| Expression dynamics of Crry at the implantation sites in normal pregnancy and response against miscarriage induction. | Expression dynamics of Crry at the implantation sites in normal pregnancy and response against miscarriage induction.
Kuniyoshi N, Hanada S, Ando R, Yustinasari LR, Kuratomi M, Kagawa S, Imai H, Kusakabe KT., Free PMC Article | 01/28/2023 |
| Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones. | Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones.
Nagano F, Mizuno T, Imai M, Takahashi K, Tsuboi N, Maruyama S, Mizuno M., Free PMC Article | 04/9/2022 |
| Our study uncovers a damaging effect of complement C3 or downstream complement activation in glaucoma, and it establishes AAV2.CR2-Crry as a viable therapeutic strategy to target pathogenic C3-mediated complement activation in the glaucomatous retina | Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma.
Bosco A, Anderson SR, Breen KT, Romero CO, Steele MR, Chiodo VA, Boye SL, Hauswirth WW, Tomlinson S, Vetter ML., Free PMC Article | 08/17/2019 |
| CRRY role in the retinal epithelium and photoreceptor degeneration | Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease.
Lenis TL, Sarfare S, Jiang Z, Lloyd MB, Bok D, Radu RA., Free PMC Article | 05/26/2018 |
| Factor H and Crry are critical for regulating complement activation at distinct anatomic sites within the kidney. | Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.
Laskowski J, Renner B, Le Quintrec M, Panzer S, Hannan JP, Ljubanovic D, Ruseva MM, Borza DB, Antonioli AH, Pickering MC, Holers VM, Thurman JM., Free PMC Article | 10/7/2017 |
| this study has provided direct evidence for a role of Crry in controlling spontaneous alternative pathway complement activation on renal tubular epithelial cells. | Tissue-specific deletion of Crry from mouse proximal tubular epithelial cells increases susceptibility to renal ischemia-reperfusion injury.
Miao J, Lesher AM, Miwa T, Sato S, Gullipalli D, Song WC., Free PMC Article | 07/4/2015 |
| HBx can up-regulate CD59 and Crry expression in podocytes through activating the P38 pathway. | [Hepatitis B virus X protein upregulates the expression of CD59 and Crry in mouse podocytes].
Yin XL, Zhou JH. | 11/5/2011 |
| Crry costimulation enhanced the in vitro expansion of natural Treg cells while maintaining their phenotypic and suppressive properties. Crry-expanded Treg cells decreasing antigen-dependent secretion of cytokines. | Complement regulatory protein Crry/p65 costimulation expands natural treg cells with enhanced suppressive properties in proteoglycan-induced arthritis.
Ojeda G, Pini E, Eguiluz C, Montes-Casado M, Broere F, van Eden W, Rojo JM, Portolés P. | 08/20/2011 |
| Stmn2 and the chromosome 14 Rarb region, but not Cr1 or Clu or Picalm, have roles in prion disease. | The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse.
Grizenkova J, Akhtar S, Collinge J, Lloyd SE., Free PMC Article | 07/26/2011 |
| There is a significant reduction in the numbers of both neutrophils and macrophages in cardiac isografts isolated from mice treated with either complement receptor 2-Crry or CR2-factor H. | Targeted complement inhibitors protect against posttransplant cardiac ischemia and reperfusion injury and reveal an important role for the alternative pathway of complement activation.
Atkinson C, He S, Morris K, Qiao F, Casey S, Goddard M, Tomlinson S. | 01/15/2011 |
| Crry is clearly present in the placentas from spontaneous abortions in mice. | Regulation of complement activity via the alternative pathway in placentas of mouse spontaneous abortions.
Takeshita A, Nagaishi S, Kondo T, Okada T, Kusakabe KT. | 12/4/2010 |
| Crry is the only membrane-bound complement regulator expressed on the basolateral surface of murine renal tubular epithelial cells under in vitro culture conditions. | The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells.
Renner B, Coleman K, Goldberg R, Amura C, Holland-Neidermyer A, Pierce K, Orth HN, Molina H, Ferreira VP, Cortes C, Pangburn MK, Holers VM, Thurman JM., Free PMC Article | 10/30/2010 |
| Data show that a single-nucleotide polymorphism in the first short consensus repeat of Sle1c Crry introduced a novel N-linked glycosylation site likely responsible for structural alteration. | An allelic variant of Crry in the murine Sle1c lupus susceptibility interval is not impaired in its ability to regulate complement activation.
