| Novel Insights into MEG3/miR664a-3p/ADH4 Axis and Its Possible Role in Hepatocellular Carcinoma from an in Silico Perspective. | Novel Insights into MEG3/miR664a-3p/ADH4 Axis and Its Possible Role in Hepatocellular Carcinoma from an in Silico Perspective.
Karunakara SH, Puttahanumantharayappa LD, Sannappa Gowda NG, Shiragannavar VD, Santhekadur PK., Free PMC Article | 01/11/2023 |
| No significant association between SNPs in the CLOCK and ADH4 genes and susceptibility to cluster headaches: A systematic review and meta-analysis. | No significant association between SNPs in the CLOCK and ADH4 genes and susceptibility to cluster headaches: A systematic review and meta-analysis.
Cui J, Peng W, Yi T, Gao P, Zhou M, Zhu T. | 06/25/2022 |
| A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells. | A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells.
Luo J, Hou Y, Ma W, Xie M, Jin Y, Xu L, Li C, Wang Y, Chen J, Chen W, Zheng Y, Yu D. | 09/18/2021 |
| Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population. | Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.
Papasavva M, Katsarou MS, Vikelis M, Mitropoulou E, Dermitzakis EV, Papakonstantinou S, Arvaniti C, Mitsikostas DD, Gozes I, Tsatsakis AM, Drakoulis N. | 02/13/2021 |
| ADH4 expression is significantly downregulated in healthy palatal mucosa of smokers | Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes.
Wang Y, Anderson EP, Tatakis DN. | 11/18/2019 |
| Association between HCRTR2, ADH4,CLOCK gene polymorphisms and cluster headache was not significant in the present study. | Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study.
Fan Z, Hou L, Wan D, Ao R, Zhao D, Yu S., Free PMC Article | 07/14/2018 |
| this current study provides substantial evidence that genetic polymorphisms of rs3805322 in the ADH4 gene may be associated with an increased risk of developing ESCC in two Chinese Han populations. | Impact of alcohol dehydrogenase gene 4 polymorphisms on esophageal squamous cell carcinoma risk in a Chinese population.
Xu X, Wang J, Zhu SM, Yang M, Fang Y, Zhao A, Song Q, Mao W., Free PMC Article | 02/27/2016 |
| This study confirmed the genetic heterogeneity of cluster headache, suggesting that mutations in the ADH4 gene might be related to cluster headache in a subset of cases. | Molecular analysis of cluster headache.
Zarrilli F, Tomaiuolo R, Ceglia C, Lombardo B, Izzo B, Castaldo G, Pastore L, De Simone R. | 08/22/2015 |
| The serum expression of ADH4 protein correlates with the progression of esophageal cancer. | The alcohol dehydrogenase isoenzyme (ADH IV) as a candidate tumour marker of esophageal cancer.
Jelski W, Laniewska-Dunaj M, Niklinski J, Kozłowski M, Laudanski J, Szmitkowski M. | 04/26/2014 |
| common ADH variants conferred risk for both schizophrenia in African-Americans and autism in European-Americans. | Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism.
Zuo L, Wang K, Zhang XY, Pan X, Wang G, Tan Y, Zhong C, Krystal JH, State M, Zhang H, Luo X., Free PMC Article | 08/31/2013 |
| expression levels of ADH4 mRNA and protein have found to be markedly reduced in hepatocellular carcinoma (HCC) tissues and significantly associated with survival. | Identification of ADH4 as a novel and potential prognostic marker in hepatocellular carcinoma.
Wei RR, Zhang MY, Rao HL, Pu HY, Zhang HZ, Wang HY. | 07/27/2013 |
| data suggest that ADH4 intronic variants play a role in alcohol dependence susceptibility in Italian populations | ADH4 intronic variations are associated with alcohol dependence: results from an Italian case-control association study.
Turchi C, Piva F, Solito G, Principato G, Buscemi L, Tagliabracci A. | 08/18/2012 |
| Variants in the ADH1B and ADH4 genes may be protective against the development of some symptoms associated with alcohol dependence. | Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a Native American community sample.
Gizer IR, Edenberg HJ, Gilder DA, Wilhelmsen KC, Ehlers CL., Free PMC Article | 03/31/2012 |
| Our results suggest that the analysed polymorphisms ofANKK1 and ADH4 can play an important part in the pathogenesis of alcohol abuse | [Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome].
