| Cholinergic Receptor Muscarinic 1 Co-Localized with Mitochondria in Cultured Dorsal Root Ganglion Neurons, and Its Deletion Disrupted Mitochondrial Ultrastructure in Peripheral Neurons: Implications in Alzheimer's Disease. | Cholinergic Receptor Muscarinic 1 Co-Localized with Mitochondria in Cultured Dorsal Root Ganglion Neurons, and Its Deletion Disrupted Mitochondrial Ultrastructure in Peripheral Neurons: Implications in Alzheimer's Disease.
Sabbir MG. | 03/13/2024 |
| The M1 muscarinic acetylcholine receptor regulates the surface expression of the AMPA receptor subunit GluA2 via PICK1. | The M1 muscarinic acetylcholine receptor regulates the surface expression of the AMPA receptor subunit GluA2 via PICK1.
Zhu Z, Wang W, Gu C, Wang M, Yan Y. | 01/14/2023 |
| Astrocytes Mediate Cholinergic Regulation of Adult Hippocampal Neurogenesis and Memory Through M1 Muscarinic Receptor. | Astrocytes Mediate Cholinergic Regulation of Adult Hippocampal Neurogenesis and Memory Through M(1) Muscarinic Receptor.
Li WP, Su XH, Hu NY, Hu J, Li XW, Yang JM, Gao TM. | 11/26/2022 |
| Hippocampal knockdown of alpha2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning. | Hippocampal knockdown of α2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning.
Mineur YS, Ernstsen C, Islam A, Lefoli Maibom K, Picciotto MR., Free PMC Article | 07/17/2021 |
| PKC and Ras are Involved in M1 Muscarinic Receptor-Mediated Modulation of AMPA Receptor GluA1 Subunit. | PKC and Ras are Involved in M1 Muscarinic Receptor-Mediated Modulation of AMPA Receptor GluA1 Subunit.
Chen MW, Zhu H, Xiong CH, Li JB, Zhao LX, Chen HZ, Qiu Y. | 01/2/2021 |
| Diverse glutamatergic inputs target spines expressing M1 muscarinic receptors in the basolateral amygdala: An ultrastructural analysis. | Diverse glutamatergic inputs target spines expressing M1 muscarinic receptors in the basolateral amygdala: An ultrastructural analysis.
McDonald AJ, Jones GC, Mott DD., Free PMC Article | 10/24/2020 |
| The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice. | The M(1) muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice.
Laspas P, Zhutdieva MB, Brochhausen C, Musayeva A, Zadeh JK, Pfeiffer N, Xia N, Li H, Wess J, Gericke A., Free PMC Article | 10/3/2020 |
| Biased M1 receptor-positive allosteric modulators reveal role of phospholipase D in M1-dependent rodent cortical plasticity. | Biased M(1) receptor-positive allosteric modulators reveal role of phospholipase D in M(1)-dependent rodent cortical plasticity.
Moran SP, Xiang Z, Doyle CA, Maksymetz J, Lv X, Faltin S, Fisher NM, Niswender CM, Rook JM, Lindsley CW, Conn PJ., Free PMC Article | 09/5/2020 |
| M1 Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex. M1 mAChRs dynamically modulate synaptic transmission at two prefrontal cortex inputs whose activity is necessary for fear extinction, and M1 mAChR function is required for proper contextual fear extinction. | M(1) Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex: Implications for Novel Treatments of Posttraumatic Stress Disorder.
Maksymetz J, Joffe ME, Moran SP, Stansley BJ, Li B, Temple K, Engers DW, Lawrence JJ, Lindsley CW, Conn PJ., Free PMC Article | 05/23/2020 |
| Chrm1 and Chrm3 double knockout chronically diminishes REM sleep to an almost undetectable level. These results suggest that muscarinic acetylcholine receptors, Chrm1 and Chrm3, are essential for REM sleep. | Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep.
Niwa Y, Kanda GN, Yamada RG, Shi S, Sunagawa GA, Ukai-Tadenuma M, Fujishima H, Matsumoto N, Masumoto KH, Nagano M, Kasukawa T, Galloway J, Perrin D, Shigeyoshi Y, Ukai H, Kiyonari H, Sumiyama K, Ueda HR. | 02/1/2020 |
| This study demonstrates that TRPC4 channels are involved in spontaneous and cholinergic-mediated contractions of the murine detrusor. | Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice.
Griffin CS, Thornbury KD, Hollywood MA, Sergeant GP., Free PMC Article | 10/12/2019 |
| This study revealed that almost all PV neuronal somata expressed M1R and some strocytes showed substantial M1R immunopositivity signals. | Immunolocalization of muscarinic M1 receptor in the rat medial prefrontal cortex.
Oda S, Tsuneoka Y, Yoshida S, Adachi-Akahane S, Ito M, Kuroda M, Funato H., Free PMC Article | 06/29/2019 |
| Results indicate that direct inhibition of acetylcholinesterase activity and up-regulation of m1 muscarinic acetylcholine receptor expression in the striatum might contribute to the beneficial effects of alpha-asarone on locomotor hyperactivity in Fmr1 knock out mice. | Alpha-asarone improves striatal cholinergic function and locomotor hyperactivity in Fmr1 knockout mice.
