| Csk restrains BCR-mediated ROS production and contributes to germinal center selection and affinity maturation. | Csk restrains BCR-mediated ROS production and contributes to germinal center selection and affinity maturation.
Inoue T, Matsumoto Y, Kawai C, Ito M, Nada S, Okada M, Kurosaki T., Free PMC Article | 07/16/2024 |
| STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN. | STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN.
Kashiwakura JI, Kawahara S, Inagaki I, Inui K, Saitoh K, Kagohashi K, Sasaki Y, Kobayashi F, Kitai Y, Muromoto R, Oritani K, Matsuda T. | 10/11/2023 |
| eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin. | eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin.
Ninchoji T, Love DT, Smith RO, Hedlund M, Vestweber D, Sessa WC, Claesson-Welsh L., Free PMC Article | 11/27/2021 |
| CSK promotes innate immune response to DNA virus by phosphorylating MITA. | CSK promotes innate immune response to DNA virus by phosphorylating MITA.
Gao P, Hu MM, Shu HB. | 11/28/2020 |
| Data show that c-Src is present on the Golgi and ER of acinar cells and its activity regulates transit of amylase along the secretory pathway. | c-Src regulates cargo transit via the Golgi in pancreatic acinar cells.
Kostenko S, Heu CC, Yaron JR, Singh G, de Oliveira C, Muller WJ, Singh VP., Free PMC Article | 11/2/2019 |
| These data suggest that inhibition of GABAergic inhibitory postsynaptic currents by morphine involves a beta-arr2/c-Src mediated mechanism. | Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src.
Bull FA, Baptista-Hon DT, Lambert JJ, Walwyn W, Hales TG., Free PMC Article | 04/27/2019 |
| This study establishes Csk and CD148 as critical molecular switches controlling the thrombotic and hemostatic capacity of platelets and reveals cell-intrinsic mechanisms that prevent pathological thrombosis from occurring. | Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.
Mori J, Nagy Z, Di Nunzio G, Smith CW, Geer MJ, Al Ghaithi R, van Geffen JP, Heising S, Boothman L, Tullemans BME, Correia JN, Tee L, Kuijpers MJE, Harrison P, Heemskerk JWM, Jarvis GE, Tarakhovsky A, Weiss A, Mazharian A, Senis YA., Free PMC Article | 03/23/2019 |
| The results suggest that Csk in Intestinal epithelial cells plays important roles in the regulation of the intestinal epithelial barrier function and protection against colitis. | Role of Csk in intestinal epithelial barrier function and protection against colitis.
Sun C, Murata Y, Imada S, Konno T, Kotani T, Saito Y, Yamada H, Matozaki T. | 03/9/2019 |
| N1-Src was implicated in L1-CAM signalling as PDN1 inhibited L1-CAM dependent neurite elongation in cerebellar granule neurons (CGNs). | Inhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM.
Keenan S, Wetherill SJ, Ugbode CI, Chawla S, Brackenbury WJ, Evans GJ., Free PMC Article | 03/9/2019 |
| identify a physiological pathway by which blood pressure is regulated, in which the insufficiency of Csk induces aldosterone production with zonal specificity in the adrenal glands, increasing sodium reabsorption and plasma volume and thus resulting in hypertension. | Csk Regulates Blood Pressure by Controlling the Synthetic Pathways of Aldosterone.
Kim SM, Kang JO, Lim JE, Hwang SY, Oh B. | 03/9/2019 |
| Our results have uncovered a previously unknown role of c-Src tyrosine kinase in regulating interneuron function in the brain and identified a novel mechanism by which TASK-1 channels are activated in neurons. | Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway.
Leist M, Rinné S, Datunashvili M, Aissaoui A, Pape HC, Decher N, Meuth SG, Budde T., Free PMC Article | 02/10/2018 |
| in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells. | The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.
Davidson D, Zhong MC, Pandolfi PP, Bolland S, Xavier RJ, Seed B, Li X, Gu H, Veillette A., Free PMC Article | 11/25/2017 |
| Csk is a causative gene in the 15q24 locus and regulates blood pressure through Src, and these findings provide a novel therapeutic target for the treatment of hypertension | Gene Silencing and Haploinsufficiency of Csk Increase Blood Pressure.
