| CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma. | CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma.
Yang Y, Chen HL, Wu SF, Bao W. | 12/21/2023 |
| HSP90beta prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53. | HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53.
Fu JL, Zheng SY, Wang Y, Hu XB, Xiao Y, Wang JM, Zhang L, Wang L, Nie Q, Hou M, Bai YY, Gan YW, Liang XM, Xie LL, Li DW., Free PMC Article | 08/14/2023 |
| The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei. | The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei.
Coyne AN, Rothstein JD., Free PMC Article | 01/29/2022 |
| Up-regulation of CHMP4B alleviates microglial necroptosis induced by traumatic brain injury. | Up-regulation of CHMP4B alleviates microglial necroptosis induced by traumatic brain injury.
Zhao P, Li C, Chen B, Sun G, Chao H, Tu Y, Bao Z, Fan L, Du X, Ji J., Free PMC Article | 05/8/2021 |
| ESCRT-III controls nuclear envelope deformation induced by progerin. | ESCRT-III controls nuclear envelope deformation induced by progerin.
Arii J, Maeda F, Maruzuru Y, Koyanagi N, Kato A, Mori Y, Kawaguchi Y., Free PMC Article | 03/6/2021 |
| CHMP4B was localized to primary cilia in mammalian cells. Knockdown of CHMP4B interfered with cilium assembly and also caused fragmentation of preexisting cilia. | ESCRT subunit CHMP4B localizes to primary cilia and is required for the structural integrity of the ciliary membrane.
Jung E, Choi TI, Lee JE, Kim CH, Kim J. | 07/11/2020 |
| Data (including data from studies using transgenic mice) suggest that the process leading to microparticle release from cardiac myocytes involves recruitment of CHMP4B protein to the forming microparticle membrane which also contains cBIN1; plasma cBIN1 is reduced in patients with heart failure as compared to control subjects. (CHMP4B = charged multivesicular body protein 4B; cBIN1 = cardiac bridging integrator 1) | The ESCRT-III pathway facilitates cardiomyocyte release of cBIN1-containing microparticles.
Xu B, Fu Y, Liu Y, Agvanian S, Wirka RC, Baum R, Zhou K, Shaw RM, Hong T., Free PMC Article | 10/14/2017 |
| homologous domain of human Bro1 domain-containing proteins, Alix and Brox, binds CHMP4B but not STAM2, despite their high structural similarity | Structural Study of the HD-PTP Bro1 Domain in a Complex with the Core Region of STAM2, a Subunit of ESCRT-0.
Lee J, Oh KJ, Lee D, Kim BY, Choi JS, Ku B, Kim SJ., Free PMC Article | 07/30/2016 |
| The ESCRT-III subunit CHMP4B is a key effector in abscission, whereas its paralogue, CHMP4C, is a component in the abscission checkpoint that delays abscission until chromatin is cleared from the intercellular bridge. | ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission.
Christ L, Wenzel EM, Liestøl K, Raiborg C, Campsteijn C, Stenmark H., Free PMC Article | 07/16/2016 |
| our results implied that CHMP4B could be a promising prognostic biomarker as well as a potential therapeutic target of HCC. | High CHMP4B expression is associated with accelerated cell proliferation and resistance to doxorubicin in hepatocellular carcinoma.
Hu B, Jiang D, Chen Y, Wei L, Zhang S, Zhao F, Ni R, Lu C, Wan C. | 07/25/2015 |
| CHMP4B, through its association with chromatin, may participate in the autophagolysosomal degradation of micronuclei and other extranuclear chromatin. | Association of CHMP4B and autophagy with micronuclei: implications for cataract formation.
Sagona AP, Nezis IP, Stenmark H., Free PMC Article | 11/22/2014 |
| CHMP4B interacts directly with CC2D1A and CC2D1B with nanomolar affinity by forming a 1:1 complex. | CC2D1A is a regulator of ESCRT-III CHMP4B.
Martinelli N, Hartlieb B, Usami Y, Sabin C, Dordor A, Miguet N, Avilov SV, Ribeiro EA Jr, Göttlinger H, Weissenhorn W., Free PMC Article | 07/14/2012 |
| CC2D1A interaction with CHMP4B/4A blocks HIV-1 budding. | Regulation of CHMP4/ESCRT-III function in human immunodeficiency virus type 1 budding by CC2D1A.
Usami Y, Popov S, Weiss ER, Vriesema-Magnuson C, Calistri A, Göttlinger HG., Free PMC Article | 06/16/2012 |
| hSnf7-1 and hSnf7-2 are preferentially associated with CHMP2A and CHMP2B, respectively, and regulate the turnover of distinct transmembrane cargos such as neurotransmitter receptors in human neurons. | ESCRT-III subunits Snf7-1 and Snf7-2 differentially regulate transmembrane cargos in hESC-derived human neurons.
Lee JA, Liu L, Javier R, Kreitzer AC, Delaloy C, Gao FB., Free PMC Article | 04/21/2012 |
| The CHMP4b- and Src-docking sites in the Bro1 domain are autoinhibited in the native state of Alix. | The CHMP4b- and Src-docking sites in the Bro1 domain are autoinhibited in the native state of Alix.
Zhou X, Pan S, Sun L, Corvera J, Lee YC, Lin SH, Kuang J. | 01/21/2010 |
| The Bro1 domain of ALIX binds specifically to C-terminal residues of the human CHMP4B. | ALIX-CHMP4 interactions in the human ESCRT pathway.
McCullough J, Fisher RD, Whitby FG, Sundquist WI, Hill CP., Free PMC Article | 01/21/2010 |
| Results suggest that efficient interaction between CHMP4s and Brox requires Brox farnesylation. | Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4).
Ichioka F, Kobayashi R, Katoh K, Shibata H, Maki M. | 01/21/2010 |
| Study demonstrates that CHMP4A and CHMP4B proteins form novel membrane-attached filaments that can promote or stabilize negative curvature and outward budding. | Plasma membrane deformation by circular arrays of ESCRT-III protein filaments.
Hanson PI, Roth R, Lin Y, Heuser JE., Free PMC Article | 01/21/2010 |
| These data provide the first evidence that CHMP4B plays a vital role the maintenance of lens transparency. | CHMP4B, a novel gene for autosomal dominant cataracts linked to chromosome 20q.
Shiels A, Bennett TM, Knopf HL, Yamada K, Yoshiura K, Niikawa N, Shim S, Hanson PI., Free PMC Article | 01/21/2010 |
| CHMP4b and Alix participate in formation of multivesicular bodies by cooperating with SKD1 | The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting.
Katoh K, Shibata H, Suzuki H, Nara A, Ishidoh K, Kominami E, Yoshimori T, Maki M. | 01/21/2010 |
| ALIX can have a dramatic effect on HIV-1 release by binding at the CHMP4B site; the ability to use ALIX may allow HIV-1 to replicate in cells that express only low levels of Tsg101 | Potent rescue of human immunodeficiency virus type 1 late domain mutants by ALIX/AIP1 depends on its CHMP4 binding site.
Usami Y, Popov S, Göttlinger HG., Free PMC Article | 01/21/2010 |