| A novel CNTF-mediated mechanism in stress-induced depressive-like behavior which points to opportunities for sex-specific treatments for depression, e.g. progesterone in females and CNTF-stimulating drugs in males. | Ciliary neurotrophic factor is a key sex-specific regulator of depressive-like behavior in mice.
Jia C, Brown RW, Malone HM, Burgess KC, Gill WD, Keasey MP, Hagg T., Free PMC Article | 03/28/2020 |
| This study demonstrated that the Inhibition of astrocyte FAK-JNK signaling promotes subventricular zone neurogenesis through CNTF. | Inhibition of astrocyte FAK-JNK signaling promotes subventricular zone neurogenesis through CNTF.
Jia C, Keasey MP, Lovins C, Hagg T., Free PMC Article | 03/30/2019 |
| Rod a-wave and cone b-wave amplitudes of electroretinograms were increased in Cntf (-/-) mice, but rod b-wave amplitudes were unchanged compared with those in WT mice. Up-regulated RPE65 and LRAT levels accelerated both the visual cycle rate and recovery rate of rod light sensitivity in Cntf (-/-) mice. | Ciliary neurotrophic factor (CNTF) protects retinal cone and rod photoreceptors by suppressing excessive formation of the visual pigments.
Li S, Sato K, Gordon WC, Sendtner M, Bazan NG, Jin M., Free PMC Article | 03/9/2019 |
| CNTF activates Akt-Nrf2 signaling to protect myocardial cells from Oxygen Glucose Deprivation (OGD)/Re-Oxygenation. | Ciliary Neurotrophic Factor (CNTF) Protects Myocardial Cells from Oxygen Glucose Deprivation (OGD)/Re-Oxygenation via Activation of Akt-Nrf2 Signaling.
Zheng K, Zhang Q, Sheng Z, Li Y, Lu HH. | 01/26/2019 |
| HGF supports hindlimb motor neurons through c-Met; CNTF supports subsets of axial motor neurons through CNTFRalpha; and Artemin acts as the first survival factor for parasympathetic preganglionic motor neurons through GFRalpha3/Syndecan-3 activation. | Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons.
Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, Gentien D, de la Grange P, Haase G., Free PMC Article | 05/26/2018 |
| Study provides new insights into the role of CNTF on the migration of corneal epithelial stem/progenitor cells and its inherent mechanism of up-regulation of matrix metalloproteinases through the Akt signaling pathway. | Ciliary Neurotrophic Factor Promotes the Migration of Corneal Epithelial Stem/progenitor Cells by Up-regulation of MMPs through the Phosphorylation of Akt.
Chen J, Chen P, Backman LJ, Zhou Q, Danielson P., Free PMC Article | 04/14/2018 |
| data suggest that All-trans retinoic acid administration upregulates CNTF expression in retinal pigment epithelial cells. | All-trans retinoic acid upregulates the expression of ciliary neurotrophic factor in retinal pigment epithelial cells.
Zhou WD, Wang LL, Zhou LB, Bin W, Bao TP, Zhang Y, Shu J, Yang WX, Hui LL, Jin R, Zhuang LL, Zhou GP. | 06/24/2017 |
| Our data reveal that haematopoietic cell-derived CNTF has roles in regulating BM B cell lymphopoiesis and both trabecular and cortical bone, the latter in a sex-dependent manner. | Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure.
Askmyr M, White KE, Jovic T, King HA, Quach JM, Maluenda AC, Baker EK, Smeets MF, Walkley CR, Purton LE., Free PMC Article | 09/17/2016 |
| CNTF is upregulated in the corticospinal tract after unilateral pyramidotomy, which likely triggers sprouting of uninjured axons. | Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3.
Jin D, Liu Y, Sun F, Wang X, Liu X, He Z., Free PMC Article | 05/28/2016 |
| Results suggest that slowly up-regulated CNTF in the subventricular zone mediates stroke-induced neurogenesis and is counteracted by inflammation | Endogenous CNTF mediates stroke-induced adult CNS neurogenesis in mice.
Kang SS, Keasey MP, Arnold SA, Reid R, Geralds J, Hagg T., Free PMC Article | 11/14/2015 |
| Ciliary neurotrophic factor activation of astrocytes decreases spreading depolarization susceptibility and increases potassium clearance | Ciliary neurotrophic factor (CNTF) activation of astrocytes decreases spreading depolarization susceptibility and increases potassium clearance.
Seidel JL, Faideau M, Aiba I, Pannasch U, Escartin C, Rouach N, Bonvento G, Shuttleworth CW., Free PMC Article | 09/26/2015 |
| STAT3 can activate CNTF transcription because it bound to its promoter and FAK antagonist-induced CNTF was reduced by blocking STAT3. | Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
Keasey MP, Kang SS, Lovins C, Hagg T., Free PMC Article | 02/28/2015 |
| data indicate that muscle cells secrete abundant TIMP-1, MCP-1, and CNTF, and that of these, only CNTF has the ability to suppress osteoblast function and gene expression in a similar manner to myotube-conditioned medium | Myokines (muscle-derived cytokines and chemokines) including ciliary neurotrophic factor (CNTF) inhibit osteoblast differentiation.
