos-Gómez B, Carrasco-Benso MP, Santa Maria EM, Escoté X, Lee V, Nunez MV, Medici V, Martínez-Ansó E, Sáinz N, Huerta AE, Laiglesia LM, Prieto J, Martínez JA, Bustos M, Havel PJ, Moreno-Aliaga MJ., Free PMC Article | 09/9/2017 |
| Cardiotrophin-1 modulates the production of adipokines in vitro and in vivo, suggesting that the regulation of the secretory function of adipocytes could be involved in the metabolic actions of this cytokine. | Cardiotrophin-1 Regulates Adipokine Production in 3T3-L1 Adipocytes and Adipose Tissue From Obese Mice.
López-Yoldi M, Marcos-Gomez B, Romero-Lozano MA, Sáinz N, Prieto J, Martínez JA, Bustos M, Moreno-Aliaga MJ. | 08/12/2017 |
| Nuclear translocation of CT-1 regulates cardiomyogenesis of ES cells and involves calcium, NO, ROS as well as CT-1 regulated signaling pathways. | Stimulation of cardiomyogenesis from mouse embryonic stem cells by nuclear translocation of cardiotrophin-1.
Mascheck L, Sharifpanah F, Tsang SY, Wartenberg M, Sauer H. | 03/12/2016 |
| Data suggest that Ctf1 up-regulates lipolysis in white adipocytes via 1) induction of perilipin, 2) activation of hormone sensitive lipase (via phosphorylation by PKA), and 3) inactivation of adipose triglyceride lipase (via up-regulation of G0S2). | Cardiotrophin-1 stimulates lipolysis through the regulation of main adipose tissue lipases.
López-Yoldi M, Fernández-Galilea M, Laiglesia LM, Larequi E, Prieto J, Martínez JA, Bustos M, Moreno-Aliaga MJ., Free PMC Article | 10/24/2015 |
| Cardiotrophin-1 (CT-1) is a hepatoprotective cytokine that modulates fat and glucose metabolism. Here we analyzed the changes in hepatic fat stores induced by recombinant CT-1 and its therapeutic potential in non-alcoholic fatty liver disease. | Cardiotrophin-1 eliminates hepatic steatosis in obese mice by mechanisms involving AMPK activation.
Castaño D, Larequi E, Belza I, Astudillo AM, Martínez-Ansó E, Balsinde J, Argemi J, Aragon T, Moreno-Aliaga MJ, Muntane J, Prieto J, Bustos M. | 05/16/2015 |
| The transgenic expression of CTF1 brought about a marked improvement on cognitive functioning in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease. | Cardiotrophin-1 (CTF1) ameliorates glucose-uptake defects and improves memory and learning deficits in a transgenic mouse model of Alzheimer's disease.
Wang D, Li X, Gao K, Lu D, Zhang X, Ma C, Ye F, Zhang L. | 10/4/2014 |
| CT-1 improves beta cell function and survival, and protects mice against STZ-induced diabetes | Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model.
Jiménez-González M, Jaques F, Rodríguez S, Porciuncula A, Principe RM, Abizanda G, Iñiguez M, Escalada J, Salvador J, Prósper F, Halban PA, Barajas M. | 10/19/2013 |
| CT-1 may be a major regulator of arterial stiffness with a major impact on the aging process. | Absence of cardiotrophin 1 is associated with decreased age-dependent arterial stiffness and increased longevity in mice.
López-Andrés N, Calvier L, Labat C, Fay R, Díez J, Benetos A, Zannad F, Lacolley P, Rossignol P. | 03/2/2013 |
| Hypoxia increased cardiotrophin-1 levels in cardiac cells through a direct regulation of CT-1 promoter by HIF-1alpha, protecting cells from apoptosis. | HIF-1-mediated up-regulation of cardiotrophin-1 is involved in the survival response of cardiomyocytes to hypoxia.
Robador PA, San José G, Rodríguez C, Guadall A, Moreno MU, Beaumont J, Fortuño A, Díez J, Martínez-González J, Zalba G. | 02/4/2012 |
| Data suggest a key role for CT-1 in cardiac remodeling induced by aldosterone independent of changes in blood pressure levels. | A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone.
López-Andrés N, Martin-Fernandez B, Rossignol P, Zannad F, Lahera V, Fortuno MA, Cachofeiro V, Díez J. | 01/28/2012 |
| We conclude that CT-1 is a master regulator of fat and glucose metabolism with potential applications for treatment of obesity and insulin resistance. | Cardiotrophin-1 is a key regulator of glucose and lipid metabolism.
Moreno-Aliaga MJ, Pérez-Echarri N, Marcos-Gómez B, Larequi E, Gil-Bea FJ, Viollet B, Gimenez I, Martínez JA, Prieto J, Bustos M. | 01/7/2012 |
| Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling | Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling.
Walker EC, McGregor NE, Poulton IJ, Pompolo S, Allan EH, Quinn JM, Gillespie MT, Martin TJ, Sims NA. | 01/21/2010 |
| aldosterone induces CT-1 expression in adult HL-1 cardiomyocytes via genomic and nongenomic mechanisms | Aldosterone induces cardiotrophin-1 expression in HL-1 adult cardiomyocytes.
López-Andrés N, Iñigo C, Gallego I, Díez J, Fortuño MA. | 01/21/2010 |
| adipose tissue can be recognized as a source of CT-1, which could account for the high circulating levels of CT-1 in patients with metabolic syndrome X | Cardiotrophin-1 is expressed in adipose tissue and upregulated in the metabolic syndrome.
Natal C, Fortuño MA, Restituto P, Bazán A, Colina I, Díez J, Varo N. | 01/21/2010 |
| Treatment of embryoid bodies grown from pluripotent murine embryonic stem (ES) cells with cardiotrophin 1 significantly stimulated cardiomyogenesis and increased nuclear expression of the proliferation marker Ki-67. | Involvement of reactive oxygen species in cardiotrophin-1-induced proliferation of cardiomyocytes differentiated from murine embryonic stem cells.
Sauer H, Neukirchen W, Rahimi G, Grünheck F, Hescheler J, Wartenberg M. | 01/21/2010 |
| In embryonic deficient mice, preganglionic sympathetic neurons were reduced. | Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla.
Oberle S, Schober A, Meyer V, Holtmann B, Henderson C, Sendtner M, Unsicker K., Free PMC Article | 01/21/2010 |
| Our data show that CT-1 is a natural defense of the liver against apoptosis. This cytokine may have therapeutic potential. | Cardiotrophin-1 is an essential factor in the natural defense of the liver against apoptosis.
Marquès JM, Belza I, Holtmann B, Pennica D, Prieto J, Bustos M. | 01/21/2010 |
| In cntf/lif/ct-1 triple-knock-out mice, various degrees of muscle fiber type grouping are found, showing that denervation & reinnervation had occurred. CNTF, LIF, & CT-1 have distinct functions for motoneuron survival and function. | Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function.
Holtmann B, Wiese S, Samsam M, Grohmann K, Pennica D, Martini R, Sendtner M., Free PMC Article | 01/21/2010 |