| NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia. | NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia.
Chen CW, Su C, Huang CY, Huang XR, Cuili X, Chao T, Fan CH, Ting CW, Tsai YW, Yang KC, Yeh TY, Hsieh ST, Chen YJ, Feng Y, Hunter T, Chang ZF., Free PMC Article | 03/15/2024 |
| Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury. | Fat mass and obesity associated protein inhibits neuronal ferroptosis via the FYN/Drp1 axis and alleviate cerebral ischemia/reperfusion injury.
Zhang Y, Gong X., Free PMC Article | 03/7/2024 |
| Imbalance of synaptic and extrasynaptic NMDA receptors induced by the deletion of CRMP1 accelerates age-related cognitive decline in mice. | Imbalance of synaptic and extrasynaptic NMDA receptors induced by the deletion of CRMP1 accelerates age-related cognitive decline in mice.
Tsai YC, Huang SM, Peng HH, Lin SW, Lin SR, Chin TY, Huang SM. | 02/12/2024 |
| Hepatocyte growth factor attenuates high glucose-disturbed mitochondrial dynamics in podocytes by decreasing ARF6-dependent DRP1 translocation. | Hepatocyte growth factor attenuates high glucose-disturbed mitochondrial dynamics in podocytes by decreasing ARF6-dependent DRP1 translocation.
Li Y, Li X, Yang Y, Li F, Chen Q, Zhao Z, Zhang N, Li H. | 11/30/2023 |
| Attenuation of PM2.5-induced alveolar epithelial cells and lung injury through regulation of mitochondrial fission and fusion. | Attenuation of PM(2.5)-induced alveolar epithelial cells and lung injury through regulation of mitochondrial fission and fusion.
Liu Q, Weng J, Li C, Feng Y, Xie M, Wang X, Chang Q, Li M, Chung KF, Adcock IM, Huang Y, Zhang H, Li F., Free PMC Article | 07/24/2023 |
| LCRMP-1 is required for spermatogenesis and stabilises spermatid F-actin organization via the PI3K-Akt pathway. | LCRMP-1 is required for spermatogenesis and stabilises spermatid F-actin organization via the PI3K-Akt pathway.
Chang JH, Chou CH, Wu JC, Liao KM, Luo WJ, Hsu WL, Chen XR, Yu SL, Pan SH, Yang PC, Su KY., Free PMC Article | 04/12/2023 |
| miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress. | miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress.
Wang H, Lin H, Kang W, Huang L, Gong S, Zhang T, Huang X, He F, Ye Y, Tang Y, Jia H, Yang H., Free PMC Article | 03/9/2023 |
| Klf4 deficiency exacerbates myocardial ischemia/reperfusion injury in mice via enhancing ROCK1/DRP1 pathway-dependent mitochondrial fission. | Klf4 deficiency exacerbates myocardial ischemia/reperfusion injury in mice via enhancing ROCK1/DRP1 pathway-dependent mitochondrial fission.
Li Y, Xiong Z, Jiang Y, Zhou H, Yi L, Hu Y, Zhai X, Liu J, Tian F, Chen Y. | 01/28/2023 |
| Collapsin Response Mediator Protein 1 (CRMP1) Is Required for High-Frequency Hearing. | Collapsin Response Mediator Protein 1 (CRMP1) Is Required for High-Frequency Hearing.
Li J, Liu C, Zhao B., Free PMC Article | 07/30/2022 |
| Here, biochemical analysis of NgR1 function uncovered a physical complex with CRMP cytoplasmic mediators, and this led to appreciation of a role for PlexinA2 in concert with NgR1 after adult spinal cord trauma. | Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma.
Sekine Y, Algarate PT, Cafferty WBJ, Strittmatter SM., Free PMC Article | 06/13/2020 |
| Results indicate that CRMP1 and CRMP4 regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex during development. | CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain.
Takaya R, Nagai J, Piao W, Niisato E, Nakabayashi T, Yamazaki Y, Nakamura F, Yamashita N, Kolattukudy P, Goshima Y, Ohshima T. | 08/12/2017 |
| this paper shows that Nav1.7, by coupling with CRMP1, mediates the axonal retrograde signaling of Sema3A in axonal guidance | A functional coupling between CRMP1 and Na(v)1.7 for retrograde propagation of Semaphorin3A signaling.
Yamane M, Yamashita N, Hida T, Kamiya Y, Nakamura F, Kolattukudy P, Goshima Y. | 05/6/2017 |
| We generated CRMP2 gene-deficient (crmp2(-/-) ) mice. The crmp2(-/-) mice showed irregular development of dendritic spines in cortical neurons. The level of CRMP1 was increased in crmp2(-/-) , but the level of CRMP2 was not altered in crmp1(-/-).The phenotypic defects had no genetic interaction between crmp1 and crmp2. | CRMP1 and CRMP2 have synergistic but distinct roles in dendritic development.
