| Chemokinergic and Dopaminergic Signalling Collaborates through the Heteromer Formed by CCR9 and Dopamine Receptor D5 Increasing the Migratory Speed of Effector CD4[+] T-Cells to Infiltrate the Colonic Mucosa. | Chemokinergic and Dopaminergic Signalling Collaborates through the Heteromer Formed by CCR9 and Dopamine Receptor D5 Increasing the Migratory Speed of Effector CD4(+) T-Cells to Infiltrate the Colonic Mucosa.
Campos J, Osorio-Barrios F, Villanelo F, Gutierrez-Maldonado SE, Vargas P, Pérez-Acle T, Pacheco R., Free PMC Article | 10/4/2024 |
| Downregulation of chemokine receptor 9 facilitates CD4[+]CD8alphaalpha[+] intraepithelial lymphocyte development. | Downregulation of chemokine receptor 9 facilitates CD4(+)CD8αα(+) intraepithelial lymphocyte development.
Ono K, Sujino T, Miyamoto K, Harada Y, Kojo S, Yoshimatsu Y, Tanemoto S, Koda Y, Zheng J, Sayama K, Koide T, Teratani T, Mikami Y, Takabayashi K, Nakamoto N, Hosoe N, London M, Ogata H, Mucida D, Taniuchi I, Kanai T., Free PMC Article | 09/1/2023 |
| CCR9 axis inhibition enhances hepatic migration of plasmacytoid DCs and protects against liver injury. | CCR9 axis inhibition enhances hepatic migration of plasmacytoid DCs and protects against liver injury.
Koda Y, Nakamoto N, Chu PS, Teratani T, Ueno A, Amiya T, Taniki N, Chiba S, Miyamoto K, Sakamoto M, Kanai T., Free PMC Article | 09/24/2022 |
| Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and alpha4beta7 Integrin and Direct Their Migration In Vitro. | Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and α4β7 Integrin and Direct Their Migration In Vitro.
Manhas KR, Marshall PA, Wagner CE, Jurutka PW, Mancenido MV, Debray HZ, Blattman JN., Free PMC Article | 03/5/2022 |
| C-C motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice. | C-C motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice.
Amiya T, Nakamoto N, Irie J, Taniki N, Chu PS, Koda Y, Miyamoto K, Yamaguchi A, Shiba S, Morikawa R, Itoh H, Kanai T. | 02/19/2022 |
| The Heteromeric Complex Formed by Dopamine Receptor D5 and CCR9 Leads the Gut Homing of CD4(+) T Cells Upon Inflammation. | The Heteromeric Complex Formed by Dopamine Receptor D(5) and CCR9 Leads the Gut Homing of CD4(+) T Cells Upon Inflammation.
Osorio-Barrios F, Navarro G, Campos J, Ugalde V, Prado C, Raïch I, Contreras F, López E, Espinoza A, Lladser A, Franco R, Pacheco R., Free PMC Article | 01/29/2022 |
| Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis. | Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis.
Morikawa R, Nakamoto N, Amiya T, Chu PS, Koda Y, Teratani T, Suzuki T, Kurebayashi Y, Ueno A, Taniki N, Miyamoto K, Yamaguchi A, Shiba S, Katayama T, Yoshida K, Takada Y, Ishihara R, Ebinuma H, Sakamoto M, Kanai T. | 01/22/2022 |
| The murine DCs transfected with DNA-plasmid encoding CCR9 demonstrate the increased migration to CCL25 and thymic cells in vitro and to the thymus in vivo. | The murine DCs transfected with DNA-plasmid encoding CCR9 demonstrate the increased migration to CCL25 and thymic cells in vitro and to the thymus in vivo.
