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    CNTN1 contactin 1 [ Homo sapiens (human) ]

    Gene ID: 1272, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Key Molecules in Bladder Cancer Affect Patient Prognosis and Immunotherapy Efficacy: Further Exploration for CNTN1 and EMP1.

    Key Molecules in Bladder Cancer Affect Patient Prognosis and Immunotherapy Efficacy: Further Exploration for CNTN1 and EMP1.
    Zhou T, Chen H, Wang Y, Wen S, Dao P, Chen M.

    07/17/2023
    Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis.

    Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis.
    Fehmi J, Davies AJ, Antonelou M, Keddie S, Pikkupeura S, Querol L, Delmont E, Cortese A, Franciotta D, Persson S, Barratt J, Pepper R, Farinha F, Rahman A, Canetti D, Gilbertson JA, Rendell NB, Radunovic A, Minton T, Fuller G, Murphy SM, Carr AS, Reilly MR, Eftimov F, Wieske L, Teunissen CE, Roberts ISD, Ashman N, Salama AD, Rinaldi S., Free PMC Article

    03/16/2023
    The molecular mechanism of gamma-aminobutyric acid against AD: the role of CEBPalpha/circAPLP2/miR-671-5p in regulating CNTN1/2 expression.

    The molecular mechanism of γ-aminobutyric acid against AD: the role of CEBPα/circAPLP2/miR-671-5p in regulating CNTN1/2 expression.
    Meng N, Pan P, Hu S, Miao C, Hu Y, Wang F, Zhang J, An L.

    02/27/2023
    Neuroaxonal and Glial Markers in Patients of the Same Age With Multiple Sclerosis.

    Neuroaxonal and Glial Markers in Patients of the Same Age With Multiple Sclerosis.
    Loonstra FC, de Ruiter LRJ, Koel-Simmelink MJA, Schoonheim MM, Strijbis EMM, Moraal B, Barkhof F, Uitdehaag BMJ, Teunissen C, Killestein J., Free PMC Article

    01/14/2023
    Neurofilament-light and contactin-1 association with long-term brain atrophy in natalizumab-treated relapsing-remitting multiple sclerosis.

    Neurofilament-light and contactin-1 association with long-term brain atrophy in natalizumab-treated relapsing-remitting multiple sclerosis.
    van Lierop ZY, Noteboom S, Steenwijk MD, van Dam M, Toorop AA, van Kempen ZL, Moraal B, Barkhof F, Uitdehaag BM, Schoonheim MM, Teunissen CE, Killestein J., Free PMC Article

    11/26/2022
    MicroRNA-200c-targeted contactin 1 facilitates the replication of influenza A virus by accelerating the degradation of MAVS.

    MicroRNA-200c-targeted contactin 1 facilitates the replication of influenza A virus by accelerating the degradation of MAVS.
    Xu S, Han L, Wei Y, Zhang B, Wang Q, Liu J, Liu M, Chen Z, Wang Z, Chen H, Zhu Q., Free PMC Article

    03/5/2022
    Serum Contactin-1 in CIDP: A Cross-Sectional Study.

    Serum Contactin-1 in CIDP: A Cross-Sectional Study.
    Wieske L, Martín-Aguilar L, Fehmi J, Lleixà C, Koel-Simmelink MJA, Chatterjee M, van Lierop Z, Killestein J, Verhamme C, Querol L, Rinaldi S, Teunissen CE, Eftimov F., Free PMC Article

    03/5/2022
    Characteristics of Anti-Contactin1 Antibody-Associated Autoimmune Nodopathies With Concomitant Membranous Nephropathy.

    Characteristics of Anti-Contactin1 Antibody-Associated Autoimmune Nodopathies With Concomitant Membranous Nephropathy.
    Xu Q, Liu S, Zhang P, Wang Z, Chang X, Liu Y, Yan J, He R, Luo X, Zou LY, Chu X, Guo Y, Huang S, Fu X, Huang Y., Free PMC Article

    02/12/2022
    Contactin-1 is a novel target antigen in membranous nephropathy associated with chronic inflammatory demyelinating polyneuropathy.

    Contactin-1 is a novel target antigen in membranous nephropathy associated with chronic inflammatory demyelinating polyneuropathy.
    Le Quintrec M, Teisseyre M, Bec N, Delmont E, Szwarc I, Perrochia H, Machet MC, Chauvin A, Mavroudakis N, Taieb G, Lanfranco L, Rigothier C, José B, Concetta C, Geneste C, Pernin V, Larroque C, Devaux J, Beyze A.

    12/11/2021
    Upregulated CNTN1 is associated with lymph node metastasis and poor prognosis of colorectal cancer.

    Upregulated CNTN1 is associated with lymph node metastasis and poor prognosis of colorectal cancer.
    Li G, Zhang Z, Ge G, Fang K, Zhu J.

    10/23/2021
    Differential Expression of a Panel of Ten CNTN1-Associated Genes during Prostate Cancer Progression and the Predictive Properties of the Panel Towards Prostate Cancer Relapse.

    Differential Expression of a Panel of Ten CNTN1-Associated Genes during Prostate Cancer Progression and the Predictive Properties of the Panel Towards Prostate Cancer Relapse.
    Gu Y, Chow MJ, Kapoor A, Lin X, Mei W, Tang D., Free PMC Article

    07/24/2021
    Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson's Disease Patients and Is Present within Lewy Bodies.

    Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson's Disease Patients and Is Present within Lewy Bodies.
    Chatterjee M, van Steenoven I, Huisman E, Oosterveld L, Berendse H, van der Flier WM, Del Campo M, Lemstra AW, van de Berg WDJ, Teunissen CE., Free PMC Article

    06/19/2021
    Findings suggest that PLP1 and CNTN1 gene variations modulate specific aspects of callosal microstructure that are in line with their gene function.

    PLP1 and CNTN1 gene variation modulates the microstructure of human white matter in the corpus callosum.
    Anderson C, Gerding WM, Fraenz C, Schlüter C, Friedrich P, Raane M, Arning L, Epplen JT, Güntürkün O, Beste C, Genç E, Ocklenburg S.

    01/26/2019
    CNTN1 promotes growth, metastasis and invasion of Hs578T breast cancer cell line.

    Overexpression of Contactin 1 promotes growth, migration and invasion in Hs578T breast cancer cells.
    Chen N, He S, Geng J, Song ZJ, Han PH, Qin J, Zhao Z, Song YC, Wang HX, Dang CX., Free PMC Article

    12/22/2018
    Proteolipid protein 1 and contactin 1 gene variation modulates interhemispheric integration

    Myelin Genes and the Corpus Callosum: Proteolipid Protein 1 (PLP1) and Contactin 1 (CNTN1) Gene Variation Modulates Interhemispheric Integration.
    Ocklenburg S, Gerding WM, Arning L, Genç E, Epplen JT, Güntürkün O, Beste C.

    07/28/2018
    CNTN-1 promotes cisplatin resistance in human cisplatin-resistant lung adenocarcinoma through inducing the Epithelial-Mesenchymal Transition process by activating the PI3K/Akt signaling pathway.

    CNTN-1 Enhances Chemoresistance in Human Lung Adenocarcinoma Through Induction of Epithelial-Mesenchymal Transition by Targeting the PI3K/Akt Pathway.
    Zhang R, Sun S, Ji F, Liu C, Lin H, Xie L, Yang H, Tang W, Zhou Y, Xu J, Li P.

    11/4/2017
    CNTN1 is a new gene which can be regulated by RET/PTC3 (Ret proto-oncogene and Ret-activating protein ELE1) rearrangement gene and the protein level of CNTN1 is increasing in thyroid cancer.

    Contactin 1 as a potential biomarker promotes cell proliferation and invasion in thyroid cancer.
    Shi K, Xu D, Yang C, Wang L, Pan W, Zheng C, Fan L., Free PMC Article

    10/8/2016
    Structurally, CASPR2 is highly glycosylated and has an overall compact architecture. CASPR2 associates with micromolar affinity with CNTN1 but, under the same conditions, it does not interact with any of the other members of the contactin family.

    Structural Characterization of the Extracellular Domain of CASPR2 and Insights into Its Association with the Novel Ligand Contactin1.
    Rubio-Marrero EN, Vincelli G, Jeffries CM, Shaikh TR, Pakos IS, Ranaivoson FM, von Daake S, Demeler B, De Jaco A, Perkins G, Ellisman MH, Trewhella J, Comoletti D., Free PMC Article

    08/13/2016
    CNTN1 promotes prostate cancer progression.

    Neural Cell Adhesion Protein CNTN1 Promotes the Metastatic Progression of Prostate Cancer.
    Yan J, Ojo D, Kapoor A, Lin X, Pinthus JH, Aziz T, Bismar TA, Wei F, Wong N, De Melo J, Cutz JC, Major P, Wood G, Peng H, Tang D.

    07/30/2016
    High CNTN-1 expression is associated with metastasis in gastric cancer.

    Significances of contactin-1 expression in human gastric cancer and knockdown of contactin-1 expression inhibits invasion and metastasis of MKN45 gastric cancer cells.
    Chen DH, Yu JW, Wu JG, Wang SL, Jiang BJ., Free PMC Article

    02/20/2016
    CNTN-1 is closely related with multidrug resistance of lung adenocarcinoma.

    Increased sensitivity of human lung adenocarcinoma cells to cisplatin associated with downregulated contactin-1.
    Zhang R, Yao W, Qian P, Li Y, Jiang C, Ao Z, Qian G, Wang C, Wu G, Li J, Ji F, Xu J.

    02/13/2016
    anti-CNTN1 IgG4 antibodies are associated with subacute onset of chronic inflammatory demyelinating polyneuropathy symptoms, sensory ataxia, and good response to corticosteroids.

    Contactin 1 IgG4 associates to chronic inflammatory demyelinating polyneuropathy with sensory ataxia.
    Miura Y, Devaux JJ, Fukami Y, Manso C, Belghazi M, Wong AH, Yuki N, CNTN1-CIDP Study Group., Free PMC Article

    08/8/2015
    under hypoxia conditions, elevated HIF-1alpha seems to up-regulate contactin-1 expression and by this activate RhoA and facilitate migration of cancer cells.

    [Under hypoxia condition contactin-1 regulates migration of MKN45 cells through RhoA pathway].
    Yang G, Song JG, Li Y, Gong SP.

    05/30/2015
    activation of AKT plays a role in contactin-1-mediated downregulation of E-cadherin.

    Contactin-1 reduces E-cadherin expression via activating AKT in lung cancer.
    Yan J, Wong N, Hung C, Chen WX, Tang D., Free PMC Article

    01/11/2014
    a completely novel function for F3/Contactin - modulator of neurogenesis

    F3/Contactin acts as a modulator of neurogenesis during cerebral cortex development.
    Bizzoca A, Corsi P, Polizzi A, Pinto MF, Xenaki D, Furley AJ, Gennarini G.

    06/29/2013
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