| The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis. | The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis.
Sekiya M, Kainoh K, Sugasawa T, Yoshino R, Hirokawa T, Tokiwa H, Nakano S, Nagatoishi S, Tsumoto K, Takeuchi Y, Miyamoto T, Matsuzaka T, Shimano H., Free PMC Article | 12/25/2021 |
| Photoreceptor Compartment-Specific TULP1 Interactomes. | Photoreceptor Compartment-Specific TULP1 Interactomes.
Ebke LA, Sinha S, Pauer GJT, Hagstrom SA., Free PMC Article | 09/11/2021 |
| The corepressor CtBP2 is required for proper development of the mouse cerebral cortex. | The corepressor CtBP2 is required for proper development of the mouse cerebral cortex.
Karaca E, Li X, Lewicki J, Neofytou C, Guérout N, Barnabé-Heider F, Hermanson O. | 01/2/2021 |
| MCRIP1 interferes with interactions of CtBP with the lung-enriched transcriptional repressors, Foxp1 and Foxp2, thereby preventing the recruitment of the CtBP co-repressor complex to the SP-B and SP-C promoters and maintaining them in an active chromatin state. Homozygous deficiency of Mcrip1 in mice causes fatal respiratory distress due to abnormal transcriptional repression of surfactant proteins. | MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing.
Weng JS, Nakamura T, Moriizumi H, Takano H, Yao R, Takekawa M., Free PMC Article | 05/2/2020 |
| VGLL4 acted as an adaptor protein that enhanced the interaction between TEAD4 and CtBP2, and this TEAD4-VGLL4-CtBP2 ternary complex dynamically existed at the early stage of adipogenesis. | The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex.
Zhang W, Xu J, Li J, Guo T, Jiang D, Feng X, Ma X, He L, Wu W, Yin M, Ge L, Wang Z, Ho MS, Zhao Y, Fei Z, Zhang L., Free PMC Article | 06/1/2019 |
| The authors postulate that RIBEYE disruption is partially compensated by several small active zone organization at each synaptic contact between inner hair cells and spiral ganglion neurons. | The synaptic ribbon is critical for sound encoding at high rates and with temporal precision.
Jean P, Lopez de la Morena D, Michanski S, Jaime Tobón LM, Chakrabarti R, Picher MM, Neef J, Jung S, Gültas M, Maxeiner S, Neef A, Wichmann C, Strenzke N, Grabner C, Moser T., Free PMC Article | 09/1/2018 |
| These findings suggest a suppressive function for Ctbp2 in reducing the protein level of beta-catenin, along with priming its position on core pluripotency genes to hinder beta-catenin deposition, which is central to commitment to the appropriate lineage. | Ctbp2-mediated β-catenin regulation is required for exit from pluripotency.
Kim TW, Kwak S, Shin J, Kang BH, Lee SE, Suh MY, Kim JH, Hwang IY, Lee JH, Choi J, Cho EJ, Youn HD., Free PMC Article | 06/9/2018 |
| studies revealed a new epigenetic pathway in the control of IL-2 production in systemic lupus erythematosus whereby low levels of miR-200a-3p accumulate the binding of the ZEB1-CtBP2 complex to the IL-2 promoter and suppress IL-2 production | Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus-Derived T Cells.
Katsuyama E, Yan M, Watanabe KS, Narazaki M, Matsushima S, Yamamura Y, Hiramatsu S, Ohashi K, Watanabe H, Katsuyama T, Zeggar S, Yoshida N, Moulton VR, Tsokos GC, Sada KE, Wada J. | 09/23/2017 |
| Our results show that RIBEYE is essential for synaptic ribbons as such, and may organize presynaptic nano-domains that position release-ready synaptic vesicles adjacent to Ca(2+) channels | How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter release.
Maxeiner S, Luo F, Tan A, Schmitz F, Südhof TC., Free PMC Article | 06/10/2017 |
| Ctbp2 preoccupies regions in active genes with the NuRD complex in undifferentiated ESCs that are directed toward H3K27me3 by PRC2 to induce stable silencing, which is pivotal for natural lineage commitment. | Ctbp2 Modulates NuRD-Mediated Deacetylation of H3K27 and Facilitates PRC2-Mediated H3K27me3 in Active Embryonic Stem Cell Genes During Exit from Pluripotency.
Kim TW, Kang BH, Jang H, Kwak S, Shin J, Kim H, Lee SE, Lee SM, Lee JH, Kim JH, Kim SY, Cho EJ, Kim JH, Park KS, Che JH, Han DW, Kang MJ, Yi EC, Youn HD. | 04/9/2016 |
| Phosphorylation of KLF3 and CtBP2 by HIPK2 strengthens the interaction between these two factors and increases transcriptional repression by KLF3. | Phosphorylation of Krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomain-interacting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity.