Grochans E, Grzywacz A, Małecka I, Samochowiec A, Karakiewicz B, Samochowiec J. | 02/4/2012 |
| the high catalytic activity of human alcohol dehydrogenase 4 studied with horse liver ADH1E | Origins of the high catalytic activity of human alcohol dehydrogenase 4 studied with horse liver A317C alcohol dehydrogenase.
Herdendorf TJ, Plapp BV., Free PMC Article | 08/27/2011 |
| This study confirms the significant relationship of ADH4 variants with AD and related phenotypes. | Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study.
Preuss UW, Ridinger M, Rujescu D, Samochowiec J, Fehr C, Wurst FM, Koller G, Bondy B, Wodarz N, Debniak T, Grzywacz A, Soyka M, Zill P, Preuss UW, Ridinger M, Rujescu D, Samochowiec J, Fehr C, Wurst FM, Koller G, Bondy B, Wodarz N, Debniak T, Grzywacz A, Soyka M, Zill P. | 07/23/2011 |
| Data indicate that further studies of EPHX1 rs1051740, ADH4 r1042364, and NQO1 rs291766 are needed to make more definitive conclusion on the role of variation in xenobiotic metabolism in ovarian cancer. | Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk.
Goode EL, White KL, Vierkant RA, Phelan CM, Cunningham JM, Schildkraut JM, Berchuck A, Larson MC, Fridley BL, Olson JE, Webb PM, Chen X, Beesley J, Chenevix-Trench G, Sellers TA, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group., Free PMC Article | 06/18/2011 |
| Our data suggest that cluster headache is associated with the ADH4 gene or a linked locus. Additional studies are warranted to elucidate the role of this gene in the etiopathogenesis of the disease. | Cluster headache is associated with the alcohol dehydrogenase 4 (ADH4) gene.
Rainero I, Rubino E, Gallone S, Fenoglio P, Negro E, De Martino P, Savi L, Pinessi L, Rainero I, Rubino E, Gallone S, Fenoglio P, Negro E, De Martino P, Savi L, Pinessi L. | 08/23/2010 |
| In this study we have identified a distal upstream enhancer, 4E, of ADH4. In HepG2 human hepatoma cells, 4E increased the activity of an ADH4 basal promoter by 50-fold. 4E was cell-specific. | Identification of a FOXA-dependent enhancer of human alcohol dehydrogenase 4 (ADH4).
Pochareddy S, Edenberg HJ., Free PMC Article | 06/14/2010 |
| ADH4 gene polymorphisms are associated with upper aerodigestive tract cancers. | Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population.
Oze I, Matsuo K, Suzuki T, Kawase T, Watanabe M, Hiraki A, Ito H, Hosono S, Ozawa T, Hatooka S, Yatabe Y, Hasegawa Y, Shinoda M, Kiura K, Tajima K, Tanimoto M, Tanaka H, Oze I, Matsuo K, Suzuki T, Kawase T, Watanabe M, Hiraki A, Ito H, Hosono S, Ozawa T, Hatooka S, Yatabe Y, Hasegawa Y, Shinoda M, Kiura K, Tajima K, Tanimoto M, Tanaka H. | 02/1/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population.
Oze I, Matsuo K, Suzuki T, Kawase T, Watanabe M, Hiraki A, Ito H, Hosono S, Ozawa T, Hatooka S, Yatabe Y, Hasegawa Y, Shinoda M, Kiura K, Tajima K, Tanimoto M, Tanaka H, Oze I, Matsuo K, Suzuki T, Kawase T, Watanabe M, Hiraki A, Ito H, Hosono S, Ozawa T, Hatooka S, Yatabe Y, Hasegawa Y, Shinoda M, Kiura K, Tajima K, Tanimoto M, Tanaka H. | 12/2/2009 |
| Class II alcohol dehydogenase (ADH4) is considered to contribute to ethanol oxidation in the liver at high concentration. | Polymorphisms in the promoter region of the human class II alcohol dehydrogenase (ADH4) gene affect both transcriptional activity and ethanol metabolism in Japanese subjects.
Kimura Y, Nishimura FT, Abe S, Fukunaga T, Tanii H, Saijoh K, Kimura Y, Nishimura FT, Abe S, Fukunaga T, Tanii H, Saijoh K. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (20) articlesInvestigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC. Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study.