Tereshchenko V, Bulygin A, Zavodskii R, Maksyutov A, Kurilin V, Fisher M, Semenyuk N, Aladev S, Sennikov S. | 01/22/2022 |
| Impaired CCR9/CCL25 signalling induced by inefficient dendritic cells contributes to intestinal immune imbalance in nonalcoholic steatohepatitis. | Impaired CCR9/CCL25 signalling induced by inefficient dendritic cells contributes to intestinal immune imbalance in nonalcoholic steatohepatitis.
Gao W, Wang Y, Bi J, Chen X, Li N, Wang Y, Tang H, Mao J. | 04/17/2021 |
| Toll-Like Receptor 4 Promotes Th17 Lymphocyte Infiltration Via CCL25/CCR9 in Pathogenesis of Experimental Autoimmune Encephalomyelitis. | Toll-Like Receptor 4 Promotes Th17 Lymphocyte Infiltration Via CCL25/CCR9 in Pathogenesis of Experimental Autoimmune Encephalomyelitis.
Zhang Y, Han J, Wu M, Xu L, Wang Y, Yuan W, Hua F, Fan H, Dong F, Qu X, Yao R. | 09/19/2020 |
| our observations of increased circulating CCR9+ IL-17+ Treg cells and its inverse correlation with the severity of intestinal tissue injury in NEC are novel | Interleukin-6-mediated CCR9(+) interleukin-17-producing regulatory T cells polarization increases the severity of necrotizing enterocolitis.
Ma F, Li S, Gao X, Zhou J, Zhu X, Wang D, Cai Y, Li F, Yang Q, Gu X, Ge W, Liu H, Xiao X, Hao H., Free PMC Article | 12/21/2019 |
| these results showed a site- and cell-specific expressions of Ccl25 and its receptor Ccr9 within both maternal and embryonic compartments of implantation sites and suggested a role in inducing specific Ccr9+ leukocytes at the maternal-fetal interface during the initial steps of embryo implantation in the mouse model | Chemokine (C-C motif) ligand 25 expressed by trophoblast cells and leukocytes bearing its receptor Ccr9: An alliance during embryo implantation?
Weingrill RB, Hoshida MS, Martinhago CD, Correa-Silva S, Cardoso E, Palmeira P, Marinho CRF, Bevilacqua E. | 07/14/2018 |
| Abrogation of CCR9 improved the post-myocardial infarction survival rate and left ventricular (LV) dysfunction and decreased the infarct size. The data reveal that CCR9 serves as a novel modulator of pathological progression following myocardial infarction through NF-kappaB and MAPK signaling. | Abrogation of CC chemokine receptor 9 ameliorates ventricular remodeling in mice after myocardial infarction.
Huang Y, Wang D, Wang X, Zhang Y, Liu T, Chen Y, Tang Y, Wang T, Hu D, Huang C., Free PMC Article | 05/26/2018 |
| Pressure overload-induced hypertrophy was greatly attenuated by CCR9 deficiency in cardiac-specific CCR9 knockout mice, whereas CCR9 overexpression in cardiac-specific transgenic mice strikingly enhanced cardiac hypertrophy. | C-C Motif Chemokine Receptor 9 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction.
Xu Z, Mei F, Liu H, Sun C, Zheng Z., Free PMC Article | 01/6/2018 |
| CCR9 and CCL25 expressions are induced in the early stages of airway inflammation and they have an important role modulating eosinophils and lymphocytes recruitment at the first stages of inflammatory process | CCR9 Is a Key Regulator of Early Phases of Allergic Airway Inflammation.
López-Pacheco C, Soldevila G, Du Pont G, Hernández-Pando R, García-Zepeda EA., Free PMC Article | 08/12/2017 |
| CCR9 and Integrin-beta7 expression has a differential effect on graft fate during acute graft-versus-host disease (GVHD) of the liver depending on the GVHD target tissue. | Differential Effects of Gut-Homing Molecules CC Chemokine Receptor 9 and Integrin-β7 during Acute Graft-versus-Host Disease of the Liver.
Schreder A, Moschovakis GL, Halle S, Schlue J, Lee CW, Schippers A, David S, Bernhardt G, Ganser A, Pabst O, Förster R, Koenecke C. | 08/20/2016 |
| data indicate that in addition to acting as a gut-homing molecule, CCR9 signaling shapes immune responses by inhibiting Treg cell development | Unexpected Regulatory Role of CCR9 in Regulatory T Cell Development.
Evans-Marin HL, Cao AT, Yao S, Chen F, He C, Liu H, Wu W, Gonzalez MG, Dann SM, Cong Y., Free PMC Article | 05/7/2016 |
| Data suggest that blocking CC chemokine receptor 9 (CCR9) may represent a novel safe therapy for rheumatoid arthritis (RA). | Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice.
Yokoyama W, Kohsaka H, Kaneko K, Walters M, Takayasu A, Fukuda S, Miyabe C, Miyabe Y, Love PE, Nakamoto N, Kanai T, Watanabe-Imai K, Charvat TT, Penfold ME, Jaen J, Schall TJ, Harigai M, Miyasaka N, Nanki T., Free PMC Article | 08/15/2015 |
| activation of Notch1 has a dominant-negative effect on Ccr9 transcription and that Notch1 and E proteins control the dynamic expression of Ccr9 during T cell development. | Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.
Krishnamoorthy V, Carr T, de Pooter RF, Emanuelle AO, Gounari F, Kee BL., Free PMC Article | 06/20/2015 |
| CCR9/CCL25 is involved in acute skin transplantation rejection and anti-CCL25 strategies might be useful in preventing acute rejection. | Anti-CCL25 antibody prolongs skin allograft survival by blocking CCR9 expression and impairing splenic T-cell function.
Li J, Xiong T, Xiao R, Xiong A, Chen J, Altaf E, Zheng Y, Zhu G, He Y, Tan J. | 10/26/2013 |
| Accumulated CD11b(+) macrophages are critical for activating hepatic stellate cells through the CCR9/CCL25 axis and therefore promote liver fibrosis. | C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice.
Chu PS, Nakamoto N, Ebinuma H, Usui S, Saeki K, Matsumoto A, Mikami Y, Sugiyama K, Tomita K, Kanai T, Saito H, Hibi T. | 08/31/2013 |
| CCR9-expressed plasmacytoid dendritic cells are possibly small intestine regulatory, antigen-presenting cells that suppress intestinal inflammation. | CCR9+ plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice.
Mizuno S, Kanai T, Mikami Y, Sujino T, Ono Y, Hayashi A, Handa T, Matsumoto A, Nakamoto N, Matsuoka K, Hisamatsu T, Takaishi H, Hibi T. | 02/16/2013 |
| CCR9 is required for recruitment of peritoneal macrophages in the steady state to control systemic sepsis during early phases of peritoneal infection. | CCR9+ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis.
Mizukami T, Kanai T, Mikami Y, Hayashi A, Doi T, Handa T, Matsumoto A, Jun L, Matsuoka K, Sato T, Hisamatsu T, Hibi T. | 01/26/2013 |
| Data show that chemokine receptor CCR9(-/-) knockout mice developed a chronic inflammatory response with over-expression of the cytokines and chemokines. | CCR9+ T cells contribute to the resolution of the inflammatory response in a mouse model of intestinal amoebiasis.
Rojas-López AE, Soldevila G, Meza-Pérez S, Dupont G, Ostoa-Saloma P, Wurbel MA, Ventura-Juárez J, Flores-Romo L, García-Zepeda EA. | 10/27/2012 |
| characterization of expression and thymus-expressed chemokine responsiveness of the murine thymus, spleen and mesenteric lymph node | Characterization of CCR9 expression and thymus-expressed chemokine responsiveness of the murine thymus, spleen and mesenteric lymph node.
Lee HS, Kim HR, Lee EH, Jang MH, Kim SB, Park JW, Seoh JY, Jung YJ. | 07/28/2012 |