Dewi V, Kwok A, Lee S, Lee MM, Tan YM, Nicholas HR, Isono K, Wienert B, Mak KS, Knights AJ, Quinlan KG, Cordwell SJ, Funnell AP, Pearson RC, Crossley M., Free PMC Article | 06/6/2015 |
| propose that Zscan4 may regulate gene transcription in mouse ES cells through interaction with LSD1 and CtBP2 | Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells.
Storm MP, Kumpfmueller B, Bone HK, Buchholz M, Sanchez Ripoll Y, Chaudhuri JB, Niwa H, Tosh D, Welham MJ., Free PMC Article | 01/10/2015 |
| RIBEYE(B) interacts with ArfGAP3 in vivo and in vitro. | ArfGAP3 is a component of the photoreceptor synaptic ribbon complex and forms an NAD(H)-regulated, redox-sensitive complex with RIBEYE that is important for endocytosis.
Dembla M, Wahl S, Katiyar R, Schmitz F., Free PMC Article | 06/21/2014 |
| CTBP2 is indispensable to create a chromatin environment conducive for RAR/RXR-mediated transcription by recruiting the histone acetyltransferase p300. | The corepressor CTBP2 is a coactivator of retinoic acid receptor/retinoid X receptor in retinoic acid signaling.
Bajpe PK, Heynen GJ, Mittempergher L, Grernrum W, de Rink IA, Nijkamp W, Beijersbergen RL, Bernards R, Huang S., Free PMC Article | 10/26/2013 |
| Study demonstrates differential regional and subcellular expression patterns for the two CtBP family members in brain and reveals a previously unknown synaptic localization for CtBP2 in particular brain regions. | Differential spatial expression and subcellular localization of CtBP family members in rodent brain.
Hübler D, Rankovic M, Richter K, Lazarevic V, Altrock WD, Fischer KD, Gundelfinger ED, Fejtova A., Free PMC Article | 12/8/2012 |
| Ctbp2 has a role in maintaining a balance in decisions to self-renewal and differentiate in embryonic stem cells and mesodermal progenitors | Delayed differentiation in embryonic stem cells and mesodermal progenitors in the absence of CtBP2.
Tarleton HP, Lemischka IR., Free PMC Article | 05/10/2010 |
| cooperates with ZEB1 and HDAC1 to suppress IL-2 gene activation in T cells | The transcription repressor, ZEB1, cooperates with CtBP2 and HDAC1 to suppress IL-2 gene activation in T cells.
Wang J, Lee S, Teh CE, Bunting K, Ma L, Shannon MF. | 01/21/2010 |
| Data show that inhibition of the white adipocyte genes depends on PPARgamma and the expression of C/EBPalpha and the corepressors, carboxy-terminal binding proteins 1 and 2 (CtBP1/2). | C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists.
Vernochet C, Peres SB, Davis KE, McDonald ME, Qiang L, Wang H, Scherer PE, Farmer SR., Free PMC Article | 01/21/2010 |
| The regulated docking of the CtBP proteins on PRDM16 controls the brown and white fat-selective gene programs. | Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM., Free PMC Article | 01/21/2010 |
| E1A may gain access to cellular promoters through conservved sequence-dependent interaction with CtBP2. | PLDLS-dependent interaction of E1A with CtBP: regulation of CtBP nuclear localization and transcriptional functions.
Zhao LJ, Subramanian T, Vijayalingam S, Chinnadurai G., Free PMC Article | 01/21/2010 |
| The CtBP2 co-repressor function is regulated by an NADH-dependent effect on CtBP2 dimerization. | The CtBP2 co-repressor is regulated by NADH-dependent dimerization and possesses a novel N-terminal repression domain.
Thio SS, Bonventre JV, Hsu SI., Free PMC Article | 01/21/2010 |
| These results identify a new CtBP interaction motif and establish ZNF217 as a transcriptional repressor protein that functions, at least in part, by associating with CtBP. | Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins.
Quinlan KG, Nardini M, Verger A, Francescato P, Yaswen P, Corda D, Bolognesi M, Crossley M., Free PMC Article | 01/21/2010 |
| These results demonstrate that the PXDLS binding cleft is functionally important but suggest that it is primarily required for localization of the CtBP2 complex to promoter-bound transcription factors. | Role of the C-terminal binding protein PXDLS motif binding cleft in protein interactions and transcriptional repression.
Quinlan KG, Verger A, Kwok A, Lee SH, Perdomo J, Nardini M, Bolognesi M, Crossley M., Free PMC Article | 01/21/2010 |
| analysis of the CtBP2 corepressor complex induced by E1A and modulation of E1A transcriptional activity by CtBP2 | Changes in C-terminal binding protein 2 (CtBP2) corepressor complex induced by E1A and modulation of E1A transcriptional activity by CtBP2.
Zhao LJ, Subramanian T, Chinnadurai G. | 01/21/2010 |
| calsenilin and CtBP2 are present in synaptic vesicles and can interact in vivo | Calsenilin interacts with transcriptional co-repressor C-terminal binding protein(s).
Zaidi NF, Kuplast KG, Washicosky KJ, Kajiwara Y, Buxbaum JD, Wasco W. | 01/21/2010 |