Tchepeleva SN, Thurman JM, Ruff K, Perkins SJ, Morel L, Boackle SA., Free PMC Article | 09/27/2010 |
| mesangial cell Crry limits complement activation and subsequent neutrophil recruitment in the setting of local immune complex deposition. | Mesangial cell complement receptor 1-related protein y limits complement-dependent neutrophil accumulation in immune complex glomerulonephritis.
Bao L, Wang Y, Chen P, Sarav M, Haas M, Minto AW, Petkova M, Quigg RJ., Free PMC Article | 02/1/2010 |
| Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury. | Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury.
Ruseva MM, Hughes TR, Donev RM, Sivasankar B, Pickering MC, Wu X, Harris CL, Morgan BP. | 01/21/2010 |
| Crry and CD59 are critical in protecting Treg cells from complement mediated injuries. | Mouse CD4+ CD25+ T regulatory cells are protected from autologous complement mediated injury by Crry and CD59.
Li Q, Nacion K, Bu H, Lin F., Free PMC Article | 01/21/2010 |
| Crry is essential for mature T-cell survival in the periphery but not for lymphogenesis in the thymus. | Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry.
Miwa T, Zhou L, Kimura Y, Kim D, Bhandoola A, Song WC., Free PMC Article | 01/21/2010 |
| Pak1 is an essential molecular target for modulating acute mast cell responses that contribute to allergic diseases. | p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.
Allen JD, Jaffer ZM, Park SJ, Burgin S, Hofmann C, Sells MA, Chen S, Derr-Yellin E, Michels EG, McDaniel A, Bessler WK, Ingram DA, Atkinson SJ, Travers JB, Chernoff J, Clapp DW., Free PMC Article | 01/21/2010 |
| Membrane complement regulator Crry helps to maintain homeostasis of the complement alternative pathway (AP) and demonstrates that Crry-deficient mice can be rescued on a partial as well as on a complete factor B- or C3-deficient maternal background. | Membrane protein Crry maintains homeostasis of the complement system.
Wu X, Spitzer D, Mao D, Peng SL, Molina H, Atkinson JP., Free PMC Article | 01/21/2010 |
| DAF and Crry double deficiency led to rapid clearance of platelets from circulation in a complement- and macrophage-dependent manner; redundant role of DAF and Crry in platelet survival | Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg.
Kim DD, Miwa T, Kimura Y, Schwendener RA, van Lookeren Campagne M, Song WC., Free PMC Article | 01/21/2010 |
| Our data suggest complement provides some protection of mature oligodendrocytes during cuprizone treatment but may be critical for subsequent remyelination events. | Astrocyte-specific expression of a soluble form of the murine complement control protein Crry confers demyelination protection in the cuprizone model.
Briggs DT, Martin CB, Ingersoll SA, Barnum SR, Martin BK. | 01/21/2010 |
| The dual function of Crry as a complement regulatory protein and as a T cell costimulator illustrates the importance of complement regulatory proteins as links between innate and adaptive immunity. | Complement regulatory protein Crry/p65-mediated signaling in T lymphocytes: role of its cytoplasmic domain and partitioning into lipid rafts.
Jiménez-Periañez A, Ojeda G, Criado G, Sánchez A, Pini E, Madrenas J, Rojo JM, Portolés P. | 01/21/2010 |
| X-ray and neutron scattering was performed on recombinant rat Crry containing the first five SCR domains (rCrry) and mouse Crry with five SCR domains conjugated to the Fc fragment of mouse IgG1 (mCrry-Ig) | The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy.
Aslam M, Guthridge JM, Hack BK, Quigg RJ, Holers VM, Perkins SJ. | 01/21/2010 |
| Long-term complement blockade with Crry, a C3 convertase inhibitor overexpressed in a transgenic mouse line, reduces renal disease and improves survival in lupus-prone MRL/lpr mice. | Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice.
Bao L, Haas M, Boackle SA, Kraus DM, Cunningham PN, Park P, Alexander JJ, Anderson RK, Culhane K, Holers VM, Quigg RJ. | 01/21/2010 |
| Crry plays a more dominant role than DAF in regulating the alternative pathway of complement C3 activation, whereas DAF and Crry are equally effective in preventing antibody-induced runaway complement activation. | Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor.
Molina H, Miwa T, Zhou L, Hilliard B, Mastellos D, Maldonado MA, Lambris JD, Song WC. | 01/21/2010 |