Qiu G, Chen S, Guo J, Wu J, Yi YH. | 12/16/2017 |
| The three receptor sets considered (mAChR, AR and TrkB receptors) intervene in modulating the conditions of the competition between nerve endings. | Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction.
Nadal L, Garcia N, Hurtado E, Simó A, Tomàs M, Lanuza MA, Santafé M, Tomàs J., Free PMC Article | 11/11/2017 |
| The memory deficits in mouse prion disease were completely restored by treatment with benzyl quinolone carboxylic acid (BQCA) and benzoquinazoline-12 (BQZ-12), two highly selective positive allosteric modulators (PAMs) of M1 mAChRs. Furthermore, prolonged exposure to BQCA markedly extended the lifespan of diseased mice. | M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss.
Bradley SJ, Bourgognon JM, Sanger HE, Verity N, Mogg AJ, White DJ, Butcher AJ, Moreno JA, Molloy C, Macedo-Hatch T, Edwards JM, Wess J, Pawlak R, Read DJ, Sexton PM, Broad LM, Steinert JR, Mallucci GR, Christopoulos A, Felder CC, Tobin AB., Free PMC Article | 09/9/2017 |
| Data suggest that the inositol phosphate accumulation assay has utility for the evaluation of M1 muscarinic acetylcholine receptor activators in vivo. | Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M(1) Receptor Activation.
Popiolek M, Nguyen DP, Reinhart V, Edgerton JR, Harms J, Lotarski SM, Steyn SJ, Davoren JE, Grimwood S. | 06/3/2017 |
| determining the phosphorylation status of the M1 mAChR at Ser(228) not only provides a means of establishing receptor activation following drug treatment both in vitro and in vivo but also allows for the mapping of the activation status of the M1 mAChR in the hippocampus | An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory.
Butcher AJ, Bradley SJ, Prihandoko R, Brooke SM, Mogg A, Bourgognon JM, Macedo-Hatch T, Edwards JM, Bottrill AR, Challiss RA, Broad LM, Felder CC, Tobin AB., Free PMC Article | 11/5/2016 |
| This study showed that M1 receptor knockout mice have higher noradrenaline levels than that of the wildtype mice, in parallel to a decrease in IgG producing B cells. | Deletion of muscarinic type 1 acetylcholine receptors alters splenic lymphocyte functions and splenic noradrenaline concentration.
Hainke S, Wildmann J, Del Rey A. | 09/17/2016 |
| M1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice | M1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice.
Rachakonda V, Jadeja RN, Urrunaga NH, Shah N, Ahmad D, Cheng K, Twaddell WS, Raufman JP, Khurana S., Free PMC Article | 08/20/2016 |
| High M1 muscarinic receptor expression is associated with acute liver injury. | M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury.
Urrunaga NH, Jadeja RN, Rachakonda V, Ahmad D, McLean LP, Cheng K, Shah V, Twaddell WS, Raufman JP, Khurana S., Free PMC Article | 10/3/2015 |
| This study demonistrated that Expression of m1-type muscarinic acetylcholine receptors by parvalbumin-immunoreactive neurons in the primary visual cortex | Expression of m1-type muscarinic acetylcholine receptors by parvalbumin-immunoreactive neurons in the primary visual cortex: a comparative study of rat, guinea pig, ferret, macaque, and human.
Disney AA, Reynolds JH., Free PMC Article | 10/11/2014 |
| The mm (chi(1) congruent with -60 degrees ; chi(2) congruent with -60 degrees ) and tp (chi(1) congruent with 180 degrees ; chi(2) congruent with +60 degrees ) rotamers were identified as the likely conduction-catalyzing conformations of the AChR's selectivity-filter glutamates. | Side-chain conformation at the selectivity filter shapes the permeation free-energy landscape of an ion channel.
Harpole TJ, Grosman C., Free PMC Article | 10/4/2014 |
| the M3 receptor has a pro-inflammatory role in cigarette smoke-induced neutrophilia and cytokine release, yet M1 and M2 receptors have an anti-inflammatory role | Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice.
Kistemaker LE, Bos IS, Hylkema MN, Nawijn MC, Hiemstra PS, Wess J, Meurs H, Kerstjens HA, Gosens R. | 08/16/2014 |
| The results of this study suggested that M1-muscarinic receptors promote fear memory consolidation via phospholipase C and the M-current. | M1-muscarinic receptors promote fear memory consolidation via phospholipase C and the M-current.
Young MB, Thomas SA., Free PMC Article | 04/5/2014 |
| mAChRs in mouse colonic epithelial cells consist of two subtypes, M1 (80 %) and M3 (20 %); The M1 subtype was likely to regulate epithelial chloride secretion negatively and was susceptible to inflammation | M1 is a major subtype of muscarinic acetylcholine receptors on mouse colonic epithelial cells.
Khan MR, Anisuzzaman AS, Semba S, Ma Y, Uwada J, Hayashi H, Suzuki Y, Takano T, Ikeuchi H, Uchino M, Maemoto A, Ushikubi F, Muramatsu I, Taniguchi T. | 03/22/2014 |