Preuss UW, Ridinger M, Rujescu D, Samochowiec J, Fehr C, Wurst FM, Koller G, Bondy B, Wodarz N, Debniak T, Grzywacz A, Soyka M, Zill P, Preuss UW, Ridinger M, Rujescu D, Samochowiec J, Fehr C, Wurst FM, Koller G, Bondy B, Wodarz N, Debniak T, Grzywacz A, Soyka M, Zill P. A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC. Cluster headache is associated with the alcohol dehydrogenase 4 (ADH4) gene.
Rainero I, Rubino E, Gallone S, Fenoglio P, Negro E, De Martino P, Savi L, Pinessi L, Rainero I, Rubino E, Gallone S, Fenoglio P, Negro E, De Martino P, Savi L, Pinessi L. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.
Ross CJ, Katzov-Eckert H, Dubé MP, Brooks B, Rassekh SR, Barhdadi A, Feroz-Zada Y, Visscher H, Brown AM, Rieder MJ, Rogers PC, Phillips MS, Carleton BC, Hayden MR, CPNDS Consortium. Genetical genomic determinants of alcohol consumption in rats and humans.
Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL, WHO/ISBRA Study on State and Trait Markers of Alcoholism. A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women.
Zuccolo L, Fitz-Simon N, Gray R, Ring SM, Sayal K, Smith GD, Lewis SJ. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Saito A, Kawamoto M, Kamatani N. ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.
Birley AJ, James MR, Dickson PA, Montgomery GW, Heath AC, Martin NG, Whitfield JB. Polymorphisms in the promoter region of the human class II alcohol dehydrogenase (ADH4) gene affect both transcriptional activity and ethanol metabolism in Japanese subjects.
Kimura Y, Nishimura FT, Abe S, Fukunaga T, Tanii H, Saijoh K, Kimura Y, Nishimura FT, Abe S, Fukunaga T, Tanii H, Saijoh K. Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.
Macgregor S, Lind PA, Bucholz KK, Hansell NK, Madden PA, Richter MM, Montgomery GW, Martin NG, Heath AC, Whitfield JB. Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test.
Luo X, Zuo L, Kranzler HR, Wang S, Anton RF, Gelernter J. Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.
Kuo PH, Kalsi G, Prescott CA, Hodgkinson CA, Goldman D, van den Oord EJ, Alexander J, Jiang C, Sullivan PF, Patterson DG, Walsh D, Kendler KS, Riley BP. Personality traits of agreeableness and extraversion are associated with ADH4 variation.
Luo X, Kranzler HR, Zuo L, Wang S, Gelernter J, Luo X, Kranzler HR, Zuo L, Wang S, Gelernter J. ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies.
Luo X, Kranzler HR, Zuo L, Lappalainen J, Yang BZ, Gelernter J. ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies.
Luo X, Kranzler HR, Zuo L, Yang BZ, Lappalainen J, Gelernter J, Luo X, Kranzler HR, Zuo L, Yang BZ, Lappalainen J, Gelernter J. Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients.
Guindalini C, Scivoletto S, Ferreira RG, Breen G, Zilberman M, Peluso MA, Zatz M. Alcohol dehydrogenase ADH2-1 and ADH2-2 allelic isoforms in the Russian population correlate with type of alcoholic disease.
Ogurtsov PP, Garmash IV, Miandina GI, Guschin AE, Itkes AV, Moiseev VS. Alcohol dehydrogenase alleles in Parkinson's disease.
Buervenich S, Sydow O, Carmine A, Zhang Z, Anvret M, Olson L. | 03/13/2008 |
| the genotypes of six ADH4 markers were associated with alcohol dependence, and all seven ADH4 markers were associated with drug dependence | ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies.
Luo X, Kranzler HR, Zuo L, Yang BZ, Lappalainen J, Gelernter J, Luo X, Kranzler HR, Zuo L, Yang BZ, Lappalainen J, Gelernter J. | 01/21/2010 |
| that personality traits and substance dependence have a partially overlapping genetic basis. | Personality traits of agreeableness and extraversion are associated with ADH4 variation.
Luo X, Kranzler HR, Zuo L, Wang S, Gelernter J, Luo X, Kranzler HR, Zuo L, Wang S, Gelernter J., Free PMC Articles: PMC1853245, PMC1853245 | 01/21/2010 |