| DIS3L2 knockdown impairs key oncogenic properties of colorectal cancer cells via the mTOR signaling pathway. | DIS3L2 knockdown impairs key oncogenic properties of colorectal cancer cells via the mTOR signaling pathway.
García-Moreno JF, Lacerda R, da Costa PJ, Pereira M, Gama-Carvalho M, Matos P, Romão L., Free PMC Article | 06/28/2023 |
| DIS3L2 and LSm proteins are involved in the surveillance of Sm ring-deficient snRNAs. | DIS3L2 and LSm proteins are involved in the surveillance of Sm ring-deficient snRNAs.
Roithová A, Feketová Z, Vaňáčová Š, Staněk D., Free PMC Article | 09/12/2020 |
| AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2. | AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2.
Yang A, Shao TJ, Bofill-De Ros X, Lian C, Villanueva P, Dai L, Gu S., Free PMC Article | 08/29/2020 |
| The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis. | The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis.
Pirouz M, Wang CH, Liu Q, Ebrahimi AG, Shamsi F, Tseng YH, Gregory RI., Free PMC Article | 08/22/2020 |
| Findings indicate a role for DIS3 like 3'-5' exoribonuclease 2 (DIS3L2) and uridylation in nonsense-mediated mRNA decay (NMD). | A role for DIS3L2 over natural nonsense-mediated mRNA decay targets in human cells.
da Costa PJ, Menezes J, Saramago M, García-Moreno JF, Santos HA, Gama-Carvalho M, Arraiano CM, Viegas SC, Romão L. | 06/6/2020 |
| our findings uncover an oncogenic role of DIS3L2, in which it promotes liver cancer progression through a previously unappreciated mechanism of regulating hnRNP U-mediated alterative splicing | DIS3L2 Promotes Progression of Hepatocellular Carcinoma via hnRNP U-Mediated Alternative Splicing.
Xing S, Li Z, Ma W, He X, Shen S, Wei H, Li ST, Shu Y, Sun L, Zhong X, Huangfu Y, Su L, Feng J, Zhang X, Gao P, Jia WD, Zhang H. | 05/30/2020 |
| These findings suggest that sequestration of the exoribonucleases DIS3L2 and XRN1 to nuclear inclusions may be related to the pathogenesis of intranuclear inclusion body disease | Immunohistochemical localization of exoribonucleases (DIS3L2 and XRN1) in intranuclear inclusion body disease.
Mori F, Tanji K, Miki Y, Toyoshima Y, Sasaki H, Yoshida M, Kakita A, Takahashi H, Wakabayashi K. | 07/28/2018 |
| The evidence has been presented that Dis3l2 controls miRNA-9 production. | Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively.
Nowak JS, Hobor F, Downie Ruiz Velasco A, Choudhury NR, Heikel G, Kerr A, Ramos A, Michlewski G., Free PMC Article | 09/9/2017 |
| Our findings establish the role of DIS3L2 and oligouridylation as the cytoplasmic quality control for highly structured ncRNAs | TUT-DIS3L2 is a mammalian surveillance pathway for aberrant structured non-coding RNAs.
Ustianenko D, Pasulka J, Feketova Z, Bednarik L, Zigackova D, Fortova A, Zavolan M, Vanacova S., Free PMC Article | 07/22/2017 |
| Studies indicate important roles of the exoribonucleases DIS3L2 and XRN1 in cellular function, viability and disease. | The roles of the exoribonucleases DIS3L2 and XRN1 in human disease.
Pashler AL, Towler BP, Jones CI, Newbury SF. | 07/15/2017 |
| these results indicate that catalytically inactive DIS3L2, characteristic of Perlman syndrome, can lead to deregulation of its target RNAs to disturb transcriptome homeostasis. | Perlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAs.
Łabno A, Warkocki Z, Kuliński T, Krawczyk PS, Bijata K, Tomecki R, Dziembowski A., Free PMC Article | 06/3/2017 |
| DIS3L2 interacts with Ago2 and governs target RNA-directed miRNA degradation. | Identification of factors involved in target RNA-directed microRNA degradation.
Haas G, Cetin S, Messmer M, Chane-Woon-Ming B, Terenzi O, Chicher J, Kuhn L, Hammann P, Pfeffer S., Free PMC Article | 08/27/2016 |
| DIS3L2 is the missing component of the LIN28-TUT4/7-DIS3L2 pathway required for the repression of let-7 in pluripotent cells. | Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs.
Ustianenko D, Hrossova D, Potesil D, Chalupnikova K, Hrazdilova K, Pachernik J, Cetkovska K, Uldrijan S, Zdrahal Z, Vanacova S., Free PMC Article | 01/18/2014 |
| in cellular models DIS3L2 knockdown is associated with abnormalities of cell growth and division | Perlman syndrome: overgrowth, Wilms tumor predisposition and DIS3L2.
Morris MR, Astuti D, Maher ER. | 10/19/2013 |
| Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility. | Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility.
Astuti D, Morris MR, Cooper WN, Staals RH, Wake NC, Fews GA, Gill H, Gentle D, Shuib S, Ricketts CJ, Cole T, van Essen AJ, van Lingen RA, Neri G, Opitz JM, Rump P, Stolte-Dijkstra I, Müller F, Pruijn GJ, Latif F, Maher ER. | 04/21/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |