| These results suggest that Lmo3 promotes anxiety-like behavior specifically in the BLA, possibly by altering Crhr1 expression. | Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3.
Savarese A, Lasek AW., Free PMC Article | 09/8/2023 |
| Changes in Corticotropin-Releasing Factor Receptor Type 1, Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and Anxiety-Like Behaviors across the Postpartum Period in Mice. | Changes in Corticotropin-Releasing Factor Receptor Type 1, Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and Anxiety-Like Behaviors across the Postpartum Period in Mice.
De Guzman RM, Rosinger ZJ, Rybka KA, Jacobskind JS, Thrasher CA, Caballero AL, Sturm KL, Sharif MS, Abbas MS, Parra KE, Zuloaga KL, Justice NJ, Zuloaga DG., Free PMC Article | 07/26/2023 |
| The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse. | The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse.
Wang T, Ma YN, Zhang CC, Liu X, Sun YX, Wang HL, Wang H, Zhong YH, Su YA, Li JT, Si TM., Free PMC Article | 01/28/2023 |
| Corticotropin-releasing factor receptor 1 in infralimbic cortex modulates social stress-altered decision-making. | Corticotropin-releasing factor receptor 1 in infralimbic cortex modulates social stress-altered decision-making.
Alizamini MM, Chen X, Nie L, Dai Z, Liu Y, Haghparast A, Wu N, Zhang J, Shen F, Sui N, Liang J. | 04/23/2022 |
| The CRF1 receptor mediates social behavior deficits induced by opiate withdrawal. | The CRF(1) receptor mediates social behavior deficits induced by opiate withdrawal.
Piccin A, Contarino A. | 04/2/2022 |
| Alterations in corticotropin-releasing factor receptor type 1 in the preoptic area and hypothalamus in mice during the postpartum period. | Alterations in corticotropin-releasing factor receptor type 1 in the preoptic area and hypothalamus in mice during the postpartum period.
De Guzman RM, Rosinger ZJ, Parra KE, Jacobskind JS, Justice NJ, Zuloaga DG., Free PMC Article | 11/6/2021 |
| Prenatally traumatized mice reveal hippocampal methylation and expression changes of the stress-related genes Crhr1 and Fkbp5. | Prenatally traumatized mice reveal hippocampal methylation and expression changes of the stress-related genes Crhr1 and Fkbp5.
Plank AC, Frey S, Basedow LA, Solati J, Canneva F, von Hörsten S, Kratz O, Moll GH, Golub Y., Free PMC Article | 08/21/2021 |
| Corticotropin-Releasing Factor Receptor-1 Neurons in the Lateral Amygdala Display Selective Sensitivity to Acute and Chronic Ethanol Exposure. | Corticotropin-Releasing Factor Receptor-1 Neurons in the Lateral Amygdala Display Selective Sensitivity to Acute and Chronic Ethanol Exposure.
Agoglia AE, Zhu M, Ying R, Sidhu H, Natividad LA, Wolfe SA, Buczynski MW, Contet C, Parsons LH, Roberto M, Herman MA., Free PMC Article | 08/7/2021 |
| Anxiogenesis induced by social defeat in male mice: Role of nitric oxide, NMDA, and CRF1 receptors in the medial prefrontal cortex and BNST. | Anxiogenesis induced by social defeat in male mice: Role of nitric oxide, NMDA, and CRF(1) receptors in the medial prefrontal cortex and BNST.
Faria MP, Laverde CF, Nunes-de-Souza RL. | 04/3/2021 |
| Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA2 phosphorylation in experimental ischemic stroke. | Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA(2) phosphorylation in experimental ischemic stroke.
Cao C, Zhou J, Wu X, Qian Y, Hong Y, Mu J, Jin L, Zhu C, Li S. | 02/6/2021 |
| Sevoflurane-induced nectin-1 and L-afadin expression decrease was mediated by CRHR1 signaling in the hippocampus. | Sevoflurane-induced learning deficits and spine loss via nectin-1/corticotrophin-releasing hormone receptor type 1 signaling.
Li Y, Zhang L, Wang C, Tang X, Chen Y, Wang X, Su L, Hu N, Xie K, Yu Y, Wang G. | 06/27/2020 |
| Data provide important information about the neurobiology of Central Nucleus of the Amygdala corticotropin-releasing factor acting at cognate type 1 receptors (CRF1+) neurons that may have critical implications for their functional role under physiological and pathological conditions. | Molecular, Morphological, and Functional Characterization of Corticotropin-Releasing Factor Receptor 1-Expressing Neurons in the Central Nucleus of the Amygdala.
Wolfe SA, Sidhu H, Patel RR, Kreifeldt M, D'Ambrosio SR, Contet C, Roberto M., Free PMC Article | 04/4/2020 |
| The data suggest that 5-HT2CR activation in the BLA contributes to neuropathic pain-related amygdala (CeA) activity by engaging CRF1 receptor signaling. | Contribution of Corticotropin-Releasing Factor Receptor 1 (CRF1) to Serotonin Receptor 5-HT(2C)R Function in Amygdala Neurons in a Neuropathic Pain Model.
Ji G, Neugebauer V., Free PMC Article | 02/8/2020 |
| we report a sexually dimorphic distribution of CRFR1 expressing cells within the paraventricular hypothalamus (PVN; males > females). | A sexually dimorphic distribution of corticotropin-releasing factor receptor 1 in the paraventricular hypothalamus.
Rosinger ZJ, Jacobskind JS, De Guzman RM, Justice NJ, Zuloaga DG., Free PMC Article | 01/11/2020 |
| Study of transgenic HP5 mice overexpressing human SSTR5 in pituitary corticotrophs shows that SSTR5-induced miR-449c suppresses both CRHR1 expression and function and concludes that corticotroph SSTR5 attenuates hypothalamic-pituitary-adrenal axis responses via CRHR1 downregulation, suggesting a role for SSTR5 in the pathogenesis of secondary adrenal insufficiency. | Somatostatin receptor subtype 5 modifies hypothalamic-pituitary-adrenal axis stress function.
Yamamoto M, Ben-Shlomo A, Kameda H, Fukuoka H, Deng N, Ding Y, Melmed S., Free PMC Article | 12/14/2019 |
| plasma extracellular vesicles from immune cells carry CRFRs as cargos and influence cell-cell communication in health and disease. | Plasma Corticotropin-Releasing Factor Receptors and B7-2⁺ Extracellular Vesicles in Blood Correlate with Irritable Bowel Syndrome Disease Severity.
Hagiwara SI, Hasdemir B, Heyman MB, Chang L, Bhargava A., Free PMC Article | 12/7/2019 |
| Proton-induced CRHR1 signaling regulates ACTH production in response to an acidic microenvironment. | Proton Sensitivity of Corticotropin-Releasing Hormone Receptor 1 Signaling to Proopiomelanocortin in Male Mice.
Kameda H, Yamamoto M, Tone Y, Tone M, Melmed S., Free PMC Article | 12/7/2019 |
| We found a profound effect on learning both at the cellular and behavioral levels without an effect on baseline motor skills after granular cell-specific ablation of CRFR1 | Cerebellar Learning Properties Are Modulated by the CRF Receptor.
Ezra-Nevo G, Prestori F, Locatelli F, Soda T, Ten Brinke MM, Engel M, Boele HJ, Botta L, Leshkowitz D, Ramot A, Tsoory M, Biton IE, Deussing J, D'Angelo E, De Zeeuw CI, Chen A., Free PMC Article | 11/2/2019 |
| results show that in response to MS, CRHR1 mediates gut injury by promoting intestinal inflammation, increasing gut permeability, altering intestinal morphology, and modulating the intestinal microbiota. In contrast, CRHR2 activates intestinal stem cells and is important for gut repair. | Inhibition of corticotropin-releasing hormone receptor 1 and activation of receptor 2 protect against colonic injury and promote epithelium repair.
Li B, Lee C, Filler T, Hock A, Wu RY, Li Q, Chen S, Koike Y, Ip W, Chi L, Zani-Ruttenstock E, Määttänen P, Gonska T, Delgado-Olguin P, Zani A, Sherman PM, Pierro A., Free PMC Article | 07/20/2019 |
| In this study, mild blast-induced traumatic brain injury (mbTBI) did not alter CRFR1 gene expression in males or females. However, mbTBI disrupted CRFR2 gene expression in different limbic structures in males and females. | Sex-Dependent Effects of Mild Blast-induced Traumatic Brain Injury on Corticotropin-releasing Factor Receptor Gene Expression: Potential Link to Anxiety-like Behaviors.
Russell AL, Handa RJ, Wu TJ. | 03/9/2019 |
| the miR-34-dependent modulation of CRFR1 expression may be involved in the dorsal raphe nuclei regulation of stress-coping strategies. | MicroRNA-34 Contributes to the Stress-related Behavior and Affects 5-HT Prefrontal/GABA Amygdalar System through Regulation of Corticotropin-releasing Factor Receptor 1.
Andolina D, Di Segni M, Accoto A, Lo Iacono L, Borreca A, Ielpo D, Berretta N, Perlas E, Puglisi-Allegra S, Ventura R. | 02/9/2019 |
| Expression of Crhr1 is decreased in the pituitary gland of corticotropin-releasing hormone knock-out mice exposed to repeat stress. | The Effect of Acute and Repeated Stress on CRH-R1 and CRH-R2 mRNA Expression in Pituitaries of Wild Type and CRH Knock-Out Mice.
Klenerova V, Kvetnansky R, Hynie S. | 08/18/2018 |
| CRF-R1 expression levels were proportional to the severity of DSS-induced colitis. Activation of CRF-R1 aggravated inflammation, and inhibition of CRF-R1 ameliorates inflammation evaluated by the DAI and histological scores in the colon samples of the DSS-treated mice. | Activation of corticotropin-releasing factor receptor 1 aggravates dextran sodium sulphate-induced colitis in mice by promoting M1 macrophage polarization.
Chen H, Shi H, Liu Y, Ren X, He S, Chang X, Yin Y., Free PMC Article | 07/14/2018 |
| report a sexually dimorphic expression of CRFR1 within the rostral portion of the anteroventral periventricular nucleus of the hypothalamus | Distribution of corticotropin-releasing factor receptor 1 in the developing mouse forebrain: A novel sex difference revealed in the rostral periventricular hypothalamus.
Rosinger ZJ, Jacobskind JS, Park SG, Justice NJ, Zuloaga DG., Free PMC Article | 06/16/2018 |
| These results revealed a prominent role for CRF1 signaling in mast cells as a positive modulator of stimuli-induced degranulation. | Frontline Science: Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology.
Ayyadurai S, Gibson AJ, D'Costa S, Overman EL, Sommerville LJ, Poopal AC, Mackey E, Li Y, Moeser AJ., Free PMC Article | 12/16/2017 |