Johnson RW, White JD, Walker EC, Martin TJ, Sims NA. | 02/21/2015 |
| results suggest that differentiation of distinct types of astrocytes in developing cerebellum may be regulated by ctnf and bmp2. | Cerebellar neural stem cells differentiate into two distinct types of astrocytes in response to CNTF and BMP2.
Okano-Uchida T, Naruse M, Ikezawa T, Shibasaki K, Ishizaki Y. | 05/17/2014 |
| Report intravitreal transplantations of modified neural stem cells as cell based delivery system for CNTF in mouse model of photoreceptor degeneration. | Genetically modified neural stem cells for a local and sustained delivery of neuroprotective factors to the dystrophic mouse retina.
Jung G, Sun J, Petrowitz B, Riecken K, Kruszewski K, Jankowiak W, Kunst F, Skevas C, Richard G, Fehse B, Bartsch U., Free PMC Article | 01/18/2014 |
| CNTF activates hypothalamic urocortin 1-expressing neurons both in vitro and in vivo. | The cytokine ciliary neurotrophic factor (CNTF) activates hypothalamic urocortin-expressing neurons both in vitro and in vivo.
Purser MJ, Dalvi PS, Wang ZC, Belsham DD., Free PMC Article | 11/30/2013 |
| CNTF may play a role in the process of remyelination by inducing the MOG expression. | Ciliary neurotrophic factor role in myelin oligodendrocyte glycoprotein expression in Cuprizone-induced multiple sclerosis mice.
Salehi Z, Hadiyan SP, Navidi R. | 10/19/2013 |
| Data indicate that aspirin increased mRNA and protein expression of CNTF in primary mouse and human astrocytes in a dose- and time-dependent manner. | Up-regulation of ciliary neurotrophic factor in astrocytes by aspirin: implications for remyelination in multiple sclerosis.
Modi KK, Sendtner M, Pahan K., Free PMC Article | 09/7/2013 |
| These studies demonstrate that endogenous CNTF and LIF act centrally to protect axons from acute inflammatory destruction via an oligodendrocyte-independent mechanism. | Leukemia inhibitory factor protects axons in experimental autoimmune encephalomyelitis via an oligodendrocyte-independent mechanism.
Gresle MM, Alexandrou E, Wu Q, Egan G, Jokubaitis V, Ayers M, Jonas A, Doherty W, Friedhuber A, Shaw G, Sendtner M, Emery B, Kilpatrick T, Butzkueven H., Free PMC Article | 07/20/2013 |
| Both CNTF and its receptor, CNTF-Ralpha, are expressed in skeletal muscle. | Exogenous ciliary neurotrophic factor (CNTF) reduces synaptic depression during repetitive stimulation.
Garcia N, Santafé MM, Tomàs M, Priego M, Obis T, Lanuza MA, Besalduch N, Tomàs J. | 07/13/2013 |
| study observed that CNTF increased the number of IFN-gamma producing CD4 T cells results indicate CNTF activates the same tripartite receptors in mouse and human cells | The cytokines cardiotrophin-like cytokine/cytokine-like factor-1 (CLC/CLF) and ciliary neurotrophic factor (CNTF) differ in their receptor specificities.
Tormo AJ, Letellier MC, Lissilaa R, Batraville LA, Sharma M, Ferlin W, Elson G, Crabé S, Gauchat JF. | 05/18/2013 |
| CNTF acts as a chemoattractant and participates in the recruitment of endogenous progenitors during myelin repair | Ciliary neurotrophic factor controls progenitor migration during remyelination in the adult rodent brain.
Vernerey J, Macchi M, Magalon K, Cayre M, Durbec P., Free PMC Article | 04/13/2013 |
| CNTF protects mice against streptozotocin-induced diabetes by increasing pancreatic islet survival, and this protection depends on SOCS3. In addition, SOCS3 expression and beta-cell fate are dependent on STAT1/STAT3 ratio. | Ciliary neurotrophic factor protects mice against streptozotocin-induced type 1 diabetes through SOCS3: the role of STAT1/STAT3 ratio in β-cell death.
Rezende LF, Santos GJ, Carneiro EM, Boschero AC., Free PMC Article | 02/16/2013 |
| Contact-mediated integrin signaling between neurons and astrocytes normally represses CNTF expression; neuronal dysfunction causes a rapid protective response by the brain in stroke. | Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice.
Kang SS, Keasey MP, Cai J, Hagg T., Free PMC Article | 09/22/2012 |
| results demonstrate that endogenous CNTF in the CNS is a pivotal regulator of depressive-like and anxiety-like behavior via effects on GABAergic neurons and associated serotonergic neurotransmission. | Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior.
Peruga I, Hartwig S, Merkler D, Thöne J, Hovemann B, Juckel G, Gold R, Linker RA. | 07/21/2012 |