Lee HJ, Kang JO, Kim SM, Ji SM, Park SY, Kim ME, Jigden B, Lim JE, Hwang SY, Lee YH, Oh B., Free PMC Article | 07/30/2016 |
| Csk plays an important role, not only in basal signaling, but also in setting the T cell antigen receptor signaling threshold and affinity recognition. | Small molecule inhibition of Csk alters affinity recognition by T cells.
Manz BN, Tan YX, Courtney AH, Rutaganira F, Palmer E, Shokat KM, Weiss A., Free PMC Article | 06/11/2016 |
| SHIP1 and Csk are part of the PSTPIP2-dependent inhibitory network that prevents the development of autoinflammatory disease. | PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk.
Drobek A, Kralova J, Skopcova T, Kucova M, Novák P, Angelisová P, Otahal P, Alberich-Jorda M, Brdicka T. | 02/6/2016 |
| If Cbp enhances the interaction between c-Src and FAK, Cbp could promote c-Src function when lipid rafts are disrupted. | Roles of raft-anchored adaptor Cbp/PAG1 in spatial regulation of c-Src kinase.
Saitou T, Kajiwara K, Oneyama C, Suzuki T, Okada M., Free PMC Article | 05/30/2015 |
| Suggest critical role of Cav1 in modulating cSrc activation, gap junction remodeling, and ventricular arrhythmias. | Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase.
Yang KC, Rutledge CA, Mao M, Bakhshi FR, Xie A, Liu H, Bonini MG, Patel HH, Minshall RD, Dudley SC Jr., Free PMC Article | 10/18/2014 |
| Differentiation of embryonic stem cells is driven by c-Src is antagonized by c-Yes. | c-Yes tyrosine kinase is a potent suppressor of ES cell differentiation and antagonizes the actions of its closest phylogenetic relative, c-Src.
Zhang X, Meyn MA 3rd, Smithgall TE., Free PMC Article | 09/6/2014 |
| critical role in preventing TCR signaling | Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.
Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A., Free PMC Article | 04/5/2014 |
| It was concluded that c-Src and NADPH oxidase components are necessary for redox-mediated production of TNF-alpha following liver ischemia-reperfusion and that hepatocytes play an important role in this process. | Hepatocytes produce TNF-α following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner.
Spencer NY, Zhou W, Li Q, Zhang Y, Luo M, Yan Z, Lynch TJ, Abbott D, Banfi B, Engelhardt JF., Free PMC Article | 09/14/2013 |
| Data indicate that chemical rescue of c-Src provided a tool to dissect the spatiotemporal mechanism of activation of the Rap1 guanine exchange factor, C3G, one of the identified potential c-Src substrates that plays a role in focal adhesion signaling. | Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics.
Ferrando IM, Chaerkady R, Zhong J, Molina H, Jacob HK, Herbst-Robinson K, Dancy BM, Katju V, Bose R, Zhang J, Pandey A, Cole PA., Free PMC Article | 12/22/2012 |
| The Csk pathway appears to be a critical signaling cascade regulating social learning and memory | Impaired social memories in 129P2 inbred mice are rescued by reduced Csk expression.
Sinai L, Mathew R, Roder JC. | 11/24/2012 |
| These data demonstrate that expression of an activated allele of c-src overcomes the block to mammary gland morphogenesis in mice arising due to the loss of the cytoplasmic C-terminal domain of Ptch1. | Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1.
Chang H, Balenci L, Okolowsky N, Muller WJ, Hamel PA. | 11/24/2012 |
| Data show that the phosphoprotein associated with glycosphigolipid-enriched microdomains (PAG)/Csk binding protein (Cbp) modulates SFK activity in the brain. | Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.
Lindquist S, Karitkina D, Langnaese K, Posevitz-Fejfar A, Schraven B, Xavier R, Seed B, Lindquist JA., Free PMC Article | 02/18/2012 |
| Caveolin-1 and C-terminal Src kinase binding protein are cooperative, and increases in their expression or phosphorylation favors repression of C-terminal Src kinase activity. | Cooperative role of caveolin-1 and C-terminal Src kinase binding protein in C-terminal Src kinase-mediated negative regulation of c-Src.
Place AT, Chen Z, Bakhshi FR, Liu G, O'Bryan JP, Minshall RD., Free PMC Article | 11/26/2011 |