Makihara H, Nakai S, Ohkubo W, Yamashita N, Nakamura F, Kiyonari H, Shioi G, Jitsuki-Takahashi A, Nakamura H, Tanaka F, Akase T, Kolattukudy P, Goshima Y. | 03/4/2017 |
| LCRMP-1 and CRMP-1 have opposing functions in regulating cancer cell invasion and metastasis | The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1.
Pan SH, Chao YC, Hung PF, Chen HY, Yang SC, Chang YL, Wu CT, Chang CC, Wang WL, Chan WK, Wu YY, Che TF, Wang LK, Lin CY, Lee YC, Kuo ML, Lee CH, Chen JJ, Hong TM, Yang PC., Free PMC Article | 10/8/2011 |
| Data demonstrate that CRMP1 tyrosine 504 is a primary target of the Src family of tyrosine kinases (SFKs), specifically Fyn. | Fyn promotes phosphorylation of collapsin response mediator protein 1 at tyrosine 504, a novel, isoform-specific regulatory site.
Buel GR, Rush J, Ballif BA., Free PMC Article | 02/26/2011 |
| Data link the reduction in PMCA2 expression with perturbations in CRMP1 expression and death of spinal cord neurons, representing an additional mechanism underlying AMPA/kainate receptor-mediated excitotoxicity with relevance to neurodegeneration in EAE. | Reduced expression of plasma membrane calcium ATPase 2 and collapsin response mediator protein 1 promotes death of spinal cord neurons.
Kurnellas MP, Li H, Jain MR, Giraud SN, Nicot AB, Ratnayake A, Heary RF, Elkabes S., Free PMC Article | 01/15/2011 |
| (CRMP-1) collapsin response mediator protein 1 transcript level was normal but a cleavage of collapsin response mediator protein 1 was observed with an abnormal expression of the truncated form until adult age | Abnormal expression of truncated CRMP-1 protein in the brain cortex of MPSIIIB mice.
Cheillan D, Malleval C, Ausseil J, Vitry S, Heard JM, Maire I, Honnorat J, Belin MF, Touret M. | 01/21/2010 |
| beyond their signalling function in axon outgrowth and guidance, CRMPs also play a role in mature neurons both in axons and in dendrites | Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain.
Bretin S, Reibel S, Charrier E, Maus-Moatti M, Auvergnon N, Thevenoux A, Glowinski J, Rogemond V, Prémont J, Honnorat J, Gauchy C. | 01/21/2010 |
| These findings suggest that Sema3A-induced spine development is regulated by phosphorylation of CRMP1 by Cdk5. | Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1.
Yamashita N, Morita A, Uchida Y, Nakamura F, Usui H, Ohshima T, Taniguchi M, Honnorat J, Thomasset N, Takei K, Takahashi T, Kolattukudy P, Goshima Y., Free PMC Article | 01/21/2010 |
| In the olfactory bulb, CRMP1, CRMP2 and CRMP5 are abundant in neuronal progenitors of the subependymal layer and in differentiating interneurons. | Expression of collapsin response mediator proteins 1, 2 and 5 is differentially regulated in newly generated and mature neurons of the adult olfactory system.
Veyrac A, Giannetti N, Charrier E, Reymond-Marron I, Aguera M, Rogemond V, Honnorat J, Jourdan F. | 01/21/2010 |
| Collapsin response mediator protein 1 (CRMP1)regulates neuronal migration by mediating Reelin signaling. | Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration.
Yamashita N, Uchida Y, Ohshima T, Hirai S, Nakamura F, Taniguchi M, Mikoshiba K, Honnorat J, Kolattukudy P, Thomasset N, Takei K, Takahashi T, Goshima Y., Free PMC Article | 01/21/2010 |
| Mice lacking Crmp1 showed a decrease in the number of granule cells migrating out of explants of developing cerebellum. | Transient alterations in granule cell proliferation, apoptosis and migration in postnatal developing cerebellum of CRMP1-/- mice.
Charrier E, Mosinger B, Meissirel C, Aguera M, Rogemond V, Reibel S, Salin P, Chounlamountri N, Perrot V, Belin MF, Goshima Y, Honnorat J, Thomasset N, Kolattukudy P. | 01/21/2010 |
| CRMP-1 may be involved in proper neurite outgrowth in the adult hippocampus. Loss of CRMP-1 may affect LTP maintenance and spatial learning and memory. | Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory.
Su KY, Chien WL, Fu WM, Yu IS, Huang HP, Huang PH, Lin SR, Shih JY, Lin YL, Hsueh YP, Yang PC, Lin SW., Free PMC Article | 01/21/2010 |
| The structural bases for Crmp1 function in plexin-dependent sempahorin3A signaling were studied. | Structural bases for CRMP function in plexin-dependent semaphorin3A signaling.
Deo RC, Schmidt EF, Elhabazi A, Togashi H, Burley SK, Strittmatter SM., Free PMC Article | 01/21/2010 |